10.1016/s0967-0653(98)80138-5

Vollständiger Abstract

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<h4>Background</h4>Cardiorespiratory fitness (CRF) is reduced in patients with psoriatic arthritis (PsA), highlighting the need for a consistent assessment of CRF in clinical practice. This study aimed to examine the associations between outcomes of clinical field tests, namely six-minute walk test (6MWT) and handgrip strength (HGS), and CRF, as well as to evaluate the accuracy of these clinical field tests in detecting impaired CRF in patients with PsA.<h4>Methods</h4>Distance walked during 6WMT (6MWD), HGS by hand dynamometry, and maximal CRF as peak oxygen uptake (VO 2 peak, ml/min/kg) by cardiopulmonary exercise testing were assessed. 6MWD and HGS were compared to reference charts of the general population using one-sided t-tests. Spearman's rank correlation coefficients (r s ), multivariable linear regression models and receiver operating curves were analysed to study associations.<h4>Results</h4>In 80 PsA patients, 6MWD was strongly associated with VO 2 peak (r S =0.65, p<0.001), with the multivariable linear regression model, consisting of 6MWD and 6MWT heart rate response and adjusted for relevant covariates, explaining 70% of variance in VO 2 peak. The threshold of 108%predicted 6MWD had sensitivity of 75% and specificity of 64% to identify patients with impaired CRF. 6MWD and HGS were not significantly decreased compared to the general population (p>0.05). A higher 6MWD was moderately to strongly correlated with more favourable outcomes regarding disease activity, cardiometabolic risk, and patient-reported outcomes. No or only weak associations between HGS and VO 2 peak as well as clinical outcomes were noted.<h4>Conclusions</h4>6MWD was strongly associated with VO 2 peak, moderately to strongly correlated with important clinical outcomes and had adequate accuracy to detect patients with impaired CRF.

Abstract: PubMed · Datensatz