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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
14.08.2026journal-article

Journal of Functional Biomaterials

Development of an Electro-Responsive Sorafenib-Loaded Polypyrrole Coating-Modified Nickel–Titanium Alloy for Tumor Ablation Therapy

Lele Liu, Peng Gu, Dan Xia, Yonghao Wen, Baoe Li, Donghui Wang, Yaohong Wu

Nickel–titanium (NiTi) stents have been widely used for the palliative management of portal vein tumor thrombosis (PVTT) due to their excellent mechanical strength and biocompatibility. However, conventional NiTi implants are therapeutically passive and lack intrinsic antitumor activity, rendering them vulnerable to tumor ingrowth and subsequent restenosis. Electrical stimulation-mediated ablation offers a controllable physical strategy for local tumor clearance; however, the native TiO2 passivation layer on the Ni …

14.08.2026journal-article

Frontiers in Nutrition

Five-year patient-reported outcomes of individualized nutrition therapy supporting nutritional ketosis in adults with type 2 diabetes

Rebecca N. Adams, Shaminie J. Athinarayanan, Stephen D. Phinney, Jeff S. Volek, Amy L. McKenzie

Introduction Sleep disturbance, depressive symptoms, and musculoskeletal pain are common in type 2 diabetes (T2D). The long-term patient-reported effects of nutrition-based interventions targeting metabolic dysfunction remain unclear. We examined 5-year changes in sleep, depressive symptoms, and knee pain in adults with T2D participating in a digitally delivered continuous care intervention providing individualized nutrition therapy supporting nutritional ketosis. Methods Adults with T2D enrolled in the interventio …

14.08.2026journal-article

Frontiers in Oncology

Inhibition of ATM, ATR and DNA-PK radiosensitises 3D uveal melanoma models to X-rays and proton beam therapy

Laura Hawkins, Ryan Morris, Helen Kalirai, Karen Aughton, Rumana Hussain, Sarah E. Coupland, Jason L. Parsons

Introduction Proton beam therapy (PBT) is a well-established treatment modality for uveal melanoma (UM), where it exerts its therapeutic effect primarily through the induction of significant DNA damage, particularly DNA double strand breaks (DSBs) that are the most challenging for the cell to repair. Following DSB induction, a coordinated repair response is orchestrated by the key protein kinases, ataxia telangiectasia mutated (ATM), ataxia telangiectasia and Rad3-related (ATR) and DNA-dependent protein kinase cata …

14.08.2026journal-article

Clinics and Practice

Development and Preliminary Assessment of a Mortality Risk Score in Patients with Coronary Artery Disease Receiving Dual Antiplatelet Therapy After Percutaneous Coronary Intervention

Friba Nurmukhammad, Sholpan Zhangelova, Akhmetzhan Sugraliyev, Alexander Arutyunov, Yermagambet Kuatbayev, Zhanetta Mukanova, Dina Kapsultanova

Background: Patients with coronary artery disease (CAD) receiving dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) remain at risk of early adverse outcomes, including in-hospital mortality. Simple risk stratification based on routinely available variables may help identify higher-risk patients, but a limited number of outcome events constrains robust prediction-model development and validation. Aim: This exploratory study aimed to derive a preliminary, interpretable clinical score bas …

14.08.2026journal-article

JMIR Rehabilitation and Assistive Technologies

Ecological Momentary Assessment of Daily Activities in Individuals With Neurological Disorders: Scoping Review

Eva Delooz, Barbara Piškur, Aki Rintala, Bruno Bonnechère, Annemie Spooren

Background Daily activities shape individuals’ health and well-being, reflecting functioning and lived health. For people with neurological conditions, these activities are often disrupted, affecting autonomy and quality of life. Traditional assessments miss subtle, real-time fluctuations, whereas ecological momentary assessment (EMA) captures moment-to-moment activity within natural contexts, offering insight into person-environment-occupation interactions. Despite its growing use, it remains unclear how EMA proto …

