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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

Frontiers in Aging

Grip strength as a systems biomarker of aging: neuromuscular junction constraints and biomarker decoupling in gene therapy

Patrick E. Sewell, Christopher Jensen

Grip strength has emerged as one of the most robust predictors of mortality, disability and healthspan across populations. Yet its predictive validity rests on an often-unstated assumption: that grip strength serves as a passive readout of systemic biological integrity rather than an isolated measure of forearm function. Here we propose that grip strength derives its prognostic power from its position as a convergent output of multiple aging-sensitive physiological systems—including neuromuscular, vascular, metabol …

27.08.2026journal-article

Frontiers in Neuroinformatics

Interpretable AI for neural signal decoding in dementia: an EEG ensemble approach to differential diagnosis

Fawad Muhammad, Irfan Ahmed Usmani, Muhammad Aamir, Mai Alduailij, Mehrez Marzougui, Rab Nawaz

Introduction The differential diagnosis between Alzheimer’s disease (AD) and frontotemporal dementia (FTD) presents a significant clinical challenge due to overlapping early-stage symptom profiles. Conventional resting-state EEG provides limited sensitivity to the impaired neural plasticity and lateralized cortical degeneration frequently observed in FTD. Methods We developed a domain-informed heterogeneous ensemble framework incorporating dynamic neural reactivity and hemispheric asymmetry metrics from 19-channel …

27.08.2026journal-article

Eng

Effect of Different Metal Oxide/Montmorillonite Nanocomposites on Aging Resistance of SBS-Modified Asphalt

Guangye Si, Genfu Liang, Gen Li, Chongzheng Zhu

To improve the aging resistance of SBS-modified asphalt (SBSMA), this study prepared two metal oxide/montmorillonite nanocomposites, TiO2/montmorillonite (TM) and CeO2/montmorillonite (CM), and investigated their effects on the rheological properties and microstructure of SBSMA before and after long-term aging. The performance differences between the two nanocomposites under different aging modes were also compared. Conventional physical property tests, dynamic shear rheometer tests (temperature sweep and linear am …

27.08.2026journal-article

The Journal of Chemical Physics

Physical aging and molecular dynamics in poly(4-alkylstyrene)

Koji Fukao, Akira Goda, Airi Kawano, Ryo Ueyoshi, Kohei Nishi, Ryo Iguchi, Jun Yoshioka, Satoru Matsushima, Saya Yamada, Atsushi Takano

To elucidate the relationship between physical aging and molecular dynamics in poly(4-alkylstyrene), three types of measurements were performed: capacitive dilatometry (CD), differential scanning calorimetry (DSC), and dielectric relaxation spectroscopy (DRS). Using CD and DSC, we successfully observed volume and enthalpy relaxation processes during isothermal aging in the glassy state. DRS measurements revealed four dynamical processes: the α-process, β-process, γ-process, and a slower process, in addition to the …

27.08.2026journal-article

Journal of Ambulatory Care Management

Formative Evaluation of a Pharmacist-Led Area Agency on Aging Community Care Transition Initiative: A Qualitative Interview Study From Staff Perspectives

Hao-Ping Chiang, Brigid Rowell, Karen B. Farris, Nathaniel Bergman, Antoinette B. Coe

Objectives: The Michigan Region VII Area Agency on Aging (AAA) conducted a community care transition initiative (CCTI) for rural, low-income older adults to reduce hospital readmission rates. The AAA CCTI included a community health worker (CHW) home visit, pharmacist telehealth comprehensive medication review, and follow-up after discharge. Our study aimed to conduct a formative evaluation of the AAA CCTI to identify areas for program refinement. Identified strategies for program refinement add to the development, …

27.08.2026journal-article

TEM Journal

Application of an Electronic Cane for Blind People - Analysis and Evaluation

Denitsa Dimitrova, Aneliya Manukova, Iovan Stoev

This study examines various methods, criteria, and technological approaches used to evaluate parameters associated with the mobility of individuals with disabilities, with particular emphasis on the development of an electronic guidance and monitoring system integrated into a cane for visually impaired users. The proposed engineering solution includes an electronic module based on an ESP32-S3 microcontroller, tested in laboratory and real conditions. Methods for determining distance and signal processing have been …

27.08.2026journal-article

Astronomy & Astrophysics

Radio spectral properties and aging of two tailed radio galaxies in a galaxy group at z=0.35

