Natural Active Ingredient Nanomicelles for Synergistic Treatment of Wound Bacterial Infections

Vollständiger Abstract

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Abstract In this study, three natural antibacterial aldehydes, including cinnamaldehyde (CA), p-anisaldehyde (PA), and vanillin (VA), were grafted onto linear polyglycidol (LPG) via pH-responsive hydrazone bonds, yielding amphiphilic conjugates (CA-LPG, PA-LPG, VA-LPG) that self-assembled into stable micelles. Quercetin (Que)-loaded micelles (Que@CA-LPG, Que@PA-LPG, Que@VA-LPG) were prepared, with Que@CA-LPG showing superior antibacterial activity against Staphylococcus aureus (MIC: 32 μg/mL), a 3-fold enhancement over free drugs. In vivo experiments on S. aureus-infected skin wounds demonstrated that topical Que@CA-LPG significantly improved antibacterial efficacy and accelerated healing compared to CA or Que alone. This pH-responsive nanodelivery system leverages synergistic effects and targeted release in acidic infection microenvironments, offering a promising antibiotic-free strategy for treating bacterial wound infections.