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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
29.08.2026journal-article

Translational Medicine

Pathophysiological mechanisms of sepsis-associated acute kidney injury in children

Yu. V. Bykov

The aim of this review was to systematize current pathophysiological mechanisms of sepsis-associated acute kidney injury (SA-AKI) in children and their relevance for early recognition of renal dysfunction. A review of 44 literature sources, published predominantly between 2021 and 2026, was conducted. SA-AKI cannot be explained solely by arterial hypotension or reduced renal perfusion. Its pathogenesis involves systemic inflammation, endothelial dysfunction, endothelial glycocalyx damage, intrarenal microcirculator …

29.08.2026journal-article

European Journal of Dentistry

The Role of Artificial Intelligence Models in Predicting Post-Prosthetic Facial Esthetics in Edentulous Patients: Clinical and Anthropometric Comparative Study

Rania Moussa, Mostafa I. Fayad, Omar M. Alaryani, Faisal Suliman Altamimi, Elaf Barri, Leen Ahmed Qarras, Marwa Kothayer

Abstract Artificial intelligence (AI) is increasingly used in esthetic dentistry; however, its accuracy in predicting post-prosthetic facial outcomes in edentulous patients remains unclear. This study aimed to evaluate the ability of AI models to simulate post-denture facial esthetics compared with actual clinical outcomes. A prospective within-subject observational study was conducted on 14 completely edentulous patients receiving new complete dentures. Standardized facial photographs were obtained pretreatment (T …

29.08.2026journal-article

Review of Primary Care Practice and Education (Kajian Praktik dan Pendidikan Layanan Primer)

Enhancing Antimalarial Treatment Adherence: A Systematic Review of Multifaceted Intervention Strategies

Elisa Nugraha Haryadi Salakay, Grace Novylian Tandialo, Ricky Lazarus Rumboirusi, Grace Fitriana Primasari Hau Mahu

Background: Despite the availability of effective antimalarial medications, poor adherence remains a significant obstacle in malaria control, particularly in endemic areas. Numerous interventions have sought to enhance adherence; however, a clear understanding of their effectiveness is lacking. Objective: This systematic review aimed to evaluate the effectiveness of intervention strategies to improve adherence to antimalarial treatments and identify the contextual factors that influence them. Method: Following the …

29.08.2026journal-article

Journal of Clinical Monitoring and Computing

Transition from mandatory to discretionary nurse-measured MEWS assessment in a continuously monitored surgical ward: Diagnostic performance of wearable-derived early warning scores

EE Jerry, MA Afonso, JC De Vries, A Akkermans, S Turco, AR Bouwman, SW Nienhuijs

Abstract Early detection of clinical deterioration on surgical wards is vital to prevent adverse outcomes. Conventional ward monitoring using the Modified Early Warning Score (MEWS) relies on intermittent nurse-measured vital signs, but its role may change when continuous wearable monitoring is already available. This study evaluated the transition from mandatory to discretionary nurse-measured MEWS assessment in a continuously monitored surgical ward and compared the diagnostic performance of two wearable-derived …

29.08.2026journal-article

Nanomaterials

Crystalline and Amorphous Cerium Phosphate Nanoparticles as Enzyme-Mimetic Nanomaterials for Regenerative Medicine

Ekaterina V. Silina, Artem S. Chizhov, Maria P. Kruglova, Alexey A. Kryukov, Svetlana A. Dodonova, Maksim A. Pugachevskii, Natalia E. Manturova, Victor A. Stupin

Wounds represent a persistent challenge in modern medicine, driving the search for novel nanomaterials capable of modulating oxidative stress and promoting tissue regeneration. While cerium oxide nanoparticles have been extensively studied for their enzyme-mimetic activity, hydrated cerium orthophosphates remain relatively unexplored despite their promising biocompatibility and redox properties. The aim of the study is the synthesis of cerium phosphate nanoparticles (CePO4 NPs) via controlled hydrolysis of a Ce(NO3 …

29.08.2026journal-article

Journal of Clinical Medicine

Agreement and Classification Performance of a Mobile Self-Triage Application Based on the Manchester Triage System in Hemodynamically Stable Adult Walk-In Emergency Department Patients: A Prospective Observational Study

Ahmet Buğra Önler, Suha Serin, Bahadir Caglar

Background/Objectives: Digital self-triage tools may support patient-flow management in crowded emergency departments (EDs), but their agreement with established professional triage systems requires prospective validation. We evaluated the agreement and classification performance of a locally developed mobile self-triage application, structured according to Manchester Triage System (MTS)-related urgency logic, compared with professional MTS assessment in adult ED patients. Methods: This prospective, observational, …

