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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
04.08.2026journal-article

Frontiers in Sports and Active Living

Effect of dance intervention on cardiorespiratory fitness and quality of life of older adults: a systematic review and meta-analysis

Zarifa Kamilova, John Buckley, Bruce Paton, Mike Loosemore

Background Physical inactivity is among the dominant risk factors for adverse health outcomes in older adults. It is crucial to investigate effective strategies to encourage older adults to maintain their physical activity. Dancing is recommended as a moderate-intensity activity to enhance cardiorespiratory fitness (CRF) and sustain activity levels. This systematic review and meta-analysis investigates existing trials and synthesizes the effectiveness of a dancing intervention compared with exercising or non-exerci …

04.08.2026journal-article

Diabetes, Obesity and Metabolism

Factors Associated With Progression From Level 1 to Level 2 Sensor‐Detected Hypoglycaemia in People With Type 1 and Insulin‐Treated Type 2 Diabetes: A Post Hoc Analysis From the Hypo‐ METRICS Study

Vaios Koutroukas, Aikaterina Tziannou, Jonah J. C. Thomas, Gilberte Martine‐Edith, Simon Heller, Julia K. Mader, Julie Maria Bøggild Brøsen, Ulrik Pedersen‐Bjergaard, Bastiaan E. de Galan, Eric Renard, Mark L. Evans, Rory J. McCrimmon, Jane Speight, Frans Pouwer, Stephanie A. Amiel, Pratik Choudhary

ABSTRACT Aims We investigated the proportion of sensor‐detected hypoglycaemic (SDH) events progressing to level 2, and associated variables. Materials and Methods We used data from Hypo‐METRICS, which recruited people with type 1 (pwT1D) and insulin‐treated type 2 diabetes (pwT2D) with ≥ 1 hypoglycaemic event in preceding 3 months, wearing blinded continuous glucose monitoring devices (CGM), additional to usual monitoring modality, and FitBits for 10 weeks. We defined: L1: SDH < 3.9 mmol/L for ≥ 15 min but ≥ 3.0 mm …

04.08.2026journal-article

Applied Research in Quality of Life

Predictive Effect of Neighborhood Disadvantage on Depressive Symptoms Among Chinese Middle-Aged and Older Adults: Social Support and Children’s Marital Status as Intervening Factors

Taixiang Duan, Daniel T. L. Shek

Abstract Depressive symptoms among Chinese middle-aged and older adults have risen substantially in recent years, yet how neighborhood and family factors relate to mental health remains insufficiently understood in China. Using survey data from 1,177 respondents in Chengdu, this study examines associations between neighborhood disadvantage and depressive symptoms, with attention to the mediating role of social support and moderating role of children’s marital status. Results indicate that neighborhood disadvantage …

04.08.2026journal-article

International Journal of Environmental Research and Public Health

Systematic Co-Design of Artificial Intelligence-Enabled Innovations for Healthy Aging: A Demonstration Study Involving Socially Assistive Robots for Dementia Care

Sajay Arthanat, Jing Wang, Dain LaRoche, Heather Fritz, Rosanne DiZazzo-Miller, Mostafa Hussein, Ola Ghattas, Moniruzzaman Akash, Momotaz Begum

Artificial intelligence-enabled technologies offer new opportunities to support healthy aging and the long-term care needs of older adults. However, inclusive practices are paramount to ensuring that accessibility, usability, privacy, and equitable use are factored into the design and deployment of these emerging technologies. This article explores the role of co-design in health technology development and highlights the application of three methodological tools—the NIH Stage Model for Behavioral Intervention Devel …

04.08.2026journal-article

Journal of Epidemiology and Community Health

Effects of personal and work-related stressful life events on mental health among middle-aged and older Australians: longitudinal evidence from 16 waves of cohort data

Md Mahmudul Hasan Sagar, Syed Afroz Keramat, Md Mehedi Hasan, Rubayyat Hashmi, Abdullah Al Mamun

