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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
14.08.2026journal-article

BMC Sports Science, Medicine and Rehabilitation

Effects of plyometric training on explosive power and swimming performance in adolescent swimmers: a systematic review and meta-analysis with dose-response analysis

Rangxi Jin, Mitchell James Finlay, Francisco Cuenca-Fernández, Wei Huang

Abstract Adolescent swimmers depend heavily on lower-limb power during critical phases such as the block start, wall turn, and sprints, with the circa-peak height velocity (PHV) period representing a sensitive window for neuromuscular development. Plyometric training (PT), utilizing the stretch-shortening cycle, is a key component of long-term athletic development, yet evidence stratified by maturation stage is lacking. This systematic review and meta-analysis searched PubMed, Web of Science, Embase, EBSCO, Cochran …

14.08.2026journal-article

Endocrine Connections

Impact of GAD-65 Antibody Detection on Antihyperglycemic Therapy in T2D

Sharon Halliburton, Eric Herber, Kevin M. Pantalone, Marcie Parker, Amanda Soric

Abstract Guidelines recommend Latent Autoimmune Diabetes in Adults be managed similar to type 1 diabetes, emphasizing early insulin initiation, while other guidances suggest incorporating non-insulin antihyperglycemic therapies based on comorbidities and C-peptide levels. The study objective was to explore whether glutamic acid decarboxylase-65 autoantibody detection in individuals diagnosed with type 2 diabetes impacts antihyperglycemic treatment. This retrospective, observational cohort study at an academic integ …

14.08.2026journal-article

INTERNATIONAL JOURNAL OF ENGLISH LANGUAGE AND COMMUNICATION STUDIES

Metaphors of Hope and Despair in President Bola Ahmed Tinubu’s May 29, 2023 Inaugural Speech

Ehuiken-Ayetin Marvellous

Studies on metaphor in political speeches have gained prominence in recent years. These studies are often interested in the versatile discourse functions of metaphors and how political leaders deploy them as powerful weapons in their armoury of political oratory. However, not much research has focused on the use of metaphors by politicians to conceptualize hope and despair. This study examined the metaphors of hope and despair in president Bola Ahmed Tinubu’s inaugural speech of May 29, 2023. The study sought to fi …

14.08.2026journal-article

Diseases of the Colon & Rectum

SHORT- VERSUS LONG-COURSE RADIATION IN TOTAL NEOADJUVANT THERAPY FOR LOCALLY ADVANCED RECTAL CANCER: A PROPENSITY-MATCHED NATIONAL CANCER DATABASE ANALYSIS

Bryan Szeglin, Michael Consul, Megan Breckheimer, James J. Whitbread, Miloslawa Stem, Alodia Gabre-Kidan, Andrea Bafford, John Migaly

BACKGROUND: Locally advanced rectal cancer is treated with total neoadjuvant therapy which consists of neoadjuvant chemotherapy, radiation, and surgery. The comparative efficacy of long and short course radiotherapy within total neoadjuvant therapy remains uncertain. OBJECTIVE: Compare overall survival and pathological outcomes between patients treated with long or short course radiation as components of total neoadjuvant therapy. DESIGN: Retrospective cohort study. SETTINGS: National Cancer Database, 2018 to 2023. …

14.08.2026journal-article

JAMA Network Open

Internet-Based Cognitive Behavioral Therapy and Telephone Coaching for Anxiety in Children

Andre Sourander, Katri Kaajalaakso, Tarja Korpilahti-Leino, Terja Ristkari, Tiia Ståhlberg, Susanna Hinkka-Yli-Salomäki, Yuko Mori, Terhi Luntamo

Importance Limited data are available on the long-term effectiveness of internet-based cognitive–behavioral therapy (iCBT) for anxiety among children. Objective To evaluate the association of an iCBT intervention with anxiety in children compared with a psychoeducation control group over 12 and 24 months. Design, Setting, and Participants This cohort study is based on 2-year follow-up data of the randomized clinical trial Master Your Worries, which was conducted between August 2017 and January 2020. Participants we …

