Vollständiger Abstract
Worum geht es in dieser Arbeit?
Abstract The epidermal growth factor receptor, or EGFR, is one of the most frequently altered oncogenes in human cancer and is a critical therapeutic target. EGFR alterations span a broad spectrum, including gene amplification, point mutations, truncations, in-frame insertions or deletions, and fusions, yet their mutational distribution is cancer type-specific. This distribution impacts the effectiveness of EGFR-targeted therapies across EGFR-mutant cancers. This review will cover what is currently known about the EGFR-driven cancer landscape in the following cell lineages: lung, brain, colon, breast and bladder. This article is part of the discussion meeting issue ‘Epidermal growth factor receptor after 40 years’.
Bibliografischer Nachweis
Publikationsdaten
- Autor:innen
- Amy Rios, Kimberly A. Jorge, Gizelle G. Ramirez, Chester A. Thompson, Tikvah K. Hayes
- Quelle
- Philosophical Transactions of the Royal Society B: Biological Sciences
- Publikation
- 2026-01-01
- Band / Ausgabe
- Nicht angegeben
- Seiten
- Nicht angegeben
- ISSN / ISBN
- 0962-8436, 1471-2970
- Zitationen
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Zitierfähiger Nachweis
Amy Rios, Kimberly A. Jorge, Gizelle G. Ramirez, Chester A. Thompson, Tikvah K. Hayes (2026). Impact of lineage-specific epidermal growth factor receptor mutations in cancer. Philosophical Transactions of the Royal Society B: Biological Sciences. https://doi.org/10.1098/rstb.2024.0501
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