Vollständiger Abstract
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Background: Congenital pulmonary airway malformation (CPAM) is a rare developmental disorder characterized by cystic lung lesions, yet its extracellular matrix (ECM) composition remains poorly understood. This study employed decellularization and data-independent acquisition (DIA) proteomics to compare ECM profiles between cystic (CPAM) and histologically normal non-diseased (ND) regions from the lungs of four patients. Results: The decellularized scaffolds retained their native architecture with minimal residual DNA (
Bibliografischer Nachweis
Publikationsdaten
- Autor:innen
- Yanan Li, Ping Yang, Miao Yuan, Xinglong Zhu, Shengqiang Mao, Ying Yang, Menglin Yao, Fei Chen, Yanyan Zhou, Ji Bao, Chang Xu, Yi Li
- Quelle
- Journal of Clinical Medicine
- Publikation
- 2026-01-01
- Band / Ausgabe
- Nicht angegeben
- Seiten
- Nicht angegeben
- ISSN / ISBN
- 2077-0383
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Zitierfähiger Nachweis
Yanan Li, Ping Yang, Miao Yuan, Xinglong Zhu, Shengqiang Mao, Ying Yang, Menglin Yao, Fei Chen, Yanyan Zhou, Ji Bao, Chang Xu, Yi Li (2026). Composition and Function of Decellularized Human Lung Extracellular Matrix from Congenital Pulmonary Airway Malformation. Journal of Clinical Medicine. https://doi.org/10.3390/jcm15176742
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Lizenzhinweise: Lizenz 1