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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
14.08.2026journal-article

Journal of Speech, Language, and Hearing Research

Pediatric Auditory-Perceptual Evaluation of Voice Part 2: A Protocol

Robert Brinton Fujiki, Sijia Huang, Rebecca Johnson, Susan L. Thibeault

Purpose: Although auditory-perceptual voice assessments are crucial for evaluating pediatric voices, no protocol designed for use with children has been established. This study created and validated the Pediatric Auditory-Perceptual Evaluation of Voice (PAPE-V) protocol for use across childhood. Influence of scale type and speaker demographics on voice rating reliability was considered. Method: Ten speech-language pathologists (SLPs) specialized in pediatric voice rated voice samples from 102 children aged 3–17 yea …

14.08.2026journal-article

Scholars Journal of Medical Case Reports

Efficacy of Azacitidine–Venetoclax Therapy Combined with Voriconazole Prophylaxis in Blastic Plasmacytoid Dendritic Cell Neoplasm: A Case Report in an Elderly Patient

Moussa Oubeche, W. El Faria, M. El Amani, S. Jennane, E.M. Mahtat, H. El Maaroufi

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and highly aggressive hematologic malignancy that predominantly affects older adults. Owing to advanced age and multiple comorbidities, intensive chemotherapy is often not feasible, making therapeutic management particularly challenging. We report the case of a 76-year-old man with BPDCN who achieved a rapid and durable response to azacitidine combined with venetoclax despite the concomitant administration of voriconazole for antifungal prophylaxis. Com …

14.08.2026journal-article

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy

Focused Update to International Consensus Recommendations for the Use of Prolonged‐Infusion Beta‐Lactam Antibiotics Among Severely Ill Adult Patients: Endorsed by the American College of Clinical Pharmacy, British Society for Antimicrobial Chemotherapy, Cystic Fibrosis Foundation, European Society of Clinical Microbiology and Infectious Diseases, Infectious Diseases Society of America, Society of Critical Care Medicine, and Society of Infectious Diseases Pharmacists

Lisa T. Hong, Alireza FakhriRavari, Marta Ulldemolins, Jason A. Roberts, Robert A. Bonomo, Marc H. Scheetz, the Prolonged‐Infusion Beta‐Lactam Consensus Panel

ABSTRACT In 2023, international consensus recommendations suggested the use of prolonged‐infusion beta‐lactam antibiotics over short‐infusion dosing in severely ill adult patients to improve mortality or clinical cure, although the certainty of evidence was very low. With the availability of several new randomized controlled trials (RCTs), this focused update re‐evaluates the efficacy of prolonged versus short infusion among severely ill adult patients. The original Population, Intervention, Comparator, and Outcome …

14.08.2026journal-article

The Future of Medicine

Personalized approach to the use of temporary uterine artery embolization as a stage in the therapy of ectopic pregnancy (Clinical case)

Anton V. Malushko, Irina D. Shchedrina, Ella G. Kmetik, Vladimir A. Makhinov, Svetlana B. Onegova

Introduction. The problem of choosing treatment tactics for not so rare forms of ectopic pregnancy, such as pregnancy in the uterine scar and cervical localization, is far from its final solution. At the present stage, minimally invasive techniques and new organ-­preserving technologies are emerging that help preserve the reproductive function of patients and avoid serious complications, in particular massive blood loss, which can often accompany these conditions. The introduction of such a relatively new method as …

24.08.2026journal-article

Seminars in Thrombosis and Hemostasis

Extended Anticoagulation Therapy with Rivaroxaban for Cancer-Associated Low-Risk Pulmonary Embolism According to Status of Concomitant Deep Vein Thrombosis: Insights from the ONCO PE Randomized Trial

Wei Xiong, Yugo Yamashita, Takeshi Morimoto, Nao Muraoka, Wataru Shioyama, Yoshihisa Nakagawa, Ryuki Chatani, Hiromi Yamamoto, Tatsuhiro Shibata, Nagisa Morikawa, Yoshihiro Fukumoto, Yuji Nishimoto, Koh Ono, Takeshi Kimura

