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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

Frontiers in Immunology

Immunotherapy-based salvage therapy in advanced soft tissue sarcoma after first-line chemotherapy: a retrospective single-center analysis with emphasis on undifferentiated pleomorphic sarcoma

Zhichao Liao, Junbo Huang, Haotian Liu, Chao Zhang, Ting Li, Hongyu Wang, Yuanxin Liu, Sijia Ren, Zhiwu Ren, Haixiao Wu, Ruwei Xing, Sheng Teng, Jun Zhao, Wanyi Xiao, Gengpu Zhang, Yun Yang, Jilong Yang

Introduction Soft tissue sarcomas (STS) are rare mesenchymal malignancies with limited treatment options in advanced stages. Anthracycline-based chemotherapy remains the standard of care but yields modest outcomes with significant toxicity, underscoring the need for more effective strategies. Methods We retrospectively analyzed 56 patients with advanced STS who received PD-1 inhibitor-based therapy at Tianjin Medical University Cancer Institute and Hospital between January 2021 and January 2026. Treatment regimens …

27.08.2026journal-article

Frontiers in Aging

Grip strength as a systems biomarker of aging: neuromuscular junction constraints and biomarker decoupling in gene therapy

Patrick E. Sewell, Christopher Jensen

Grip strength has emerged as one of the most robust predictors of mortality, disability and healthspan across populations. Yet its predictive validity rests on an often-unstated assumption: that grip strength serves as a passive readout of systemic biological integrity rather than an isolated measure of forearm function. Here we propose that grip strength derives its prognostic power from its position as a convergent output of multiple aging-sensitive physiological systems—including neuromuscular, vascular, metabol …

27.08.2026journal-article

AIDS Research and Therapy

Long-term survival analysis of HIV patients receiving antiretroviral treatment in Congo: a 14-year retrospective analysis, 2003–2017

Gilbert Ndziessi, Ange Clauvel Niama, Arkadit Jeandria Nkodia, Merlin Diafouka

Abstract Background Long-term survival of people living with HIV (PLHIV) on antiretroviral therapy (ART) is poorly documented in the Republic of Congo. Methods We conducted a retrospective cohort study of 2,309 adults initiating ART between 2003 and 2017. Survival was estimated using the Kaplan-Meier method, and determinants were assessed using Cox regression. Results The median age of participants was 49 years (IQR 42–57), and women represented 68.6% of the cohort. The 14-year overall survival probability was 83% …

27.08.2026journal-article

Stroke

2026 Guideline for Adult Stroke Rehabilitation and Recovery: A Guideline From the American Heart Association and American Stroke Association

Lorie G. Richards, Nneka L. Ifejika, Joel Stein, Mona N. Bahouth, Martha Abshire Saylor, A.M. Barrett, Peii Chen, Anne F. Deutsch, Wendy Dusenbury, Charles Ellis, Janice Eng, Jamie Fleet, Heather R. Ford, Emily S. Grattan, Richard L. Harvey, Corinne A. Jones, Chandramouli Krishnan, Sara Kutzle, Deven Matthews, Nicole Mazwi, Jamila Minga, Dawn M. Nilsen, Elizabeth Noser, Heather R. Porter, Preeti Raghavan, Dorian K. Rose, Elizabeth R. Skidmore, Marie-Pierre St-Onge, Mary Ellen Stoykov, Amelia Tenberg Schettini, Alexandra L. Terrill, David L. Tirschwell, Paul Vilar, Alicen Whitaker-Hilbig, Richard Zorowitz, Warren D. Lo, George F. Wittenberg, Allison E. Gaffey, Dipika Aggarwal, Maria Cecilia Alpasan

AIM: The “2026 Guidelines for Adult Stroke Rehabilitation and Recovery” replaces the 2016 “Guidelines for Adult Stroke Rehabilitation and Recovery.” This updated guideline is intended to provide a comprehensive, up-to-date, evidence-based set of recommendations. The intended audience includes physicians, allied health professionals, and caregivers. METHODS: A comprehensive search for literature published since the 2016 guideline, derived from research involving human participants, published in English, and indexed …

1 Zitationen
27.08.2026journal-article

Health, sport, rehabilitation

Differentiating playing roles in professional Counter-Strike 2 by performance indicators: an observational study

