10.3389/fpsyg.2012.00132

Vollständiger Abstract

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<h4>Objective</h4>To conduct an exploratory neurophysiological pilot analysis of transient resting-state EEG alterations induced by a single peripheral magnetic stimulation (PMS) session in older adults with schizophrenia.<h4>Methods</h4>In a randomized sham-controlled study, 40 older inpatients received either active PMS (30 minutes on the quadriceps) or a sham intervention. Eyes-closed resting-state EEG (59 channels) was recorded pre- and post-intervention. Spectral power (δ, θ, α, β, γ), scalp topographies, and weighted phase lag index (dwPLI) functional connectivity were analyzed.<h4>Results</h4>Active PMS induced significant, frequency-specific changes: decreased δ/θ power and increased α/β/γ power. Topographically, low-frequency reductions were prominent in the midline-right hemisphere, while high-frequency enhancements occurred in frontoparietal regions. Connectivity analyses revealed a dual pattern: potentially strengthened long-range δ-θ coupling (frontal/midline to right posterior) and enhanced short-range high-frequency synchrony in frontal and lateral parietal areas. These dwPLI connectivity findings derive from exploratory analyses and were not prespecified formal study outcomes. The sham group showed no comparable changes.<h4>Conclusions</h4>This exploratory pilot study identified transient band-specific resting-state EEG shifts following one PMS session, including reduced low-frequency oscillations and elevated high-frequency power and connectivity in older adults with schizophrenia. These preliminary neurophysiological patterns require replication in larger controlled trials; no definitive clinical therapeutic inferences can be drawn from this small exploratory dataset.<h4>Significance</h4>This exploratory pilot analysis offers preliminary novel electrophysiological observations of PMS-related brain rhythm modulation in older adults with schizophrenia. These exploratory findings lay a foundation for future larger, confirmatory neurophysiological trials peripheral magnetic stimulation; schizophrenia; resting-state EEG; older adults.<h4>Clinical trial registration</h4>ClinicalTrials.gov, identifier NCT07194460.

Abstract: PubMed · Datensatz