14.08.2026journal-article

İşletme Bilimi Dergisi

Examining the Association between Healthcare Workers’ Pandemic Fear and Occupational Anxiety Levels and Their Life Satisfaction

Zeynep Merve Dinler, İbrahim Halil Cankul, Abdul Yusuf Tuncer

Healthcare workers experience high levels of job stress and occupational anxiety, and the emergence of infectious diseases may further increase their fear and anxiety levels. This study aimed to examine the associations between healthcare workers’ fear of COVID-19, occupational anxiety, and life satisfaction. This descriptive, cross-sectional, and correlational study was conducted with 205 healthcare workers, including doctors, nurses, and healthcare technicians, who volunteered from a population of 235 employees a …

14.08.2026journal-article

Frontiers in Oncology

Targeted therapy plus chemotherapy for advanced or metastatic triple-negative breast cancer: a PRISMA 2020 systematic review and meta-analysis

Yanbing Li, Zijun Li, Xin Shi, Hongbo Zuo

Objective To systematically review the efficacy of chemotherapy combined with targeted therapy in the handling of advanced triple-negative breast cancer (TNBC). Methods A thorough literature search was carried out across several databases, including PubMed, EMBASE, ScienceDirect, and Chinese medical databases, for case-control trials on TNBC patients treated with chemotherapy combined with targeted therapy versus chemotherapy alone. Two separate researchers extracted the data, and the risk of bias was assessed usin …

14.08.2026journal-article

Frontiers in Neurology

Efgartigimod as a salvage therapy for anti-NMDAR encephalitis patients after first-line treatment failure: a case series

Yanbo Zhang, Zhijiao Song, Lulu Zheng, Lantao Liang, Hui Zhao, Hui Bu

Background As an Fc receptor inhibitor, efgartigimod (EFG) could reduce serum IgG level, which might have a positive effect in the treatment of anti-N-methyl-D-aspartate-receptor (NMDAR) encephalitis (NMDARE). This study aimed to evaluate the treatment effects and safety of EFG on NMDARE patients following a first-line treatment failure. Methods We retrospectively reviewed five NMDARE patients who failed in first-line treatment. All patients received intravenous EFG (10 mg/kg/week). We conducted neurological functi …

14.08.2026journal-article

Cancer Immunology Research

TIM3 blockade with hypomethylating therapy restores NK-cell and cytotoxic CD4+ T-cell activity in patients with AML or MDS

Jani Huuhtanen, Sofia Forstén, Brittany Ford, Johannes Smolander, Oscar Brück, Sofie Lundgren, Anna Kreutzman, Olli Dufva, Matti Kankainen, Mette Ilander, Hanna Lähteenmäki, Tiina Kasanen, Jay Klievink, Judith Leitner, Peter Steinberger, Mika Kontro, Marc R. Pelletier, Harri Lähdesmäki, Catherine Sabatos-Peyton, Mikael L. Rinne, Kimmo Porkka, Karita Peltonen, Satu Mustjoki

Abstract Occasional complete responses to immune checkpoint inhibitor therapy demonstrate that acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) can be immune-sensitive when appropriately targeted. Here, we analyzed AML/MDS patients (n=14) treated with the anti-TIM3 sabatolimab and the hypomethylating agent decitabine in a phase Ib clinical trial (NCT03066648) using single-cell RNA and T cell receptor (TCR) sequencing (n=6) and functional co-culture assays. Unlike T cell–restricted CTLA4 and PD1, TIM3 …

14.08.2026journal-article

Pharmaceutics

A Preliminary Evaluation of 177Lu-PSMA-617-Based Targeted Radioligand Therapy with X-Ray Stimulated PSMA Relocation Using the PiggyBac Reporter-Gene-Engineered Orthotopic Prostate Tumor Model