Volodymyr Paskiv, Igor Zanevskyy, Volodymyr Koman

Background and purpose. In professional Counter-Strike 2 a single composite rating still carries most of the weight in judging players, even though the game grants no mechanical class asymmetry, so playing roles arise as a codified yet largely unexamined division of labour. We therefore asked whether those roles can be recovered from the standard per-round indicators, and how their differentiation is organised. Material and methods. Under a single twelve-month filter we drew thirty-nine per-round indicators for 105 …

27.08.2026journal-article

Cancer Research

Allele-Specific Mechanisms Guide Salvage Therapy to Overcome Daraxonrasib Resistance in Pancreatic Cancer

Daniel Dorbin, Juliannie Herrera, Raven Davidson, Naveen Kumar Chandrashekar, Gabrielle Scheuber, Priyanga Jayakrishnan, Christabelle Rajesh, Grayson Johnson, Jason Yuan, Matthew A. Sochor, John F. Langenheim, Mohammed Aldakkak, Charles Messerly, Jacquelyn Wittmann, Aniko Szabo, Forough Azam Sayahpour, Nathan L. Atallah, Francis C. Peterson, Brian F. Volkman, Mahmoud Ali, Eugene Ke, Douglas B. Evans, Susan Tsai, Nikki K. Lytle, Y. David Seo, Razelle Kurzrock, G. Aaron Hobbs, Mandana Kamgar, Thomas McFall

Abstract Clinical-grade RAS inhibitors raise an unresolved question as to whether KRAS alleles impose constraints on adaptive resistance that can be exploited therapeutically. Using daraxonrasib (RMC-6236), a multi-selective RAS(ON) inhibitor, we compared resistance mechanisms between KRASG12D and KRASG12R, mutants with fundamentally different RAS network dynamics. Daraxonrasib inhibited KRASMUT primarily through steric occlusion of effector binding, while engaging RASWT only modestly (~20%). KRASG12R was marked by …

27.08.2026journal-article

International Journal of Molecular Sciences

Macrophages as Drivers of Resistance to Dabrafenib Plus Trametinib Therapy in Anaplastic Thyroid Cancer

Ricardo Rodrigues, Beatriz Garcia, Miguel Rito, Rúben Roque, Teresa Pereira, Sónia Morgado, Vanessa Tavares, Tiago Nunes da Silva, Valeriano Leite, Branca Maria Cavaco

Anaplastic thyroid carcinoma (ATC) is an aggressive malignancy with poor response to standard therapies. While Dabrafenib plus Trametinib (DT) combination therapy has improved the survival of patients with BRAF-mutant ATC, resistance remains a challenge. Given the association of macrophages with poor prognosis, and that SPRY4 has emerged as a mediator in ATC–macrophage interactions, we investigated their role in DT resistance and evaluated the therapeutic potential of macrophage targeting. Transwell co-cultures of …

27.08.2026journal-article

Child Language Teaching and Therapy

Negotiating and building SLT–teacher trust relationships for effective interprofessional collaboration when delivering a tier-1 interactive reading program

Paméla McMahon-Morin, Pamela Filiatrault-Veilleux, Marie-Pier Gingras, Wenonah Campbell

Collaboration between teachers and school-based speech-language therapists (SLTs) is essential to high-quality universal tier-1 practices that support children's language and literacy skills in inclusive settings. Trust is central to interprofessional collaboration and successful implementation of new practices. This exploratory qualitative study used a secondary data analysis from two studies, each offering a complementary perspective on how teachers and SLTs negotiate and build trust when they collaborate to impl …

27.08.2026journal-article

Renal Replacement Therapy

Suspected heparin-resistant contact activation during membrane-based therapeutic plasma exchange: a case report

Atsuto Niwa, Sanae Kikuchi, Yuki Nakai, Ayumi Tomoi, Akinori Kitamura, Jun Matsuoka, Norihiko Tanimoto, Miyuki Nakano, Yoshiki Okuno, Mitsuaki Oki, Shinpei Nogami, Masaomi Sato, Yoshihiro Taniyama, Kentaro Hayashida

