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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

Cancers

Trends in Treatment and Survival Among Patients with Glioblastoma in the United States from 2000 to 2020

Jianan Chen, Catherine M. Boldig, Qiong Wu, Hannah M. Cardenas, Kaitlyn N. Bernard, Kwadwo Darko, Patrick T. Grogan, Yu Sun, Robert J. Macaulay, Ekokobe Fonkem, Arnold B. Etame

Background: Population-level patterns in the real-world use of initial treatment combinations for glioblastoma (GBM) remain poorly characterized. Materials and Methods: We assessed temporal trends in treatment and survival among patients with GBM in the SEER registry. Guideline-concordant multimodal therapy was defined as cancer-directed surgery combined with radiotherapy and chemotherapy. Outcomes were further stratified by extent of resection, including gross total resection (GTR) versus subtotal resection. Resul …

27.08.2026journal-article

AIDS Research and Therapy

Long-term survival analysis of HIV patients receiving antiretroviral treatment in Congo: a 14-year retrospective analysis, 2003–2017

Gilbert Ndziessi, Ange Clauvel Niama, Arkadit Jeandria Nkodia, Merlin Diafouka

Abstract Background Long-term survival of people living with HIV (PLHIV) on antiretroviral therapy (ART) is poorly documented in the Republic of Congo. Methods We conducted a retrospective cohort study of 2,309 adults initiating ART between 2003 and 2017. Survival was estimated using the Kaplan-Meier method, and determinants were assessed using Cox regression. Results The median age of participants was 49 years (IQR 42–57), and women represented 68.6% of the cohort. The 14-year overall survival probability was 83% …

27.08.2026journal-article

Neuro-Oncology

79 Diagnostic Utility of DNA Methylation Profiling in CNS Tumors: A Comparative Study of FFPE and Fresh-Frozen Tissues

Jyotsna Singh, Shabnam Mansoori, Ashish Suri, Vaishali Suri

Abstract Introduction DNA methylation–based classification has become an essential adjunct to histopathology in central nervous system (CNS) tumor diagnostics. Although both fresh-frozen and formalin-fixed paraffin-embedded (FFPE) tissues are used for methylation profiling, comparative real-world data on their diagnostic performance remain limited. Methods We analysed 179 CNS tissue samples (162 tumors, 17 non-neoplastic controls), comprising 42 FFPE and 137 fresh-frozen specimens, all with ≥50% tumor cellularity. …

27.08.2026journal-article

Neuro-Oncology

46 Anti-tumour immune responses in melanoma brain metastases require cDC1 population and the extracranial tumour

Dario Guglietta, Alca Revalova, Fiona James, Christopher Fife, Jennifer Williams, William Brackenbury, Sukhveer Kaur Mann, Karen Hogg, Tsuneyasu Kaisho, Andrew MacDonald, Mihaela Lorger

Abstract Introduction Brain metastases (BrM) are associated with poor prognosis, partially due to the specialized immune-microenvironment in the brain. Our previous study demonstrated that intracranial tumours alone are poorly immunogenic, but simultaneous presence of a subcutaneous tumour, mimicking the extracranial disease observed in patients, greatly enhances immune checkpoint blockade efficacy. Here we aim to elucidate the role of conventional dendritic cells type 1 (cDC1) in anti-tumour immune responses in Br …

27.08.2026journal-article

Cancer Research

Allele-Specific Mechanisms Guide Salvage Therapy to Overcome Daraxonrasib Resistance in Pancreatic Cancer

Daniel Dorbin, Juliannie Herrera, Raven Davidson, Naveen Kumar Chandrashekar, Gabrielle Scheuber, Priyanga Jayakrishnan, Christabelle Rajesh, Grayson Johnson, Jason Yuan, Matthew A. Sochor, John F. Langenheim, Mohammed Aldakkak, Charles Messerly, Jacquelyn Wittmann, Aniko Szabo, Forough Azam Sayahpour, Nathan L. Atallah, Francis C. Peterson, Brian F. Volkman, Mahmoud Ali, Eugene Ke, Douglas B. Evans, Susan Tsai, Nikki K. Lytle, Y. David Seo, Razelle Kurzrock, G. Aaron Hobbs, Mandana Kamgar, Thomas McFall

Abstract Clinical-grade RAS inhibitors raise an unresolved question as to whether KRAS alleles impose constraints on adaptive resistance that can be exploited therapeutically. Using daraxonrasib (RMC-6236), a multi-selective RAS(ON) inhibitor, we compared resistance mechanisms between KRASG12D and KRASG12R, mutants with fundamentally different RAS network dynamics. Daraxonrasib inhibited KRASMUT primarily through steric occlusion of effector binding, while engaging RASWT only modestly (~20%). KRASG12R was marked by …

