Vollständiger Abstract
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Colon cancer is a major global malignancy with significant mortality. Right-sided (RCC) and left-sided colon cancers (LCC) exhibit distinct clinicopathological characteristics. Tumor microenvironment score (TMS) combines Klintrup-Mäkinen grade, tumor stroma percentage, and tumor budding, classifying cases into 4 groups (TMS 0-3). Evaluation of TMS is an integrative method for prognostic classification; however, further validation is needed, and differences between RCC and LCC remain unclear. A discovery cohort (n=940) and a validation cohort (n=613) were retrospectively included. TMS was evaluated from hematoxylin-eosin-stained slides. Five-year disease-specific survival (DSS) was analyzed using life-table methods and Cox regression. Associations with clinicopathological variables were assessed. In both the discovery and validation cohorts, higher TMS was associated with worse 5-year DSS in univariable analyses for both RCC and LCC. In multivariable analysis, high TMS (TMS3 vs. TMS0) remained independently associated with survival in the discovery cohort (RCC—HR: 2.47, 95% CI: 1.36-4.46, P =0.003; LCC—HR: 3.08, 95% CI: 1.46-6.45, P =0.003). In the validation cohort, the prognostic impact of TMS was more pronounced in RCC (HR: 4.35, 95% CI: 2.32-8.14, P
Bibliografischer Nachweis
Publikationsdaten
- Autor:innen
- Mari J. Jawad, Vilja V. Tapiainen, Ville K. Äijälä, Päivi H. Sirniö, Anne E. Tuomisto, Hanna Elomaa, Maarit Ahtiainen, Olli Helminen, Erkki-Ville Wirta, Toni T. Seppälä, Jan Böhm, Jukka-Pekka Mecklin, Henna Karjalainen, Meeri Kastinen, Timo Väisänen, Vesa-Matti J. Pohjanen, Markus J. Mäkinen, Jukka M. Rintala, Heikki Huhta, Juha P. Väyrynen
- Quelle
- American Journal of Surgical Pathology
- Publikation
- 2026-01-01
- Band / Ausgabe
- Nicht angegeben
- Seiten
- Nicht angegeben
- ISSN / ISBN
- 0147-5185, 1532-0979
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Zitierfähiger Nachweis
Mari J. Jawad, Vilja V. Tapiainen, Ville K. Äijälä, Päivi H. Sirniö, Anne E. Tuomisto, Hanna Elomaa, Maarit Ahtiainen, Olli Helminen, Erkki-Ville Wirta, Toni T. Seppälä, Jan Böhm, Jukka-Pekka Mecklin, Henna Karjalainen, Meeri Kastinen, Timo Väisänen, Vesa-Matti J. Pohjanen, Markus J. Mäkinen, Jukka M. Rintala, Heikki Huhta, Juha P. Väyrynen (2026). The Tumor Microenvironment Score and Its Subsite-Specific Relevance in Colon Cancer. American Journal of Surgical Pathology. https://doi.org/10.1097/pas.0000000000002599
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