Abstract The ONCO PE trial showed that 18-month rivaroxaban was superior to 6-month rivaroxaban for preventing recurrent venous thromboembolism (VTE) in patients with cancer-associated low-risk pulmonary embolism (PE). However, the influence of concomitant deep vein thrombosis (DVT) on this benefit was unclear. The current post-hoc subgroup analysis of the ONCO PE trial categorized patients into DVT subgroup (N = 104) and no DVT subgroup (N = 74) based on the presence or absence of a concomitant DVT at PE diagnosis …

13.08.2026journal-article

Physiotherapy Research International

Upper‐Limb Paresis Severity Is Associated With Practice Dosage During Task‐Oriented Training in Subacute Stroke—An Exploratory Secondary Analysis

Subramanian Durairaj, Akhila Jagadish, John M. Solomon, Mindy F. Levin

ABSTRACT Background and Purpose Intensive, high‐repetition practice is one of the strategies incorporated into upper‐limb task‐oriented training (UL‐TOT) to promote experience‐dependent neural plasticity after stroke. Although a target of 300 repetitions during a one‐hour UL‐TOT session is feasible, considerable variability in the practice dosage achieved across individuals has been observed. Multiple factors may influence practice dosage during UL‐TOT. Therefore, this exploratory secondary analysis aimed to examin …

13.08.2026journal-article

Medical and Health Science Journal

The Effect of 432 Hertz Frequency Music Therapy on Auditory Hallucinations in Schizophrenia Patients: A Quasi-Experimental Study

Muhammad Taufiqul Akbar, Ririn Kurniawati, Dwi Bagas Febriyanto

Background: Schizophrenia is a severe and chronic mental disorder characterized by cognitive impairment and difficulties in performing daily activities. Approximately 20% of patients with schizophrenia experience hallucinations. The 432 Hertz frequency is considered close to the natural resonance of the human body and is widely used in sound healing; Objective: This study aimed to investigate the effect of 432 Hertz frequency music therapy on the reduction of auditory hallucinations in schizophrenia patients at Gri …

13.08.2026journal-article

Journal of Cardiopulmonary Rehabilitation and Prevention

Implementing Cardiac Rehabilitation as a First-Line Treatment for Stable Angina Pectoris: PERSPECTIVES OF CARDIOLOGISTS AND PATIENTS

Eva W. Verkerk, Esther Deuning-Smit, Noa Beernink, Angelique T. E. F. Schlief, Joyce M. Heutinck, Iris A. de Koning, Hareld M. C. Kemps, Dick H. J. Thijssen, Rudolf B. Kool

Purpose: Cardiac rehabilitation (CR) is a promising treatment for patients with stable angina pectoris (SAP) and has been postulated as a safe and effective alternative to revascularization in low-risk patients. We assessed the barriers and facilitators for the implementation of CR for patients with SAP. Methods: We interviewed 12 clinicians (cardiologists and CR case managers) and 6 patients to assess perceived and expected barriers and facilitators in choosing CR as first-choice treatment for SAP in the Netherlan …

13.08.2026journal-article

Russian Journal of Cardiology

Clinical and economic modeling of using quadruple combination therapy with angiotensin-converting enzyme inhibitors or angiotensin receptor-neprilysin inhibitors in the Russian population

E. V. Derkach, V. I. Ignatyeva

Aim . Using modeling, to evaluate the economic rationale of using quadruple the­rapy in the Russian population. Material and methods . Based on clinical trials on the effectiveness of combination therapy in patients with heart failure with reduced ejection fraction (HFrEF), a Markov model with 5- and 10-year time horizons and a cycle duration of 1 month was constructed. The analysis was conducted from the perspective of the state taxpayer. Three following strategies were compared: triple therapy (angiotensin-conver …

13.08.2026journal-article

Current Opinion in Endocrinology, Diabetes & Obesity

Thyroxine withdrawal prior to radioiodine therapy in papillary thyroid carcinoma – current scenarios

Saumya Sunny, Julie Hephzibah

Purpose of review This review aims to compare the different methods of achieving adequate thyroid-stimulating hormone (TSH) stimulation prior to radioiodine (RAI) therapy in patients with differentiated thyroid carcinoma (DTC). It focuses on thyroid hormone withdrawal strategies and recombinant human TSH, examining their relative efficacy, safety, and impact on patient quality of life. Additionally, the review highlights recent guideline updates, and how these approaches influence postoperative risk stratification, …

