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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
26.08.2026journal-article

Diseases

Exercise-Based Rehabilitation Following Lower-Limb Revascularisation in Patients with Peripheral Arterial Disease: A Scoping Review

Shinichi Watanabe, Takayasu Koike, Kenji Tsujimoto, Ryoma Tahara, Tomohiko Kamo, Katsuyoshi Suzuki, Keisuke Suzuki

Objective: Exercise therapy is recommended for patients with peripheral arterial disease (PAD) to improve walking capacity and functional outcomes. However, rehabilitation programmes after lower-limb revascularisation remain poorly defined. We aimed to map the existing literature on exercise-based rehabilitation following lower-limb revascularisation in patients with PAD and summarise key intervention features and reported outcomes. Data Sources: PubMed/MEDLINE, Embase, the Physiotherapy Evidence Database (PEDro), …

26.08.2026journal-article

Radiation Sciences in Oncology

Associations of psoas muscle index and inflammatory markers with FDG PET/CT-derived metabolic response after total neoadjuvant therapy in locally advanced rectal cancer

Gizem Kavak, Mehmetcan Atak, Osman Sütçüoğlu, Semra Demirtaş Şenlik, Özlem Özmen, Ömür Berna Çakmak Öksüzoğlu, Yıldız Güney

Objective: Total neoadjuvant therapy (TNT) is increasingly used for locally advanced rectal cancer, but factors associated with metabolic tumor response remain unclear. This study aimed to explore correlations between fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT)-derived metabolic tumor response and patient-related factors, including body composition, systemic inflammatory markers, and imaging-based biomarkers, in patients receiving TNT. Materials and Methods: This retrospective s …

26.08.2026journal-article

Journal of Clinical Medicine

How Early Is Early? Defining Functional Rehabilitation After Acute Achilles Tendon Rupture: A Narrative Review

Masanori Hashimoto, Youichi Yasui, Tomoyuki Nakasa, Hirotaka Kawano, Wataru Miyamoto

Early functional rehabilitation after acute Achilles tendon rupture is increasingly used in nonoperative protocols, but the definition of “early” remains highly heterogeneous across the literature and no standardized timing threshold has been established. This narrative review clarifies the conceptual and operational definitions of early rehabilitation and examines the unresolved timing-threshold problem. Existing evidence supports early functional rehabilitation without a demonstrated increase in rerupture risk co …

26.08.2026journal-article

Journal of Occupational Health

Heat-mitigation effects of protective sheets in the construction industry for the prevention of heat stress disorders

Chikage Nagano, Kimiyo Mori, Yumi Nakao, Seichi Horie

Abstract Purpose This study experimentally investigated whether highly heat-shielding protective sheets used at construction sites could reduce heat stress. Methods A construction-site simulation apparatus was installed in an artificial climate chamber, and direct solar radiation was simulated using infrared heating. Tempered glass partitions allowed the installation of different sheet materials. Wet bulb globe temperature (WBGT), air temperature (Ta), globe temperature (Tg), and relative humidity (RH) were continu …

27.08.2026journal-article

Annals of Work Exposures and Health

Examining the psychometric properties of the Occupational Stress Injury Resiliency Tool with comparison of concurrent, and predictive validity with other leading indicators of work-related psychological conditions

Peter Smith, Marta Pienkowski, Jackie Sam, Teresa D'Elia

Abstract Background This study assesses the psychometric properties of a measure of work-related exposures associated with psychological conditions—the Occupational Stress Injury Resiliency Tool (OSIRT). It also compares the associations between the OSIRT, and 2 other leading indicator measures, with 3 mental health outcomes, cross-sectionally and longitudinally. Methods Three surveys were completed between August 2024 and September 2025. In an initial sample of 895 respondents, the validity and reliability of OSIR …

26.08.2026journal-article

World Journal of Cardiology

Assessing residual cardiovascular risk and vulnerable plaques via non-traditional lipids: From biomarkers to novel targets for precision therapy

Zi-Yi Lu, Ya-Fei Li, Lei Bao, Xu-Tong Wang, Hui Wu, Yin-Fei Xu, Yi Wang, Yan Chen

Coronary artery disease is a leading cause of death and disability-adjusted life-years worldwide. Acute coronary syndrome, a major clinical manifestation of coronary artery disease, commonly results from disruption of vulnerable atherosclerotic plaques. Conventional lipid parameters, especially low-density lipoprotein cholesterol, play a central role in cardiovascular risk assessment and management. However, these traditional markers have important limitations in their ability to fully capture the complexity of ath …

26.08.2026journal-article

International Journal of Sports Science & Coaching

Concordance of large language models with a hamstring strain guideline: Implications for athlete rehabilitation and return-to-sport guidance

Ahmet Murat Çörekci, Sergen Devran, Sertaç Yakal, Abdullah Faruk Uyanık, Gökhan Metin