14.08.2026journal-article

Gynecology and Minimally Invasive Therapy

Misdiagnosed Scar Ectopic Pregnancy: From Suction Evacuation to Laparoscopic Excision – A Case Report

Ipsita Mohapatra, Saubhagya Kumar Jena, Laveti Sai Sarvazna, Subha Ranjan Samantaray

Abstract Scar ectopic pregnancy, a rare form of ectopic pregnancy, is implanted in the myometrium at the site of a previous cesarean section scar. With the increasing rate of cesarean deliveries, the incidence of cesarean scar ectopic pregnancies has been increasing. It is the implantation of blastocyst in the uterine scar of previous cesarean delivery. Scar ectopic pregnancies are challenging to diagnose, especially in the early stages. On ultrasound, they may appear similar to normal intrauterine pregnancies or o …

14.08.2026journal-article

Frontiers in Pharmacology

Investigation of complex miRNA-mRNA interaction networks during JAK inhibitor therapy in rheumatoid arthritis

János Rózsa, Dóra Csige, Monika Bodoki, Zsófia Hagymási-Szabó, Ferenc Tóth, Szilvia Szamosi, Ágnes Horváth, Nóra Bodnár, Edit Végh, Sándor Szántó, Gabriella Szűcs, Zsófia Pethő, Zsuzsanna Gyetkó, Levente Bodoki, János Kádas, Zoltán Szekanecz, Szilárd Póliska

Background MicroRNAs (miRNAs) are small molecules that contribute to the regulation of gene expression by binding to messenger RNAs (mRNAs), controlling the amount of proteins being produced. In the past few decades, biologic and targeted synthetic therapies (e.g., Janus kinase (JAK) inhibitors) have emerged for the treatment of rheumatoid arthritis (RA), which have promised new possibilities for treating the disease. By inhibiting the inflammatory cascade, these drugs are able to moderate further mRNA expression o …

14.08.2026journal-article

Small

In Situ Self‐Assembled Nanoparticles for Cascade‐Instructed Photodynamic Therapy and Real‐Time Treatment Feedback Imaging

Taoli Sun, Wenbin Liu, Minghui Yu, Beibei Wang, Zhengjie Liu, Zijuan Hai

ABSTRACT Although the cancer treatment efficacy has significantly improved, delayed and isolated evaluation methods are difficult to prevent excessive or insufficient treatment. Therefore, the single molecule for simultaneous therapy and feedback has become a promising tool. Herein, we develop an in situ self‐assembled probe (HPO‐CYFF‐TPP) for cascade‐instructed therapy and feedback imaging. Under the dephosphorylation of alkaline phosphatase, HPO‐CYFF‐TPP converts to HO‐CYFF‐TPP and self‐assembles into nanoparticl …

14.08.2026journal-article

American Journal of Speech-Language Pathology

Comparing Traditional Motor Speech Practice to Contextualized Speech Practice in Preschoolers With Childhood Apraxia of Speech

Kerry A. McNamara, Nicole F. Caballero, Jonathan L. Preston

Purpose: The aim of this study was to compare retention of real-word targets across practice conditions (contextualized vs. motor-only) within a modified integral stimulation treatment for preschoolers with childhood apraxia of speech (CAS). Method: A single-subject experimental design with alternating treatments was used with matched target sets randomly assigned to contextualized practice, motor-only practice, or no treatment. Three preschoolers with CAS completed 18 therapy sessions, each consisting of two 25-mi …

14.08.2026journal-article

BJU International

Evaluation of triplet therapy combined with robot‐assisted cytoreductive prostatectomy for high‐volume metastatic prostate cancer: a multicentre randomised controlled trial protocol

Xiangwei Yang, Zhuobin He, Jian Chen, Hanqi Lei, Binyuan Yan, Linze Chen, Hong Liu, Jun Pang

