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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
22.08.2026journal-article

Cell Death & Disease

NEK2-AURKA axis drives ubiquitin-dependent IFT88 degradation to suppress ciliogenesis and promote basal-type bladder cancer

E Du, Wei Wang, Qiang Su, Wei Huang, Yuanjiong Qi, Weijie Tang, Zhihong Zhang, Changwen Zhang, Jingxian Li

Abstract Loss of primary cilia is common in cancer, but its relevance to molecular subtypes of muscle-invasive bladder cancer (MIBC) is unclear. Here, we combined transcriptomic and co-expression analyses with experiments in bladder cancer cell lines, human tumor specimens, and xenografts to investigate the basis of cilia loss in basal MIBC. Primary cilia were less frequent in basal than in luminal MIBC. Depletion of IFT88 reduced ciliogenesis and increased cell proliferation and migration. Conversely, IFT88 overex …

22.08.2026journal-article

Journal of the American Chemical Society

In Situ Construction of a Reticulated Peptide Scaffold via Responsive Self-Assembly and Proximal Covalent Labeling for Enhanced Tumor Imaging and Therapy

Ruxin Feng, Yunfeng Qiu, Yang Zhao, Rixin Wang, Weilu Xu, Jinhui Ning, Yumin Li, Juyue Zhou, Dingqing Feng, Suying Xu, Leyu Wang

Abstract Precise imaging and specific retention of therapeutic agents at solid tumors were particularly desirable yet hindered by limited specificity and fast diffusion. Herein, we established a dual-trigger-mediated synergistic strategy to form a reticulated peptide network in situ by functional peptide (CL-YPFG) through responsive self-assembly and covalent labeling for prolonged imaging and boosted accumulation of drugs. Specifically, the CL-YPFG underwent morphology transformation from nanoparticles to nanofibe …

22.08.2026journal-article

Indian Journal of Medical Research

Stage-specific lipidomic signatures as biomarkers in progression of cervical cancer

Akshata Kishore Karekar, Sandhya Kaustubh Kamat, Padmaja Yashwant Samant, Sucheta Prakash Dandekar, Dinesh Amrith Uchil, Mayuri Nalinkumar Gandhi, Jayanti Mania-Pramanik, Shilpa Chandrakant Kerkar

Background and objectives Lipidomics has advanced cancer research by uncovering biomarkers that reveal key mechanisms of tumourigenesis. By analysing endpoint lipid metabolites influenced by genetic and environmental factors, the lipidome closely reflects a cell’s functional state. Mass spectrometry, strengthened by modern bioinformatics and biostatistics, now enables precise detection of cancer-related lipid changes, motivating us to adopt this approach. Methods We have applied advanced mass spectrometry and machi …

22.08.2026journal-article

Indian Journal of Palliative Care

Exercise-Induced Modulation of Inflammation and Fatigue in Patients with Head and Neck Cancer Undergoing Chemoradiotherapy: A Pilot Randomised Controlled Trial

Cherishma Dsilva, Vijith V Shetty, Jean Pierre Baeyens, Donald J Fernandes, Suchetha Kumari N, Dhanesh Kumar KU, Cyanna Joseph Dsouza

Objectives: Fatigue and systemic inflammation are among the most prevalent and distressing complications in patients with head-and-neck cancer (HNC) undergoing chemo-radiation therapy (CRT). Exercise has emerged as an effective supportive care intervention; however, high-quality evidence supporting its use during active CRT remains limited. This pilot randomised controlled trial evaluated the efficacy of a supervised exercise programme in reducing fatigue and systemic inflammation in patients with HNC undergoing CR …

22.08.2026journal-article

International Journal of Drug Delivery Technology

CLINICAL EFFICACY OF AYURVEDIC TREATMENT REGIMEN IN THE MANAGEMENT OF KASHTARTAVA (PRIMARY DYSMENORRHEA) – A RANDOMIZED CONTROLLED CLINICAL TRIAL

Kamini Dhiman

Background: Dysmenorrhoea refers to the pain associated with menstruation, typically occurring in the lower abdomen or pelvis. The intensity of pain can vary from mild to severe, and in some cases, the discomfort is debilitating enough to interfere with daily activities, including work and school attendance. Kashtartava (painful menstruation/primary dysmenorrhea) in Ayurvedic terms is characterized by painful menstrual cramps and is often associated with Vata dosha (bio-energetic force responsible for movement) imb …