Abstract Background Therapeutic plasma exchange (TPE) is recommended for steroid-refractory acute optic neuritis associated with aquaporin-4 (AQP4)-IgG-positive neuromyelitis optica spectrum disorder. However, clotting-related events in the extracorporeal circuit can interrupt treatment and jeopardize timely completion of the planned TPE course. Case presentation A 42-year-old woman presented with rapidly progressive bilateral optic neuritis, with no light perception in the right eye and finger count vision in the …

27.08.2026journal-article

Frontiers in Endocrinology

Low baseline HbA1c and reduced eGFR are associated with relatively unfavorable body recomposition after SGLT2 inhibitor therapy in type 2 diabetes

Mizuki Gobaru, Nao Hasuzawa, Noboru Kurinami, Nobuhiko Wada, Lixiang Wang, Ayako Nagayama, Kenji Ashida, Yoshinori Moriyama, Hideaki Jinnouchi, Masatoshi Nomura

Aims Sodium-glucose cotransporter 2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1RAs) improve glycemic control and promote weight loss, but their effects on the relative balance between skeletal muscle and fat mass remain incompletely understood. This study examined treatment-associated body composition changes in patients with type 2 diabetes mellitus (T2DM), focusing on muscle-to-fat balance. Methods In this multicenter retrospective cohort study, we analyzed body composition changes 12 …

27.08.2026journal-article

Journal of Current Southeast Asian Affairs

Fake news and the dual threat to free speech: Information disorder and securitisation in the Philippines and Singapore

Oliver Benjamin Ward

This article examines how fake news and government responses affect free speech in the Southeast Asian cases of the Philippines and Singapore. It employs the information disorder framework to analyse dis-information production and circulation, and securitisation theory to examine how governments justify anti-fake news legislation. In the Philippines, populist, fragmented politics enabled Rodrigo Duterte's 2016 dis-information campaign, which damaged free speech quality by distorting public debate and undermining sh …

27.08.2026journal-article

Fertility Science and Research

Synergistic Impact of Environmental Pollution and Occupational Stress on Sperm DNA Integrity Unveiling Hidden Drivers of Male Infertility

Devuni Vageeshwari

Infertility is the inability of a sexually active couple to conceive within 1 year. It affects 10-15% of couples globally, with male factors accounting for 40-50% of these cases. The decline in semen quality, often with unknown causes, emphasises the need to evaluate sperm count, motility, and morphology when assessing male reproductive health. Environmental, occupational, and lifestyle factors are increasingly recognised as important contributors to male infertility, often linked to oxidative stress and disruption …

27.08.2026journal-article

American Journal of Hematology

Impact of Response to Hypomethylating Agent‐Based Therapy on Survival Outcomes in the Context of Baseline Clinical‐Molecular Risk and Transplant Status in Patients With Higher‐Risk Myelodysplastic Syndromes/Neoplasms: An analysis From the International Consortium for MDS (icMDS)

Benjamin Rolles, Jan Philipp Bewersdorf, Tariq Kewan, Ondrej Blaha, Jessica M. Stempel, Luca Lanino, Najla H. Al Ali, Amy E. DeZern, Mikkael A. Sekeres, Geoffrey L. Uy, Samuel Urrutia, Hetty E. Carraway, Pinkal Desai, Elizabeth A. Griffiths, Eytan M. Stein, Andrew M. Brunner, Christine McMahon, Rory M. Shallis, Joshua F. Zeidner, Michael R. Savona, Shougat Barua, Namrata Sonia Chandhok, Constantine Logothetis, Aram Bidikian, Ted M. Getz, Gail J. Roboz, Eunice S. Wang, Amyah C. Harris, Maria L. Amaya, Hayley Hawkins, Somedeb Ball, Justin Grenet, Parisa Abedi, Shai Shimony, R. Coleman Lindsley, Zhuoer Xie, Yazan F. Madanat, Yasmin Abaza, Talha Badar, Torsten Haferlach

ABSTRACT Baseline IPSS‐M risk, response to hypomethylating agent (HMA) therapy, and receipt of allogeneic stem cell transplant (allo‐HCT) have all been individually shown to impact overall survival (OS) in patients with myelodysplastic syndromes (MDS). However, the prognostic impact of response when adjusting for IPSS‐M risk and treatment strategy remains unclear. Hence, we used the VALIDATE database of the International Consortium for MDS (icMDS) to evaluate the impact of International Working Group (IWG) 2023 bes …