Yen-Ta Chen, Ke-Hsin Huang, Chun-Yi Wu, Yi-Jang Lee

Background/Objectives: Because human prostate cancer (PCa) typically exhibits slow tumor growth, establishing reliable PCa tumor models is often time-consuming and unpredictable, thereby limiting the efficiency of preclinical theranostic research. To overcome this limitation, this study employed a non-viral PiggyBac transposon system to introduce triple-reporter genes into PSMA-expressing C4-2 cells, generating orthotopic and subcutaneous xenograft models that allow noninvasive, real-time monitoring of PCa progress …

14.08.2026journal-article

American Journal of Speech-Language Pathology

EmotionaL and Language Recovery in Aphasia (ELLA): Codesigning and Proof-of-Concept Testing a Novel Intervention

Sarah Northcott, Niamh Devane, Nicholas Behn, Shirley Thomas, Anne Morris, Laura Sockett, May Wickham, Katerina Hilari

Purpose: People with aphasia are at risk of becoming depressed, anxious, and isolated. They want therapy to focus on improving communication, confidence, and finding ways to live well; family members want to be involved in the therapy process. We aimed to codesign and test a novel intervention (EmotionaL and Language recovery in Aphasia [ELLA]) that would address these priorities through integrating two evidence-based therapy approaches: elaborated semantic feature analysis (SFA), a naming therapy, and solution-foc …

14.08.2026journal-article

REVISTA DE ESTUDOS INTERDISCIPLINARES

VIVÊNCIAS ACADÊMICAS E QUALIDADE DE VIDA NO ENSINO SUPERIOR

Beatriz Freitas Launé, Cleiziane Lima de Oliveira, Elson Ferreira Costa Costa, Lucivaldo da Silva Araújo, Debóra Ribeiro da Silva Campos Folha

O estudo analisou a relação entre vivências acadêmicas e qualidade de vida de estudantes do curso de Terapia Ocupacional da Universidade do Estado do Pará. A pesquisa permite a compreensão de que o ingresso e permanência no ensino superior exige adaptações significativas e pode impactar tanto o desempenho acadêmico quanto o bem-estar dos discentes. O objetivo central buscou analisar as vivências acadêmicas e as percepções sobre a qualidade de vida de estudantes de Terapia Ocupacional, considerando aspectos sociodem …

14.08.2026journal-article

BDJ Open

Impact of post-resection maxillofacial defects on outcomes of 3D-printed prosthetic rehabilitation in oral cancer patients: a scoping review protocol

Smitha Sammith Shetty, Shibani Shetty, Sameep S. Shetty, Swapna BV

Abstract Introduction Oral cancer patients undergoing surgical resection often develop extensive maxillofacial defects that compromise function, aesthetics, and quality of life. Three-dimensional (3D) printing has enabled the development of customized, patient-specific prostheses, offering improved precision in rehabilitation. However, the extent to which defect type and location influence prosthetic outcomes remains inadequately synthesized in the current literature. Objective To map and synthesize the available e …

14.08.2026journal-article

Gynecology and Minimally Invasive Therapy

Resection of Ovarian Teratoma for the Treatment of Anti-N-Methyl-D-aspartate Receptor Encephalitis – The New Battey’s Operation: A Case Report

Poh Ting Lim, Siak Ming Goh, Satish Kumar Reddy Challa, Simon Robert Ling

Abstract We present the case of a 14-year-old girl diagnosed with Anti-N-Methyl-D-aspartate Receptor (NMDAR) encephalitis following the onset of acute seizures associated with dysautonomia and hallucinations, successfully treated after a laparoscopic ovarian cystectomy and immunotherapy. Histology of the ovarian cyst confirmed the diagnosis of an ovarian teratoma with neural tissues. She then underwent neurorehabilitation and had full recovery of her neurological and functional status. This case highlights the impo …

14.08.2026journal-article

eneuro

Auditory brainstem encoding of speech-in-noise predicts word identification, narrative comprehension, and subjective listening effort in a selective attention task

