Frequency of gastroptosis and gastroparesis in children with treatment-resistant dyspepsia and duodenogastric reflux: a prospective study

Vollständiger Abstract

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Background. Studies on gastroptosis and gastroparesis in children are limited. This prospective study aimed to evaluate the frequency of gastroptosis and gastroparesis and their association with duodenogastric reflux (DGR) and treatment-resistant dyspeptic symptoms in children. Methods. The study evaluated pediatric patients aged 2-18 years with dyspepsia who underwent upper gastrointestinal endoscopy between March 2020 and June 2022. Fluoroscopy and gastric emptying scintigraphy were performed in 88 patients (50 with DGR and 38 with treatment-resistant dyspepsia). Results. The mean age of the patients was 13.7±3.6 years, and 62 (70.5%) were girls. Gastroptosis was detected in 22 (25%) and gastroparesis in 24 (27%) of all 88 patients. Gastroptosis was present in 10 (20%) and gastroparesis in 20 (40%) of the 50 patients with DGR. Gastroptosis was present in 12 (32%) and gastroparesis in 4 (11%) of the 38 patients with treatment-resistant dyspepsia. Gastroparesis was more common in those with DGR (40%) than in those with treatment-resistant dyspepsia (11%) (p=0.09). Gastroptosis was also detected in 14 (58.3%) patients with gastroparesis. The median body mass index (BMI) z-score of those with gastroptosis was significantly lower than those without gastroptosis (p=0.002). Conclusions. Gastroptosis and gastroparesis were frequently identified in children with treatment-resistant dyspeptic symptoms or DGR. These conditions should be considered and investigated in this patient population.