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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
24.08.2026journal-article

Seminars in Thrombosis and Hemostasis

Extended Anticoagulation Therapy with Rivaroxaban for Cancer-Associated Low-Risk Pulmonary Embolism According to Status of Concomitant Deep Vein Thrombosis: Insights from the ONCO PE Randomized Trial

Wei Xiong, Yugo Yamashita, Takeshi Morimoto, Nao Muraoka, Wataru Shioyama, Yoshihisa Nakagawa, Ryuki Chatani, Hiromi Yamamoto, Tatsuhiro Shibata, Nagisa Morikawa, Yoshihiro Fukumoto, Yuji Nishimoto, Koh Ono, Takeshi Kimura

Abstract The ONCO PE trial showed that 18-month rivaroxaban was superior to 6-month rivaroxaban for preventing recurrent venous thromboembolism (VTE) in patients with cancer-associated low-risk pulmonary embolism (PE). However, the influence of concomitant deep vein thrombosis (DVT) on this benefit was unclear. The current post-hoc subgroup analysis of the ONCO PE trial categorized patients into DVT subgroup (N = 104) and no DVT subgroup (N = 74) based on the presence or absence of a concomitant DVT at PE diagnosis …

13.08.2026journal-article

Physiotherapy Research International

Upper‐Limb Paresis Severity Is Associated With Practice Dosage During Task‐Oriented Training in Subacute Stroke—An Exploratory Secondary Analysis

Subramanian Durairaj, Akhila Jagadish, John M. Solomon, Mindy F. Levin

ABSTRACT Background and Purpose Intensive, high‐repetition practice is one of the strategies incorporated into upper‐limb task‐oriented training (UL‐TOT) to promote experience‐dependent neural plasticity after stroke. Although a target of 300 repetitions during a one‐hour UL‐TOT session is feasible, considerable variability in the practice dosage achieved across individuals has been observed. Multiple factors may influence practice dosage during UL‐TOT. Therefore, this exploratory secondary analysis aimed to examin …

13.08.2026journal-article

Medical and Health Science Journal

The Effect of 432 Hertz Frequency Music Therapy on Auditory Hallucinations in Schizophrenia Patients: A Quasi-Experimental Study

Muhammad Taufiqul Akbar, Ririn Kurniawati, Dwi Bagas Febriyanto

Background: Schizophrenia is a severe and chronic mental disorder characterized by cognitive impairment and difficulties in performing daily activities. Approximately 20% of patients with schizophrenia experience hallucinations. The 432 Hertz frequency is considered close to the natural resonance of the human body and is widely used in sound healing; Objective: This study aimed to investigate the effect of 432 Hertz frequency music therapy on the reduction of auditory hallucinations in schizophrenia patients at Gri …

13.08.2026journal-article

Journal of Cardiopulmonary Rehabilitation and Prevention

Implementing Cardiac Rehabilitation as a First-Line Treatment for Stable Angina Pectoris: PERSPECTIVES OF CARDIOLOGISTS AND PATIENTS

Eva W. Verkerk, Esther Deuning-Smit, Noa Beernink, Angelique T. E. F. Schlief, Joyce M. Heutinck, Iris A. de Koning, Hareld M. C. Kemps, Dick H. J. Thijssen, Rudolf B. Kool

Purpose: Cardiac rehabilitation (CR) is a promising treatment for patients with stable angina pectoris (SAP) and has been postulated as a safe and effective alternative to revascularization in low-risk patients. We assessed the barriers and facilitators for the implementation of CR for patients with SAP. Methods: We interviewed 12 clinicians (cardiologists and CR case managers) and 6 patients to assess perceived and expected barriers and facilitators in choosing CR as first-choice treatment for SAP in the Netherlan …

13.08.2026journal-article

Russian Journal of Cardiology

Clinical and economic modeling of using quadruple combination therapy with angiotensin-converting enzyme inhibitors or angiotensin receptor-neprilysin inhibitors in the Russian population

E. V. Derkach, V. I. Ignatyeva

Aim . Using modeling, to evaluate the economic rationale of using quadruple the­rapy in the Russian population. Material and methods . Based on clinical trials on the effectiveness of combination therapy in patients with heart failure with reduced ejection fraction (HFrEF), a Markov model with 5- and 10-year time horizons and a cycle duration of 1 month was constructed. The analysis was conducted from the perspective of the state taxpayer. Three following strategies were compared: triple therapy (angiotensin-conver …

