Reanalyzing a Randomized Controlled Trial of Invasive Aspergillosis Using a Desirability of Outcome Ranking Approach: Voriconazole Versus Amphotericin B Deoxycholate

Julio C Zuniga-Moya; Marcela Araujo de Oliveira Santana; Luis Ostrosky-Zeichner; George R Thompson; Thomas J Walsh; Andrej Spec

doi:10.1093/cid/ciag457

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Abstract Efficacy of antifungal therapy in invasive aspergillosis relies primarily on mortality, overlooking critical measures of treatment response. We used the Mycoses Study Group Education & Research Consortium (MSG) Desirability of Outcome Ranking (DOOR) framework to assess efficacy of antifungal therapies by integrating mortality, treatment failure, and severe adverse events. Voriconazole achieved better overall outcomes than amphotericin B using the DOOR approach.

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Autor:innen: Julio C Zuniga-Moya, Marcela Araujo de Oliveira Santana, Luis Ostrosky-Zeichner, George R Thompson, Thomas J Walsh, Andrej Spec
Quelle: Clinical Infectious Diseases
Publikation: 2026-01-01
Band / Ausgabe: Nicht angegeben
Seiten: Nicht angegeben
ISSN / ISBN: 1058-4838, 1537-6591
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Julio C Zuniga-Moya, Marcela Araujo de Oliveira Santana, Luis Ostrosky-Zeichner, George R Thompson, Thomas J Walsh, Andrej Spec (2026). Reanalyzing a Randomized Controlled Trial of Invasive Aspergillosis Using a Desirability of Outcome Ranking Approach: Voriconazole Versus Amphotericin B Deoxycholate. Clinical Infectious Diseases. https://doi.org/10.1093/cid/ciag457

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