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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

Clinical and Translational Gastroenterology

Diagnostic Performance of Six Tests for Helicobacter pylori Infection in Peptic Ulcer Bleeding: A Prospective Head-to-Head Comparison

Tanawat Geeratragool, Thanapat Atthakitmongkol, Supathep Tansirichaiya, Pubet Weeranawin, Somchai Leelakusolvong, Monthira Maneerattanaporn

Background: Rapid urease test (RUT) is widely used for diagnosing Helicobacter pylori (HP) because it is inexpensive and practical. However, its accuracy is reduced in peptic ulcer bleeding (PUB). We prospectively performed a head-to-head comparison of diagnostic tests in the same patients to evaluate their performance in this setting. Methods: After endoscopic hemostasis, gastric biopsies were obtained for RUT, histology, and PCR. Blood samples were collected for current infection marker (CIM) and anti-urease anti …

27.08.2026journal-article

Arthroscopy, Sports Medicine, and Rehabilitation

Availability and Pricing of Orthobiologic Knee Injections Vary by Practice Type but Not by Community Socioeconomic Vulnerability in Suburban New York

Tracy M. Tauro, Benjamin Hershfeld, Katharine Chen, Ran Lampert, Adam D. Bitterman, Randy M. Cohn, Nicholas A. Sgaglione

Purpose To assess the availability, price transparency, and pricing of platelet‐rich plasma (PRP), bone marrow aspirate concentration, and stem cell injections for knee osteoarthritis (OA) among orthopaedic sports medicine (OSM) practices and alternative clinics in suburban New York and to evaluate the impact of the economic status of a population on the availability and pricing of biologic injections. Methods Between July and September 2025, OSM practices and alternative clinics offering PRP, bone marrow aspirate …

27.08.2026journal-article

World Journal of Otorhinolaryngology - Head and Neck Surgery

Safety, Efficacy, and Mechanism of Action of Budesonide in Rhinitis and Rhinosinusitis: A Systematic Review

David W. Kennedy, Lei Cheng, De‐Yun Wang

ABSTRACT Objective Budesonide is a corticosteroid with unique pharmacokinetic and pharmacodynamic properties that has been a frontline treatment for patients with allergic rhinitis (AR) and chronic rhinosinusitis (CRS) since the 1990s. As research on budesonide continues to produce new insights, our aim was to synthesize recent investigations and provide up‐to‐date information on safety, clinical, and mechanism of action (MOA) outcomes. Data Sources Searches were restricted to PubMed from 2014/01/01 to 2025/02/26. …

27.08.2026journal-article

Neuro-Oncology

98 Barriers and opportunities in the integrated histopathological-molecular diagnosis of adult diffuse gliomas: a national survey of neuropathology units in UK&I

Vassili Crispi, Ute Pohl, Federico Roncaroli, Kathereena Kurian, Ashiward Merve, Peter Auguste, Arabella Scantlebury, Colin Watts, Victoria Wykes

Abstract Introduction Integrated histopathological–molecular diagnosis is central to the contemporary classification and management of adult diffuse gliomas. The delivery of timely integrated diagnosis remains operationally complex, resource-intensive, and variably implemented across healthcare systems. Methods We conducted an online cross-sectional national survey of all 23 neuropathology units covering 34 adult neurosurgical units across the United Kingdom and Ireland to characterise current diagnostic pathways f …

27.08.2026journal-article

Clinical Journal of Health Sciences

Investigation of the Relationship Between Psychopathological Symptoms, Acculturation, and University Adjustment Among Students from Eastern and Western Türkiye Studying in the TRNC

Merve Nehir Kurt, Mehmet Çakıcı, Atakan Taşkıran

The aim of this study was to compare the acculturation attitudes, university adjustment levels, and psychopathological symptoms of university students from the eastern and western regions of Türkiye studying in the Turkish Republic of Northern Cyprus (TRNC), and to examine the relationships among these variables. This descriptive cross-sectional study included a total of 100 university students enrolled at Near East University, comprising 50 students from the eastern regions and 50 students from the western regions …

27.08.2026journal-article

Tijdschrift voor Urologie

Klinische kenmerken en chirurgische behandeling van urogenitale endometriose: een retrospectief cohortonderzoek

Hanzhe Dong, Eefje Oude Lohuis, Johanna M. A de Bruin, Bob Theodoor Merks

Samenvatting Endometriose kan verscheidene orgaansystemen aantasten. Urogenitale endometriose (UGE) is een zeldzame vorm van diepe endometriose met betrokkenheid van blaas en/of ureters. In dit retrospectieve cohortonderzoek werden 80 vrouwen met UGE geïdentificeerd onder 1.568 geopereerde patiënten met diepe endometriose (2018–2024), overeenkomend met een prevalentie van 5,1 %. Blaasendometriose kwam voor bij 34 patiënten, ureterbetrokkenheid bij 32 en gecombineerde ziekte bij 14. Dysurie trad vaker op bij blaasbe …

