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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
29.08.2026journal-article

Journal of the Pediatric Infectious Diseases Society

Clinical Practice Changes in the Diagnosis and Management of Bacterial Tracheitis in Ventilator-Dependent Children in the Outpatient Setting After Introduction of a Novel Pathway

Geneviève A Donahey, Glenn J Rapsinski

Abstract Background Diagnosis and management of bacterial tracheitis (BT) in tracheostomy- and ventilator-dependent children (VC) is highly variable among outpatient subspecialty providers (OP). Stewardship efforts are generally limited to the inpatient setting, thus further studies are needed to examine and improve outpatient practices. Many OP report desire for guidance in the diagnosis and management of BT and feel a decision support tool would be helpful in their daily practice, thus we developed a pathway for …

29.08.2026journal-article

Journal of the Pediatric Infectious Diseases Society

Clinical Characteristics and Outcomes of Respiratory Viral Infections in Pediatric Cancer Patients, Single center experience

Mona Mohammed, Yassin Taher, Maha Mohammed, Naiven Mohamed, Nehad Abd Elfatah, Marwa Jamal, Omnya Ahmed, Amira Sameh, Mohamed Kamal, Youssef Madney

Abstract Background Respiratory viral (RV) infections cause morbidity and mortality in immunocompromised pediatric patients undergoing cancer treatment. The burden of RV infections in pediatric oncology populations from low- and middle-income countries (LMICs) remain limited. We aimed to detect the prevalence of viruses causing respiratory infections among pediatric patients with cancer and guide empiric therapy and improve patient outcomes. Methods Retrospectively we collected nasopharyngeal swabs and clinical and …

29.08.2026journal-article

Journal of the Pediatric Infectious Diseases Society

A Ten-Year Retrospective Study on the Clinical and Microbiological Characteristics of Early Onset Neonatal Sepsis at a Single Tertiary Care Institution

Vilma Antonette B Prado, Amanda Louise Du

Abstract Background Early-onset neonatal sepsis remains a significant cause of morbidity and mortality globally. Although Group B Streptococcus and Escherichia coli were commonly known to be the most common causes of Early-onset neonatal sepsis, this can vary per institution, thus creating a challenge in management. Understanding the clinical and microbiological profile of neonatal sepsis in a single-center study is crucial to improving diagnosis and treatment, strategies. Objectives This study aimed to characteriz …

29.08.2026journal-article

Journal of Robotic Surgery

Robotic-assisted compartmental dissection for retroperitoneal sarcoma: a feasibility study on cadavers with the da Vinci Xi system

Jonas Wakker, Adrian Ohlde, Victoria van Rüth, Simone Schewe, Nathaniel Melling, Felix Nickel, Oliver Mann, Thilo Hackert, Volker Spindler, Sophie Kurmann, Rouven Berndt, Markus Albertsmeier, Jens Jakob, Anna Duprée

Abstract Retroperitoneal sarcomas (RPS) pose major technical challenges because of their size, anatomical complexity, and need for multivisceral resection. We evaluated the feasibility of a standardized robotic approach for right- and left-sided retroperitoneal sarcoma (RPS) compartmental resection using the da Vinci Xi system in tumour-free human cadavers. In a two-phase IDEAL-D Stage 0 cadaveric study, two sarcoma surgeons first compared four trocar configurations in two cadavers to identify optimal port template …

29.08.2026journal-article

Clinical Transplantation

Primary Language, Social Determinants of Health, and the Lived Patient Experience After Heart Transplantation: A Comparative Qualitative Study

Mansi K. Shah, Zara Latif, Carolina Lemos, Adi Hertz, Elena Donald, Byron Fuselier, Jordan Lindekens, Fabian Vargas, Afsana Rahman, Farhana Latif, Kevin J. Clerkin, Gabriel Sayer, Nir Uriel, Ersilia M. DeFilippis

ABSTRACT Background Over 4,500 individuals undergo heart transplantation (HT) in the United States every year. Limited qualitative data exist evaluating challenges and barriers in the evaluation and post‐transplant process and their association with primary language spoken. Methods We conducted semi‐structured interviews with individuals who received HT at a high‐volume urban academic medical center between 2015 and 2024. Primary English and Spanish speaking patients were included; interviews were conducted by a ce …

29.08.2026journal-article

Journal of Orthopaedic Science and Research

The Role of Biopsy Accuracy in the Treatment of Musculoskeletal Tumors

Hannah Werner, Bennie Lindeque

Background: The accurate treatment of Musculoskeletal (MSK) tumors necessitates appropriate timely biopsy of the mass of interest. With regards to malignant neoplasms biopsy plays a crucial role in the direction of treatment courses and patient outcome. Methods: This is a retrospective single-center chart review of 924 biopsies from 2013-2023. Patients included were between 18-85 with MSK tumors that necessitated biopsy and subsequent surgical treatment. Biopsy and final resection histopathology reports were compar …

