10.1111/acn.v9999.9999

Vollständiger Abstract

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<h4>Aim</h4>This study examined the associations of periodontal status with incident dementia and its subtypes in a Japanese community.<h4>Materials and methods</h4>The 1396 participants aged ≥ 60 years without dementia were followed for 10 years. Periodontal status at baseline and 5 years was assessed using mean probing pocket depth (PPD), clinical attachment level (CAL) and percentage of bleeding on probing (%BOP), categorized into quartiles. Cox proportional hazards and time-varying Cox models were used.<h4>Results</h4>During follow-up, 267 participants developed dementia; 194 and 51 had Alzheimer's disease (AD) and vascular dementia (VaD), respectively. Compared with the lowest quartile, the highest quartiles of PPD, CAL and %BOP at baseline were associated with increased dementia risk (hazard ratio 1.72 [95% confidence interval 1.18-2.46], 1.59 [1.07-2.38] and 1.56 [1.09-2.22], respectively, all p for trend < 0.05). Elevated %BOP was associated with AD risk (p for trend = 0.023). Higher PPD tended to be associated with VaD (p for trend = 0.076). Similar associations for all-cause dementia were observed in time-varying Cox analyses.<h4>Conclusions</h4>Poor periodontal status was associated with dementia in older Japanese adults. These findings highlight the potential public health importance of preventing periodontitis to reduce the risk of dementia.

Abstract: PubMed · Datensatz