27.08.2026journal-article

Frontiers in Medicine

Day-4 antipseudomonal and anti-MRSA de-escalation was not associated with higher mortality in critically ill patients with sepsis

Yuhang Zhang, Guoying Liao, Jianli Song, Yinsheng Liao, Lulu Zhang

Background Broad empiric antibiotics are often appropriate at the start of intensive care unit (ICU) sepsis care; however, continued antipseudomonal or anti-methicillin-resistant Staphylococcus aureus (MRSA) coverage may no longer be justified by the day-4 reassessment. We examined antibiotic de-escalation at this clinical decision point. Materials and methods We emulated two parallel target trials in Medical Information Mart for Intensive Care IV (MIMIC-IV) v3.1 and conducted a supportive multicenter analysis in t …

27.08.2026journal-article

Recycling

Life Cycle Assessment of Anaerobic Digestion Pathways for Winery Residues: Influence of Functional Unit Selection on Wastewater Treatment and Grape Pomace Valorization

Mara Silva, Vitor Coelho Barroso, José Pereira, Ana Catarina Faria

Winery activities generate large amounts of residues requiring sustainable management. Anaerobic digestion offers opportunities for resource recovery while reducing the environmental burdens associated with these residues. This study presents a gate-to-gate Life Cycle Assessment (LCA) of two anaerobic digestion pathways: winery wastewater treatment (Scenario A) and grape pomace valorization (Scenario B). Inventory data were obtained from pilot-scale operation and complemented with the Ecoinvent 3.10 database. Envir …

27.08.2026journal-article

Oral Surgery

Chondrosarcoma of the Temporomandibular Joint: A Case Report

Thamyryz Rafaela Almeida Simões, Lais de Oliveira Melo, Marcio Tadashi Tino, Gilberto Fenelon das Neves

ABSTRACT Objective Tumours affecting the temporomandibular joint (TMJ) are rare and may mimic common temporomandibular disorders, leading to delayed diagnosis. This study reports a case of TMJ chondrosarcoma initially presenting with long‐standing TMJ symptoms. Methods A 56‐year‐old female presented with right preauricular pain during mouth opening, closing and mastication for approximately 10 years. Clinical examination revealed a maximum interincisal opening of 20 mm with pain in the right TMJ. Cone‐beam computed …

27.08.2026journal-article

European Journal of Cancer Prevention

Impact of screening compliance on gastric cancer risk and eligibility for endoscopic treatment: a nationwide population-based cohort study

Jinju Choi, Joo Hyun Lim, Kyungdo Han, Cheol Min Shin, Byung-Ha Jeon, Ho-Kyoung Lee, Eun Hyo Jin, Seung Joo Kang

To evaluate the association between compliance with the Korean national gastric cancer screening program and both gastric cancer incidence and eligibility for endoscopic treatment. Using the Korean National Health Insurance Service database, we conducted a nationwide cohort study of individuals who underwent screening endoscopy in 2012 and 2014 without prior gastric cancer. Participants were classified as high compliance, moderate compliance, or low compliance according to screening history from 2008 to 2014. Gastr …

27.08.2026journal-article

Small

Sequential Integration of Microenvironment Regulation Utilizing Aggregation‐Induced Emission Luminogen‐Based Carbon Dots for Diabetic Wound Treatment

Judun Zheng, Miaomiao Kang, Minghai Zhao, Shuang Guo, Qihu Xie, Zhijin Fan, Sitong Zhou, Zhijun Zhang, Qin Zeng, Zeyu Liu, Yinghui Liu, Jialin Huang, Xu Chen, Bowen Shu, Bin Li, Kexiang Rao, Hongfang Liu, Xiaoping Zhong, Ronghua Yang, Yunxia Wu, Dong Wang, Yuhui Liao

ABSTRACT Effective management of diabetic wound healing remains challenging due to the complex wound microenvironment, characterized by persistent infections and inflammation, as well as obstacles in tissue repair, including impaired extracellular matrix (ECM) remodeling and re‐epithelialization. Herein, we propose a sequential integrating microenvironment regulation and re‐epithelialization promotion (SIMREP) strategy based on zinc‐doped glycyrrhizinate carbon dots loaded with aggregation‐induced emission luminoge …

27.08.2026journal-article

Journal of Occupational & Environmental Medicine

The Effectiveness of Ergonomic Training and Chiropractic Treatment in Industrial Workers with Nonspecific Chronic Neck Pain: A Randomized Controlled Trial