29.08.2026journal-article

Journal of Clinical Medicine

Novel Quantitative Metrics for Foveal Hypoplasia Derived from Optical Coherence Tomography Angiography Using AngioTool

Charlotte Egbring, Sarah Kleemann, Nicole Eter, Jens Julian Storp

Background/Objectives: This monocentric case–control study prospectively recruited patients with foveal hypoplasia (FH) and compared them with retrospectively selected age- and sex-matched healthy controls. It is the first study to employ AngioTool software to quantitatively assess retinal microvascular alterations in FH using Optical Coherence Tomography Angiography (OCT-A). Methods: In total, 19 patients with FH and 19 age- and sex-matched healthy controls were included at Münster University Hospital, Germany, an …

29.08.2026journal-article

Structural Health Monitoring

Semantic knowledge transfer framework for wind turbine gearbox compound fault diagnosis via zero-shot learning

Qi Deng, Weixiong Jiang, Jun Wu, Xuesong He, Yiwei Cheng

Compound fault diagnosis of wind turbine gearboxes (WTGs) has received extensive attention. Existing deep learning-based methods typically require sufficient compound fault samples for model training. However, collecting such samples is extremely difficult and often impractical in real-world industrial scenarios. Inspired by zero-shot learning, this paper proposes a semantic knowledge transfer framework to diagnose compound faults using only single-fault data for training. Within this framework, a semantic knowledg …

29.08.2026journal-article

Maltepe Tıp Dergisi

Effect Clinical Characteristics and Outcomes of Acute Pulmonary Embolism in Older Adults: A Comparison of Patients Aged 65–75 Years and ≥75 Years

Gökçe Külah, Ayşe Çapar, Harun Çıtlak, Şeyma Başlılar

Amaç: Pulmoner emboli (PE), özellikle yaşlı gruplarda morbidite ve mortalitenin önemli bir nedenidir. Bu çalışmada, yaşın hastalık seyrine etkisini incelemek için 65 yaş ve üzeri PE hastalarının klinik, demografik ve laboratuvar bulguları karşılaştırılmıştır. Materiyal- metodlar: Bu retrospektif gözlem çalışması, PE tanısı ile hastaneye yatırılan 188 hastayı içermektedir. Hastaların demografik özellikleri, komorbiditeleri, laboratuvar parametreleri, ekokardiyografi bulguları ve klinik seyri hastane kayıtlarından el …

29.08.2026journal-article

PKLI Journal of Health Sciences

The Effect of Arteriovenous Fistula Aneurysm Morphology on Patient Satisfaction and Quality of Life: A Cross-Sectional Study

Abdul Rehman Arshad, Nauman Sarir, Muhammad Iqbal, Muhammad Umar Rafique, Ghulam Abbas Khan Niazi

Objective This study was done to determine the frequencies of different types of arteriovenous fistula aneurysms and to study their association with patient satisfaction and quality of life. Methods Patients reporting to dialysis unit for routine hemodialysis sessions were selected by convenience sampling. Inclusion criteria included age greater than 18 years, arteriovenous fistulas in use for more than 3 months. Unwilling patients were excluded. A detailed inspection of fistula vein was done to classify aneurysms, …

29.08.2026journal-article

The European Research Journal

Clinical Outcomes Following Revision Total Knee Arthroplasty for Septic vs Aseptic Indications: A Comparative Analysis With at Least 1-Year Follow-up

Yakup Doğan, Alpaslan Öztürk, Oğuz Çetin, Ali Ömer Kaya, Nazan Çevik, Yavuz Akalın, Hüseyin Yetkin

Objective: This study aimed to retrospectively compare the clinical, functional, and radiographic outcomes of revision total knee arthroplasty (rTKA) performed for septic and aseptic indications and to evaluate postoperative changes within each group. Methods: A total of 27 patients (30 knees), including 18 females and 9 males, were included in the study. Patients were categorized into 2 groups: those who underwent rTKA due to septic loosening (13 patients, 13 knees) and those with aseptic causes (14 patients, 17 k …

29.08.2026journal-article

International Journal of Research in Medical Sciences

Clinical spectrum and prognostic impact of precipitating factors in hepatic encephalopathy among patients with liver cirrhosis: a cross-sectional observational study

Yafas Nazir Khan, Mansi, Rolanda Saint Louis, Shehla Ashraf, Purna Chand Paidi

Background: Hepatic encephalopathy (HE) is a serious neuropsychiatric complication of liver cirrhosis associated with significant morbidity and mortality. Early identification of precipitating factors is essential for timely management and improved clinical outcomes. Methods: A hospital-based cross-sectional observational study was conducted among 110 patients with cirrhosis of liver presenting with hepatic encephalopathy at a tertiary care teaching hospital. Clinical history, physical examination, laboratory inves …