27.08.2026journal-article

International Journal of Molecular Sciences

Macrophages as Drivers of Resistance to Dabrafenib Plus Trametinib Therapy in Anaplastic Thyroid Cancer

Ricardo Rodrigues, Beatriz Garcia, Miguel Rito, Rúben Roque, Teresa Pereira, Sónia Morgado, Vanessa Tavares, Tiago Nunes da Silva, Valeriano Leite, Branca Maria Cavaco

Anaplastic thyroid carcinoma (ATC) is an aggressive malignancy with poor response to standard therapies. While Dabrafenib plus Trametinib (DT) combination therapy has improved the survival of patients with BRAF-mutant ATC, resistance remains a challenge. Given the association of macrophages with poor prognosis, and that SPRY4 has emerged as a mediator in ATC–macrophage interactions, we investigated their role in DT resistance and evaluated the therapeutic potential of macrophage targeting. Transwell co-cultures of …

27.08.2026journal-article

The Canadian Journal of Chemical Engineering

A target‐adaptive latent‐temporal ensemble soft sensor for robust multi‐effluent quality prediction in full‐scale wastewater treatment plants

Toqeer Ahmed, Abid Aman, Zhenjun Ge, Yiqi Liu

Abstract Real‐time prediction of effluent quality is essential for stable wastewater treatment plant (WWTP) operation, but direct laboratory measurements of chemical oxygen demand (CODe), total nitrogen (TNe), and total phosphorus (TPe) are often delayed and discontinuous. This study proposes a target‐adaptive latent‐temporal ensemble soft‐sensing framework, named the hybrid latent‐temporal ensemble network (HEM‐Net), for simultaneous multi‐effluent quality prediction in a full‐scale wastewater treatment plant. The …

27.08.2026journal-article

Neuro-Oncology

47 Exploring the need for more biologically relevant models to assess migration across the Blood-Brain Barrier

Sofie Edwards, Aoife Hurrell, Sally Prior, Jessica Senior, Anke Brüning-Richardson

Abstract Introduction In vitro Blood-brain barrier (BBB) models are difficult to recapitulate due to the difficulty in representing the diverse BBB environment. The BBB consists of different cell types such as endothelial cells, astrocytes and pericytes, each of which play a crucial role in maintaining the BBB, however, this can be problematic in management of disorders such as Glioblastoma (GBM), due to low permeability. Advanced BBB models are therefore required for enhanced drug delivery with minimal disruption. …

27.08.2026journal-article

Neuro-Oncology

76 Metabolic Heterogeneity in Brain Tumours: Distinguishing Brain Metastases from Glioblastomas

Ishana Rajgopal, Bryan Marzullo, Sana Manan, Victoria Wykes, Daniel Tennant

Abstract Introduction Brain metastases account for nearly 20% of cancer-related deaths and have a five-year survival rate of 2.4%, most commonly arising from breast and lung cancers. Despite therapeutic advances, prognosis remains poor, highlighting the need for novel treatment strategies. Metabolic reprogramming is a hallmark of cancer, reflecting the ability of malignant cells to remodel metabolic pathways to support invasion, proliferation, and survival. The brain microenvironment is metabolically distinct, char …

27.08.2026journal-article

Neuro-Oncology

74 Development and evaluation of a personalised prognostic prediction model for overall survival in patients with glioblastoma using machine-learning methods

Alina Morozova, Elizabeth Ford, Giles Critchley, Frances Pearl, Stephen Robinson, Histo-Mol GBM Collaborative

Abstract Introduction Glioblastoma has substantial variation in survival according to treatment, with a recent population-based study reporting median overall survival (OS) ∼7 months, increasing to 16 months among patients receiving multimodal treatment. However, only 29% of patients received multimodality therapy, while 21% received no oncological treatment. Using the Histo-Mol GBM dataset a prognostic modelling framework was developed to predict individualised, time-dependent survival probability curves up to 50 …

27.08.2026journal-article

Asia-Pacific Journal of Clinical Oncology

Advancing Homologous Recombination Repair Mutation Testing in Prostate Cancer in Australia: Shifting the Focus to Hormone Sensitive Prostate Cancer