Background Stressful life events are recognised determinants of mental health, yet their effects in later life remain unclear. Reflecting increasing longevity, our study examined links between stressful life events, both personal and work-related, and mental health outcomes among middle-aged and older Australians aged 50 and over. Methods We analysed 95 603 person-year observations from 11 187 individuals across 16 waves (2006–2021) of the nationally representative Household, Income and Labour Dynamics in Australia …

04.08.2026journal-article

Current Alzheimer Research

Safety Comparison of Acetylcholinesterase Inhibitors Using FAERS Spontaneous-Reporting Data: Drug-Specific Reporting Signals and Time-to-Onset Dynamics

Yidan Du, Jia Li, Fei Han, Jianjun Li, Hong Lin, Fangfang Ge

Introduction/Objective: Acetylcholinesterase Inhibitors (AChEIs) are widely used for symptomatic treatment of Alzheimer’s disease, but their post-marketing reporting profiles may differ. This study compared FAERS disproportional reporting signals and Time-To-Onset (TTO) patterns for donepezil, galantamine, and rivastigmine. Methods: FAERS reports from Q1 2004 to Q2 2025 were analyzed. Reports listing donepezil, galantamine, or rivastigmine as the primary suspect drug were retained. Unique case–drug–Preferred Term ( …

13.08.2026journal-article

European Journal of Public Health

Feasibility and implementation insights from implementing the health navigator model for cancer prevention among people experiencing homelessness across Europe

Katerina Belogianni, Alejandro Gil-Salmerón, Tobias Fragner, Julia Gawronska, Rosa Trenado Gomez, Ioanna Tabaki, Maria Moudatsou, Lee Smith, Tamara Alhambra-Borras, Vicent Blanes Selva, Archontoula Dalma, Matina Kouvari, Igor Grabovac

Abstract Cancer-related mortality among People Experiencing Homelessness (PEH) is twice as high as in the housed population, with one-third of deaths in this community linked to conditions preventable through timely healthcare. The Health Navigator Model (HNM) is a person-centred approach to improve healthcare access for PEH. This study assessed the feasibility of implementing the HNM across four European countries. A non-randomised, single-arm pilot study was conducted from June 2022 to December 2023 in Austria, S …

04.08.2026journal-article

The International Journal of Aging and Human Development

Interrelationships Between Social and Emotional Loneliness and Multiple Domains of Cognition in Later Life: A Longitudinal Approach

Bert Hayslip, Robert J. Maiden, Arthur L. Greil

While the literature suggests that loneliness may undermine cognitive functioning in later life, no work has simultaneously examined the associations between these constructs, taking a multidimensional approach to the assessment of each, where 360 older adults comprised the initial sample and 220 such persons comprised the 1-year longitudinal sample. Based upon correlational and regression-based data analyses, we found that social loneliness at Time 1 predicted everyday cognitive failures at Time 2, and that Time 1 …

04.08.2026journal-article

Qualitative Health Research

Between Denial and Delay: Barriers to Accessing Nonpharmacological Interventions for Seniors With Mild-to-Moderate Dementia in Canada

Jasmine Jihye Hwang, Tam Truong Donnelly, Sandra Davidson, Shelley Raffin Bouchal

Dementia is a growing public health concern in Canada, yet timely access to nonpharmacological interventions (NPIs) for persons with dementia (PWDs) remains poorly understood. This critical ethnographic study explored factors influencing access to NPIs among private-dwelling seniors with mild-to-moderate dementia and their family/friend care partners (CPs) in Alberta, Canada. Guided by McLeroy et al.’s Ecological Perspective and Habermas’ Critical Social Theory, we conducted 53 semi-structured interviews with eight …

04.08.2026journal-article

Qualitative Health Research

Illness Identity and Its Influence on Self-Management in Older Adults With Multimorbidity: A Hybrid Thematic Analysis