22.08.2026journal-article

Angewandte Chemie International Edition

MitoGPS: A Mitochondrial DNA G‐Quadruplex‐Targeting Strategy for Tumor‐Preferential Type I Photodynamic Therapy

Yu‐Hui Guo, Yao‐Hui Shi, Pei‐Min Huang, Gui‐Xue Tang, Shu‐Min Xu, Mao‐Lin Li, Jia‐Hao Yuan, Xiu‐Cai Chen, Zhi‐Shu Huang, Yi‐Yong Yan, Jia‐Heng Tan, Jin‐Wu Yan, Shuo‐Bin Chen

ABSTRACT Photodynamic therapy (PDT) is a clinically promising, minimally invasive cancer treatment offering precise spatiotemporal control. However, achieving preferential tumor accumulation remains a critical challenge, which limits therapeutic efficacy and induces off‐target toxicity. Here, we introduce the mitoGPS (mitochondrial G‐quadruplex–targeting photosensitizer) strategy, a rational design framework for developing photosensitizers (PSs) with prolonged intratumoral retention through targeting mitochondrial …

22.08.2026journal-article

Small

Engineering Biomimetic Tumor Organoids Inspired by Janus Stiffness–Driven Cell Stemness

Ziyu Zhu, Siyi Zhou, Tianyi Gu, Yu Liu, Kuoran Xing, Jiaxing Gong, Lixuen Siow, Yun Jiang, Xin Ye, Kejie Lu, Yemu Yang, Yunxia Gao, Jianlu Kong, Ying Qian, Chaoying Zhang, David Tai Leong, Huiming Wang, Mengfei Yu

ABSTRACT Organoids become powerful platforms for modeling cancer biology but poorly preserve stemness due to inadequate biophysical cues. Cancer stem cells (CSCs), crucial for tumor growth, are rare and lose stemness under conventional in vitro conditions, limiting drug screening. While chemical and genetic stemness regulators are identified, the role of spatial matrix mechanics remains unclear and largely absent from current organoid architectures. Here, we demonstrate that stemness depends not on stiffness alone …

22.08.2026journal-article

Quality of Life Research

Implementation of patient-reported outcome measures in oncology practice: a communication-centered qualitative study on patient and healthcare professional perspectives

Linwei He, Anouk E. W. Teunissen, Nadine Bol, Kelly M. de Ligt, Emiel Krahmer

Abstract Purpose Patient-reported outcome measures (PROMs) are increasingly used in oncology to support patient-centered care, yet their implementation in routine practice remains inconsistent. Using a communication-centered perspective which conceptualizes PROMs implementation as a process of meaning exchange between patients, clinicians, and implementation staff, this study examined PROMs implementation as a multi-stage process and explored how it unfolds in real-life oncology care, drawing on both patient and he …

22.08.2026journal-article

Japanese Journal of Clinical Oncology

A Bayesian reanalysis of the THOR trial cohort 1 using reconstructed individual patient data: interval-specific effects and clinically interpretable estimands under non-proportional hazards

Gaku Okumura, Soichiro Yoshida, Kohei Hirose, Shugo Yajima, Wei Chen, Hiroyuki Sato, Akihiro Hirakawa, Motohiro Fujiwara, Yuki Arita, Hiroshi Fukushima, Yosuke Yasuda, Hajime Tanaka, Hitoshi Masuda, Yasuhisa Fujii

Abstract Background The phase 3 THOR trial (cohort 1) showed improved overall survival (OS) and progression-free survival (PFS) with erdafitinib versus chemotherapy in FGFR2/3-altered advanced urothelial carcinoma after prior programmed cell death protein 1 (PD-1) / programmed death-ligand 1 (PD-L1) inhibitor therapy. When the assumption of proportional hazards (PH) is violated, a single hazard ratio (HR) may be difficult to interpret. Methods We derived reconstructed individual patient data (rIPD) for OS and PFS f …

22.08.2026journal-article

Diseases of the Esophagus

PD09.02. Nutritional Vulnerability Predicts Treatment Delivery and Survival in Locally Advanced Esophageal Squamous Cell Carcinoma Undergoing Neoadjuvant Immunochemotherapy