P. Vulić, V. Smolčić, A. Finoguenov, G. Gozaliasl, H.S.B. Algera, I. Delvecchio

We present a study of two tailed radio galaxies located in the core of a massive, dynamically young galaxy group, previously identified as an early group-group merger. Using broadband VLA 3 GHz and 1.4 GHz, MeerKAT 1.35 GHz, and GMRT 610 MHz and 325 MHz observations, we investigate the radio spectral properties as well as the spectral and dynamical ages of both sources. The radio morphologies show clear evidence of an interaction with the intragroup medium (IGM). One galaxy is a wide-angle tail (WAT) source with we …

27.08.2026journal-article

Healthcare

Effects of a Nurse-Led Web-Based Fall Prevention Program on Fall Risk and Fear of Falling Among Older Adults: A Randomized Controlled Trial

Nur Sema Kaynar Demirel, Selda Secginli

Objectives: This study aimed to evaluate the effects of a nurse-led Web-Based Fall Prevention Program (Web-FPP) on fall risk, fear of falling, fall-preventive behaviors, and the number of falls among community-dwelling older adults aged 65 years and older. Methods: A single-blind, stratified randomized controlled trial was conducted with 72 older adults (36 intervention, 36 control) in Türkiye. The Web-FPP was delivered over six weeks and included educational content, video-based exercises, and home safety strategi …

27.08.2026journal-article

Alzheimer Disease & Associated Disorders

Projected Global and SDI-Region Care Costs for Alzheimer Disease and Associated Dementias, 2023 to 2050

Dandan Xu, Li Jiang, Qizhi Yang, Roy Rillera Marzo, Zhijuan Peng, Yali Yao, Ruolei Li, Xia Zhang, Linjie Zhu, Jin Qian, Rui Ji, Wenwen Zhao

Objective: To project the economic burden of Alzheimer disease and associated dementias (ADAD) care globally and across sociodemographic index (SDI) quintiles from 2023 to 2050, explore disparities by age, sex, and region, and provide evidence for targeted care policies. Methods: Based on Global Burden of Disease 2021 data, we estimated ADAD care costs by integrating years lived with disability, caregiving hours, and wage rates. Regions were stratified into 5 SDI levels, with sex- and age-specific subgroup analyses …

27.08.2026journal-article

Nutrients

Proteomic and Phosphoproteomic Signatures Link Molecular Remodeling to Behavioral Outcomes Following Elderberry and DHA Supplementation in Aging Mice

Wenyan Yu, Jiankun Cui, Tamanna Mony, Stephen Mensah, Marcus Jackson, Runting Li, Ethan Pan, Grace Y. Sun, Andrew L. Thomas, C. Michael Greenlief, Zezong Gu

Background: Aging is a risk factor for Alzheimer’s disease and related dementias, which are associated with synaptic dysfunction and cognitive decline. Elderberry (Sambucus spp.) is rich in anthocyanins with antioxidant and anti-inflammatory properties. Docosahexaenoic acid (DHA), an essential fatty acid, plays a key role in neuronal membrane integrity during brain aging. However, it remains unclear whether elderberry and DHA exert overlapping or distinct effects on brain aging and how these relate to molecular sig …

27.08.2026journal-article

The Journals of Gerontology, Series B: Psychological Sciences and Social Sciences

Early life predictors of subjective cognitive function in older age: Emerging longitudinal associations over six decades

Gideon Neidenmark, Catherine Tuvblad, Jonas Persson

Abstract Objectives Self-rated memory impairment is common in older age and has been related to objective cognitive decline and dementia. Recently, there has been growing interest in early-life predictors of late-life cognition, but research has been limited due to the absence of data spanning the entire lifespan. The present study investigated whether psychological health, social well-being, socioeconomic status (SES), and cognitive abilities at age 10 and 13 predicted subjective memory almost six decades later. M …

27.08.2026journal-article

Frontiers in Psychology

Effects of exercise adherence on subjective wellbeing in middle-aged and older adults: a three-wave longitudinal chain mediation study

Jixin Wang, Hui Jia, Hui Wang

Objective This study examined whether exercise identity and positive emotional expressivity statistically explain the prospective association between exercise adherence and subjective wellbeing among middle-aged and older adults. Drawing on identity theory, self-determination perspectives, and the broaden-and-build theory of positive emotions, we tested a three-wave longitudinal chain mediation model while controlling for baseline subjective wellbeing and demographic covariates. Methods Community-dwelling adults ag …