29.08.2026journal-article

Veterinary Medicine and Science

Isolation and Antibiogram of Staphylococcus aureus Isolated From Bovine Mastitis in Bardaghat Municipality, Nepal

Biswash Ghimire, Shambhu Shah, Akash Adhikari, Sujan Adhikari, Asmita Regmi, Sirjan Bastola

ABSTRACT Background Mastitis in dairy animals is a major economic and public health concern in Nepal, exacerbated by the emergence of antimicrobial‐resistant pathogens. This study aimed to determine the prevalence and antibiotic resistance patterns of Staphylococcus aureus isolated from bovine milk in Bardaghat Municipality, Nepal. Results A cross‐sectional survey screened 196 milk samples from lactating cows and buffaloes using the California Mastitis Test (CMT). The overall prevalence of S. aureus was 39.79%. Str …

29.08.2026journal-article

Journal of Clinical Medicine

Total Pectoral Muscle Area and Prognostic Nutritional Index Provide Complementary Prognostic Information for Patients Hospitalized with HFmrEF/HFrEF

Çetin Alak, Hasan Emin Kaya, Fazıl Çağrı Hunutlu, Muhammed Batuhan Daştan, Zeynep Kumral, Tunay Şentürk

Background: Skeletal muscle depletion and malnutrition are common in heart failure (HF) and are associated with poor outcomes. Whether imaging-derived skeletal muscle reserve and laboratory-based nutritional indices provide complementary prognostic information remains unclear. We evaluated the prognostic value of total pectoral muscle area (TPMA), Prognostic Nutritional Index (PNI), and Controlling Nutritional Status (CONUT) scores in patients hospitalized with HFmrEF/HFrEF. Methods: In this retrospective single-ce …

29.08.2026journal-article

Journal of Clinical Medicine

CT-Based Peritumoral and Perirenal Fat Radiomics in Renal Cell Carcinoma: A Systematic Review and Meta-Analysis of Grade, Stage, and Adherent Perinephric Fat Prediction

Abdulrahman Al Mopti, Ali H. D. Alshehri, Abdulsalam Alqahtani

Background/Objectives: Preoperative risk stratification in renal cell carcinoma (RCC) remains challenging for tumor aggressiveness and for adherent perinephric fat (APF) relevant to surgical planning. Although intratumoral radiomics are established, the peritumoral and perirenal fat microenvironment is biologically active and may encode imaging biomarkers. This systematic review and meta-analysis evaluated CT-based peritumoral and perirenal fat radiomics for preoperative grading, staging, and APF prediction and exa …

29.08.2026journal-article

Journal of Clinical Medicine

Self-Care Experiences of Individuals with Heart Failure: A Systematic Review and Metasynthesis

Israr Ahmad, Agata Bielecka-Dabrowa, Brunilda Subashi, Yi Chen

Background: Heart failure (HF) is a complex, life-threatening syndrome associated with substantial morbidity and mortality, reduced functional capacity, diminished quality of life, and considerable healthcare costs. Globally, HF affects more than 64 million individuals. Chronic heart failure (CHF) imposes a significant economic and personal burden on individuals, society, and the healthcare system, and places substantial demands on effective self-care. Objective: The purpose of this metasynthesis was to explore the …

29.08.2026journal-article

Advances in Respiratory Medicine

Morphological Analysis of the Flow–Volume Curve for Identifying Fixed Airflow Obstruction: A Scoping Review

Alirio Bastidas-Goyes, Luis F. Giraldo-Cadavid, Eduardo Tuta-Quintero, Diana Diaz-Quijano, Daniel Botero-Rosas, Adriana Maldonado-Franco, Alejandra Vargas, Paula Rincón, Lina López, Juan S. Hernández, Juan Castro, Isabella Criado, Charbel Faizal-Gómez, David Jiménez, Ingrid Mora, Juan León

Background/Objective: The morphology of the flow–volume curve has emerged as a potential source of additional functional information by enabling the analysis of concavity, slope-based metrics, area-derived measures, and mathematical models extracted from the expiratory tracing. Therefore, the aim of this study was to map and describe the available evidence on morphological analysis methods of the expiratory flow–volume curve for the identification and characterization of fixed airflow obstruction. Methods: A scopin …

29.08.2026journal-article

Journal of Personalized Medicine

Personalizing Peri-Intubation Oxygenation in Patients at Risk of Acute Hypoxemic Respiratory Failure: A Phenotype-Driven Narrative Review of High-Flow Nasal Oxygen and Non-Invasive Ventilation

