Development of a Pediatric Oncology Financial Toxicity Outcome Measure With Content and Face Validity: The Parent-Reported Instrument of Costs and Experiences (PRICE)

Vollständiger Abstract

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PURPOSE To address a lack of validated outcome measures of financial toxicity in pediatric oncology settings, we developed a novel caregiver-reported instrument. METHODS We first conducted qualitative concept elicitation interviews with family caregivers, then drafted de novo survey items guided by salient content domains. Items were reviewed by an expert panel who provided numeric ratings of item relevance to calculate content validity index (CVI), along with feedback on clarity and content. Items were removed or revised through a consensus process, organized into a preliminary measure, and forward- and back-translated to Spanish. We pretested items with caregivers in English and Spanish through iterative rounds of language-concordant cognitive interviews, revising between rounds to optimize comprehension, decision/response processes, and flow. RESULTS Concept elicitation with 21 caregivers (47% college-educated, 14% in Spanish) informed creation of 56 initial items across five content domains. CVI was