Isil Coklar-Okutkan, Séamus Harvey, Julie Doyle, Filipa Teixeira, John Dinsmore

Illness identity refers to the way people integrate health conditions into their sense of self and plays a vital role in managing chronic illness. While most research has examined illness identity in relation to a single diagnosis, this study addressed the added complexity of living with multiple conditions in later life. The aim was to examine how illness identity shapes self-management among older persons with multimorbidity (PwMs) and to refine the relevance of existing illness identity categories by deepening u …

04.08.2026journal-article

British Journal of Learning Disabilities

‘Our Time to Shine’ —Development and Qualitative Evaluation of the Be a Leader Leadership Training for People With Learning Disabilities

Lisa Richardson, Steven Chapman, Ann‐Marie Lillis, Mollie Mattingly, Daniel Marsden, Emilia Ashley, Tricia Nicoll, Matt Clifton

ABSTRACT Background Opportunities for people with learning disabilities to develop as leaders are rare, except through self‐advocacy groups. A leadership training course for people with learning disabilities in Kent‐ Be a Leader‐ was designed to address this gap. Method The 6‐month training was co‐designed and delivered to six learners with learning disabilities and their co‐learners, who learnt alongside and supported them. All learners developed a vision in an area where they wanted to demonstrate leadership. Int …

04.08.2026journal-article

Advanced Materials

Nanoscale Adhesive Architecture Coordinates With Matrix Stiffness to Regulate Stem Cell Aging via Focal Adhesion‐Mediated Chromatin Remodeling and FOXO1 Activation

Jiacheng Lei, Ruihao Xue, Qingqing Liang, Ge Yang, Xiaokai Pan, Tianxiang Ren, Kaikai Zheng, Qiang Wei, Ze Gong, Xiaojing Liu

ABSTRACT Stem cell aging critically limits the efficacy of regenerative biomaterials, yet how mechanical cues within the microenvironment modulate this process remains insufficiently understood. Here, we reveal that the nanoscale spacing of adhesive ligands imposes stiffness‐dependent effects on mesenchymal stem cell (MSC) senescence. Wider spacing (distance 150 nm) accelerates aging on stiff hydrogels (50 kPa) but mitigates it on soft hydrogels (5 kPa), relative to dense spacing (distance 30 nm). Using a molecular …

04.08.2026journal-article

Journal of the American Heart Association

Association of Genetic Variants With Rivaroxaban Pharmacokinetics and Pharmacodynamics in Older Patients With Atrial Fibrillation: A Prospective Cohort Study

Guoquan Chen, Haiping Wang, Jiale Chen, Ling Wang, Qiang Zhao, Ganbo Que, Wenchang Zhang, Shuqiao Hu, Wei Hu, Congli Hu

Background Rivaroxaban is frequently used for stroke prevention in atrial fibrillation. Clinicians increasingly encounter complex decision‐making regarding oral anticoagulant prescription in older patients with atrial fibrillation. Genetic contributors to variability in rivaroxaban exposure and clinical outcomes remain uncertain. Methods A total of 168 eligible participants were consecutively recruited in this prospective observational study. Rivaroxaban dose regimens were accounted for using dose‐specific standard …

04.08.2026journal-article

Pilot and Feasibility Studies

Virtual reality mindfulness-based cognitive therapy for reducing psychological distress in people with depression and/or anxiety symptoms: two uncontrolled feasibility studies

Rebecca L. Gould, Matthew Hoad-Robson, Kim Bevan, Amy Bedingham

Abstract Background Group mindfulness-based cognitive therapy (MBCT) is recommended for the treatment of subthreshold-to-mild depressive symptoms. Timely access to MBCT, however, is limited by accessibility issues. Self-help MBCT can overcome these issues, but is associated with poorer engagement. Incorporating virtual reality into self-help MBCT (VR-MBCT) may improve engagement, but relatively little is known about its feasibility and acceptability. Consequently, the aims of this study were to examine the acceptab …

08.08.2026journal-article

The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences

Compositional data analysis of 24hr activity and its associations with muscle strength and power: The Study of Muscle, Mobility and Aging