Arun A. Azad, Declan G. Murphy, Edmond M. Kwan, Anthony M. Joshua

ABSTRACT Homologous recombination repair (HRR) gene alterations are key drivers of disease in prostate cancer. This has led to great interest in HRR targeted therapies, particularly polyadenosine diphosphate‐ribose inhibitors (PARPi), in the treatment of metastatic castrate resistant prostate cancer (mCRPC). HRR alterations are typically early events in prostate cancer tumorigenesis. As a result, clinical trials are investigating the efficacy of PARPi therapy in metastatic hormone sensitive prostate cancer (mHSPC). …

27.08.2026journal-article

Molecules

Beneficial Role of Quercetin in Prevention and Treatment of Ischemic Stroke: Mechanisms of Action and Administration Strategies

Aleksandra Szychowska, Mikołaj Grabarczyk, Weronika Szczepańska, Ewa Smolińska, Andrzej Glabinski, Piotr Szpakowski

Polyphenols are a complex class of plant secondary metabolites that exert numerous beneficial effects on human health. The content of individual polyphenolic compounds varies considerably among plant species. Over the past few decades, polyphenols have attracted increasing interest because of their antioxidant and antimicrobial properties. They have also demonstrated beneficial effects in the prevention and treatment of various diseases, including cardiovascular and nervous system disorders, as well as different ty …

27.08.2026journal-article

The American Journal of Tropical Medicine and Hygiene

Determinants of Treatment Adherence in Hepatitis C Patients in a Public Sector Setting in India

Sunvir Kaur Rai, Harpreet Singh, Simmi Oberoi, Amandev Singh, Rahul Bhargava

ABSTRACT. The National Viral Hepatitis Control Program has rapidly scaled hepatitis C virus (HCV) treatment. However, poor adherence and loss to follow-up have led to drug resistance, treatment failure, and increased healthcare costs. Given this background, the present study was conducted to evaluate the rate of loss to follow-up, assess adherence patterns to treatment, and identify factors associated with both of these among HCV patients. A prospective cohort study was conducted among 385 adult HCV patients at Gov …

27.08.2026journal-article

Frontiers in Oncology

Müllerian clear cell carcinoma arising from sigmoid endometriosis with pericolic lymph node metastasis in the absence of adnexal disease: a case report

Matteo Girlando, Jose Manuel Garcia, Caterina Ravaioli, Antonio De Leo, Francesco Mezzapesa, Pierandrea De Iaco, Anna Myriam Perrone

Background Malignant transformation of endometriosis is rare and most commonly involves the ovary. Extraovarian transformation, particularly in the gastrointestinal tract, is exceptional, and clear cell carcinoma (CCC) arising from intestinal endometriosis is rarely reported. Case presentation We report a 64-year-old postmenopausal woman with no prior history of endometriosis in whom a sigmoid lesion was incidentally detected during follow-up for a presumed benign ovarian cyst. Colonoscopic biopsy revealed a poorly …

27.08.2026journal-article

Frontiers in Oncology

Chaperone-mediated autophagy as a regulator of hallmarks of cancer

Meenakshi Tiwari, Lokendra Kumar Sharma, Bandana Chakravarti, Veena Kumari Singh, Shruti Singh, Ashutosh Shrivastava

Chaperone-mediated autophagy (CMA) is a selective lysosomal degradation pathway that maintains cellular homeostasis by degrading soluble proteins containing KFERQ-like motifs. Although CMA has traditionally been recognized for its role in protein quality control and cellular stress adaptation, increasing evidence shows that it is frequently altered in cancer, where it regulates multiple processes that promote tumor initiation, progression, and therapy resistance. The growing number of identified CMA substrates invo …

27.08.2026journal-article

Academia Global and Public Health

Preventive health practices and colorectal cancer screening in women veterans

Emma Schnittka, Promila Banerjee, Hepsi Kalapala

Introduction: Colorectal cancer (CRC) is the fourth-leading cause of cancer-related mortality among U.S. women and the second-leading cause among women younger than 50 years. Although screening reduces CRC incidence and mortality, adherence remains below national targets. This study evaluated associations between CRC screening compliance and other preventive health practices among women veterans. Materials and methods: A retrospective cross-sectional analysis was conducted at the Edward Hines Jr. Veterans Affairs ( …

27.08.2026journal-article

Cancer Research Communications

The GENIE Data Model: A Solid Tumor, Person-Centric Framework for Scalable, Harmonized Precision Oncology Data Collection

Jennifer N. Hoppe, Jocelyn Lee, Tomi F. Akinyemiju, Danielle S. Bitterman, Michael Brudno, Michelle F. Green, Vojtech Huser, Jafi A. Lipson, Sanjay Mishra, Daniel P. Nussbaum, Jai N. Patel, Valentina I. Petkov, Kelli M. Rasmussen, Sahussapont Joseph. Sirintrapun, Patricia A. Spears, Sebastiaan Van Sandijk, Anne-Marie Meyer, Umit Topaloglu, Jeremy L. Warner