13.08.2026journal-article

3D Printing in Medicine

Custom prosthetic rehabilitation of ocular defects with a digital workflow

Siyi Wang, Qingwen Cai, Jin Pan, Xiaoyu Gu

Abstract Purpose To use digital technologies, including high-resolution imaging, computer-aided design (CAD), and three-dimensional (3D) printing, to introduce a streamlined process by enabling rapid, reproducible, and cost-effective digital fabrication of orbital prostheses, thereby addressing the limitations of conventional manual prostheses, which remain labor-intensive, poorly reproducible, and often fail to achieve optimal marginal adaptation. Materials and methods This study presented a digital workflow for s …

13.08.2026journal-article

International Journal of Molecular Sciences

Emerging Immune Cell Biomarkers in Primary Membranous Nephropathy: Immune Cell Profiling During Anti-CD20 B Cell-Targeted Therapy

Christos Georgopoulos, Eleni Stamellou, Anila Duni, Lefkothea Dova, Georgios Vartholomatos, Ekaterini Siomou, Haralampos Milionis, Evangelia Dounousi

Primary membranous nephropathy (pMN) is an antibody-mediated podocytopathy, most commonly caused by autoantibodies against the M-type phospholipase A2 receptor (PLA2R1). Rituximab (RTX), an anti-CD20 monoclonal antibody, is a first-line treatment for moderate-to-high-risk pMN, inducing partial or complete remission in about 60% of patients within 24 months. However, treatment response varies considerably, and current biomarkers, including anti-PLA2R1 titers and peripheral B cell counts, have limited predictive valu …

13.08.2026journal-article

Haematologica

Macrophage migration inhibitory factor promotes immune evasion in multiple myeloma through myeloid-derived suppressor cell immunosuppression and major histocompatibility complex class I downregulation: implications for targeted therapy

Jingjing Wen, Jingcao Huang, Juan Xu, Pan Zhao, Xiaohui Zhao, Siyao He, Linfeng Li, Xiang Liu, Hongmei Luo, Ziyue Mi, Yue Zhang, Qianwen Gao, Haonan Yang, Yu Feng, Xinyu Zhai, Fangfang Wang, Dan Zhang, Li Zhang, Wenjiao Tang, Enguang Bi, Ting Niu, Yuhuan Zheng

Macrophage migration inhibitory factor (MIF), derived from either tumor cells or the tumor microenvironment, promotes multiple myeloma (MM) progression by suppressing T cell-mediated antitumor responses. Here, we demonstrate that MIF drives immune evasion in MM through both TME-mediated and tumor-intrinsic mechanisms. In the TME, MIF promotes the expansion of myeloid-derived suppressor cells (MDSCs) and enhances the expression of immunosuppressive molecules, including CD84, PD-L1, and CD38, thereby augmenting MDSC- …

13.08.2026journal-article

Dermatologic Surgery

Surgical Outcomes for Hidradenitis Suppurativa: Does Biologic Therapy Make a Difference?

Nicole Schiraldi, Richard Rookwood, Yael Weitzner, Solbie Choi, Ilene Tisnovsky, Rebecca Kann, Megan Darrell, Brittany Lala, David Ciocon

BACKGROUND Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition that often requires both medical and surgical management. Biologic therapies are increasingly used for moderate-to-severe disease, but their effect on surgical outcomes remains unclear. OBJECTIVE The aim of this study was to evaluate the impact of biologic therapy on postoperative outcomes in patients undergoing excisional surgery for HS. MATERIALS AND METHODS The authors conducted a retrospective chart review of adult patients who un …

13.08.2026journal-article

International Journal of Engineering Research and Science & Technology

AN INTERPRETABLE SPEECH ANALYTICS FRAMEWORK FOR EARLY PARKINSON'S DISEASE IDENTIFICATION USING K-NEAREST NEIGHBORS

Ayesha Fathima, Dr. Safia Khanum, Ruqiya Fatima

Parkinson's disease (PD) is a long-term, degenerative neurological condition that affects the nerve system of the body and causes problems with speech, movement, and coordination. Dysphonia, a voice problem marked by changes in vocal quality, pitch, and loudness, is one of the early signs of Parkinson's disease. Vocal feature analysis becomes a useful method for early identification because between 70 and 90 percent of people with Parkinson's disease have speech problems. Previous research has used a variety of mac …

