Vollständiger Abstract
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We describe a 1-year-2-month-old boy with KMT2A -rearranged leukemia presenting with concurrent acute myeloid leukemia in bone marrow and B-lymphoblastic leukemia/lymphoma in a right calf mass. Both lesions harbored an identical KMT2A::MLLT10 fusion, confirming common clonal origin. This represents the first documented case of spontaneous “spatial lineage divergence” at diagnosis, distinct from therapy-induced lineage switch. The finding highlights the potential need for multi-site biopsy and molecular profiling in extramedullary disease.
Bibliografischer Nachweis
Publikationsdaten
- Autor:innen
- Huan Zhang, Qiuling Miao, Yue Wang, Li Li, Meng Yi, Xianping Jiang
- Quelle
- Pediatric and Developmental Pathology
- Publikation
- 2026-01-01
- Band / Ausgabe
- Nicht angegeben
- Seiten
- Nicht angegeben
- ISSN / ISBN
- 1093-5266, 1615-5742
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Zitierfähiger Nachweis
Huan Zhang, Qiuling Miao, Yue Wang, Li Li, Meng Yi, Xianping Jiang (2026). Spatial Lineage Divergence at Diagnosis in a Pediatric KMT2A -Rearranged Leukemia Presenting with Concurrent AML and B-LBL. Pediatric and Developmental Pathology. https://doi.org/10.1177/10935266261478989
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