27.08.2026journal-article

Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi

Postoperative Complications in Older Adults After Local Surgical Procedures; Risk Factor Analysis and Comparison of Machine Learning Methods

Emrah Işıktekin, Ali Sezgin

Older adults frequently undergo excision of cutaneous lesions under local anesthesia and may be at increased risk of postoperative complications due to comorbid conditions and concomitant medications. This study aimed to identify predictors of postoperative complications in patients aged 65 years and older and to compare the predictive performance of logistic regression with machine-learning models. This retrospective study included 314 patients who underwent cutaneous lesion excision under local anesthesia. Demogr …

27.08.2026journal-article

The Gerontologist

Gratitude and savoring interventions for older adults: a narrative review

Noortje Kloos, Rebecca Baxter, David Edvardsson, Debby Gerritsen, Ernst Bohlmeijer

Abstract Background and Objectives Gratitude and savoring have great potential to support well-being in older age, but most studies on positive psychology interventions have been conducted among healthy young adults. This narrative review explored gratitude and savoring interventions for older adults, with or without dementia, including (1) the characteristics of these interventions, (2) their acceptability for older users, and (3) their effect on mental health. Research Design and Methods Scopus, PubMed, PsychInfo …

27.08.2026journal-article

Archiv Euromedica

SOCIAL MEDIA AND MENTAL HEALTH SELF-DIAGNOSIS: RISKS, BENEFITS, AND CLINICAL IMPLICATIONS FOR ADOLESCENTS AND YOUNG PEOPLE

Bogna Błachowska, Wojciech Frączyk, Agata Świątek, Kamil Andruszkiewicz, Bartosz Machnio, Natalia Jasińska, Mateusz Krysiak, Natalia Turzyńska, Katarzyna Mania, Julia Bąk, Agnieszka Stankowska

Background Adolescents increasingly use social media platforms, including TikTok, Instagram, and Reddit, to obtain information about mental health and psychiatric disorders. Such content may facilitate mental health literacy, validation, and help seeking, but may also expose users to misinformation, oversimplified diagnostic narratives, and algorithmically reinforced content. Aim To examine the potential benefits and risks of mental health self-diagnosis through social media among adolescents and young people, with …

27.08.2026journal-article

Work, Aging and Retirement

Retirement, Economic Vulnerability, and Subjective Wellbeing: A 13-Year Panel Study from the UK

Jie Liu, Frank Agyemang Karikari, Seth Acquah Boateng, Alexander Opoku

Abstract Retirement constitutes a major life transition with significant implications for wellbeing, yet whether economically vulnerable individuals benefit equally remains underexplored. Drawing on continuity theory, activity theory, and the job demands-resources (JDR) framework, this study develops competing predictions about how economic vulnerability shapes the relationship between retirement and wellbeing. We examine the relationship between retirement and subjective wellbeing among UK adults aged 50–75, and i …

27.08.2026journal-article

The Journals of Gerontology, Series B: Psychological Sciences and Social Sciences

Associations between indicators of self-rated health, cognitive function, risk of cognitive impairment, and dementia: A coordinated data analysis

Eileen K Graham, Kayla Garner, Emorie D Beck, Kathryn L Jackson, Jing Luo, Gabrielle N Pfund, Tomiko Yoneda, Rongxin Cheng, Adam Nissen, Anne Zola, Chloe Fawns-Ritchie, Lily Pieramici, Winnie Wang, Stephen Antonoplis, Philip J Batterham, Tom Booth, Raul A España, Matthew J D Pilgrim, Christopher Beam, Katherina K Hauner, Andrew Steptoe, Elizabeth Zelinski, Simon R Co, Martijn Huisman, William J Chopik, Daniel K Mroczek

Abstract Objectives A growing body of literature suggests that self- or patient- reported health may be associated with objective health outcomes. Self-reported health could thus be a non-invasive and low-cost way of identifying who is at risk of poor health in later life. However, no prior study has systematically examined this relationship using multiple large datasets. The goal of the current study was thus to examine the extent to which self-rated health was associated with cognitive function, a distinct outcom …

27.08.2026journal-article

Journal of Clinical Medicine

Prevalence and Predictors of Self-Reported Swallowing Difficulty in Community-Dwelling Older Adults