Maohui Chen, Yizhou Huang, Taidui Zeng, Chun Chen, Bin Zheng

Abstract Topic Esophageal Cancer: Other Background Malnutrition is highly prevalent in esophageal squamous cell carcinoma (ESCC) and may critically modulate host resilience to intensive multimodal therapy. In the era of neoadjuvant immunochemotherapy (nICT), the prognostic utility of structured nutritional assessment remains incompletely defined. This study aimed to establish clinically relevant Patient-Generated Subjective Global Assessment (PG-SGA) thresholds and to determine their associations with treatment fea …

22.08.2026journal-article

Diseases of the Esophagus

P1.169. Magnetic and ICG High Risk Lymph Node Mapping in Upper GI Cancer: A Safety, Feasibility and Diagnostic Performance Clinical Study

Markus Trochsler, David Liu, David Watson, Tim Bright, Shalvin Prasad, Andrew Dwyer, Susan Gan, Andrew Ruszkiewicz, Cuong Duong, Conrad stranz, Brendan DESMOND, John Spillane, David Williams, Lauren Kennedy, Louise Jackett, David Moffat, Essa El-Aklouk, Anil Shetty, Aidan Cousins, Emma Bradshaw, Sweet Ping, Harsh Kanhere

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background Accurate localisation of high-risk lymph node (HRLN) stations in upper gastrointestinal cancer could enable tailored resection and focused ultra-staging while avoiding unnecessary lymphadenectomy. Clinically practical tracers and workflows remain limited. Preliminary results are provided at submission, with planned update to the final dataset before abstract publication. Methods This multi-centre observational comparator study enro …

22.08.2026journal-article

Diseases of the Esophagus

P1.067. Multinational Comparison of Surgical Approaches and Postoperative Outcomes in Esophageal Cancer: An International Multicenter Cohort Study

Simiao Lu, Yi Zhu, Yongtao Han, Qiuling Shi, Xuefeng Leng

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background Esophagectomy for esophageal cancer carries substantial morbidity, yet the extent to which institutional surgical strategy—encompassing operative approach, lymphadenectomy extent, and neoadjuvant treatment protocol—determines postoperative complication profiles remains poorly characterized across different geographic practice environments. Methods We performed a retrospective analysis of a prospectively maintained international mul …

22.08.2026journal-article

Diseases of the Esophagus

V-06. Surgical Treatment of Gastroesophageal Reflux Disease in a Patient With Situs Inversus Totalis and Kartagener Syndrome

Sergio Szachnowicz, Evelyn Moura de Assis, Rodrigo de Andrade Lima Vieira de Melo, Camila Maria de Câmara, Rubens antonio Aissar Sallum, Ulysses Jr Ribeiro, Paulo Herman

Abstract Topic Benign Disease: Gastro-Esophageal Reflux and Hiatal Hernia Background Situs inversus totalis is a rare genetic condition characterized by a complete mirror-image transposition of thoracic and abdominal organs. This anatomical anomaly poses technical challenges for surgeons, often requiring adaptations in surgical techniques. Kartagener syndrome, a subset of primary ciliary dyskinesia, includes situs inversus totalis, chronic sinusitis, and bronchiectasis. Patients with this syndrome may develop gastr …

22.08.2026journal-article

Diseases of the Esophagus

P1.193. Neoadjuvant Therapies vs Upfront Surgery for cT2N0 Oesophageal Cancer – a Systematic Review and Meta-Analysis

Dr Eiran Gannon, Dr Matt Davey, Dr Jessie Elliott, Dr John Reynolds, Dr Noel Donlon, Dr Carmen Mueller, Dr Lorenzo Ferri

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background In March 2026, the International Society for Diseases of the Esophagus (ISDE) made ‘conditional’ recommendations in support of neoadjuvant therapy (NAT) over primary surgical resection (PSR) for patients diagnosed with cT2N0 oesophageal cancer. Notwithstanding this, controversial exists due to potential overtreatment. Our aim was to perform a systematic review and meta-analysis to evaluate oncological and survival outcomes in patie …

22.08.2026journal-article

Diagnostics

Ultrasound-Visible 3D Nickel–Titanium Clip for Tumor Localization After Neoadjuvant Therapy in Early Breast Cancer: A Prospective Multicenter Real-World Study