29.08.2026journal-article

Internal and Emergency Medicine

Antidiabetic medications and arterial thrombotic risk reduction: a narrative review

Francesca Santilli, Paola Simeone, Rossella Liani

Abstract Diabetes mellitus is associated with a persistent prothrombotic state driven by platelet hyperreactivity, endothelial dysfunction, oxidative stress, and chronic low‑grade inflammation, all of which contribute to increased cardiovascular (CV) risk. Importantly, a substantial residual thrombotic risk persists even with optimal glycemic control, indicating that glucose lowering alone is insufficient to prevent vascular complications. In this context, antidiabetic therapies have emerged as important modulators …

29.08.2026journal-article

Journal of the Pediatric Infectious Diseases Society

It Takes Two to Tango: Impact of a Reverse Two-Step Algorithm for Clostridioides difficile Infection Diagnosis in Pediatric Oncology and Hematopoietic Cell Transplant Populations

Dolores Freire Jijon, Christopher P Ouellette, Stacie Rhoades, Eunkyung Song

Abstract Background Implementation of a reverse two-step algorithm (RTSA) for diagnosing C. difficile infection (CDI) in the adult population has improved diagnostic accuracy and reduced CDI-directed antibiotic exposure. The impact of the RTSA in pediatric CDI is unknown. This study aimed to evaluate the impact of RTSA implementation on CDI rates, anti-C. difficile antibiotic exposure, and clinical outcomes among hospitalized pediatric oncology and hematopoietic stem cell transplantation (HCT) patients. Methods In …

29.08.2026journal-article

Modern Rheumatology

Clinical Characteristics of Enthesitis-Related Arthritis and Outcomes of Treatment with Salazosulfapyridine

Yuko Akutsu, Yuko Hayashi, Masaaki Mori, Masaki Shimizu

Abstract Objectives Enthesitis-related arthritis (ERA), characterized by chronic arthritis and/or enthesitis, is a relatively rare subtype of juvenile idiopathic arthritis (JIA). Achieving sustained disease control can be challenging. We aimed to characterize ERA and to evaluate the efficacy of salazosulfapyridine (SASP) treatment. Methods We retrospectively reviewed 23 patients with ERA treated in our institute between 2015 and 2025. Clinical characteristics, laboratory findings, and treatment courses were analyze …

29.08.2026journal-article

Journal of Personalized Medicine

Molecular Residual Disease in Non-Small Cell Lung Cancer: Technology or Patient Outcomes?

Paul R. Walker

Molecular residual disease (MRD) testing approaches with plasma next-generation sequencing (NGS) testing to identify circulating tumor DNA (ctDNA) in resectable-stage non-small cell lung cancer (NSCLC) are evolving. The MRD concept is to better guide perioperative systemic treatment and identify recurrent NSCLC before symptomatic radiographic recurrences. Multiple tumor-informed assays are available with technology driving lower levels of ctDNA detection. However, it remains unclear that individual patients derive …

29.08.2026journal-article

Cancer

Adjuvant CDK4/6 inhibitors in early‐stage breast cancer: Clinical evidence and considerations for risk stratification and treatment selection

Austin D. Williams, Anna Weiss

Abstract Hormone receptor–positive, human epidermal growth factor receptor 2–negative breast cancer is the most common biologic subtype and carries a persistent risk of recurrence, particularly in patients with high‐risk, early‐stage disease. Cyclin‐dependent kinase 4 and 6 inhibitors, initially established as a standard component of first‐line therapy in the metastatic setting based on improvements in progression‐free and overall survival, have since been evaluated in the adjuvant setting. While adjuvant palbocicl …

29.08.2026journal-article

Journal of Psychology and Psychotherapy Research

Clinical Pharmacology of Bipolar Disorder: An Updated Review of Pharmacotherapeutic Strategies

Michel Bourin

Bipolar disorder (BD) is a chronic, recurrent psychiatric illness characterized by episodes of mania, hypomania, and depression that substantially impair psychosocial functioning and quality of life. Pharmacotherapy remains the cornerstone of both acute symptom management and long-term relapse prevention. Over the past decade, advances in clinical trials and international treatment guidelines have refined the role of mood stabilizers, second-generation antipsychotics, and adjunctive therapies across different phase …

29.08.2026journal-article

Scientific Reports in Medicine

Co-Mutation Landscape of PIK3CA Across Multiple Adenocarcinomas: Insights from TCGA Data<b></b>