Hamstring strain injury is a common sports-related injury with substantial recurrence risk, and large language models are increasingly used as sources of health information by athletes, coaches, and clinicians. This study evaluated the concordance of three contemporary large language models with the 2022 hamstring strain injury clinical practice guideline. Fourteen guideline-derived clinical questions were submitted to ChatGPT-5.2, Gemini 3 Pro, and DeepSeek-3.2v using identical single-turn prompts on January 17, 2 …

26.08.2026journal-article

World Journal of Stem Cells

Mesenchymal stem cells therapy ameliorates esophageal dysmotility in gastroesophageal reflux disease by modulating smooth muscle contractility, alleviating senescence by targeting the DNMT3a-HIF1α axis

Yi Li, Wen-Ya Zhu, Bo Zhang, Ze-Rui Wang, Zhao-Yang Chen, Qian-Qian Chen, En-Qiang Linghu

BACKGROUND Gastroesophageal reflux disease (GERD) is associated with esophageal dysmotility, leading to impaired acid clearance and persistent symptoms. Mesenchymal stem cell (MSC) therapy holds promise for tissue regeneration and functional restoration. AIM To investigate the therapeutic efficacy and underlying molecular mechanisms of MSC treatment on esophageal dysmotility in a rat model of GERD and in human esophageal smooth muscle cells (HESMCs). METHODS A rat model of chronic GERD was established surgically. R …

26.08.2026journal-article

Drug Metabolism and Personalized Therapy

Safinamide dual molecular mechanisms: sodium channel and glutamate modulation as a translational rationale for neuropathic pain – A narrative review

Utpal Bhui, Radheshyam Pal, Amit Chakraborty, Sathvik Belagodu Sridhar, Uttam Prasad Panigrahy, Shubhrajit Mantry, Bimlesh Kumar

Abstract Introduction Neuropathic pain is a chronic and debilitating condition characterized by maladaptive changes in peripheral and central nervous system pathways. It is driven by abnormal neuronal excitability and excitatory neurotransmission. Among the key contributors are voltage-gated sodium channels (VGSCs) and glutamatergic mechanisms, both of which play pivotal roles in peripheral and central sensitization. Content This narrative review was conducted through a structured literature search of PubMed/MEDLIN …

26.08.2026journal-article

Exploring Science Academic Conference Series

Sensorimotor Closed-Loop Control in Post-Stroke Wrist-Hand Rehabilitation Robots: A Structured Narrative Review

Shengwei Chai

Post-stroke wrist-hand rehabilitation robots can increase training intensity, repetition, and measurement. Still, systems centered mainly on mechanical assistance may not fully address the sensorimotor impairments that constrain functional recovery. This structured narrative review examines how sensorimotor closed-loop control may reshape wrist-hand robotic rehabilitation by linking somatosensory feedback, voluntary motor effort recognition, and home-based translation. The review was informed by a PubMed-based lite …

26.08.2026journal-article

International Journal of Cognitive Sciences

A Systematic Review of Relationships Between Self-Directed Speech and Self-Processes

Cassidy Sterling, Alain Morin

Self-directed speech is a well-established aspect of human cognition, although its relationships with self-processes such as self-consciousness, self-rumination, mindfulness, self-concept clarity, and self-esteem remain poorly understood. The present study aimed to synthesize existing empirical findings to clarify how individual differences in self-directed speech relate to self-processes. Guided by PRISMA-informed systematic review procedures, this narrative review examined studies published between 2000 and 2025 …

26.08.2026journal-article

Diabetology

Limitations of a Recent Study on Insulin Pen Needle Preferences in People with Diabetes. Comment on Gentile et al. Enhancing Insulin Therapy Adherence Through Technology: Which Needles Do People with Diabetes Prefer? Diabetology 2026, 7, 56

David C. Klonoff, Mandy M. Shao, Agatha F. Scheideman

We read with interest a recent article in Diabetology titled “Enhancing Insulin Therapy Adherence Through Technology: Which Needles Do People with Diabetes Prefer [...]

