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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

Clinical Science

Maternal gut microbiota–psychotropic drug interactions and their impact on offspring neurodevelopment

Ashlee M. Craig, Kelly J. Clemens, Sarah-Jane Leigh

Abstract Pregnancy is associated with a unique and dynamic gut microbiota profile that supports fetal growth and neurodevelopment. Psychotropic drug–gut microbiota interactions are documented in the general population, yet less well described in pregnant women. Research has independently linked both perinatal psychotropic exposure and alterations to the maternal gut microbiome with potential changes to offspring neurodevelopment; therefore, it is plausible that similar interactions occur during pregnancy where they …

27.08.2026journal-article

Australian Health Review

Concordance of surveillance colonoscopy recommended intervals with Australian guidelines: a clinical audit in six Victorian public hospitals

Jonathan Foo, Corey Joseph, Alexandra Gorelik, Martin Hensher, Harriet Hiscock, Alison Hutchinson, Karin A. Thursky, Ralph Audehm, Andrew O'Loughlin, Grant Russell, Alan Moss, Elizabeth Hristov, Kumanan Nalankilli, Radha Nair, Anne Van Berkel, Sophie Ping, Jaclyn Bishop, Judi Debney, Kirsten Carr, Julianne Schultz, Denise A. O'Connor

Objective Appropriate intervals for repeat (surveillance) colonoscopy are important for early colorectal cancer detection and treatment, timely patient access, and minimising patient risks. This study aimed to assess the concordance of endoscopist-recommended surveillance colonoscopy intervals with those recommended by the 2018 Australian Cancer Council surveillance colonoscopy guidelines. Methods Three metropolitan and three rural public hospitals in Victoria, Australia, each retrospectively audited at least 35 co …

27.08.2026journal-article

Renal Replacement Therapy

Suspected heparin-resistant contact activation during membrane-based therapeutic plasma exchange: a case report

Atsuto Niwa, Sanae Kikuchi, Yuki Nakai, Ayumi Tomoi, Akinori Kitamura, Jun Matsuoka, Norihiko Tanimoto, Miyuki Nakano, Yoshiki Okuno, Mitsuaki Oki, Shinpei Nogami, Masaomi Sato, Yoshihiro Taniyama, Kentaro Hayashida

Abstract Background Therapeutic plasma exchange (TPE) is recommended for steroid-refractory acute optic neuritis associated with aquaporin-4 (AQP4)-IgG-positive neuromyelitis optica spectrum disorder. However, clotting-related events in the extracorporeal circuit can interrupt treatment and jeopardize timely completion of the planned TPE course. Case presentation A 42-year-old woman presented with rapidly progressive bilateral optic neuritis, with no light perception in the right eye and finger count vision in the …

27.08.2026journal-article

Frontiers in Public Health

High prevalence of fatigue in patients with inflammatory bowel disease: association with physical activity intensity and sedentary behavior

María Dolores Herrera, Antoni Aguiló, Pedro Tauler, José Antonio Mingorance, Daniel Ginard, Eva Puchol, Sonia Martínez

Introduction Fatigue is reported to be a common and disabling manifestation in patients with inflammatory bowel disease. Specialized units and nurse-led services play key roles in delivering holistic, long-term care for these patients. The aim of this study was to determine the prevalence of fatigue among inflammatory bowel disease patients attending a day hospital. The association between fatigue and physical activity was also analyzed, potentially providing clinically relevant information for nursing assessment a …

27.08.2026journal-article

Frontiers in Health Services

Causes of medical disputes in China and Japan from physicians' perspectives: a qualitative study

Hua Xu, Atsushi Asai, Masao Tabata, Yasuhiro Kadooka

Background Medical disputes and strained doctor–patient relationships (DPRs) remain pressing challenges in China. This comparative qualitative study examined Chinese and Japanese doctors' perspectives on the causes of medical disputes to identify context-specific factors, elucidate causal mechanisms, and inform strategies for improvement. Method Using purposive sampling, 20 practicing physicians from each country were recruited primarily through the authors' personal networks. Semi-structured interviews were conduc …

27.08.2026journal-article

Molecular Medicine

Short-chain fatty acids as key mediators of the microbiota–gut–brain axis in chronic cerebral hypoperfusion: mechanisms and therapeutic

Junchen Si, Peijian Wang, Zhongchen Li, Jiheng Hao, Jiyue Wang, Liyong Zhang

Abstract Chronic cerebral hypoperfusion (CCH) is an important contributor to vascular cognitive impairment and neurodegenerative disorders, characterized by neuronal injury, blood–brain barrier (BBB) disruption, neuroinflammation, mitochondrial dysfunction, and synaptic impairment. Increasing evidence suggests that the microbiota–gut–brain axis plays a crucial role in ischemic brain injury. CCH is associated with gut microbiota dysbiosis, intestinal barrier dysfunction, and reduced production of microbiota-derived …