Perçin Pazarcı

Objective: PIK3CA is one of the most frequently mutated oncogenes across multiple cancer types, playing a crucial role in tumorigenesis via the PI3K/AKT/mTOR signaling pathway. Understanding its genuine co-mutation landscape is essential for identifying oncogenic interactions and refining targeted therapeutic strategies. In this study, we analyzed the true functional co-mutation patterns of PIK3CA in colorectal adenocarcinoma (COAD), cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), stomach a …

29.08.2026journal-article

Journal of the American Heart Association

Distribution and Clinical Utility of the Kidney Disease Improving Global Outcomes Chronic Kidney Disease Risk Classification in Patients Undergoing Atrial Fibrillation Ablation

Hironori Ishiguchi, Yasuhiro Yoshiga, Shintaro Hashimoto, Masakazu Fukuda, Goki Nakashima, Masafumi Fujinaka, Masaki Shibuya, Takuya Omuro, Shigeki Kobayashi, Motoaki Sano

Background Chronic kidney disease (CKD) is a key component of the cardiovascular–kidney–metabolic framework. However, in patients undergoing atrial fibrillation ablation, the distribution of CKD across Kidney Disease: Improving Global Outcomes risk categories and its prognostic value remain unclear. Methods Patients undergoing atrial fibrillation ablation with preprocedural urinalysis were studied. Patients were classified into Kidney Disease: Improving Global Outcomes CKD risk categories (low, moderate, high, very …

29.08.2026journal-article

Asian Journal of Advanced Research and Reports

Identification and Management of Myofascial Trigger Points in Shoulder Pain: A Critical Narrative Review with Particular Reference to the Indian Clinical Context

Himanshu Devki Nandan Sharma, Geetanjali Bhatnagar, Pallav Bhatnagar

Shoulder pain is a persistent and costly musculoskeletal complaint, and myofascial trigger points have been proposed as one of its principal peripheral contributors. The construct nevertheless remains contested. Palpation-based identification is imperfectly reproducible, instrumented alternatives remain investigational, and treatment trials frequently report short-lived analgesia obtained under conditions of incomplete blinding. These uncertainties acquire additional significance in India, where the occupational pr …

29.08.2026journal-article

Journal of Musculoskeletal Surgery and Research

Management of tuberculous hip ankylosis using dual-approach total hip arthroplasty and gluteal reconstruction: A case report

Shihab A. Bostaji, Khalid M. Alhomayani, Abdullah M. Alshanqiti, Abdulrahman M. Alshanqiti

Tuberculous hip ankylosis is an uncommon but disabling sequela of osteoarticular tuberculosis. We report a 34-year-old man with long-standing post-tuberculous complete osseous ankylosis of the right hip, severe deformity, and abductor deficiency. Magnetic resonance imaging showed complete fusion and advanced fatty degeneration of the gluteus medius and minimus without features of active infection. He underwent dual- approach total hip arthroplasty using a dual-mobility acetabular construct, cementless conical stem …

29.08.2026journal-article

Veterinary Medicine and Science

The Estimation of Phenotypic and Genetic Parameters for Growth Rate Traits of Abergelle Goat Under the Community‐Based Breeding Programme in the North‐Eastern Parts of Ethiopia

Yeshiwas Walle Abebe, Wossenie Shibabaw Meberatie, Zeleke Tesema Wondie

ABSTRACT Background Understanding phenotypic performance and genetic parameter estimation is important for effective genetic progress in animal breeding and genetics. The data were collected for 6 years (2018–2023) from the established village of Abergelle goat community‐based breeding programme (CBBP) area in Sekota Dryland Agricultural Research Center. The investigated traits were birth weight (BWT), 3‐month weight (TMWT), 6‐month weight (SMWT), 9‐month weight (NMWT), yearling weight (YWT), average daily weight g …

29.08.2026journal-article

Surgery Today

Initial surgical results of subcostal uniportal robotic lung resection: a study of the perioperative outcomes and a CUSUM analysis of the learning curve

Teruhisa Kawaguchi, Fumiaki Watanabe, Shinji Kaneda, Daisuke Ito, Koji Kawaguchi

Abstract Purpose Anatomical lung resection using the da Vinci SP system was recently introduced in Japan. We retrospectively evaluated our initial experience and analyzed the learning curve for the first 53 consecutive cases. Methods Fifty-three patients with primary lung cancer underwent anatomical resection, including lobectomy and segmentectomy, using the da Vinci SP system. We reviewed the perioperative outcomes, including the operative time, console time, conversion rates, and complications. The learning curve …