Deniz Balikçi, Beyzanur Dikmen Hoşbaş, Ömer Şevgin

OBJECTIVE: To evaluate whether adding chiropractic treatment to ergonomic training improves pain, function, and sleep in industrial workers with chronic nonspecific neck pain. METHODS: Forty-five male industrial workers were randomized (15 per group) to ergonomic training plus chiropractic treatment (CTG), plus sham manipulation (SMTG), or alone (CG) for four weeks. Pain (VAS), biopsychosocial impact (BNQ), disability (NDI), and sleep quality (PSQI) were assessed before and after. The group × time interaction was t …

27.08.2026journal-article

Discover Oncology

Ovarian cancer tumor immune microenvironment and its clinical trial implications

Barbora Vavrušáková, Renata Bartošová, Michal Hendrych, Tomáš Kazda, Lukáš Moráň, Marek Svoboda

Abstract Ovarian cancer is the most lethal gynecologic malignancy, primarily because of late-stage diagnosis, rapid disease progression, and marked molecular and immunologic heterogeneity. It remains the leading cause of gynecologic cancer-related death, affecting approximately 1 in 70 women in developed countries over their lifetimes. Tumor development and progression are orchestrated within the tumor immune microenvironment, a dynamic and complex structural niche that supports malignant transformation and immune …

27.08.2026journal-article

Frontiers in Cardiovascular Medicine

Association of glucagon-like peptide-1 receptor agonists with atrial fibrillation recurrence after catheter ablation: a systematic review and meta-analysis

Dan He, Defu Lv, Jiaxin Tang, Xiaojuan Liao, Ping Mao, Zhu Tian

Background Current studies suggest a potential association between the use of glucagon-like peptide-1 receptor agonists (GLP-1RAs) and atrial fibrillation (AF) recurrence after catheter ablation, but the findings remain controversial. Therefore, we conducted a meta-analysis to evaluate this association, aiming to provide evidence for clinical prevention and treatment. Methods We systematically searched PubMed, Embase, Web of Science, Cochrane Library, and four Chinese databases (CNKI, WanFang, VIP, and CBM) up to J …

27.08.2026journal-article

Microsurgery

Dedicated Robotic‐Assisted Microsurgery Platforms in Plastic and Reconstructive Surgery: A Systematic Review

Simon M. Kratzer, Mehmet Ergisi, Laura Awad, Deepak M. Kalaskar, Peter Butler, Dariush Nikkhah

ABSTRACT Background Dedicated robotic‐assisted microsurgical systems (RAMS), including the Symani Surgical System and MUSA, were developed to overcome physiological tremor, surgeon fatigue, and restricted maneuverability in deep surgical fields. Existing reviews of robotic plastic surgery largely span heterogeneous applications beyond microsurgery or lack structured risk‐of‐bias appraisal specific to dedicated microsurgical platforms. This review systematically synthesizes clinical outcomes, learning‐curve dynamics …

27.08.2026journal-article

Oral Surgery

Influence of Radiotherapy on Dental Implant Prognosis: A Scoping Review

Elizabeth Madathil, Akash Raj Sharma, Anshul Trivedi, Apoorva Mowar, Snigdha Singh, Sooraj S. Pillai

ABSTRACT Background Radiotherapy is an integral component of head and neck cancer management but produces lasting changes in bone and soft tissues, including hypovascularity, hypocellularity, fibrosis, and a predisposition to osteoradionecrosis, all of which can compromise osseointegration and long‐term stability of dental implants. At the same time, implant‐supported prostheses offer substantial functional and quality‐of‐life benefits to cancer survivors, particularly in the presence of xerostomia and altered oral …

27.08.2026journal-article

JGH Open

Plant and Animal Protein Sources in Inflammatory Bowel Disease: Current Evidence and Clinical Implications

Mustafa Mohamedrashed, Ayushi Chauhan, Vaios Svolos, Abhinav Vasudevan, Chu K. Yao

ABSTRACT With the consumption of protein consumption increasing globally, there are gaps in our understanding of the differences in protein sources, particularly between animal and plant proteins and their recommendations for patients with Inflammatory Bowel Disease (IBD). This narrative review synthesizes current evidence of how animal and plant proteins differentially exert physiological effects, influence IBD risk, and outcomes. First, protein sources vary in their amino acid profiles, co‐existence with other nu …

27.08.2026journal-article

Global Spine Journal

AO Spine Clinical Practice Recommendations: Proximal Junctional Kyphosis and Failure Prevention

Juan P. Sardi, Ahmed Shawky, Sultan Aldebeyan, Fred Nicholls, Nelson Astur, Charles Fisher, Eric O. Klineberg, Justin S. Smith, AO Spine Knowledge Forum Deformity