Kelsey Mankel, Daniel C. Comstock, Brett M. Bormann, Soukhin Das, Doron Sagiv, Hilary Brodie, Lee M. Miller

The auditory brainstem plays a crucial role in speech-in-noise listening, refining numerous acoustic features such as pitch and spatial location under continual descending influence from cortex. However, the difficulty of characterizing brainstem activity during continuous speech listening has obscured its functional role in ecologically valid contexts—not only the effects of selective attention on neural responses, but also their impact on comprehension and listening effort. Here, we evaluated the role of the brai …

14.08.2026journal-article

International Journal of Law and Society

Juridical Analysis of Criminal Punishment and Rehabilitation for Narcotics Offenders in Islamic Criminal Law.

Resi Darwis, A. Husin Ritonga, Hermanto Harun, Abdul Halim

This study aims to analyze the criminalization provisions for narcotic abuse under Indonesian positive law, examine the concept of rehabilitation for narcotic abusers within the Indonesian legal system, and investigate the Islamic criminal law perspective on the criminalization and rehabilitation of narcotic abusers. This research employs a normative-juridical approach using qualitative methods through library research. Data were collected from primary sources including the Qur'an, Hadith, and narcotic-related legi …

14.08.2026journal-article

Journal of Monolingual and Bilingual Speech

Referent Mention When Parents Tell a Story: A Means to Explain Children's Referential Uses in Narratives

Camille Dupret

Abstract This study aims to describe parents’ referential choices while recounting a story to their child. Indeed, in choosing referring expressions (REs), until the 8 years of age or even later, children are less sensitive to discourse accessibility than factors such as visual accessibility or characters’ status within the story. In this study, 24 parents’ narratives co-constructed with their child (mean age: 6;06) from a textless picture book were video-recorded. REs were coded according to their form (pronouns, …

14.08.2026journal-article

Turkish Journal of Biology

Profiling arbutin as a potent cholinesterase and GSK-3β inhibitor and evaluating its cytotoxicity in SH-SY5Y cells for Alzheimer’s disease therapy

SHIRIN TARBIAT, TUĞBA BAL, DENİZ GÜLMEZ

Background/aim: Alzheimer’s disease (AD) is a neurodegenerative disorder linked to cognitive decline and memory loss, marked by hyperphosphorylated tau tangles and decreased acetylcholine levels, which are affected by acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activity. Glycogen synthase kinase-3 beta (GSK-3β) also plays a role in AD through abnormal activation. In this study, the potential of β-arbutin to inhibit cholinesterases and GSK-3β was investigated, utilizing in vitro assays, cytotoxicit …

14.08.2026journal-article

Monoclonal Antibodies in Immunodiagnosis & Immunotherapy

Monoclonal Antibody-Based Anti-Cryptococcosis Therapy

Marcos William de Lima Gualque, Gabriel Rezende Pimenta, Daniel Gomes de Sousa, Lara Yukari Ogasawara, Aline Ruan Wu, Mariana Macul, Matheus Torrichelli Antunes, Marcela Santana Demarchi, Giovana Moreno Fratus, Maria Júlia Siqueto, Andrei Moroz, Maria José Soares Mendes Giannini, Ana Marisa Fusco Almeida

Cryptococcosis remains one of the most severe invasive fungal diseases worldwide, causing high morbidity and mortality, particularly among immunocompromised individuals. Despite the availability of antifungal drugs, current therapeutic regimens are limited by drug toxicity, prolonged treatment, antifungal resistance, biofilm-associated tolerance, and frequent disease relapse, highlighting the need for novel therapeutic approaches. Monoclonal antibodies (mAbs) have emerged as promising immunotherapeutic agents becau …

14.08.2026journal-article

International Journal of Innovative Technologies in Social Science

ISOTRETINOIN THERAPY AND ITS IMPACT ON DEPRESSION: A COMPREHENSIVE LITERATURE REVIEW

Filip Kamyszek, Marta Krężołek, Julia Dobrowolska, Alicja Palus, Kornel Pawlak, Marcin Stępiński, Mateusz Balicki, Oliwia Zynek, Paula Kaczmarczyk, Tomasz Arkuszyński