Lauren S Roe, Elsa S Strotmeyer, Peggy M Cawthon, Nancy W Glynn, Reagan E Garcia, Yan Ma, Megan Hetherington-Rauth, Nina Z Heilmann, Kelley P Gabriel, Stephen B Kritchevsky, Jane A Cauley

Abstract Background Physical activity (PA) and inactivity have opposing associations with skeletal muscle function and are often studied separately but are codependent. We evaluated cross-sectional associations between 24-h time-use behaviors with muscle strength and power. Methods Sample included 751 community-dwelling older adults (76 ± 5 years, 57% women). Compositional data analysis determined 24-h proportions of time in moderate-to-vigorous PA (MVPA) and light intensity PA (LPA), inactivity, and sleep. Multipl …

04.08.2026journal-article

BMC Public Health

Association between living environmental quality and risk of gastrointestinal diseases among middle-aged and older adults: evidence from a national study

Endian Liu, Yanbin Wei, Minjiao Wang, Yanqing Liu, Xin Yao, Jie Xing

Abstract Background With the rapid progression of population aging in China, gastrointestinal (GI) diseases have become one of the most common chronic conditions among middle-aged and older adults, substantially impairing quality of life and increasing healthcare burdens. However, evidence regarding the combined effects of multiple living environment factors and their potential interactions on GI health remains limited. Methods This study used data from the China Health and Retirement Longitudinal Study from 2011 t …

04.08.2026journal-article

Journal of Organizational Effectiveness: People and Performance

When does difference make a difference? A bibliometric analysis and process-contingency framework of cognitive diversity research

Amarnath Padhi, Anil Kumar

Purpose Research on cognitive diversity (CD) reveals a persistent paradox: some studies link it to creativity and adaptability, while others associate it with conflict and reduced performance. This research resolves these contradictions by synthesizing 2 decades of CD studies and identifying the processes and conditions that influence its outcomes. Design/methodology/approach We analyzed 210 peer-reviewed articles (2000–2024) from Scopus using bibliometric methods. The study examines publication trends, citation pa …

04.08.2026journal-article

Dentistry Journal

Mechanical Properties of Dental Occlusal Splint Materials After Accelerated Aging in Artificial Saliva: An In Vitro Study

Iulia Karla Nică, Lucian Toma Ciocan, Vlad Gabriel Vasilescu, Robert Cătălin Ciocoiu, Federico Foschi, Andreea Mihaela Custură, Elisei Adelin Radu, Alexandru Titus Farcașiu, Silviu Mirel Pițuru, Marina Imre

Background: Occlusal splints are exposed to prolonged intraoral conditions, including saliva, temperature fluctuations, and mechanical loading, which may alter their mechanical performance over time. The increasing use of SLA 3D-printed photopolymer resins for splint fabrication has introduced new materials whose aging-related mechanical stability remains insufficiently characterized. Objectives: This in vitro study evaluated the effects of accelerated aging in artificial saliva on the Shore D hardness and flexural …

04.08.2026journal-article

Clinical Infectious Diseases

Multimorbidity Trajectories and Hospitalization Risk Among People With Human Immunodeficiency Virus in Sub-Saharan Africa: A Longitudinal Analysis From the African Cohort Study

Remle Scott, Cara H Olsen, James D Mancuso, Hannah Kibuuka, Jonah Maswai, John Owuoth, Valentine Sing’oei, Emmanuel Bahemana, Zahra Parker, Julie A Ake, Neha Shah, Trevor A Crowell, Elizabeth H Lee

Abstract Background Increasing multimorbidity among people with human immunodeficiency virus (PWH; HIV) in sub-Saharan Africa can result in hospitalization. We investigated longitudinal associations between multimorbidity trajectories and hospitalization risk within the African Cohort Study (AFRICOS). Methods AFRICOS enrolls people with and without HIV from HIV clinics in Uganda, Kenya, Tanzania, and Nigeria. These analyses restricted PWH aged ≥18 years enrolled between 2013 and 2024. Multimorbidity (≥chronic condi …