13.08.2026journal-article

Current Opinion in Endocrinology, Diabetes & Obesity

Thyroxine withdrawal prior to radioiodine therapy in papillary thyroid carcinoma – current scenarios

Saumya Sunny, Julie Hephzibah

Purpose of review This review aims to compare the different methods of achieving adequate thyroid-stimulating hormone (TSH) stimulation prior to radioiodine (RAI) therapy in patients with differentiated thyroid carcinoma (DTC). It focuses on thyroid hormone withdrawal strategies and recombinant human TSH, examining their relative efficacy, safety, and impact on patient quality of life. Additionally, the review highlights recent guideline updates, and how these approaches influence postoperative risk stratification, …

13.08.2026journal-article

3D Printing in Medicine

Custom prosthetic rehabilitation of ocular defects with a digital workflow

Siyi Wang, Qingwen Cai, Jin Pan, Xiaoyu Gu

Abstract Purpose To use digital technologies, including high-resolution imaging, computer-aided design (CAD), and three-dimensional (3D) printing, to introduce a streamlined process by enabling rapid, reproducible, and cost-effective digital fabrication of orbital prostheses, thereby addressing the limitations of conventional manual prostheses, which remain labor-intensive, poorly reproducible, and often fail to achieve optimal marginal adaptation. Materials and methods This study presented a digital workflow for s …

13.08.2026journal-article

International Journal of Molecular Sciences

Emerging Immune Cell Biomarkers in Primary Membranous Nephropathy: Immune Cell Profiling During Anti-CD20 B Cell-Targeted Therapy

Christos Georgopoulos, Eleni Stamellou, Anila Duni, Lefkothea Dova, Georgios Vartholomatos, Ekaterini Siomou, Haralampos Milionis, Evangelia Dounousi

Primary membranous nephropathy (pMN) is an antibody-mediated podocytopathy, most commonly caused by autoantibodies against the M-type phospholipase A2 receptor (PLA2R1). Rituximab (RTX), an anti-CD20 monoclonal antibody, is a first-line treatment for moderate-to-high-risk pMN, inducing partial or complete remission in about 60% of patients within 24 months. However, treatment response varies considerably, and current biomarkers, including anti-PLA2R1 titers and peripheral B cell counts, have limited predictive valu …

13.08.2026journal-article

Haematologica

Macrophage migration inhibitory factor promotes immune evasion in multiple myeloma through myeloid-derived suppressor cell immunosuppression and major histocompatibility complex class I downregulation: implications for targeted therapy

Jingjing Wen, Jingcao Huang, Juan Xu, Pan Zhao, Xiaohui Zhao, Siyao He, Linfeng Li, Xiang Liu, Hongmei Luo, Ziyue Mi, Yue Zhang, Qianwen Gao, Haonan Yang, Yu Feng, Xinyu Zhai, Fangfang Wang, Dan Zhang, Li Zhang, Wenjiao Tang, Enguang Bi, Ting Niu, Yuhuan Zheng

Macrophage migration inhibitory factor (MIF), derived from either tumor cells or the tumor microenvironment, promotes multiple myeloma (MM) progression by suppressing T cell-mediated antitumor responses. Here, we demonstrate that MIF drives immune evasion in MM through both TME-mediated and tumor-intrinsic mechanisms. In the TME, MIF promotes the expansion of myeloid-derived suppressor cells (MDSCs) and enhances the expression of immunosuppressive molecules, including CD84, PD-L1, and CD38, thereby augmenting MDSC- …

13.08.2026journal-article

Dermatologic Surgery

Surgical Outcomes for Hidradenitis Suppurativa: Does Biologic Therapy Make a Difference?

Nicole Schiraldi, Richard Rookwood, Yael Weitzner, Solbie Choi, Ilene Tisnovsky, Rebecca Kann, Megan Darrell, Brittany Lala, David Ciocon

BACKGROUND Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition that often requires both medical and surgical management. Biologic therapies are increasingly used for moderate-to-severe disease, but their effect on surgical outcomes remains unclear. OBJECTIVE The aim of this study was to evaluate the impact of biologic therapy on postoperative outcomes in patients undergoing excisional surgery for HS. MATERIALS AND METHODS The authors conducted a retrospective chart review of adult patients who un …

