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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

Frontiers in Medicine

Efficacy and safety of 2 Hz versus 100 Hz electroacupuncture for pain-dominant shoulder periarthritis: a study protocol for a single-center randomized controlled trial

Chengyu Liu, Shiwei Zhuang, Yi Shang, Xiangzhen Miao, Hongfeng Wang, Bing Yan

Background Pain-dominant shoulder periarthritis is characterized by shoulder pain, restricted range of motion (ROM), and impaired daily function. Electroacupuncture (EA) is a controllable acupuncture modality used for shoulder pain disorders; however, direct evidence comparing 2 Hz and 100 Hz EA in this disease stage remains limited. Objective This study aims to compare the efficacy and safety of low-frequency EA (2 Hz) and high-frequency EA (100 Hz) for pain-dominant shoulder periarthritis. Methods This is a singl …

27.08.2026journal-article

Frontiers in Immunology

Immunotherapy-based salvage therapy in advanced soft tissue sarcoma after first-line chemotherapy: a retrospective single-center analysis with emphasis on undifferentiated pleomorphic sarcoma

Zhichao Liao, Junbo Huang, Haotian Liu, Chao Zhang, Ting Li, Hongyu Wang, Yuanxin Liu, Sijia Ren, Zhiwu Ren, Haixiao Wu, Ruwei Xing, Sheng Teng, Jun Zhao, Wanyi Xiao, Gengpu Zhang, Yun Yang, Jilong Yang

Introduction Soft tissue sarcomas (STS) are rare mesenchymal malignancies with limited treatment options in advanced stages. Anthracycline-based chemotherapy remains the standard of care but yields modest outcomes with significant toxicity, underscoring the need for more effective strategies. Methods We retrospectively analyzed 56 patients with advanced STS who received PD-1 inhibitor-based therapy at Tianjin Medical University Cancer Institute and Hospital between January 2021 and January 2026. Treatment regimens …

27.08.2026journal-article

Frontiers in Aging

Grip strength as a systems biomarker of aging: neuromuscular junction constraints and biomarker decoupling in gene therapy

Patrick E. Sewell, Christopher Jensen

Grip strength has emerged as one of the most robust predictors of mortality, disability and healthspan across populations. Yet its predictive validity rests on an often-unstated assumption: that grip strength serves as a passive readout of systemic biological integrity rather than an isolated measure of forearm function. Here we propose that grip strength derives its prognostic power from its position as a convergent output of multiple aging-sensitive physiological systems—including neuromuscular, vascular, metabol …

27.08.2026journal-article

Frontiers in Pain Research

Exploring the associations of cortical connectivity-modulation with clinical and psychological measures in acute low back pain

Sabina Hotz-Boendermaker, Bart Boendermaker, Roman Buechler, Lars Michels

Background Low back pain (LBP) represents a significant global health burden. Transitioning from the traditional “self-limiting” perspective, emerging evidence suggests that neural plasticity and central maladaptation in the acute phase are pivotal in the progression to chronicity. Objectives This study investigated whole-brain functional connectivity and sensorimotor processing during acute LBP. Methods Thirteen participants with acute LBP (<4 weeks duration) underwent clinical, psychometric, and functional mag …

27.08.2026journal-article

International Journal of Molecular Sciences

Hypokalemic Hypochloremic Metabolic Alkalosis in Cystic Fibrosis: A Retrospective Observational Study with Clinical Characterization, CFTR Genetic Profiling, and a Comparative Genetic Analysis with Patients from a Brazilian Reference Center

Andressa Oliveira Peixoto, Larissa Ferreira Selicani, Camila Bento Safi, Daniela Souza Paiva Borgli, Adyléia Aparecida Dalbo Contrera Toro, Nathália Mariana Santos Sansone, Andrea de Melo Alexandre Fraga, Fernando Augusto Lima Marson, José Dirceu Ribeiro

Cystic fibrosis is a genetic disorder caused by pathogenic variants in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene and may be complicated by hypokalemic hypochloremic metabolic alkalosis (HHMA), resulting from excessive electrolyte loss through sweat. This retrospective study aimed to clinically characterize individuals with cystic fibrosis who developed HHMA, characterize their CFTR genetic profile and compare it with that of other individuals with cystic fibrosis followed at a Brazilian te …