04.08.2026journal-article

Physics in Medicine & Biology

Machine learning for predicting full-count FDG PET brain images from low-count acquisitions in suspected dementia: a clinical and quantitative evaluation

Lydia Lim, David Little, Stewart Redman, Andrew Cookson

Abstract Objective. Artificial intelligence methods for denoising low-count (LC) FDG positron emission tomography (PET) brain images are usually evaluated using image quality metrics alone, with limited direct clinical assessment, particularly in suspected dementia. This study evaluated a machine-learning image quality transfer (IQT) method for predicting full-count FDG PET brain images from LC acquisitions using both quantitative metrics and blinded clinical assessment. Approach . Forty-one FDG PET/CT patients wit …

04.08.2026journal-article

Cells

Vesicular Communication in the Bone–Muscle Unit: Physiological Functions, Aging, and Therapeutic Potential

Virginia Veronica Visconti, Chiara Greggi, Antonio Matticari, Riccardo Iundusi, Elena Gasbarra, Annalisa Botta, Umberto Tarantino

Extracellular vesicles (EVs) have emerged as fundamental pillars of intercellular communication, acting as primary mediators of the bidirectional biochemical crosstalk within the integrated bone–muscle unit. This review provides a comprehensive synthesis of EV-mediated signaling across the bone–muscle axis, offering a side-by-side mapping of vesicular biogenesis, cargo composition, and functional roles in both tissues. Under physiological conditions, skeletal muscle- and bone-derived EVs orchestrate tissue homeosta …

04.08.2026journal-article

Materials

Influence of Temperature on the Chemical and Rheological Aging Kinetics of Corn Starch-Modified Bitumen

Paulina Rozpędowska, Małgorzata Wójcik, Mateusz Golda, Agnieszka Woszuk, Lidia Bandura, Szymon Malinowski, Wojciech Franus

The increasing demand for sustainable bitumen modifiers has stimulated interest in bio-based materials capable of improving binder performance while reducing environmental impact. This study investigates the influence of corn starch on the thermo-oxidative aging kinetics of paving-grade bitumen. Unmodified 50/70 bitumen and binders containing 4, 6 and 8 wt.% corn starch were subjected to laboratory aging at 100 °C and 140 °C for up to 120 h. The aging process was evaluated using dynamic viscosity measurements, FTIR …

04.08.2026journal-article

The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences

A technology-blended exercise intervention for cognitive risk reduction and brain health in middle-aged and older adults with type 2 diabetes in Singapore: a mixed-methods study

Jinghua Zhang, Wilson Wai San Tam, Jinhua Lu, Junjie Chen, Jed Montayre, Joji Kusuyama, Yanhong Dong, Xin Yi Yap, Wentao Zhou, Na Wang, Hui Nan Yeo, Frena Jia Sy Lee, Vivien Xi Wu

Abstract Background Type 2 diabetes mellitus (T2DM) is a major modifiable risk factor for accelerated brain ageing, cognitive decline, and dementia. However, sustainable lifestyle interventions targeting cognitive health in at-risk older adult populations remain limited. This mixed-methods study evaluated the effects of a 12-week technology-blended Intensive Aerobic and Resistance Exercise Program (IAREP) on cognitive risk and related health outcomes among middle-aged and older adults with T2DM in a primary care se …

04.08.2026journal-article

Frontiers in Aging Neuroscience

Abdominal CT-derived metabolic phenotypes are associated with the MRI-derived brain age gap in women

Chongwon Pae, Minchul Kim, Inpyeong Hwang, Joon Ho Moon, Kyu Sung Choi

Background Metabolic dysfunction is increasingly recognized as a systemic contributor to adverse brain aging; however, conventional clinical markers may not fully capture tissue-level variations in liver attenuation, abdominal adiposity, and muscle quality. We examined whether abdominal CT-derived metabolic phenotypes were associated with MRI-derived brain age gap (BAG) in women. Methods This retrospective health-screening cohort included 1,280 women who underwent both abdominal CT and brain MRI between 2019 and 20 …