10.1556/jfchem.2011.00016

Vollständiger Abstract

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<h4>Background and aim</h4>Aging in mammals is a complex, multifaceted process involving the progressive decline of physiological functions, in which energy metabolism plays a pivotal role. <i>β</i>-oxidation-the primary pathway for converting fatty acids into energy-is tightly linked to aging and to female reproductive senescence. In the present study, we investigated how ovarian tissue remodels hepatic proteins central to the <i>β</i>-oxidation pathway.<h4>Methods</h4>Liver proteomes were analyzed in CBA/J control mice at 4, 13, 23, and 27 months of age and compared with those of 23-month-old mice that received transplants of young ovarian tissue at 13 months. <i>β</i>-oxidation proteins were quantified using high-resolution mass spectrometry. Serum triglycerides were measured enzymatically, and metabolic cage analyses were performed to assess substrate utilization and energy balance.<h4>Results</h4>Ovarian tissue transplantation substantially modulates the expression of <i>β</i>-oxidation-related proteins and reduces systemic lipid accumulation in aged mice. These proteomic shifts are consistent with enhanced metabolic efficiency and decreased oxidative stress-mechanisms well-established as drivers of extended health span and longevity. Results apply to menopause dyslipidemia, insulin resistance, metabolic syndrome, NAFLD, and aging. Transplants reduce <i>β</i>-oxidation proteins and triglycerides, improving hepatic lipid clearance and steatosis risk. Identifying ovarian signals enables non-surgical mimics via peptides or modulators. Changes align with PPARα agonists, CPT1 modulators, mitochondria-targeted antioxidants (MitoQ), and NAD + /sirtuin pathways-offering testable routes to replicate ovarian benefits.<h4>Conclusions</h4>Ovarian-derived signals induce metabolic reprogramming in aged mice, characterized by reduced <i>β</i>-oxidation protein expression, decreased triglyceride accumulation, and improved metabolic efficiency. These findings provide a molecular framework for understanding how ovarian-derived factors may govern metabolism and organismal health during aging, with potential implications for interventions targeting age-related metabolic decline.

Abstract: PubMed · Datensatz