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Plasmapheresis as rescue therapy in fulminant seronegative autoimmune hepatitis

Nissanka Sanduni de Silva, Krishantha Jayasekara, Ranjith P. Jayasinghe

Anuradhapura Medical Journal · 2026

Vollständiger Abstract

Worum geht es in dieser Arbeit?

Autoimmune hepatitis (AIH) is an immune-mediated inflammatory liver disease that may present a broad clinical spectrum, including acute liver failure. We report a 71-year-old Sri Lankan female presenting with jaundice, hepatocellular liver injury and acute liver failure secondary to AIH. The diagnosis was confirmed by liver biopsy despite negative serological markers. She was initially treated with corticosteroids and due to progression to liver failure, ultimately with plasma exchange. This case highlights diagnostic challenges and management strategies in elderly patients with seronegative AIH complicated by infection and hepatic encephalopathy, especially within resource-limited settings.

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Publikationsdaten

Autor:innen
Nissanka Sanduni de Silva, Krishantha Jayasekara, Ranjith P. Jayasinghe
Quelle
Anuradhapura Medical Journal
Publikation
2026-01-01
Band / Ausgabe
Nicht angegeben
Seiten
Nicht angegeben
ISSN / ISBN
2345-9719, 2279-3771
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Zitierfähiger Nachweis

Nissanka Sanduni de Silva, Krishantha Jayasekara, Ranjith P. Jayasinghe (2026). Plasmapheresis as rescue therapy in fulminant seronegative autoimmune hepatitis. Anuradhapura Medical Journal. https://doi.org/10.4038/amj.v20i1.7945
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