Mattea Reinisch, Efstathia Cremer, Kilian Pankert, Diana Weber, Volker Hanf, Katja Engellandt, Sebastian Hentsch, Cordula Müller, Peter Dall, Matthias Losch, Petra Deuschle, Alexander Traut, Satyen Shenoy, Anita Engel, Dorothea Schindowski, Sherko Kuemmel, Simona Gipe

Background: Neoadjuvant systemic therapy (NST) enables tumor downsizing and increases the feasibility of breast-conserving surgery (BCS) in patients with early breast cancer (EBC). Reliable tumor localization after NST remains challenging, particularly in patients with a complete clinical response. If clips are not visible on ultrasound, stereotactic mammography-guided wire localization is required, which involves additional radiation exposure and may increase patient discomfort and procedural complexity. The 3D-sh …

22.08.2026journal-article

Diseases of the Esophagus

P1.207. Reduced Risk of Postoperative Chyle Leak in Patients With Obesity After Esophagectomy for Esophageal Cancer - a Nationwide Cohort Study

Ellinor Eriksson, Jakob Hedberg, Gustav Linder

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications Background Esophagectomy is a cornerstone in the treatment of esophageal cancer. Although postoperative chyle leak (PCL) is uncommon, it is clinically important due to its associated morbidity and often challenging management. This study aimed to investigate risk factors for PCL and associations with survival in a nationwide cohort. Methods All patients with esophageal cancer, registered in the Swedish Natio …

22.08.2026journal-article

Diseases of the Esophagus

P1.132. Assessing the Impact of Radiomics Features on Machine Learning Models for Predicting Multidisciplinary Treatment Decisions in Oesophageal Cancer

Dylag Jakub, Dan Burns, Nav Thavanesan, Tayyaba Azim, Zehor Belkhatir, Zoë Walters, Sarvapali Ramchurn, Timothy Underwood, Ganesh Vigneswaran

Abstract Topic Esophageal Cancer: Other Background Medical Artificial Intelligence (MAI) is expanding within surgical oncology with new tools emerging for assisting cancer multidisciplinary teams (MDTs) in cancer types such as oesophageal cancer (OC). Radiomics has similarly gained popularity with proponents arguing that it provides comparable performance to human agents when assessing medical imaging however it’s value within OC remains unclear. This study evaluated machine learning (ML) models which combine radio …

22.08.2026journal-article

Neurosurgical Review

Brain-spine interface: an exploration of a potential future treatment for spinal cord injury

Vijay Sivan, Zahin Alam, Hanish Polavarapu, Shreyes Manivel, Rohit Prem Kumar, Geoffrey R. O’Malley, Francis Ruzicka, Nitesh V. Patel

Abstract Spinal cord injuries (SCIs) profoundly impact millions globally, leading to loss of motor and sensory functions below the injury site. Brain-spine interfaces (BSIs) represent an early-stage neuroprosthetic strategy that attempts to restore functional communication between cortical motor-intention signals and spinal sensorimotor circuits below the level of injury. Although early preclinical and highly selected clinical studies have shown encouraging motor outcomes, the evidence remains preliminary, and rout …

22.08.2026journal-article

European Journal of Nuclear Medicine and Molecular Imaging

Total-body [11C]carfentanil PET: Liver-brain axis in methadone vs. buprenorphine treatment

Elizabeth J. Li, Corinde E. Wiers, Chia-Ju Hsieh, Hsiaoju Lee, Alexander Schmitz, Anthony J. Young, Timothy Pond, Joseph Chang, Erin K. Schubert, Robert H. Mach, Henry R. Kranzler, Jacob G. Dubroff

Abstract Purpose To examine the relationship between brain mu opioid receptor (MOR) availability and liver activity in opioid use disorder (OUD) patients treated with methadone (MET) or buprenorphine (BUP). Methods 10 OUD patients, 5 treated with MET and 5 with BUP, as well as 13 healthy controls (HCs) underwent total-body PET [ 11 C]carfentanil (CFN) imaging. MOR availability was quantified using distribution volume ratio (DVR) in key MOR-rich brain regions, and hepatic distribution volume (Vt) was used as an inde …

22.08.2026journal-article

Annals of Surgical Oncology

Impact of Textbook Outcome (TO) and Textbook Oncological Outcome (TOO) on Survival Following Surgery for Esophagogastric Cancer: A Systematic Review and Meta-analysis