Background: The association between isotretinoin therapy and depression remains controversial. Early case reports suggested a potential link with psychiatric adverse effects, whereas contemporary large-scale studies have produced conflicting results. Methods: A structured literature review was conducted using PubMed/MEDLINE, Cochrane Library, and Google Scholar. Studies included systematic reviews, meta-analyses, cohort studies, and mechanistic research published between 2000 and 2024. Results: Most high-quality st …

14.08.2026journal-article

Mindfulness

Acceptability and Feasibility of Mindfulness-Based Cognitive Therapy in Adults with Inflammatory Bowel Disease: A Mixed-Methods Study

Milou M Ter Avest, Loes HC Nissen, Sabien JE Bosman, Ilse Dijkman, Anne EM Speckens, Marloes J Huijbers

Abstract Objectives The high psychological burden of inflammatory bowel diseases (IBD) underscores the need for effective and feasible psychological treatment options. This study aimed to explore the acceptability and feasibility of mindfulness-based cognitive therapy (MBCT) for adults with IBD. Method This mixed-methods study was embedded in a multicenter randomized controlled trial on the effectiveness of MBCT in IBD. Reasons for participation were discussed in the context of the trial and reasons for non-partici …

14.08.2026journal-article

European Journal of Case Reports in Internal Medicine

Splenic artery embolization, a therapy that can be life-saving for small bowel variceal bleeding

Rached Radwan, Marianne Ghantous, Johny Salem, Joe Khoury, Antoine Geagea, Khalil Chidiac

Introduction: Small bowel varices are a rare manifestation of portal hypertension, accounting for only 1–5% of variceal gastrointestinal bleeding. Their diagnosis and management remain challenging because of their uncommon occurrence, difficult anatomical accessibility, and lack of standardized treatment strategies. We report a case of refractory small bowel variceal bleeding successfully treated with splenic artery embolization after failure of conventional therapeutic options. Case presentation: A 45-year-old man …

14.08.2026journal-article

NEW SOLUTIONS: A Journal of Environmental and Occupational Health Policy

Translation and Validation of the Job Factor Questionnaire (JFQ) and Quick Exposure Check (QEC) into Malay Language for Small and Medium Food Manufacturing Industries (SME)

Melor Amran, Dayana Hazwani Mohd Suadi Nata, Ismarulyusda Ishak, Putri Anis Syahira Mohamad Jamil

Reliable assessment of ergonomic and job-related risk factors requires tools that are linguistically, culturally, and contextually appropriate. This study translated, culturally adapted, and preliminarily evaluated Malay versions of the Job Factor Questionnaire (JFQ) and Quick Exposure Check (QEC) among workers in Malaysian food manufacturing small- and medium-sized enterprises. The process included forward and backward translation, expert review, face validation, pilot testing, and psychometric evaluation. The ins …

14.08.2026journal-article

Annals of the American Thoracic Society

Digital Exposure Therapy to Reduce Posttraumatic Stress Disorder Symptoms After Critical Illness: A Pilot Feasibility Study

Nadia Liyanage-Don, Karin Maria Nylocks, Sheila Rauch, Barbara Rothbaum, George E Sayde, Robin Cumella, Nakesha Fray, Talea Cornelius, Miguel Mendieta, Sheau-Yan Ho, Carla M Sevin, Ian M Kronish

Abstract Background Posttraumatic stress disorder (PTSD) is common after critical illness. Therapist-delivered exposure therapy is a first-line treatment, but often inaccessible due to cost, limited therapist availability, and perceived stigma. Mobile app-delivered exposure therapy may help address these barriers. Messy Memories is a novel smartphone app that guides patients through core exposure therapy techniques, including self-directed processing of prior distressing experiences. We evaluated the feasibility, a …