27.08.2026journal-article

Functional Foods in Health and Disease

Matrix-dependent functional behavior of plant pectins in vegetable canned food systems

Laura Sengirbekova, Talgat Kulazhanov, Laila Syzdykova, Karlygash Abdiyeva, Gulnara Shambulova, Gulshat Zhaхylykova, Sanavar Azimova

Background: Plant pectins are natural hydrocolloids and soluble dietary fibers whose technological and nutritional performance depends on interactions with proteins, lipids, starch, native cell- wall material, minerals, and phenolic compounds. Understanding this matrix dependence is essential for selecting an appropriate food vehicle for bioactive ingredients and for designing vegetable foods with predictable quality. Objective: To determine how pumpkin, zucchini, and apple pectins behave in liquid and structured v …

27.08.2026journal-article

Frontiers in Medicine

Real-world safety profile of alectinib: a 10-year pharmacovigilance study based on the FDA adverse event reporting system

Le Zhang, DanDan Li, ChenJing Luo, Li Fan, Min Hu, Fei Ye, Peng Gu

Objective Alectinib is the standard first-line therapy for treatment-naïve ALK-positive non-small cell lung cancer (NSCLC). Given its increasing clinical utilization, a comprehensive pharmacovigilance evaluation of its adverse events (AEs) is warranted. Methods We assessed alectinib-associated AEs using the FDA Adverse Event Reporting System (FAERS) database from Q4 2015 to Q3 2025. AEs were categorized per MedDRA, and four disproportionality analysis algorithms were used to detect potential safety signals. Results …

27.08.2026journal-article

Frontiers in Medicine

Aggregate index of systemic inflammation and glaucoma status: population-based evidence with clinical validation

Songxin Yang, Li Li, Xianming Ouyang, Rui Zhang, Gang Lin, Sunkun Pan, Guiquan Xie, Zhen Lv, Dieran Huang, Guoyan Luo, Kunpeng Pang

Objective Glaucoma is a major cause of irreversible visual impairment, but evidence on the association between the aggregate index of systemic inflammation (AISI) and glaucoma remains limited, particularly with clinical validation. Methods We analyzed National Health and Nutrition Examination Survey (NHANES) data from participants aged 40 years and older. Weighted multivariable logistic regression models were used to examine the association between AISI and glaucoma. The primary outcome was composite glaucoma, defi …

27.08.2026journal-article

Frontiers in Endocrinology

Low baseline HbA1c and reduced eGFR are associated with relatively unfavorable body recomposition after SGLT2 inhibitor therapy in type 2 diabetes

Mizuki Gobaru, Nao Hasuzawa, Noboru Kurinami, Nobuhiko Wada, Lixiang Wang, Ayako Nagayama, Kenji Ashida, Yoshinori Moriyama, Hideaki Jinnouchi, Masatoshi Nomura

Aims Sodium-glucose cotransporter 2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1RAs) improve glycemic control and promote weight loss, but their effects on the relative balance between skeletal muscle and fat mass remain incompletely understood. This study examined treatment-associated body composition changes in patients with type 2 diabetes mellitus (T2DM), focusing on muscle-to-fat balance. Methods In this multicenter retrospective cohort study, we analyzed body composition changes 12 …

27.08.2026journal-article

Frontiers in Medicine

Reduced heart rate variability is associated with disease severity in AL amyloidosis: a retrospective cohort study

Xiao-hang Pei, Su-qiong Zuo, Pan Zhou, Rong-jun Ma, Zun-min Zhu, Xiao-li Yuan

Background Autonomic nervous system involvement is common in systemic amyloidosis, yet the clinical relevance of heart rate variability (HRV) in immunoglobulin light-chain (AL) amyloidosis remains incompletely defined. Methods In this retrospective cohort study, 56 patients with biopsy-proven AL amyloidosis and 33 age- and sex-comparable healthy controls underwent 24 h Holter monitoring. Time- and frequency-domain HRV parameters were recorded. Associations of HRV with cardiac involvement assessed by cardiac magneti …

27.08.2026journal-article

The Journal of Clinical Endocrinology & Metabolism

Effects of Semaglutide versus Bariatric Surgery on Noninvasive Markers of Hepatic Steatosis and Fibrosis in Obesity with MASLD

Paula Lünswilken, Katarzyna Worobiec, Lara S Braun, Julia Altrogge, Andrea Schenk, Lina Jegodzinski, Britta Wilms, Jens U Marquardt, Svenja Meyhöfer

Abstract Aims Obesity is a key driver of metabolic dysfunction-associated steatotic liver disease (MASLD). Beyond lifestyle modification, pharmacological and surgical therapies were recently established. This study compared the effects of lifestyle therapy, lifestyle plus semaglutide, and bariatric surgery on non-invasive markers of hepatic steatosis and fibrosis. Materials and Methods In this single-center, prospective, observational cohort study, ninety-two adults with obesity were analyzed over 72 weeks. Patient …