27.08.2026journal-article

Frontiers in Medicine

Focusing on persistent hypoxemia during VV-ECMO secondary to traumatic tricuspid valve injury: a case report

Yunpeng Zhao, Jing Liu, Kun Chen

Background Veno-venous extracorporeal membrane oxygenation (VV-ECMO) is a life-saving salvage therapy for treating severe respiratory failure. We present a case of trauma-related hypoxemia with severe tricuspid chordae tendinae rupture managed with VV-ECMO. Case presentation We report the successful use of VV-ECMO in a 29-year-old patient with severe acute respiratory distress syndrome (ARDS). Refractory hypoxemia persisted despite maximal conventional therapy during the course of treatment at the outside hospital. …

27.08.2026journal-article

AIDS Research and Therapy

Long-term survival analysis of HIV patients receiving antiretroviral treatment in Congo: a 14-year retrospective analysis, 2003–2017

Gilbert Ndziessi, Ange Clauvel Niama, Arkadit Jeandria Nkodia, Merlin Diafouka

Abstract Background Long-term survival of people living with HIV (PLHIV) on antiretroviral therapy (ART) is poorly documented in the Republic of Congo. Methods We conducted a retrospective cohort study of 2,309 adults initiating ART between 2003 and 2017. Survival was estimated using the Kaplan-Meier method, and determinants were assessed using Cox regression. Results The median age of participants was 49 years (IQR 42–57), and women represented 68.6% of the cohort. The 14-year overall survival probability was 83% …

27.08.2026journal-article

Health Research Journal of Indonesia

Pengaruh Edukasi VIDSION (Video and Simulation) Terhadap Pengetahuan dan Keterampilan Ibu Dalam Penanganan Tersedak Balita

Nabella Ayu Dwi Jayanti, Isni Lailatul Maghfiroh, Aprelia Afidatul Hanafi

Pendahuluan: Tersedak merupakan kondisi kegawatdaruratan pada balita yang dapat menyebabkan kematian apabila tidak ditangani secara cepat dan tepat. Rendahnya pengetahuan dan keterampilan ibu dalam memberikan pertolongan pertama memerlukan edukasi yang efektif. Tujuan: Penelitian ini bertujuan mengetahui pengaruh edukasi VIDSION (Video and Simulation) terhadap pengetahuan dan keterampilan ibu dalam penanganan tersedak pada balita. Metode: Penelitian ini menggunakan desain quasi-experimental dengan pendekatan one-gr …

27.08.2026journal-article

IIARD International Journal of Banking and Finance Research

Initial Public Offering Timing and Equity Puzzles in Nigeria Capital Market: Evidence from Quoted Small and Medium Scale Enterprises

Hachituru TRIUMPH

The study empirically examines initial public offering and the equity puzzle of quoted small and medium scale enterprises in the Nigerian Capital Market for a period of 3 years from 2022-2024. The equity prices variation in the Nigerian Stock Market and the Nigerian Treasury Bill Rate were used to ascertain the existence or otherwise of equity risk premium puzzle. The equity prices variation was measured as the log of current price index as a ratio of lagged price index of quoted small and medium scale enterprises. …

27.08.2026journal-article

Pigment International

The divergent management of melasma: a 2026 clinical review comparing traditional standards in lighter photo types to novel athermal and biological modalities in Fitzpatrick IV–VI

Dalitso Namutowe, Yun Xu, Jin Gong

Melasma (historically chloasma) remains a complex, recalcitrant pigmentary disorder affecting millions worldwide. This article elucidates the paradigm shift in management strategies observed in early 2026 for Fitzpatrick III-VI, its comparison with Fitzpatrick I–III, and the transition from aggressive mono-therapies to a multi-layered, synergistic approach. To locate, select, and extract relevant data, a comprehensive search of recent clinical protocols and emerging technological studies was conducted. This literat …