Study Design Literature Review with expert consensus–based clinical practice recommendations. Objectives To synthesize current evidence on risk factors and preventive strategies for proximal junctional kyphosis (PJK) and proximal junctional failure (PJF) following adult spinal deformity (ASD) surgery, and to provide clinically actionable recommendations. Methods A focused literature review was conducted by the AO Spine Knowledge Forum Deformity, identifying 30 relevant studies on PJK/PJF. Four studies were selected …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Long-term outcomes following successful treatment of acute mesenteric ischemic event: A population-based observational study

Karri Kase, Merli Koitmäe, Annika Reintam Blaser, Kadri Tamme, Peep Talving, Marko Murruste

BACKGROUND There is a lack of studies reporting long-term outcomes in patients surviving initial event of acute mesenteric ischemia (AMI). AIM To identify population-based outcomes and risk factors for mortality according to AMI subtypes. METHODS We performed overall survival analysis of all enrolled AMI patients and follow-up investigation on patients who survived beyond index admission. The demographics, diagnostic and management variables, in addition to causes of death, were accrued from the Estonian National E …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Severe postoperative infections following surgery for digestive system diseases

Ya Liu, Li Chen

BACKGROUND Postoperative infection following digestive system surgery is a critical complication that leads to high rates of morbidity and mortality. Current studies on the incidence and, more importantly, the risk and microbiological factors related to these infections in patients undergoing surgery on the digestive system are lacking. Identifying such factors can aid in detecting patients who may be at post-operative infection risk and enable the modification of perioperative practices. AIM To describe the incide …

27.08.2026journal-article

Light: Science & Applications

Label-free ovarian cancer histopathological diagnosis using two-photon autofluorescence microscopy with a joint denoising and segmentation framework

Zhengyuan Pan, Naikun Song, Shanshan Cheng, Wen Pang, Hongen Liao, Yu Wang, Bobo Gu

Abstract Two-photon autofluorescence (TPAF) microscopy is a promising modality for rapid, label-free assessment of unstained tissue, but is fundamentally limited by the poor visibility of nuclei, which are one of the gold-standard cancer biomarkers, due to their negative contrast nature. A restoration method capable of distinguishing these signal voids from stochastic noise to render quantitative pathology is lacking. Here, we proposed a deep learning framework of AFN-DeSeg (Auto-Fluorescence Nuclei Denoising and S …

27.08.2026journal-article

Journal of Veterinary Pharmacology and Therapeutics

Pharmacokinetics and Efficacy Assessment of Long‐Term Ivermectin Treatment in Canine Demodicosis: Drug Disposition and Clinical Outcomes Relationship

S. Martínez, M. J. Del Sole, L. Maté, S. Sánchez Bruni, A. Lifschitz, M. Ballent

ABSTRACT Canine demodicosis is an inflammatory skin disease caused by Demodex canis mites. While newer isoxazoline classes currently represent the standard of care where licensed and available, prolonged ivermectin treatment remains an effective and cost‐effective alternative under specific socioeconomic contexts or clinical challenges associated with specific presentations, such as refractory pododemodicosis. Prolonged ivermectin treatment remains the primary choice, especially in resource‐limited settings and cer …

27.08.2026journal-article

Environments

Role of a Wastewater Treatment Plant in the Dissemination and Control of Antimicrobial Resistance in Wastewater and Receiving Water

Vanesa Benito, Naroa Lopez-Herguedas, Maite Cabañas, Santos Paunero, Ane Rivas-Macho, Iker Alvarez-Mora, Manu Soto, Felipe Goñi-de-Cerio

Wastewater treatment plants (WWTPs) are key nodes in the environmental dissemination of antimicrobial resistance (AMR), although their net role as sources or barriers of antibiotic-resistant bacteria (ARB) and antibiotic resistance genes (ARG) under full-scale conditions remains insufficiently understood. This study evaluated the occurrence and dynamics of ARB and ARG in a full-scale urban WWTP and its receiving river over a two-year monitoring campaign. Samples were collected from the WWTP influent and effluent, a …

27.08.2026journal-article

Mathematics

A Condition-Disentangled Representation Optimization Framework for Domain Generalization Under Distribution Shift: Application to Fault Diagnosis

Shiqi Zhao, Yaqiong Lv, Xiaohu Zhang, Jian Hao

Domain generalization under distribution shift remains a fundamental challenge in representation learning, where predictive models trained on multiple source domains are expected to generalize to previously unseen operating conditions. For rotating machinery fault diagnosis, variations in operating conditions often introduce domain-specific characteristics that interfere with fault-related representations, resulting in significant performance degradation across unseen domains. To address this issue, this paper form …