Background Prostate cancer (PCa) is the second most common cancer in men. For patients with high‐volume metastatic PCa (mPCa) who are fit for docetaxel, a triplet therapy regimen consisting of androgen deprivation therapy (ADT), chemotherapy, and an androgen receptor pathway inhibitor (ARPI) is recommended. Adding local radiotherapy to triplet therapy has been shown to alleviate symptoms and reduce disease progression. However, the benefit of combining triplet therapy with local surgery remains unclear and warrants …

14.08.2026journal-article

Medicine

Prophylactic negative pressure wound therapy reduces surgical site infection in gastrointestinal, hepatobiliary, and pancreatic laparotomy

Yanyun Long, Xiaohui Gu, Xin Wang, Kelei Wang, Yong Guan, Shaocong Wang, Chao Liu

Background: Surgical site infections (SSIs) remain a major complication following gastrointestinal, hepatobiliary-pancreatic, and pancreatic surgery. This systematic review and meta-analysis aimed to assess the efficacy of prophylactic negative pressure wound therapy (NPWT) in reducing SSIs following closed abdominal incisions. Methods: A systematic search was conducted in PubMed, Embase, the Web of Science, and the Cochrane Library for studies published from January 2016 to December 2025; all databases were last s …

14.08.2026journal-article

Children

Combined Letrozole and Growth Hormone Therapy in Late-Pubertal Males with Advanced Bone Age and Open Knee Physes

Hui Zhang, Pengxiang Zhou, Yunpu Cui, Xuemei Wang, Huiqiang Liu, Jinfang Yuan, Hua Zhang, Rongsheng Zhao, Tongyan Han, Xinli Wang

Background/Objectives: The therapeutic window for growth hormone (GH) therapy in late-pubertal males with advanced bone age (BA ≥ 15 years) is generally considered closed. Yet, open knee physes may indicate residual growth potential. This single-arm retrospective study evaluated the efficacy and safety of letrozole combined with GH in Chinese males with short stature, advanced BA (15 –< 18 years), and open knee physes. Methods: We included 139 male adolescents stratified by baseline BA: 15 ≤ BA < 16 (n = 24), 16 ≤ …

14.08.2026journal-article

Pediatria. Journal named after G.N. Speransky

EVOLUTION OF THERAPY FOR ACUTE LYMPHOBLASTIC LEUKEMIA IN CHILDREN: FROM FIRST REMISSIONS TO MOLECULARLY TARGETED IMMUNOTHERAPY (ON THE CENTENARY OF THE BIRTH OF N.S. KISLYAK)

A.I. Karachunsky, Yu.V. Rumyantseva, E.G. Mansurova, A.G. Rumyantsev

The centenary of the birth of Academician Natalia Sergeevna Kislyak (1926–2008) — the founder of pediatric hematology in Russia — provides an occasion to reflect on one of the most significant medical achievements of the 20th–21st centuries: the transformation of acute lymphoblastic leukemia (ALL) from a fatal disease into one that is curable in the majority of children. This article traces the logic of that evolution — from the first remission induced by S. Farber in 1948 and D. Pinkel's «total therapy» to the met …

14.08.2026journal-article

Muscles, Ligaments and Tendons Journal

Manual therapy for temporomandibular myofascial pain: a phenotype-guided narrative review

Tuba Yerlikaya, Melis Bagkur, Nima Jabri

Background: Manual therapy for temporomandibular myofascial pain is commonly used within conservative care for muscle-related temporomandibular disorders, which involve masticatory muscle pain, trigger-point sensitivity, impaired mandibular mobility, and functional limitation. Conservative and reversible interventions are preferred as first-line management. Objective: This narrative review summarizes the rationale, clinical application, evidence limitations, and safety considerations of manual therapy for temporoma …

14.08.2026journal-article

Baltic Journal of Sport and Health Sciences

Implementation Challenges and Enablers of Wearable Health Technologies in Physiotherapy Among English-Speaking Participants in India: A Qualitative Study