Daniele Salvatore Paternò, Luigi La Via, Rossella Moltisanti, Antonio Putaggio, Angela Maria Piccolo, Giorgia Maria Noce, Roberta Scuto, Gilberto Duarte-Medrano, Natalia Nuño-Lámbarri, Emilia Concetta Lo Giudice, Massimiliano Sorbello

Tracheal intubation in patients at risk of acute hypoxemic respiratory failure (AHRF) carries a high risk of life-threatening desaturation, and the choice of peri-intubation oxygenation strategy critically influences patient safety. This narrative review synthesizes current evidence on non-invasive oxygenation techniques—high-flow nasal oxygen (HFNO), non-invasive ventilation (NIV), and their combination—across the pre-oxygenation, apneic, and awake-intubation phases of airway management. We examine the physiologic …

29.08.2026journal-article

International Journal of Research in Medical Sciences

Leveraging ChatGPT to address patient queries on fever of unknown origin: opportunities and limitations

Prajwal Gundala

Fever of unknown origin (FUO) remains one of the most intriguing and diagnostically challenging syndromes in internal medicine. The term FUO itself implies a passive/negative approach to diagnosis, suggesting a state of uncertainty that may perpetuate medical inertia. FUO is defined as a temperature ≥38.3°C (101°F) on several occasions for at least three weeks without an established diagnosis despite appropriate evaluation.1 In resource-limited settings an active and pragmatic approach is essential to expedite diag …

29.08.2026journal-article

International Journal of Research in Medical Sciences

An interesting case of Contarini’s syndrome in a young patient

Abhishek Agarwal, Armaan Singh, Ambikesh Gupta, Anish Goyal

Pleural effusion is a common disease of the pleura. The pleural effusion is usually unilateral and bilateral pleural effusion is less commonly seen. In bilateral pleural effusions usually the same etiology is present on both the sides but bilateral pleural effusions due to the two different etiologies on the two sides is rare. Here we are describing an interesting case of Contarini’s syndrome where exudative pleural effusion was present on each side but due to the two different etiologies on the two sides.

29.08.2026journal-article

BMC Medical Education

Defining leadership competencies for rural community-based medicine: a Delphi study and field-based curriculum evaluation for undergraduate medical students

Koichi Hamabira, Marie Amitani, Hayato Sakiyama, Kimiko Mizuma, Rie Ibusuki, Tetsuhiro Owaki

Abstract Background Leadership is essential in community-based medicine, yet inconsistently taught in Japan’s undergraduate medical curricula. This study aimed to: (1) identify essential community-based leadership competencies using a Delphi approach, (2) develop and pilot a structured curriculum, and (3) evaluate outcomes through a multi-day interprofessional field programme. Methods We adopted Kern’s six-step approach to curriculum development. A literature review extracted preliminary competencies. A two-round D …

29.08.2026journal-article

Journal of the Pediatric Infectious Diseases Society

Candidemia Among Pediatric Cancer Patients: Clinical Features, Resistance Pattern, and Treatment Outcome

Youssef Madney, Reham Khedr, Hanfy Hafiz, Naglaa Adel, Mervat Elanany, Khaled Alsheshtawi, Lobna Shalaby, Alaa El Haddad

Abstract Background Candidemia presents a significant challenge for pediatric cancer patients, especially with the increasing incidence of echinocandin-resistant Candida and breakthrough candidemia. Recent data highlight a notable shift in the epidemiology of candidemia, with a predominance of non-albicans species, such as C. glabrata, C. parapsilosis, and C. tropicalis, over C. albicans. The incidence of invasive disseminated candidiasis among children ranges from 9% to 10% and is linked to mortality rates between …

29.08.2026journal-article

Journal of the Pediatric Infectious Diseases Society

Patient outcomes associated with carbapenem-sparing management of febrile neutropenia

Alexander Pruett, Jose Ferrolino, Ronald Dallas, Yilun Sun, Elisabeth Adderson

Abstract Background Febrile neutropenia (FN) guidelines recommend that local epidemiology inform empiric antibacterial treatment, but that efforts be made to restrict carbapenem administration to unstable patients. At our institution most stable patients are treated with cefepime. We examined the clinical consequences of this regimen in the context of rising rates of antimicrobial resistance (AR). Methods This retrospective single-center study included patients <22 years of age with cancer or HCT who had receive …

29.08.2026journal-article

Journal of Neonatal-Perinatal Medicine

Expanding the diagnostic lens: Whole exome sequencing in a neonate with arthrogryposis–renal dysfunction–cholestasis (ARC) syndrome

Gayathri Sreenivasan, Jane Hedrick, Anita Ware, Melanie Leong

We report a term neonate who presented with early-onset conjugated hyperbilirubinemia, acholic stools, and imaging findings concerning for biliary atresia, including a contracted gallbladder and triangular cord sign on abdominal ultrasound. However, intraoperative cholangiography demonstrated normal bile flow. Persistently normal gamma-glutamyl transpeptidase (GGT), cholestasis, and renal tubular dysfunction prompted expanded evaluation. Whole-exome sequencing identified a pathogenic VPS33B variant, confirming Arth …