13.08.2026journal-article

International Journal of Engineering Research and Science & Technology

AN INTERPRETABLE SPEECH ANALYTICS FRAMEWORK FOR EARLY PARKINSON'S DISEASE IDENTIFICATION USING K-NEAREST NEIGHBORS

Ayesha Fathima, Dr. Safia Khanum, Ruqiya Fatima

Parkinson's disease (PD) is a long-term, degenerative neurological condition that affects the nerve system of the body and causes problems with speech, movement, and coordination. Dysphonia, a voice problem marked by changes in vocal quality, pitch, and loudness, is one of the early signs of Parkinson's disease. Vocal feature analysis becomes a useful method for early identification because between 70 and 90 percent of people with Parkinson's disease have speech problems. Previous research has used a variety of mac …

13.08.2026journal-article

Journal of Clinical Medicine

Association of Maintenance Therapy Strategies with Survival Following First-Line Bevacizumab-Based Combination Chemotherapy in Metastatic Colorectal Cancer: A Single-Center Retrospective Observational Study

Simay Çokgezer, Burak Şakar, Senem Karabulut

Objectives: This study evaluated the association between maintenance therapy and survival outcomes following first-line bevacizumab-based combination chemotherapy in metastatic colorectal cancer (mCRC) using real-world data. Methods: This retrospective study included 94 mCRC patients achieving disease control, defined as complete response (CR), partial response (PR), or stable disease (SD), after first-line bevacizumab-based chemotherapy (2015–2025). Patients were divided into maintenance (fluoropyrimidine ± bevaci …

13.08.2026journal-article

Advanced Electromagnetics

Study on the Mechanism of Music Therapy in Improving Sleep Quality of Patients with Chronic Insomnia Based on EEG Signal Analysis

Y. Zhang

Chronic insomnia is a common sleep disorder that can severely compromise physical and mental health, cognitive function and occupational safety. As a non-pharmacological intervention, music therapy has demonstrated unique advantages in improving sleep quality. By collecting electroencephalogram (EEG) signals of patients with chronic insomnia before and after music therapy, this study explores the regulatory effect of music therapy on cerebral neural activity. The results show that music therapy can significantly al …

13.08.2026journal-article

HIV Infection and Immunosuppressive Disorders

Аntiretroviral therapy for young adults perinatally infected with HIV: the treatment experience from childhood through adulthood

A. V. Samarina, E. Zh. Sereda, N. V. Sizova, I. A. Abramova, N. S. Dyldina, E. K. Fertikh, O. L. Mozaleva

From 2018 to 2024, the Russian Federation witnessed an increase in the number of young people with perinatally acquired HIV (PHIV) who reached the age of 18 years and transitioned to adult care. It is known that young individuals with PHIV have a duration of HIV infection equal to their age (more than 18 years), with delayed or late initiation of antiretroviral therapy (ART), often in the setting of advanced disease stages. In addition to the direct damaging effect of HIV and the associated chronic inflammation, th …

13.08.2026journal-article

Inorganic Chemistry

Dinuclear Ir(III)/Ru(II)/Os(II) Bis-terpyridine Complexes Tethered by Tetrathienyl-Substituted Diketopyrrolopyrrole: Synthesis, Photophysics, and Antimicrobial Photodynamic Therapy

Xinyang Sun, Md Razzak, Giulia Kassab, Guorong Sun, Kalara D. Gamage, Maharajan Sivasubramanian, Habiba Afrin, Kuo-Hao Chen, Svetlana Kilina, Juan Chen, Gang Zheng, Leu-Wei Lo, Wenfang Sun

Abstract Three dinuclear bis-terpyridine Ir(III)/Ru(II)/Os(II) complexes DPP-M (M = Ir, Ru, Os) tethered by tetrathienyl-substituted diketopyrrolopyrrole were synthesized and characterized as near-IR photosensitizers. Photophysical studies, including UV–vis absorption, emission, and transient absorption, were conducted to investigate the singlet and triplet excited states of the complexes and to understand how different metals influence their photophysical properties. All complexes demonstrated panchromatic absorpt …

13.08.2026journal-article

Renal Replacement Therapy

Elevated serum ferritin levels and infection-related mortality in maintenance hemodialysis patients: 10-year outcomes of the Q-Cohort study

Yutaro Hirashima, Hiroto Hiyamuta, Shunsuke Yamada, Hiromasa Kitamura, Masatomo Taniguchi, Kazuhiko Tsuruya, Tetsuro Ago, Toshiaki Nakano

Abstract Background Serum ferritin guides iron therapy in hemodialysis patients but also reflects inflammation and systemic illness. We examined the association between baseline serum ferritin and infection-related mortality in maintenance hemodialysis patients. Methods We analyzed 3529 participants in the Japanese Q-Cohort Study. The primary analysis categorized serum ferritin into quartiles. Clinically motivated supplementary analyses used clinical categories, a 300 ng/mL cutoff, and log-transformed ferritin. Inf …