Shahd Mobarak, Hasanat K. Ahmed, Zak Shehata, Sorrel Burden, Matthew Gittins, Bilal H. Alkhaffaf

Abstract Background Textbook outcome (TO) and textbook oncological outcome (TOO) are increasingly used as composite measures of surgical success but are limited by heterogeneity in their definitions. This systematic review and meta-analysis aims to synthesize the association between composite outcome measures (TO/TOO) and survival in both gastric and esophageal cancer. Materials and Methods A systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) …

22.08.2026journal-article

Bioconjugate Chemistry

“Imaging Triplets on Two Wheels”: 61Cu-, 64Cu-, and 68Ga-labeled Bicyclic Peptides Targeting Nectin-4 Enable High-Contrast PET Imaging of Urothelial Carcinoma and Triple-Negative Breast Cancer

Johanna Mauersberger, Tobias Krönke, Martin Ullrich, Markus Laube, Florian Brandt, Marc Pretze, Fabian Lohaus, Sebastian Hoberück, Christian Thomas, Matthias Miederer, Ralph A. Bundschuh, Sven Stadlbauer, Klaus Kopka, Jens Pietzsch, Robert Wodtke

Abstract Nectin-4 is a validated target for theranostic approaches toward urothelial carcinoma, and radiolabeled ligands for PET and SPECT imaging are gaining increasing interest for noninvasive quantification of Nectin-4 prior to a targeted therapy. The goal of this study was to develop bicyclic peptides that allow radiolabeling with three different radionuclides (61Cu, 64Cu, and 68Ga) and to evaluate their suitability for high-contrast PET imaging in urothelial carcinoma (UC) and triple-negative breast cancer (TN …

22.08.2026journal-article

Diseases of the Esophagus

V-23. Double-Flap Technique for Reconstruction After Thoracoscopic/Laparoscopic or Robot Assisted Ivor-Lewis Esophagectomy for EGJ Cancer

Hirofumi Kawakubo, Masashi Takeuchi, Satoru Matsuda, Yuko Kitagawa

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – technique Background The selection of surgical procedures for esophagogastric junction (EGJ) cancer varies among institutions. Thoracoscopic/Laparoscopic or Robot assisted proximal gastrectomy (LPG/RPG) has been performed as a minimally invasive procedure for gastric cancer in the upper third of the stomach. However, gastroesophageal reflux disease (GERD) remains a significant concern after PG. Thus, several techniques have been reported to …

22.08.2026journal-article

Diseases of the Esophagus

P1.165. Low Preoperative Fat-Free Mass Index Predicts Anastomotic Leakage and Poor Survival in Esophageal Cancer

Jiarong Zhang, Weiming Chen, Weikun Su, Ruirong Lin, Yijin Lin, Guibin Weng, Lin Chen, Weimin Fang

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – long term outcomes Background Esophageal cancer is one of the most common gastrointestinal malignancies worldwide. In China, most patients are diagnosed at intermediate and advanced stages, and the treatment mainly includes neoadjuvant therapy, surgery and postoperative adjuvant therapy. Although the therapeutic effect has been greatly improved, clinical challenges still exist. Therefore, it's urgent to explore new and effective prognostic …

22.08.2026journal-article

Diseases of the Esophagus

PD02.05. Long-Term Incidence and Treatment Outcomes of Gastric Conduit Cancer After Esophagectomy

Hyun Ki Jeong, Sung Yong Park, Tae Se Kim, Yang Won Min, Dong Ryul Oh, Seh Hoon Park, Jong Mu Sun, Yeong Jeong Jeon, Jung Hee Lee, Jong Ho Cho, Hong Kwan Kim, Yong Soo Choi

Abstract Topic Esophageal Cancer: Other Background Gastric conduit cancer (GCC), a primary carcinoma arising in the reconstructed gastric conduit after esophagectomy, is rare, and its true incidence and long-term outcomes remain unclear. We aimed to determine its cumulative incidence and treatment-related outcomes. Methods We retrospectively reviewed 4,490 patients who underwent esophagectomy with gastric conduit reconstruction between 1994 and August 2025. Among them, 93 developed GCC during follow-up. Clinical ch …