Abstract Adequately powered analyses in precision oncology often require combining cohorts across institutions. Yet integration is constrained by the least granular source and may become infeasible when data elements are too heterogeneous to harmonize and map to a common data model. This challenge is acute in multi-institutional precision oncology research, where real-world evidence requires harmonized clinico-omic data integration. Existing models often lack sufficient treatment patterns, outcomes, and genomic dat …

27.08.2026journal-article

Arab Media Renewal Journal

معالجة الأزمات الإنسانية في الصحافة الرقمية المصرية والأمريكية: دراسة تحليلية مقارنة

شروق حسنين قاسم

استهدفت الدراسة رصد وتحليل معالجة الصحافة الرقمية الأمريكية والمصرية للأزمات الإنسانية، بالتطبيق على موقعَي «اليوم السابع» المصري، و»USA Today» الأمريكي، وذلك في إطار نظرية المسؤولية الاجتماعية، ونظرية المشاركة الديمقراطية. وقد اعتمدت الدراسة على استخدام منهج المسح، وأسلوب المقارنة المنهجية، بالاعتماد على استمارة تحليل المضمون لجمع بيانات الدراسة، التي شملت (603) موضوعًا صحفيًا إنسانيًا تم نشرها خلال فترتين زمنيتين مختلفتين، هما (يناير-أبريل 2017) و(يناير-أبريل 2022) بموقعي الدراسة.وأظهرت النتائج تقاربًا في الحجم ا …

27.08.2026journal-article

Frontiers in Oncology

Nanomedicine strategies for remodeling the solid tumor microenvironment: stromal targeting, hypoxia modulation, and photodynamic immunotherapy

Mohd Ahmar Rauf, Duy Luong, Farhan Shah, Arun K. Iyer

The tumor microenvironment is more than a backdrop for malignant cells: stromal fibroblasts, extracellular matrix, abnormal vasculature, hypoxia, and immunosuppressive myeloid and lymphoid populations act together to limit both drug delivery and treatment response. Here, we examine nanomedicine along three linked axes: stromal remodeling, hypoxia control, and photodynamic immune activation. CAF-directed and matrix-responsive carriers can improve perfusion and intratumoral transport; however, because fibroblasts are …

27.08.2026journal-article

Angewandte Chemie

Photoactivated Platinum Complexes: Targeting Membrane Proteins and Organelles for Precision Cancer Therapy

Shu Chen, Qiyuan Zhou, Jiaqian Xu, Guangyu Zhu

ABSTRACT Photodynamic therapy (PDT) and photoactivated chemotherapy (PACT) have emerged as promising anticancer modalities due to their noninvasive nature, spatiotemporal precision, and high tumor suppression efficacy. Integrating platinum with these phototherapies addresses key limitations of conventional platinum chemotherapy, specifically systemic toxicity and pervasive drug resistance. Since cancer cell membrane proteins, including receptors and transporters, and subcellular organelles play a pivotal role as th …

27.08.2026journal-article

Diagnostics

Simultaneous Preoperative Prediction of Locally Advanced Breast Cancer, DCIS Component, and Multifocality Using Structured Mammographic Features and Gradient-Boosting Machine Learning

Sorour Raeiskarimi, Mahdi Saeedi-Moghadam, Fariba Zarei, Banafsheh Zeinali-Rafsanjani

Background/Objectives: Accurate preoperative detection of locally advanced breast cancer is essential for neoadjuvant therapy planning. We developed and validated gradient-boosting models using structured BI-RADS mammographic features to simultaneously predict locally advanced breast cancer (LABC), DCIS component, and multifocality in a multi-center cohort. Methods: This retrospective study enrolled 2295 patients from three university-affiliated hospitals; features were coded according to BI-RADS. CatBoost and logi …

27.08.2026journal-article

Neuro-Oncology

16 Computational dissection of invasive glioblastoma reveals druggable and regulatory targets

Maria Shah, Stuart Smith, Emyr Bakker, Ruman Rahman

Abstract Introduction Glioblastoma (GBM) recurrence is driven by residual disease that infiltrates beyond the resection margin, a region poorly characterised at the molecular level. Fluorescence-guided surgery using 5-aminolevulinic acid (5ALA) identifies metabolically active invasive tumour populations and provides an opportunity to interrogate the biology underpinning local invasion and recurrence. Methods Spatially resolved bulk RNA-seq data derived from 5ALA-defined GBM regions were analysed to identify genes e …