Divya Sharma, Franz Hessel, Vaibhavi Dargude

Introduction: Wearable medical devices are increasingly integrated in physiotherapy to enable exercise optimisation, remote monitoring of therapy progress, and tailoring of treatment plans based on individual needs. However, their current utilisation in clinical practice in India remains limited and at an early stage, as physiotherapy largely remains a manual skill-based profession in which hands-on techniques often supersede wearable devices. This study aimed to identify the potential facilitators and barriers to …

14.08.2026journal-article

Biology

Combinatorial Therapy with Long-Acting Tenofovir and Tizoxanide Controls Viral Replication and Liver Inflammation in a Murine AAV-HBV Model of Chronic Hepatitis B

Mojisola O. Ogunnaike, Ashrafi Sultana, Samiksha Raut, Weimin Wang, Grace Bybee, Howard E. Gendelman, Benson J. Edagwa, Natalia A. Osna, Larisa Y. Poluektova

Chronic hepatitis B (CHB) infection is a major risk factor for progressive cirrhosis and hepatocellular carcinoma. Persistent virus-induced inflammation alters liver function, leading to accelerated disease and increased mortality. Although lifelong treatment with nucleos(t)ide analogs (NAs) is highly effective at suppressing viral replication, covalently closed circular DNA (cccDNA) persists in hepatocytes to sustain chronic infection, underscoring the need for better interventions and combination therapies. The d …

14.08.2026journal-article

Machines

Reinforcement Learning-Based Interactive Control of an Omnidirectional Mobile Lower Limb Rehabilitation Robot

Suyang Yu, Yangqing Yu, Changlong Ye

This paper proposes a hierarchical control architecture that is established at both lower limb joint and platform levels based on a simplified admittance model, where compliance is regulated through virtual mass and damping. At the lower limb joint level, admittance control governs lower limb motion tracking, while at the platform level it adjusts the omnidirectional mobile platform velocity in response to human interaction forces. Within this framework, a Sarsa-based reinforcement learning agent dynamically optimi …

14.08.2026journal-article

Journal of Traumatic Stress

Enhancing cognitive processing therapy via stellate ganglion blocks: A pilot randomized trial

Philip Held, Sarah A. Pridgen, Dale L. Smith, Daniel R. Szoke, Asokumar Buvanendran, Robert J. McCarthy

Abstract Although trauma‐focused psychotherapies, such as cognitive processing therapy (CPT), are effective treatments for posttraumatic stress disorder (PTSD), a substantial portion of individuals exhibit a diminished response. Stellate ganglion block (SGB), an anesthetic procedure targeting the sympathetic nervous system, has shown promise for PTSD but has only recently begun to be evaluated as an augmentation to evidence‐based psychotherapy. This randomized, placebo‐controlled, double‐blind pilot trial assessed …

14.08.2026journal-article

Epidemiologia

Work-Related Illnesses and Work Disability in Brazil: A Scoping Review of the Epidemiological Profile and Determinants of Sick Leave and Occupational Accidents

Luciano Garcia Lourenção, Luciano Silveira Pacheco de Medeiros

Background: This scoping review maps and synthesizes the scientific evidence on the epidemiological profile and determinants of sick leave and work-related accidents in Brazil, with an emphasis on studies using data from the Brazilian Federal Medical Expert Service of the Ministry of Social Security. Methods: Following the PRISMA-ScR guidelines and the JBI Manual for Evidence Synthesis, eight databases (SciELO, PubMed/MEDLINE, Scopus, Web of Science, LILACS, CINAHL, PsycINFO, Embase) were searched for quantitative …

14.08.2026journal-article

Open Research Europe

European Network for Optimization of Veterinary Antimicrobial Therapy (ENOVAT) guidelines for antimicrobial and non-steroidal anti-inflammatory drug use in bovine respiratory disease