1 Zitationen
26.08.2026journal-article

Frontiers in Rehabilitation Sciences

Factors of family-centered care associated with state anxiety in parents of children and adolescents with disabilities

Yasuaki Kusumoto, Nobuaki Himuro, Yuta Sasaki, Eri Takahashi, Dai Iwase, Yukie Metoki, Kounosuke Tomori

Objective This study compared the family situations, specifically parents' perceptions of receiving family-centered care and their children's behavioral difficulties, among four parental groups classified by their combinations of state and trait anxiety levels, and investigated factors associated with state anxiety in parents of children and adolescents with disabilities. Methods Cross-sectional data of 95 parents of children and adolescents admitted as outpatients were analyzed. Responses were collected to the Sta …

26.08.2026journal-article

International Journal of Contemporary Pediatrics

Balanced crystalloids versus normal saline for fluid therapy in pediatrics diabetic ketoacidosis: a systematic review

Danny Alsalloum, Prabhakar Patil

Fluid therapy is a cornerstone of management in paediatric diabetic ketoacidosis (DKA). Although normal saline has traditionally been the preferred resuscitation fluid, concerns regarding hyperchloremic metabolic acidosis have led to increasing interest in balanced crystalloids such as Ringer’s lactate and Plasma-lyte. However, evidence regarding their efficacy and safety in children with DKA remains limited and has not been comprehensively synthesized. A systematic review of the literature was conducted to evaluat …

26.08.2026journal-article

Nature Communications

Human iPSC-cardiomyocyte-aggregate cell therapy in non-human primates and correlation of heart recovery with contractile and electrophysiological cardiomyocyte properties

Ina Gruh, Andreas Martens, Serghei Cebotari, Annette Schrod, Alexandra Haase, Caroline Halloin, Wiebke Triebert, Nils Kriedemann, Tobias Goecke, Morsi Arar, Klaus Hoeffler, Paul Frank, Karen Lampe, Amir Moussavi, Anna Kuleshova, Vojtech Hradil, Veronika Fricke, Monika Szepes, Kerstin Mätz-Rensing, Jörg Eiringhaus, Anna-Lena de Vries, Stephan Hohmann, Merlin Witte, Tim Kohrn, Jana Teske, Kevin Cyrys, Sara Szadocka, Annika Franke, Christopher Werlein, Karlo Komorowski, Mark Kühnel, Danny Jonigk, Susann Boretius, Christian Veltmann, David Duncker, Jonathan Jung, Nissim Benvenisty, Jeanne de la Roche, Martin Fischer, Axel Haverich

Abstract This study demonstrates the successful production and injection of human induced pluripotent stem cell cardiomyocyte aggregates into infarcted cynomolgus monkey hearts, resulting in substantial, structured human grafts three months after cell transplantation. Transient graft-induced arrhythmias decreased over time. Both the arrhythmogenicity and the substantial heart function recovery in vivo notably seemed to correlate with induced pluripotent stem cell clone-dependent contractile and electrophysiological …

26.08.2026journal-article

JMIR Serious Games

Effects of Virtual Reality–Based Intervention Combined With Conventional Therapy on Upper-Limb Function in Children With Hemiplegic Cerebral Palsy: Systematic Review and Meta-Analysis of Randomized Controlled Trials

Chengqian Feng, Yang Li, Letian Cheng, Baizhen Xiong, Zhicheng Lin, Caihua Huang

Background Hemiplegic cerebral palsy (CP) commonly affects upper-limb function in children and may limit functional use of the affected arm and hand. Virtual reality (VR)–based rehabilitation can provide interactive, feedback-based, and task-oriented practice, but whether adding VR-based intervention to conventional therapy provides additional benefits remains uncertain. Previous reviews have often included broader CP populations, mixed comparators, or broad upper-limb outcome labels, limiting domain-specific inter …

26.08.2026journal-article

Modern Therapy in Psychiatry and Neurology Journal

On the issue of verification of post-traumatic stress disorder and readaptation of patients

Nadezhda Kravchenko, Oksana Suetina

The article discusses different points of view on some clinical aspects of post-traumatic stress disorder, the difficulties of its unambiguous verification, as well as the psychological problems of participants in armed conflicts that arise when they return to civilian life.

26.08.2026journal-article

Cancer Medicine

Diagnostic BMI and Induction Therapy Weight Change Associated With Hepatotoxicity in Pediatric Patients With Acute Lymphoblastic Leukemia

Emily J. Mason, John P. Woodhouse, Jeremy M. Schraw, Joanna S. Yi, Karen R. Rabin, M. Monica Gramatges, Mark C. Zobeck, Baojiang Chen, Melissa B. Harrell, Olga A. Taylor, Michael E. Scheurer, Philip J. Lupo, Van Huynh, Steven D. Mittelman, Etan Orgel, Austin Brown

ABSTRACT Background Hepatotoxicity is a common treatment‐related complication in pediatric acute lymphoblastic leukemia (ALL). Excess adiposity at diagnosis has been identified as a risk factor, but the impact of weight change during therapy has not been examined. Methods We included patients aged 2–20 years newly diagnosed with ALL between 2005 and 2021. Hepatotoxicity was defined as: (1) transaminitis (ALT/AST > 10× the upper limit of normal), or (2) conjugated hyperbilirubinemia (cbili; > 3.0 mg/dL during induct …

26.08.2026journal-article

Frontiers in Oncology

Construction and internal validation of a risk prediction model for rapid bone loss during aromatase inhibitor therapy