13.08.2026journal-article

Journal of Clinical Medicine

Association of Maintenance Therapy Strategies with Survival Following First-Line Bevacizumab-Based Combination Chemotherapy in Metastatic Colorectal Cancer: A Single-Center Retrospective Observational Study

Simay Çokgezer, Burak Şakar, Senem Karabulut

Objectives: This study evaluated the association between maintenance therapy and survival outcomes following first-line bevacizumab-based combination chemotherapy in metastatic colorectal cancer (mCRC) using real-world data. Methods: This retrospective study included 94 mCRC patients achieving disease control, defined as complete response (CR), partial response (PR), or stable disease (SD), after first-line bevacizumab-based chemotherapy (2015–2025). Patients were divided into maintenance (fluoropyrimidine ± bevaci …

13.08.2026journal-article

Advanced Electromagnetics

Study on the Mechanism of Music Therapy in Improving Sleep Quality of Patients with Chronic Insomnia Based on EEG Signal Analysis

Y. Zhang

Chronic insomnia is a common sleep disorder that can severely compromise physical and mental health, cognitive function and occupational safety. As a non-pharmacological intervention, music therapy has demonstrated unique advantages in improving sleep quality. By collecting electroencephalogram (EEG) signals of patients with chronic insomnia before and after music therapy, this study explores the regulatory effect of music therapy on cerebral neural activity. The results show that music therapy can significantly al …

13.08.2026journal-article

HIV Infection and Immunosuppressive Disorders

Аntiretroviral therapy for young adults perinatally infected with HIV: the treatment experience from childhood through adulthood

A. V. Samarina, E. Zh. Sereda, N. V. Sizova, I. A. Abramova, N. S. Dyldina, E. K. Fertikh, O. L. Mozaleva

From 2018 to 2024, the Russian Federation witnessed an increase in the number of young people with perinatally acquired HIV (PHIV) who reached the age of 18 years and transitioned to adult care. It is known that young individuals with PHIV have a duration of HIV infection equal to their age (more than 18 years), with delayed or late initiation of antiretroviral therapy (ART), often in the setting of advanced disease stages. In addition to the direct damaging effect of HIV and the associated chronic inflammation, th …

13.08.2026journal-article

Inorganic Chemistry

Dinuclear Ir(III)/Ru(II)/Os(II) Bis-terpyridine Complexes Tethered by Tetrathienyl-Substituted Diketopyrrolopyrrole: Synthesis, Photophysics, and Antimicrobial Photodynamic Therapy

Xinyang Sun, Md Razzak, Giulia Kassab, Guorong Sun, Kalara D. Gamage, Maharajan Sivasubramanian, Habiba Afrin, Kuo-Hao Chen, Svetlana Kilina, Juan Chen, Gang Zheng, Leu-Wei Lo, Wenfang Sun

Abstract Three dinuclear bis-terpyridine Ir(III)/Ru(II)/Os(II) complexes DPP-M (M = Ir, Ru, Os) tethered by tetrathienyl-substituted diketopyrrolopyrrole were synthesized and characterized as near-IR photosensitizers. Photophysical studies, including UV–vis absorption, emission, and transient absorption, were conducted to investigate the singlet and triplet excited states of the complexes and to understand how different metals influence their photophysical properties. All complexes demonstrated panchromatic absorpt …

13.08.2026journal-article

Renal Replacement Therapy

Elevated serum ferritin levels and infection-related mortality in maintenance hemodialysis patients: 10-year outcomes of the Q-Cohort study

Yutaro Hirashima, Hiroto Hiyamuta, Shunsuke Yamada, Hiromasa Kitamura, Masatomo Taniguchi, Kazuhiko Tsuruya, Tetsuro Ago, Toshiaki Nakano