27.08.2026journal-article

Nursing Edição Brasileira

Disfunção do Eixo Hipotálamo-hipófise-adrenal em Transtornos de Ansiedade: Evidências Clínicas e Pré-clínicas

Gustavo Leonel Rios Braga, Karoline Louise Rocha Soares, Liliana Malaman Brollo, Rafaela Guimarães de Souza

O presente estudo consiste em uma revisão sistemática da literatura acerca da disfunção do eixo hipotálamo-hipófise-adrenal (HHA) em transtornos de ansiedade. O eixo HHA é o principal sistema neuroendócrino de resposta ao estresse, e sua desregulação é frequentemente associada à fisiopatologia de quadros ansiosos. Através da análise de dados clínicos e pré-clínicos, investigou-se como o desequilíbrio na secreção de glicocorticoides e na sensibilidade dos receptores de cortisol contribui para a cronicidade e a gravi …

27.08.2026journal-article

Research in Veterinary Science and Medicine

Effects of Room Temperature Storage Duration on the Quality of Cauda Epididymal Spermatozoa Recovered from Red Sokoto Bucks

Linda Ijeoma Okoro, Philip Makama Dawuda, Gbemi Olatunde Fanaiye, Hope Mhohe Agama, Mlumun Love Ayila

Objectives: The conservation of valuable genetic resources in livestock is essential for sustainable breeding programs, particularly when superior breeding males die unexpectedly before semen collection. This study evaluated the quality of cauda epididymal spermatozoa recovered from Red Sokoto Bucks immediately after slaughter and following storage of testes-epididymides at room temperature. Material and Methods: Forty pairs of testes-epididymides were collected from apparently healthy mature Red Sokoto Bucks and r …

27.08.2026journal-article

Health, sport, rehabilitation

Differentiating playing roles in professional Counter-Strike 2 by performance indicators: an observational study

Volodymyr Paskiv, Igor Zanevskyy, Volodymyr Koman

Background and purpose. In professional Counter-Strike 2 a single composite rating still carries most of the weight in judging players, even though the game grants no mechanical class asymmetry, so playing roles arise as a codified yet largely unexamined division of labour. We therefore asked whether those roles can be recovered from the standard per-round indicators, and how their differentiation is organised. Material and methods. Under a single twelve-month filter we drew thirty-nine per-round indicators for 105 …

27.08.2026journal-article

Cancer Research

Allele-Specific Mechanisms Guide Salvage Therapy to Overcome Daraxonrasib Resistance in Pancreatic Cancer

Daniel Dorbin, Juliannie Herrera, Raven Davidson, Naveen Kumar Chandrashekar, Gabrielle Scheuber, Priyanga Jayakrishnan, Christabelle Rajesh, Grayson Johnson, Jason Yuan, Matthew A. Sochor, John F. Langenheim, Mohammed Aldakkak, Charles Messerly, Jacquelyn Wittmann, Aniko Szabo, Forough Azam Sayahpour, Nathan L. Atallah, Francis C. Peterson, Brian F. Volkman, Mahmoud Ali, Eugene Ke, Douglas B. Evans, Susan Tsai, Nikki K. Lytle, Y. David Seo, Razelle Kurzrock, G. Aaron Hobbs, Mandana Kamgar, Thomas McFall

Abstract Clinical-grade RAS inhibitors raise an unresolved question as to whether KRAS alleles impose constraints on adaptive resistance that can be exploited therapeutically. Using daraxonrasib (RMC-6236), a multi-selective RAS(ON) inhibitor, we compared resistance mechanisms between KRASG12D and KRASG12R, mutants with fundamentally different RAS network dynamics. Daraxonrasib inhibited KRASMUT primarily through steric occlusion of effector binding, while engaging RASWT only modestly (~20%). KRASG12R was marked by …

27.08.2026journal-article

JAMA Ophthalmology

Digital Defocus Vision Training Using Virtual Reality for Myopia Control

Jing Zhong, Yu Liu, Tianli Peng, Jing Ma, Ziting Huang, Xiao Yang, Shi-Ming Li, Jin Yuan