Lana Fluk, Yuval Nachalon, Amit Shiff, Haya Fogel-Grinvald, Nogah Nativ-Zeltzer

Objectives: Dysphagia in older adults is associated with malnutrition, aspiration, and reduced quality of life. This study aimed to estimate the prevalence of self-reported swallowing difficulties among community-dwelling older adults in Israel and to identify demographic, medical, and socioeconomic predictors. Method: In this cross-sectional study, 1064 community-dwelling adults aged ≥ 60 years (mean 75.1 ± 7.5 years; 68.1% female) completed an online questionnaire capturing demographics, medical diagnoses, physic …

27.08.2026journal-article

Frontiers in Medicine

An easy-to-use model for screening type 2 myocardial infarction in geriatric patients with acute coronary syndrome: a retrospective cohort study

Yun-yue Luo, Hui Wang, Xiao-ya Ma, Yue Li, Wu-lin Li, Yue Liu, Yu-xin Wang, Wen-hui Kang, Jian-jun Xia, Fei Wang

Objective In this study, we aimed to develop and validate an easy-to-use model for screening type 2 myocardial infarction (T2MI) in geriatric patients with acute coronary syndrome (ACS). Method From January 2017 to December 2022, 891 geriatric patients who were clinically diagnosed with ACS and who underwent coronary angiography visited the Chest Pain Center of the Emergency Department at Jiading District Central Hospital affiliated Shanghai University of Medicine & Health Sciences were included. Univariate and …

27.08.2026journal-article

Nicotine & Tobacco Research

Awareness and use of oral tobacco and nicotine products among people who smoke or recently stopped smoking: Descriptive findings from the 2024 EASE/ITC New Zealand Survey

Jude Ball, Jane Zhang, Janet Hoek, James Stanley, Andrew Waa, El-Shadan Tautolo, Thomas Agar, Anne C K Quah, Geoffrey T Fong, Richard Edwards

ABSTRACT Introduction Aotearoa New Zealand (NZ) disallows sales of oral tobacco and nicotine products, although importation for personal use is permitted. The government proposes legalising sales, claiming this will aid smoking cessation among “older, long-term smokers.” We examined awareness and use of tobacco-free oral nicotine products (ONPs), snus, and other oral tobacco products among adults who smoke or who recently stopped smoking. Methods We analysed Wave 5 (2024) data from the EASE/International Tobacco Co …

27.08.2026journal-article

Frontiers in Aging Neuroscience

Transcriptomic signatures as biomarkers for the progression of mild cognitive impairment

Juan Yang, Jiajia Li, Liuyuan Mao, Haiyan Ren, Qiang Li, Xiang Geng, Qiuyun Lu, Chen Peng, Jia Zhang, Xiaokun Liu, Yanyan Zhang, Benju Zhu, Tianfang Jiang

Objective Mild cognitive impairment (MCI) is acknowledged as an early and potentially modifiable stage of Alzheimer’s disease (AD). Despite this, there is a paucity of reliable molecular markers for predicting MCI progression. This study utilizes next-generation sequencing to elucidate alterations in RNA expression within peripheral blood mononuclear cells (PBMCs) associated with the progression of MCI. Methods RNA was extracted from PBMCs of three groups: 30 MCI non-progressors (NPG), 30 MCI progressors (PG), and …

27.08.2026journal-article

Frontiers in Public Health

Recognizing muscle health in healthy aging and non-communicable disease policy: a public health perspective

Alvaro Puelles-Diaz

Population aging and the rising burden of non-communicable diseases (NCDs) place sustained pressure on health systems. In this perspective, I argue that muscle health—muscle mass, strength, and physical function—should be recognized as an explicit and prognostically distinct target within policies for healthy aging and NCD prevention. Two arguments distinguish this from generic physical activity promotion: muscle strength predicts mortality, regardless of activity level, and the most significant gains are produced …

27.08.2026journal-article

Healthcare

Association of Physical Activity with Psychological Distress and Poor Mental Health Days Among Informal Caregivers of Older Adults: Findings from the 2023 BRFSS Caregiver Module

Damián Pereira-Payo, Raquel Pastor-Cisneros, María Mendoza-Muñoz, Amparo Rodríguez-Gutiérrez

Background/Objectives: Informal caregivers of older adults are a high-burden population for psychological problems, yet evidence on the relationship between physical activity (PA) and mental health in this population is still limited. The aim of this work is to examine the association between PA status and self-reported mental health indicators (psychological distress and the number of poor mental health days) among caregivers of older adults. Methods: This cross-sectional study used data from the 2023 Behavioral R …