10.1177/1056789514562152

Vollständiger Abstract

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<h4>Purpose</h4>To describe how 15-letter loss of visual acuity (VA) in patients with neovascular age-related macular degeneration (nAMD) results in transient fluctuations in vision. In addition, to compare recoverability of letter loss in patients treated with antivascular endothelial growth factor (anti-VEGF) with untreated patients.<h4>Methods</h4>Patients with previously untreated nAMD in the Comparisons of AMD Treatments Trials were assigned to transient and nontransient groups based on recovery of baseline best-corrected VA within 8 weeks. Magnitude of recoverable letter loss was modeled via linear regression.<h4>Results</h4>Two hundred fifty-three of 1018 patients (25%) experienced 15-letter loss: 68 transient (7%) and 185 nontransient (18%). Two-year outcomes were better without 15-letter loss (+12 letters, 95% CI, 11-13, n = 772) compared with transient 15-letter loss (+0.4 letters, 95% CI, -4 to 5) and nontransient 15-letter loss (-14 letters, 95% CI, -17 to -12). Nontransient losses up to -2.5 letters were expected to be recoverable (95% CI, -6.0 to 1.0). Fifteen-letter loss was associated with smoking (<i>P</i> = .02) and poor nontransient outcomes with higher blood pressure (<i>P</i> = .04).<h4>Conclusions</h4>Patients experiencing transient and nontransient 15-letter loss differed significantly in outcomes. Nontransient losses were not expected to be recoverable. These findings may help guide the selection of measures in clinical trial design.

Abstract: PubMed · Datensatz