Importance Virtual reality–based digital defocus vision training (DDVT) may offer a home-based strategy to slow myopia progression in children, but evidence is limited. Objective To evaluate efficacy and safety of a head-mounted virtual reality–based DDVT system on myopia progression. Design, Setting, and Participants This randomized clinical trial was conducted among children aged 6 to 12 years with myopia enrolled in July 2024, with follow-up completed in September 2025. The trial was conducted at a single center …

27.08.2026journal-article

Journal of Clinical Medicine

Drug-Induced Sleep Endoscopy in Pediatric Obstructive Sleep Apnea: Clinical Applications, Classification Systems, and Anesthetic Considerations

Patryk Oskar Manycz, Monika Morawska-Kochman, Jakub Zieliński

Background/Objectives: Drug-induced sleep endoscopy (DISE) enables dynamic, real-time visualization of the level, severity, and configuration of upper airway collapse during pharmacologically induced sleep, providing anatomical information that polysomnography cannot. It is increasingly used to guide individualized surgical planning in obstructive sleep apnea (OSA), particularly in children with persistent OSA after adenotonsillectomy or at elevated risk of surgical failure. However, the absence of a universally ac …

27.08.2026journal-article

Bioengineering

Preliminary Clinical Outcomes of an Alternating-Current-Assisted Implant Surface Decontamination Protocol: A Prospective Case Series with 12-Month Follow-Up

Dorian Kostandini, Antonella Mattei, Giovanni Falisi, Arianna Viarchi, Davide Gerardi, Angelo Bruni, Edra Qorri, Lia A. Hoz-Rodriguez, Eduardo Basañes Rivera, Sofia Rastelli, Roberto Gatto, Marco Severino, Gianluca Botticelli

Background: Treatment of peri-implantitis remains challenging because biofilm removal from microstructured implant surfaces is often incomplete. The present study is an uncontrolled, prospective feasibility case series involving six patients (six implants), not a controlled clinical trial, in which short-term clinical outcomes following use of a multimodal protocol to decontaminate the titanium implant surface were obtained; consequently, the independent contribution of the Ximplant® device to the observed outcomes …

27.08.2026journal-article

International Journal of Molecular Sciences

Macrophages as Drivers of Resistance to Dabrafenib Plus Trametinib Therapy in Anaplastic Thyroid Cancer

Ricardo Rodrigues, Beatriz Garcia, Miguel Rito, Rúben Roque, Teresa Pereira, Sónia Morgado, Vanessa Tavares, Tiago Nunes da Silva, Valeriano Leite, Branca Maria Cavaco

Anaplastic thyroid carcinoma (ATC) is an aggressive malignancy with poor response to standard therapies. While Dabrafenib plus Trametinib (DT) combination therapy has improved the survival of patients with BRAF-mutant ATC, resistance remains a challenge. Given the association of macrophages with poor prognosis, and that SPRY4 has emerged as a mediator in ATC–macrophage interactions, we investigated their role in DT resistance and evaluated the therapeutic potential of macrophage targeting. Transwell co-cultures of …

27.08.2026journal-article

Borneo Nursing Journal (BNJ)

Hubungan Pengetahuan Ibu Nifas Tentang Asupan Nutrisi Dengan Produksi ASI Di Wilayah Puskesmas Sukorame Kota Kediri

Agshely Wahyu Wulan Kusuma, Rahajeng Siti Nur Rahmawati, Ririn Indriani, Sunny Dwi Antono

Produksi ASI yang optimal dipengaruhi oleh asupan nutrisi ibu selama masa nifas, namun capaian ASIeksklusif di Puskesmas Sukorame Kota Kediri menurun dan belum mencapai target nasional.Pengetahuan ibu tentang asupan nutrisi berperan penting dalam mendukung kelancaran produksi ASI.Penelitian ini bertujuan menganalisis hubungan pengetahuan ibu nifas tentang asupan nutrisi denganproduksi ASI. Penelitian kuantitatif dengan pendekatan cross sectional dilaksanakan di wilayah kerjaPuskesmas Sukorame Kota Kediri dengan sam …

27.08.2026journal-article

Brazilian Journal of Implantology and Health Sciences

Desafio Diagnóstico e Conduta Cirúrgica em Lesão de Assoalho Bucal: Relato de Caso com Divergência Clínico-Patológica