Renda Jiang, Luning Wu, Liangying Zhao, Jiang Wang, Dalei Chen, Lingqiao Hu, Shiyu Wu, Chaoqun Chen, Guinv Hu

Purpose To establish and validate a risk prediction model for identifying hormone receptor-positive breast cancer patients at high risk of aromatase inhibitor-associated rapid bone loss. Methods This single-center retrospective study enrolled 247 patients receiving aromatase inhibitor (AI) therapy between 2016 and 2025. Rapid bone loss, defined as an annual bone mineral density (BMD) loss rate greater than 4% at either the lumbar spine or total hip, was the primary outcome. Predictor selection was conducted using t …

26.08.2026journal-article

Frontiers in Psychiatry

A pilot randomized controlled study of a digital art therapy paradigm for children with ASD: integrating pivotal response treatment into video animation and physical model design

Huili She, Xinyi Dai, Ting Deng, Ruhao Liu, Wenting Jiang, Xufeng Ma

Background The integration of digital technology into art therapy for children with autism spectrum disorder (ASD) represents an emerging trend, yet systematic design frameworks that translate evidence-based interventions into digital media remain underdeveloped. This study developed and evaluated a digital art therapy paradigm that structurally integrates pivotal response treatment (PRT) into video animation design while maintaining cross-media consistency with physical generalization tools. Methods Based on the b …

26.08.2026journal-article

Journal of Clinical Medicine

Cardiac Rehabilitation in Heart Failure: Evidence, Coverage, and Implementation

Pushan Aggarwal, Aishwarya Yannamani, Jyoti Jain, Ilija Klipa, Andrew Oehler, Hayah Kassis-George

Cardiac rehabilitation (CR) is a multicomponent secondary prevention intervention that improves functional capacity and quality of life across cardiac diagnoses, yet remains markedly underused in heart failure (HF). Existing reviews treat efficacy, coverage, delivery, and equity separately; this narrative review integrates them to clarify why uptake in HF remains low despite an established evidence base. We searched PubMed/MEDLINE and the Cochrane Library from January 2009 through December 2025, prioritizing clinic …

26.08.2026journal-article

Equine Veterinary Journal

Spatial and temporal radiation exposure during equine bone scintigraphy: Implications for occupational safety and post‐scintigraphy isolation

Mahmoud Mageed, Shahlaa Dyab, Maciej Przewoźny

Abstract Background Bone scintigraphy is a valuable diagnostic modality in equine orthopaedics, but it is associated with occupational radiation exposure and regulatory requirements for post‐procedural isolation. Objectives To quantify radiation dose rates emitted from horses undergoing bone scintigraphy, to evaluate the effects of distance (spatial) and time (temporal) on radiation exposure, and to derive evidence‐based recommendations for post‐scintigraphy isolation periods. Study Design Prospective, cross‐sectio …

26.08.2026journal-article

European Journal of Heart Failure

The C-MIC II Follow-Up Study: Safety and Efficacy Results 12 months After Deactivation of Cardiac Microcurrent Therapy

Jesus E Rame, Dragana N Kosevic, Tamara Kovacevic-Preradovic, Sasko Jovev, Marija Zdravkovic, Nermir Granov, Tanja Popov, Igor Rudez, Petar Vukovic, Velibor Ristic, Annette Holtdirk, Tim Friede, Muhammad Shahzeb Khan, Miodrag Peric, Faouzi Kallel, Marat Fudim, Stefan D Anker

Abstract Background The C-MIC II trial demonstrated benefits of 6 months of cardiac microcurrent (C-MIC) therapy in patients with non-ischemic heart failure with reduced ejection fraction (HFrEF). The prospective C-MIC II Follow-Up Study evaluates safety and efficacy outcomes post-device deactivation. Methods Primary safety-related endpoints included all-cause, cardiovascular and device-related mortality and hospitalizations and adverse events (AEs). Secondary efficacy-related endpoints included changes in left ven …

26.08.2026journal-article

Thoracic Cancer

Validity and Feasibility of the Constant‐Load Cycle Endurance Test in Lung Cancer Patients Undergoing Radiation Therapy

Junghwa Do, Sungeun Park, Sei Won Lee, A. Hyun Kim, Sang Ah Kim, Seung Hak Lee, Hwayeong Cheon, Jae Yong Jeon

ABSTRACT Purpose This study evaluated the validity of the constant‐load cycle endurance test (CET), performed at 75% of maximal power output, in patients with lung cancer undergoing radiation therapy. Its feasibility, responsiveness to pulmonary rehabilitation (PR), and clinical applicability were also examined. Methods Thirty‐three patients participated in a 4‐week PR program during radiation therapy. CET time was compared with the 6‐min walk test (6MWT) to assess concurrent validity. Patients were stratified by 6 …