Vollständiger Abstract
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ABSTRACT Severe congenital protein C (PC) deficiency is a rare inherited coagulation disorder that can be difficult to control with conventional medical treatment alone. We report a single‐center case series of three pediatric patients with severe congenital PC deficiency who underwent liver transplantation (LT). In all patients, plasma PC activity levels exceeded 64% after LT and remained stable without anticoagulation treatment or PC supplementation. Two patients were followed for more than 10 years, representing the longest reported outcomes to date. Stable anticoagulant function persisted despite rejection, graft dysfunction, and subsequent surgery, demonstrating durable restoration of physiological anticoagulant function after LT.
Bibliografischer Nachweis
Publikationsdaten
- Autor:innen
- Kotaro Sakaya, Akira Ishiguro, Atsushi Sakamoto, Shouichi Ohga, Akinari Fukuda, Seisuke Sakamoto, Mureo Kasahara
- Quelle
- Pediatric Blood & Cancer
- Publikation
- 2026-01-01
- Band / Ausgabe
- Nicht angegeben
- Seiten
- Nicht angegeben
- ISSN / ISBN
- 1545-5009, 1545-5017
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Zitierfähiger Nachweis
Kotaro Sakaya, Akira Ishiguro, Atsushi Sakamoto, Shouichi Ohga, Akinari Fukuda, Seisuke Sakamoto, Mureo Kasahara (2026). Long‐Term Restoration of Anticoagulant Function After Liver Transplantation for Severe Congenital Protein C Deficiency: A Single‐Center Experience Involving Three Pediatric Patients. Pediatric Blood & Cancer. https://doi.org/10.1002/1545-5017.70646
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