Association of maternal and perinatal factors with umbilical cord blood thyroid profile in newborns: a prospective observational study

Vollständiger Abstract

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Background: Congenital hypothyroidism (CH) is a preventable cause of intellectual disability. Cord blood thyroid-stimulating hormone (TSH) is widely used for newborn screening; however, several perinatal factors may influence TSH levels and increase false-positive results. Objectives were to evaluate the effect of maternal and perinatal factors on cord blood thyroid profiles in neonates. Methods: A hospital-based cross-sectional observational study was conducted among 90 neonates. Cord blood samples collected at birth were analyzed for TSH levels. Maternal age, parity, gestational age, mode of delivery, weight of the baby, gender, and birth asphyxia were recorded. A student's t test, one-way ANOVA, and chi-square test were used to analyze the data. Statistical significance was considered at p20 µIU/ml) was observed in 14.4% of neonates. Higher cord blood TSH levels were significantly associated with parity (p=0.010), mode of delivery (p