Karolina Scahill, Sébastien Buczinski, Clair L. Firth, Bart Pardon, Maria Stokstad, Amelia R. Woolums, Ramazan Yildiz, Lise Marie Ånestad, Mickael Cargnel, Luis Pedro Carmo, Pierre-Louis Toutain, Luca Guardabassi

Background Bovine respiratory disease (BRD) is a major cause of morbidity, mortality, impaired welfare, production loss, and antimicrobial use in cattle. These European Network for Optimization of Veterinary Antimicrobial Therapy (ENOVAT) guidelines provide evidence-based recommendations for antimicrobial and non-steroidal anti-inflammatory drug (NSAID) use in cattle with acute, undifferentiated BRD, balancing animal-level outcomes with antimicrobial stewardship. Methods Recommendations were developed using the GRA …

14.08.2026journal-article

JMIR Medical Education

Effects of an Immersive 180° Video–Based Virtual Reality Instructional Module on Learning Satisfaction, Technology Acceptance, Motivation, and Quiz-Based Learning Achievement in Undergraduate Physical Therapy Students: Randomized Controlled Trial

Hyoshil Yoon, Yongwoo Lee

Abstract Background Virtual reality (VR) offers immersive learning opportunities in health professions education, yet its effects on learner experience and short-term learning outcomes in education on execution of musculoskeletal special tests remain underexplored. Objective This randomized controlled trial evaluated the effects of an immersive 180° video–based VR instruction, compared with conventional 2D video–based instruction, on undergraduate physical therapy students’ learning satisfaction, technology accepta …

14.08.2026journal-article

Cell Biochemistry and Biophysics

A Three-Dimensional Hyaluronic Acid-Based Scaffold Model for Electroporation-Enhanced Resveratrol Therapy in Triple-Negative Breast Cancer

Pragatheiswar Giri, Monica Dettin, Annj Zamuner, Maria Teresa Conconi, Ignacio G. Camarillo, Nicolò Martinelli, Luigi Dall’Olmo, Elisabetta Sieni, Raji Sundararajan

Abstract Triple-negative breast cancer (TNBC) is an aggressive malignancy defined by the absence of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). These molecular characteristics render targeted therapies less effective and contribute to poor clinical outcomes. Towards this, we studied the electroporation-mediated delivery of resveratrol, a polyphenolic compound with pleiotropic anticancer activities, on MDA-MB-231, human TNBC cell line. Both conventional tw …

14.08.2026journal-article

Cancers

Overcoming Therapy Resistance in Ovarian Cancer: From Molecular Mechanisms to Emerging Therapeutic Strategies

Zofia Pietrasik, Mikołaj Kapała, Joanna Pietrasik, Monika Stefaniak, Sebastian Szubert, Krzysztof Książek, Justyna Mikuła-Pietrasik

Background/Objectives: Epithelial ovarian cancer (EOC) remains a gynecologic malignancy with a poor prognosis, with a 5-year survival of approximately 29% in advanced-stage disease. Despite cytoreductive surgery and platinum- and taxane-based chemotherapy, most patients relapse within 2 years. Major therapeutic barriers include chemoresistance, molecular heterogeneity, and an immunosuppressive peritoneal microenvironment. This review summarizes emerging therapeutic strategies for EOC, their mechanisms of action, an …

14.08.2026journal-article

Journal of Acute Care Physical Therapy

Development of Interprofessional Collaboration and Communication Through Simulation-Based Learning Experiences for Physical Therapy and Speech-Language Pathology Learners

Sheri R. Kiami, Sarah Young-Hong, Wendy C. Georgan, Heidi Cheerman

ABSTRACT Background and Purpose: Literature has shown that interprofessional simulation-based learning experiences (Sim IPE) are effective at preparing future healthcare providers for interprofessional practice and an impactful way to meet health professions’ accreditation standards. However, there is a lack of literature examining outcomes of Sim IPE among entry-level Doctor of Physical Therapy (DPT) and Master of Science Speech-Language Pathology (MS-SLP) learners. The purpose of this study is to examine how part …