29.08.2026journal-article

International Science Journal

Physiological Impact of Carbon Dioxide Pneumoperitoneum on Cardiovascular Function and Respiratory Mechanics in Advanced Laparoscopic Surgery

Daniel Fernando Camargo Medina, Gary Bastian Medina Jimenez, Ana Carla Naranjo González, Diego Clemente Moreno, María Fernanda Carbajal Hernández, Susana María López Rojas, Jeanina de los Angeles Montero Galban, Pablo Eduardo Navarro López, Vicente Treviño Caballero, Justin Santiago Palacios Moreira

Carbon dioxide pneumoperitoneum is an essential component of advanced laparoscopic surgery, but the increase in intra-abdominal pressure required to create the surgical workspace produces important hemodynamic and respiratory alterations. This study analyzed the principal physiological effects of pneumoperitoneum on cardiovascular performance and respiratory mechanics, considering the influence of insufflation pressure, patient positioning, obesity, duration of surgery, mechanical ventilation, and cardiopulmonary r …

29.08.2026journal-article

Journal of Feline Medicine and Surgery Open Reports

EXPRESS: Common bile duct adenocarcinoma in a cat treated with surgical excision, choledochoduodenostomy and adjuvant toceranib phosphate

Qiao Ying Pauline Chan, Alen Lai

Case summary A 2-year-old male neutered domestic shorthair cat was referred one month after medical management of extrahepatic biliary tract obstruction (EHBTO) for progressive lethargy and hyperbilirubinemia. Abdominal ultrasonography identified a 10mm obstructive common bile duct mass. The cat underwent common bile duct mass resection, choledochoduodenostomy and oesophagostomy tube placement, complicated by transient cardiac arrest. Histopathology confirmed biliary adenocarcinoma. Ongoing toceranib phosphate (toc …

29.08.2026journal-article

Turkish Journal of Cerebrovascular Diseases

Disease of cervical arteries: contemporary imaging, medical management and endovascular treatment

Ezgi Yılmaz, Alper Eren, Özlem Aykaç, Yasemin Dinç, Nazım Kızıldağ, Demet Funda Baş, Talip Asil

Cervical artery diseases, encompassing both atherosclerotic and non-atherosclerotic disorders of the carotid and vertebral arteries, remain a major cause of ischemic stroke and transient ischemic attack (TIA) worldwide. Although luminal stenosis has traditionally guided diagnostic and therapeutic decision-making, recent advances have shifted the focus toward comprehensive vascular assessment, incorporating plaque vulnerability, vessel wall pathology, inflammatory activity, and individualized cerebrovascular risk st …

29.08.2026journal-article

Journal of Clinical Medicine

Rectal Shaving in Colorectal Endometriosis Surgery—Definition, Evidence and Variability

Petya Tanovska, Jörg Keckstein, Mihai Constantin, Maya Sophie de Wilde, Petra Klein, Harald Krentel

Objectives: We aim to evaluate how rectal shaving is defined in the current literature, how consistently this definition is used, and what this means for the results and comparability of the respective research about surgery in deep rectal endometriosis. Methods: A literature search was performed in PubMed covering the period from 1990 to 2026, using multiple search terms combining “rectal shaving”, “shaving”, “conservative surgery” and “endometriosis”. Records were screened by title and abstract; methods sections …

29.08.2026journal-article

Journal of Clinical Questionon

Bispecific Antibodies Targeting PD-1/PD-L1 and VEGF in Non-Small Cell Lung Cancer

Aleena Kuriakose, Salem Gogah, Elina Beleva

Immune checkpoint inhibition has transformed the treatment of advanced non-small cell lung cancer (NSCLC), but primary and acquired resistance remain common. Vascular endothelial growth factor (VEGF) contributes to both tumor angiogenesis and immune suppression by promoting abnormal vasculature, limiting lymphocyte trafficking, and fostering an immunosuppressive tumor microenvironment. These complementary mechanisms provide a rationale for simultaneously targeting the programmed cell death protein 1 (PD-1)/programm …

29.08.2026journal-article

Journal of Clinical Monitoring and Computing

Accelerometers improve detection of movement related artifact in bedside ICU data

Ian Piper, Rob Donald, Katarina Sandall, Annemarie Docherty

Abstract Routinely collected real time data from ICU bedside monitors is a valuable source of information which can assist the clinical team caring for a patient. This data almost always contains artifacts caused by clinical staff attending to the patient throughout the day, e.g. blood samples being taken, body washing, administration of IV medication. We present a small (10 patient) study but with accurately annotated clinical event data constructed by observing standard clinical procedures and merging this inform …