Nurse‐Led Patient‐Reported Outcome Assessment of Symptom Burden and Quality of Life in Myeloproliferative Neoplasms: An Observational Study

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ABSTRACT Aim To investigate the symptom burden associated with MPNs and its impact on patients' psychophysical well‐being and quality of life through a structured PROM‐based nurse‐led visit. Design Observational study. Methods We included MPN patients followed at the haematology outpatient clinic of a large university‐affiliated hospital in Italy. Data were collected from September 2024 to March 2025 on 102 patients who underwent a structured PROM‐based nurse‐led visit supported by a dedicated symptom diary. Results Symptom burden was substantial (85% were symptomatic) across all disease subtypes, with fatigue emerging as the most prominent symptom, affecting 72% of patients and accompanied by marked psychological distress (42% and 44% with anxious and depressive symptoms, respectively). Overall health‐related quality of life was predominantly moderate (mean score: 70.7 ± 21.3). Nearly all moderate‐to‐severe symptoms, including fatigue, inactivity, pain, itching, and abdominal discomfort, were strongly associated with impaired global health. 43% of patients need support in becoming more proactive in managing their disease, and satisfaction with the visit was very high (mean score 9.3 ± 1.3/10). Conclusion The impact of MPNs was significant and multifaceted, affecting patients' physical, emotional, and social well‐being. Structured PROM‐based nurse‐led visits play a key role in detecting patients' needs and supporting symptom management across all domains of well‐being, fostering motivated engagement. Implications for the Profession and Patient Care Integrating structured PROM‐based nurse‐led visits into routine haematology care may improve symptom monitoring, support patient engagement, and guide timely and tailored supportive interventions. Impact Patients with MPNs experience a substantial physical and psychosocial symptom burden. Symptom clusters are associated with anxiety, depression, and reduced quality of life. Structured PROM‐based nurse‐led visits may facilitate the early identification of unmet supportive care needs. Reporting Method Guidelines for reporting observational studies (STROBE): Patient Contribution Patients actively participated during the nurse‐led visit and in data collection.