27.08.2026journal-article

Frontiers in Medicine

Research progress of cerebroplacental ratio in obstetric complications

Xinran Bi, Ruotong Qi, Haiying Chen

Cerebroplacental ratio (CPR), defined as fetal middle cerebral artery pulsatility index (MCA-PI)/umbilical artery pulsatility index (UA-PI), quantifies intrauterine hemodynamic redistribution driven by the fetal brain-sparing response to placental insufficiency. With the advancement of ultrasonic technology and in-depth clinical research, CPR has been widely applied in early screening, condition assessment, prognosis evaluation and intervention guidance of various obstetric complications, especially showing unique …

27.08.2026journal-article

Nursing Edição Brasileira

Avanços no Uso de Imagens Multimodais no Estadiamento e Monitoramento dos Tumores Intraoculares Malignos

Gabriela Brahim Moreira, Taís Bruna Michelon

O estadiamento preciso e o monitoramento contínuo de tumores intraoculares malignos, como o melanoma de coroide e o retinoblastoma, são cruciais para o prognóstico e a preservação da visão. Tradicionalmente, o diagnóstico baseava-se em exames clínicos e ultrassonografia convencional. Contudo, a introdução de imagens multimodais permitiu uma caracterização tecidual sem precedentes, combinando informações estruturais, vasculares e metabólicas. Esta revisão sistemática analisa como a integração de tomografia de coerên …

27.08.2026journal-article

Health Research Journal of Indonesia

Potensi Antikanker Teripang: Tinjauan Sistematis Senyawa Bioaktif dan Mekanisme Molekuler

Hisyam Abdu Rasyad, Hesti Riasari

Kanker merupakan salah satu penyebab kematian utama di dunia, dan keterbatasan terapi konvensional mendorong pencarian agen antikanker baru dari sumber alam laut. Teripang (Holothuroidea) telah lama dikenal kaya akan senyawa bioaktif dengan potensi antikanker yang menjanjikan. Tinjauan sistematis ini bertujuan mengidentifikasi spesies teripang dengan aktivitas antikanker terkuat, mengkarakterisasi senyawa bioaktif yang berperan, serta mengelaborasi mekanisme molekuler yang mendasarinya. Penelusuran literatur dilaku …

27.08.2026journal-article

Clinical Kidney Journal

Managing hyponatremia: fast or slow? why, when, how, and controversies

Kamel S Kamel, Ziv Harel, Martin Schreiber

Abstract Hyponatremia is the most common electrolyte disorder encountered in clinical practice. Its management is challenging because treatment must balance the risk of cerebral edema in acute hyponatremia against the risk of osmotic demyelination syndrome (ODS) from overly rapid correction of chronic hyponatremia. Recent observational studies have questioned current correction limits, prompting renewed debate regarding optimal management. This narrative review presents a physiology-based approach to the evaluation …

27.08.2026journal-article

Advances in Anesthesia and Pain Medicine

Low-concentration dual-baricity thoracic segmental spinal anesthesia for laparoscopic cholecystectomy: a retrospective case series

Paolo Scimia, Massimiliano Luca D'Agostino, Antonio De Cato, Franco Marinangeli, Simone Cicconi, Riccardo Moretti, Federica Venturoni, Fabrizio Fattorini, Roberto Starnari, Domenico Pietro Santonastaso, Luca Gentili

Laparoscopic cholecystectomy (LC) is usually performed under general anesthesia (GA), which provides airway protection and optimal surgical conditions but may expose vulnerable patients to cardiopulmonary stress and other anesthesia-related adverse effects. Thoracic segmental spinal anesthesia (TSSA) may represent an alternative in selected patients. We evaluated the feasibility, safety, and perioperative outcomes of a low-concentration dual-baricity TSSA protocol for LC. This retrospective descriptive case series …

27.08.2026journal-article

Journal of Intensive Care Medicine

Development and Validation of an Interpretable Machine Learning Model for Predicting In-Hospital Mortality in Diabetic Patients with Sepsis-Associated Acute Kidney Injury

Yanni Wang, Hongjie Shen, Shengze Wu, Suibi Yang, Feng Guo, Min Yang, Zhongheng Zhang

Background Sepsis-associated acute kidney injury (SA-AKI) is a common and severe complication in critically ill patients, with poor prognosis. Diabetes may further increase adverse outcomes through infection susceptibility, immune dysfunction, and renal vulnerability. However, mortality prediction models for patients with diabetes complicated by SA-AKI remain limited. This study aimed to develop and validate a machine learning-based model for early in-hospital mortality prediction in this population. Methods A tota …

