10.3390/polym8030084

Vollständiger Abstract

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<i>Akkermansia muciniphila</i> is regarded as a beneficial mucin-degrading commensal, yet in Japanese populations the genus <i>Akkermansia</i> occurs at low abundance and is frequently undetectable. We examined its dietary correlates and its relationship with physical function in 786 community-dwelling older Japanese adults (age ≥ 65 years). Dietary patterns were derived from 31 food groups by principal component analysis (PCA) with varimax rotation, and <i>Akkermansia</i> was quantified by 16S rRNA gene sequencing and expressed as centered log-ratio (CLR)-transformed z-scores. <i>Akkermansia</i> was undetectable in 356 participants (45.3%) and of low abundance among carriers (median ≈ 0.35%). A noodle-based dietary pattern (principal component [PC] 4) was inversely associated with <i>Akkermansia</i> after adjustment for age, sex, body mass index, and lifestyle/comorbidity covariates (β = -0.125; <i>p</i> = 0.0007), with a dose-response across quartiles (<i>p</i> for trend = 0.004). In a two-part model, this association was confined to detection (adjusted odds ratio per 1 standard deviation = 0.80; 95% confidence interval, 0.69-0.93) and was absent among carriers (<i>p</i> = 0.25), indicating that diet was related to whether <i>Akkermansia</i> was present rather than to its abundance. <i>Akkermansia</i> was unrelated to grip strength, muscle mass, and frailty; weak carrier-restricted associations did not survive false discovery rate correction (<i>p</i> = 0.056) and are considered exploratory. These findings provide limited evidence for a role of <i>Akkermansia</i> in physical function in this low-abundance population.

Abstract: PubMed · Datensatz