Optical and Structural Characterization of Sn@Zn and Sn Core-Shell Nanoparticles Synthesized by PLAL: Evaluation of Prostate Cancer

Vollständiger Abstract

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In this study, Sn nanoparticles and Sn/Zn core-shell nanoparticles were synthesized using (PLA) techniques. Pulsed laser ablation with a (1064 nm) wavelength, (6 Hz) frequency, (300 mJ) energy, and (250 pulses) number of shots was used to subject colloidal dispersions of Sn and Zn, and bimetallic Sn@Zn core/shell nanoparticles were generated by the metal target in 15 mL of distilled water (DW). The investigation of nanoparticles was done by X-ray diffraction (XRD), atomic force microscopy (AFM), UV-VIS spectroscopy, FESEM, zeta potential, and transmission electron microscopy (TEM). The efficiency of the prepared nanomaterial was assessed for cytotoxicity, as the test was performed on normal cell lines and the prostate cancer line (PC3). This study employed a nanosecond timeframe to synthesize high-purity Sn and Sn@Zn core/shell, with subsequent analysis of their properties via multiple methodologies. Coating Sn nanoparticles with Zn nanoparticles produces composite nanoparticles with relatively low toxicity. The zeta potential analysis indicated that the core-shell of Sn and Sn@Zn had a moderate electrostatic potential. It is excellent for anti- prostate cancer applications. From these results, it was found that the Sn@Zn core-shell nanoparticles can kill cancer cells more than pure Sn nanoparticles.