27.08.2026journal-article

Asia-Pacific Journal of Clinical Oncology

Advancing Homologous Recombination Repair Mutation Testing in Prostate Cancer in Australia: Shifting the Focus to Hormone Sensitive Prostate Cancer

Arun A. Azad, Declan G. Murphy, Edmond M. Kwan, Anthony M. Joshua

ABSTRACT Homologous recombination repair (HRR) gene alterations are key drivers of disease in prostate cancer. This has led to great interest in HRR targeted therapies, particularly polyadenosine diphosphate‐ribose inhibitors (PARPi), in the treatment of metastatic castrate resistant prostate cancer (mCRPC). HRR alterations are typically early events in prostate cancer tumorigenesis. As a result, clinical trials are investigating the efficacy of PARPi therapy in metastatic hormone sensitive prostate cancer (mHSPC). …

27.08.2026journal-article

PLOS Digital Health

Bridging the health literacy gap: Women and community stakeholders’ perspectives on maternal and child health communication in peri-urban Karachi, Pakistan

Sameeta Kumari, Ayesha Khalid, Hajra Malik, Mahim Maher, Muhammad Imran Nisar, Fyezah Jehan, Zahra Hoodbhoy

Health literacy significantly influences health outcomes, particularly in Low-and Middle-Income Countries. Communication of maternal and child heath messages occurs via text messages, phone calls, television, newspaper articles, and home visits. An exploratory qualitative study was conducted in four peri-urban sites of Bin Qasim Town, Karachi to explore the perspectives of women and community stakeholders on effective health messaging strategies in peri-urban Karachi, Pakistan. Seven focus group discussions (FGDs) …

27.08.2026journal-article

Karya Journal of Health Science

EARLY ERGONOMIC STRESS IN DENTAL EDUCATION: CHANGES IN PRESSURE PAIN THRESHOLDS, BODY AWARENESS AND MUSCULOSKELETAL DISCOMFORT AMONG PRECLINICAL DENTAL STUDENTS

Fatmagül Varol, Nesime Ayşenur Gülaydın, Sevde Koçyiğit, Pınar Baştürk Merç

Objective: Dentistry is widely recognized as an ergonomically challenging profession, with work-related musculoskeletal disorders (WMSDs) often developing early during undergraduate education. While physical workload is heavily studied, how preclinical education affects body awareness and pain sensitivity remains unexamined. This prospective observational study aimed to investigate concurrent changes in self-reported musculoskeletal discomfort, subjective body awareness, and objective pressure pain thresholds (PPT) …

27.08.2026journal-article

Borneo Nursing Journal (BNJ)

Hubungan Tingkat Literasi Kesehatan Dengan Perilaku Manajemen Diri Pada Penderita Hipertensi Di Komunitas

Marcela Dwi Stevani, Juliati Koesrini

Penelitian ini bertujuan menganalisis hubungan tingkat literasi kesehatan dengan perilaku manajemen diri pada penderita hipertensi di Kampung Anyar, Desa Sukolilo, Jabung, Malang. Desain penelitian menggunakan deskriptif analitik dengan pendekatan cross-sectional. Sampel sebanyak 32 responden diambil menggunakan teknik total sampling. Pengumpulan data menggunakan kuesioner Health Literacy Survey-Short Form (HLS-SF) dan Hypertension Self-Management Care Questionnaire (HSMCQ). Analisis data menggunakan uji statistik …

27.08.2026journal-article

Axioms

Constrained Bayesian Reconstruction of Latent Public Preferences Under Dynamic Elimination Rules: An Uncertainty-Aware Expert–Public Fusion Framework

Liang Fang, Xiaoyu Wang, Jiashuo Fan, Shengyu He, Wenhui Chen

Expert–public selection systems often reveal expert scores, institutional rules, and discrete elimination outcomes while concealing public-vote information. This paper develops a constrained Bayesian inverse-inference framework for inferring rule-compatible latent public-preference distributions. Public preferences are represented as simplex-valued latent variables, and rank-based, percentage-based, and judges’ save mechanisms are encoded through rule-induced likelihood constraints. We formally characterize the rul …

27.08.2026journal-article

The American Journal of Tropical Medicine and Hygiene

Determinants of Treatment Adherence in Hepatitis C Patients in a Public Sector Setting in India

Sunvir Kaur Rai, Harpreet Singh, Simmi Oberoi, Amandev Singh, Rahul Bhargava

ABSTRACT. The National Viral Hepatitis Control Program has rapidly scaled hepatitis C virus (HCV) treatment. However, poor adherence and loss to follow-up have led to drug resistance, treatment failure, and increased healthcare costs. Given this background, the present study was conducted to evaluate the rate of loss to follow-up, assess adherence patterns to treatment, and identify factors associated with both of these among HCV patients. A prospective cohort study was conducted among 385 adult HCV patients at Gov …