Davi Barbosa Portela, Helóisa De Colo, Maria Clara Fernandes, Cristiane Elisa Ribas, Alissa Dos Santos Coelho, Eugenio Esteves Costa

Introdução: A rânula é uma lesão cística de extravasamento ou retenção de muco que acomete o assoalho bucal, intimamente relacionada à glândula sublingual. Seu diagnóstico é primariamente clínico, fundamentado em características como coloração azulada, flutuação e localização anatômica. O tratamento varia desde a micromarsupialização até a exérese da glândula sublingual. Objetivos: Relatar um caso clínico de lesão em assoalho bucal com hipótese diagnóstica de rânula, submetida à marsupialização com dreno, destacand …

27.08.2026journal-article

Frontiers in Surgery

Laryngeal transplantation: from experimental feasibility to multidisciplinary clinical reality

Lu Zeng, Longhao Wang

Laryngeal transplantation represents one of the most complex forms of vascularized composite allotransplantation (VCA), aiming to restore respiration, phonation, and swallowing in patients with irreversible laryngeal dysfunction. Over the past decades, systematic preclinical research—including refinement of large-animal and rodent models, organ preservation optimization, and elucidation of immunological mechanisms—has laid the scientific foundation for clinical translation. Advances in static cold storage, emerging …

27.08.2026journal-article

Clinical Science

Maternal gut microbiota–psychotropic drug interactions and their impact on offspring neurodevelopment

Ashlee M. Craig, Kelly J. Clemens, Sarah-Jane Leigh

Abstract Pregnancy is associated with a unique and dynamic gut microbiota profile that supports fetal growth and neurodevelopment. Psychotropic drug–gut microbiota interactions are documented in the general population, yet less well described in pregnant women. Research has independently linked both perinatal psychotropic exposure and alterations to the maternal gut microbiome with potential changes to offspring neurodevelopment; therefore, it is plausible that similar interactions occur during pregnancy where they …

27.08.2026journal-article

Australian Health Review

Concordance of surveillance colonoscopy recommended intervals with Australian guidelines: a clinical audit in six Victorian public hospitals

Jonathan Foo, Corey Joseph, Alexandra Gorelik, Martin Hensher, Harriet Hiscock, Alison Hutchinson, Karin A. Thursky, Ralph Audehm, Andrew O'Loughlin, Grant Russell, Alan Moss, Elizabeth Hristov, Kumanan Nalankilli, Radha Nair, Anne Van Berkel, Sophie Ping, Jaclyn Bishop, Judi Debney, Kirsten Carr, Julianne Schultz, Denise A. O'Connor

Objective Appropriate intervals for repeat (surveillance) colonoscopy are important for early colorectal cancer detection and treatment, timely patient access, and minimising patient risks. This study aimed to assess the concordance of endoscopist-recommended surveillance colonoscopy intervals with those recommended by the 2018 Australian Cancer Council surveillance colonoscopy guidelines. Methods Three metropolitan and three rural public hospitals in Victoria, Australia, each retrospectively audited at least 35 co …

27.08.2026journal-article

Renal Replacement Therapy

Suspected heparin-resistant contact activation during membrane-based therapeutic plasma exchange: a case report

Atsuto Niwa, Sanae Kikuchi, Yuki Nakai, Ayumi Tomoi, Akinori Kitamura, Jun Matsuoka, Norihiko Tanimoto, Miyuki Nakano, Yoshiki Okuno, Mitsuaki Oki, Shinpei Nogami, Masaomi Sato, Yoshihiro Taniyama, Kentaro Hayashida

Abstract Background Therapeutic plasma exchange (TPE) is recommended for steroid-refractory acute optic neuritis associated with aquaporin-4 (AQP4)-IgG-positive neuromyelitis optica spectrum disorder. However, clotting-related events in the extracorporeal circuit can interrupt treatment and jeopardize timely completion of the planned TPE course. Case presentation A 42-year-old woman presented with rapidly progressive bilateral optic neuritis, with no light perception in the right eye and finger count vision in the …