Abstract Background Serum ferritin guides iron therapy in hemodialysis patients but also reflects inflammation and systemic illness. We examined the association between baseline serum ferritin and infection-related mortality in maintenance hemodialysis patients. Methods We analyzed 3529 participants in the Japanese Q-Cohort Study. The primary analysis categorized serum ferritin into quartiles. Clinically motivated supplementary analyses used clinical categories, a 300 ng/mL cutoff, and log-transformed ferritin. Inf …

13.08.2026journal-article

Clinical and Preventive Medicine

USE OF MODULAR PHYSICAL MODELS AND DYNAMIC SIMULATIONS IN THE TRAINING OF SPECIALISTS IN THERAPY AND REHABILITATION

Nataliia V. Stuchynska, Halyna V. Khrapiichuk, Oksana M. Melnyk

Introduction. Russia’s military aggression has sharply intensified the problem of training specialists in therapy and rehabilitation. During the years of the full-scale invasion, the number of wounded requiring prosthetics and orthotics has increased substantially. Overcoming the crises and challenges of wartime requires prompt responses and integration of innovative teaching methods that enhance professional training by combining theoretical knowledge with practical experience.Aim. To investigate the effectiveness …

13.08.2026journal-article

Antibiotics

Efficacy and Safety of Adjusting Antimicrobial Therapy in Episodes of Fever and Neutropenia Catalogued as Fever of Unknown Origin in Children with Cancer: A Randomized Clinical Trial

Carolina Ibáñez, Romina Valenzuela, Marlon Barraza, Ana M. Álvarez, Ernesto Paya, Verónica Contardo, Valentina Gutiérrez, Karen Ducasse, Juan P. Torres, Paulina Coria, Verónica de la Maza, Daniela Martínez, Tamara Inostroza, María E. Santolaya

Background/Objectives: The objective of this study is to evaluate the efficacy and safety of maintaining antimicrobial (AM) therapy or adjusting AM therapy during episodes of febrile neutropenia (FN) catalogued as a fever of unknown origin (FUO) in children with cancer. Methods: This is a prospective, multicenter, noninferiority, randomized study, approved by ethics committee, in children with episodes of FN in eight hospitals in Chile. Microbiological and molecular samples were drawn at admission. Patients with FU …

13.08.2026journal-article

Journal of Endovascular Therapy

Updated Systematic Review of Long-Term Outcomes of Endovascular Popliteal Artery Aneurysm Repair: Evidence From 2014 to 2025

Paula Dias, Miguel Castro e Silva, Luís Orelhas, Jorge Costa, Beatriz Tavares, Ricardo Vale Pereira, Manuel Fonseca

Introduction: Endovascular repair has increasingly been adopted as a less-invasive alternative to open surgery for popliteal artery aneurysms, yet its long-term durability remains debated. Since the last comprehensive review in 2015, substantial new data with extended follow-up have emerged. This systematic review aimed to evaluate long-term outcomes after endovascular popliteal artery aneurysm repair (EPAR) and summarise contemporary evidence published between 2014 and 2025. Methods: In accordance with Preferred R …

13.08.2026journal-article

Advanced Healthcare Materials

Overcoming Photodynamic Therapy Resistance: GSH‐Responsive AIE Photosensitizer‐Hydroxycamptothecin Nanoliposomes for Extrahepatic Cholangiocarcinoma

Yong Qu, Tao Peng, Yating Zhang, Juanmei Cao, Birong Wang, Chuxing Chai, Zhiyuan Gao, Yiting Xu, Yifan Jin, Yuqing Wang, Zhuoxia Li, Xu Liu, Tianqi Zhao, Yufan Chen, Weimin Lv, Di Lu, Changzheng Huang, Dan Ding, Jinxiang Zhang, Min Li

ABSTRACT Photodynamic therapy (PDT) has been shown to improve survival and quality of life in patients with unresectable extrahepatic cholangiocarcinoma. However, its therapeutic efficacy is frequently limited by the survival of residual tumor cells that can re‐enter the proliferative cycle. Our previous studies showed that residual cholangiocarcinoma cells can re‐enter the proliferative cycle following PDT accompanied by hypoxia‐induced activation of the HIF‐1α survival pathway and intracellular antioxidant progra …