27.08.2026journal-article

Angewandte Chemie

Photoactivated Platinum Complexes: Targeting Membrane Proteins and Organelles for Precision Cancer Therapy

Shu Chen, Qiyuan Zhou, Jiaqian Xu, Guangyu Zhu

ABSTRACT Photodynamic therapy (PDT) and photoactivated chemotherapy (PACT) have emerged as promising anticancer modalities due to their noninvasive nature, spatiotemporal precision, and high tumor suppression efficacy. Integrating platinum with these phototherapies addresses key limitations of conventional platinum chemotherapy, specifically systemic toxicity and pervasive drug resistance. Since cancer cell membrane proteins, including receptors and transporters, and subcellular organelles play a pivotal role as th …

27.08.2026journal-article

Frontiers in Pediatrics

Risk factors for abnormal bone mineral density in Duchenne muscular dystrophy and the association of regular rehabilitation with bone health

Yi Chen, Shaowei Dong, Meihuan Huang, Guixiang Liu, Turong Chen, Chunming Zhou, Mingsheng Zhang

Background We investigated the prevalence and risk factors of abnormal bone mineral density (BMD) in Duchenne muscular dystrophy (DMD) and explored the potential association of regular rehabilitation with BMD. Methods A cross-sectional study including 215 boys with DMD was conducted. Multivariate logistic regression was used to identify independent predictors, and mediation analysis was performed to explore the pathway linking rehabilitation and BMD. Results Abnormal BMD was found in 62 patients (28.8%). Age was th …

27.08.2026journal-article

British Journal of Occupational Therapy

Integrating sensory-oriented electrical stimulation with occupation-based, client-centered occupational therapy to support upper limb use after degenerative cervical myelopathy: A case report

Mikari Toki, Takuya Hirose, Sho Maruyama, Hiroki Himeda, Kanta Ohno

Introduction: Degenerative cervical myelopathy often results in persistent upper limb sensory impairment after surgery, limiting functional hand use despite motor recovery. This case report aimed to describe an occupational therapy intervention integrating sensory-oriented electrical stimulation with occupation-based, client-centered practice to support upper limb use after degenerative cervical myelopathy surgery. Method: This case report describes a woman in her seventies with postoperative degenerative cervical …

27.08.2026journal-article

Veterinary Sciences

Hemodynamic Effects of Intravenous Ephedrine Administration During General Anesthesia for Radiation Therapy in Cats

Daichi Seki, Seijirow Goya, Kenji Teshima, Yoshiki Yamaya

Ephedrine is used as a vasopressor in cats, but the hemodynamic effects of intravenous (IV) administration have not been characterized. This study evaluated the hemodynamic effects of IV ephedrine in 10 cats that developed hypotension during anesthesia. Cats received either saline (SE) or atropine (AE) before ephedrine for hypotension (mean arterial pressure < 60 mmHg). Hemodynamic variables were analyzed using a linear mixed-effects model. No significant differences were observed between groups in the response rat …

27.08.2026journal-article

Physiotherapy Research International

Shared Decision‐Making and Patient Enablement in Outpatient Rehabilitation: An Observational Study

Naoto Iwasawa, Shota Hori, Hitoshi Fujita, Takuya Yamada, Hirono Ishikawa

ABSTRACT Objectives To examine the association between shared decision‐making (SDM) and patient enablement in outpatient rehabilitation consultations. Methods In this observational cross‐sectional study, 158 patients attending outpatient rehabilitation at four facilities in Japan were assessed, of whom 93 were included in the final analyses. Sociodemographic data, disease severity (modified Rankin Scale), treatment expectations, control preferences, and health literacy were collected via self‐administered questionn …

27.08.2026journal-article

Environmental Toxicology

Integrated Alpha–Gamma Radiation Exposure From Natural Radionuclides in Cement and Gypsum Production: Implications for Occupational Lung Cancer Risk

Adil M. Hussien, Kardo O. Mamand, Hiwa M. Qadir, Berun N. Ghafoor, Goran H. Mohammad

ABSTRACT Natural radionuclides in cement and gypsum production materials pose significant risks of occupational radiation exposure that are not well documented in Iraqi Kurdistan. This study quantifies alpha and gamma radiation levels from naturally occurring radioactive materials, specifically 222 Rn, 238 U, 232 Th, and 40 K, in cement and gypsum samples from regional production facilities. Radionuclide activity concentrations were measured using alpha counting techniques and gamma spectrometry. The air concentrat …

27.08.2026journal-article

Physiotherapy Research International

Effect of Global Postural Re‐Education in Individuals With Text Neck Syndrome: A Randomized Controlled Trial

Heba Saeid Mohamed, Omaima M. Ali Kattabei, Hassan Hussein Ahmed, Heba M. Elfeky, Rania Reda Mohamed

ABSTRACT Background and Purpose This study investigated the effect of Global Postural Re‐Education (GPR) versus conventional physical therapy in text neck syndrome (TNS). A prospective, single‐blinded, parallel‐group randomized controlled trial design was used. Methods Sixty participants with TNS (aged 18–40 years) were randomly assigned to either conventional treatment or GPR plus conventional treatment. Both groups received supervised therapy for three sessions per week over 4 weeks. Outcome measures included cra …

27.08.2026journal-article

Journal of International Research in Medical and Pharmaceutical Sciences

Nanoparticle-Mediated Targeting of the Arthritic Joint: A Critical Narrative Review of Drug Delivery and Molecular Therapy

Jharna Sahu, Chandrika Ahirwal

Nanoparticle-based delivery is being developed to concentrate anti-inflammatory, disease-modifying and molecular therapeutics within arthritic joints while limiting systemic exposure. Yet “joint targeting” encompasses several distinct problems: vascular access to inflamed synovium, persistence after intra-articular administration, penetration through dense avascular cartilage, cell-selective uptake and release of an active payload at the intended intracellular or extracellular site. This critical narrative review e …

27.08.2026journal-article

Physiotherapy Quarterly

The effect of supervised exercise intervention program on the quality of life, disability, anxiety, and depression in post-lumbar discectomy patients

Neveen Yaseen, Ahmed A. Najim, Adnan M.M. Naser, Mosab Aldabbas

Introduction Lumbar discectomy is commonly performed to relieve nerve root compression, but many patients experience ongoing pain and disability post-surgery. Supervised physiotherapy may improve these outcomes, though its benefits remain underexplored. This study aimed to evaluate the impact of a physiotherapy program on quality of life, pain, disability, anxiety, and depression after lumbar discectomy. Methods A Quasi-Experimental Study was conducted involving 34 patients (17 males, 17 females; mean age 48.38 ± 6 …

27.08.2026journal-article

BMC Oral Health

Oral findings and antiresorptive therapy exposure duration in postmenopausal women with osteoporosis: a cross-sectional cohort study

Safiyye Süslü, Håvard J Haugen, Tormod Bjartveit Krüger, Bente B. Herlofson, Janne Elin Reseland, Erik Fink Eriksen

Abstract Background Oral findings are common among older adults, but it is unclear whether they vary with the duration of antiresorptive therapy (ART) exposure or relate to the severity of osteoporosis in postmenopausal women. Methods In this cross-sectional cohort ( n = 129), postmenopausal women undergoing osteoporosis assessment/follow-up were stratified by ART exposure duration: no current ART control (G1, n = 50), short ART (G2, 3–5 years; n = 39), and long ART (G3, > 5 years; n = 40). The prespecified primary …

27.08.2026journal-article

Neuro-Oncology

29 Repetitive Transcranial Magnetic Stimulation (rTMS) for Motor Rehabilitation in Neuro-Oncology: the impact of the Orpington Prognostic Score (OPS)

Katie Mirocha, Amy Jones, Jose Lavrador, Keyoumars Ashkan, Ranj Bhangoo, Francesco Vergani

Abstract Introduction rTMS is well-evidenced in the stroke population. Its therapeutic use is increasing in post-operative neuro-oncology patients. Functional outcomes using the OPS, a prognostic indicator for onwards rehabilitation needs, are yet to be explored. This is an exploratory study assessing the feasibility of the OPS to monitor functional outcomes and guide rehabilitation streams in post-operative neuro-oncology patients receiving the rTMS motor rehabilitation protocol for new motor deficit. Method Over …