13.08.2026journal-article

Clinical and Preventive Medicine

USE OF MODULAR PHYSICAL MODELS AND DYNAMIC SIMULATIONS IN THE TRAINING OF SPECIALISTS IN THERAPY AND REHABILITATION

Nataliia V. Stuchynska, Halyna V. Khrapiichuk, Oksana M. Melnyk

Introduction. Russia’s military aggression has sharply intensified the problem of training specialists in therapy and rehabilitation. During the years of the full-scale invasion, the number of wounded requiring prosthetics and orthotics has increased substantially. Overcoming the crises and challenges of wartime requires prompt responses and integration of innovative teaching methods that enhance professional training by combining theoretical knowledge with practical experience.Aim. To investigate the effectiveness …

13.08.2026journal-article

Antibiotics

Efficacy and Safety of Adjusting Antimicrobial Therapy in Episodes of Fever and Neutropenia Catalogued as Fever of Unknown Origin in Children with Cancer: A Randomized Clinical Trial

Carolina Ibáñez, Romina Valenzuela, Marlon Barraza, Ana M. Álvarez, Ernesto Paya, Verónica Contardo, Valentina Gutiérrez, Karen Ducasse, Juan P. Torres, Paulina Coria, Verónica de la Maza, Daniela Martínez, Tamara Inostroza, María E. Santolaya

Background/Objectives: The objective of this study is to evaluate the efficacy and safety of maintaining antimicrobial (AM) therapy or adjusting AM therapy during episodes of febrile neutropenia (FN) catalogued as a fever of unknown origin (FUO) in children with cancer. Methods: This is a prospective, multicenter, noninferiority, randomized study, approved by ethics committee, in children with episodes of FN in eight hospitals in Chile. Microbiological and molecular samples were drawn at admission. Patients with FU …

13.08.2026journal-article

Advanced Healthcare Materials

Overcoming Photodynamic Therapy Resistance: GSH‐Responsive AIE Photosensitizer‐Hydroxycamptothecin Nanoliposomes for Extrahepatic Cholangiocarcinoma

Yong Qu, Tao Peng, Yating Zhang, Juanmei Cao, Birong Wang, Chuxing Chai, Zhiyuan Gao, Yiting Xu, Yifan Jin, Yuqing Wang, Zhuoxia Li, Xu Liu, Tianqi Zhao, Yufan Chen, Weimin Lv, Di Lu, Changzheng Huang, Dan Ding, Jinxiang Zhang, Min Li

ABSTRACT Photodynamic therapy (PDT) has been shown to improve survival and quality of life in patients with unresectable extrahepatic cholangiocarcinoma. However, its therapeutic efficacy is frequently limited by the survival of residual tumor cells that can re‐enter the proliferative cycle. Our previous studies showed that residual cholangiocarcinoma cells can re‐enter the proliferative cycle following PDT accompanied by hypoxia‐induced activation of the HIF‐1α survival pathway and intracellular antioxidant progra …

13.08.2026journal-article

Journal of Endovascular Therapy

Updated Systematic Review of Long-Term Outcomes of Endovascular Popliteal Artery Aneurysm Repair: Evidence From 2014 to 2025

Paula Dias, Miguel Castro e Silva, Luís Orelhas, Jorge Costa, Beatriz Tavares, Ricardo Vale Pereira, Manuel Fonseca

Introduction: Endovascular repair has increasingly been adopted as a less-invasive alternative to open surgery for popliteal artery aneurysms, yet its long-term durability remains debated. Since the last comprehensive review in 2015, substantial new data with extended follow-up have emerged. This systematic review aimed to evaluate long-term outcomes after endovascular popliteal artery aneurysm repair (EPAR) and summarise contemporary evidence published between 2014 and 2025. Methods: In accordance with Preferred R …

13.08.2026journal-article

Obstetrics & Gynecology

Cost-Effectiveness Analysis of Menopausal Hormone Therapy

Elizabeth Gill, Wu Zeng, Katerina Shvartsman, Jill Brown

OBJECTIVE: To evaluate the cost effectiveness of menopausal hormone therapy (MHT) based on the risk–benefit profiles of current MHT formulations. METHODS: We used a Markov model to examine the cost effectiveness of MHT for hypothetical 50-year-old women with vasomotor symptoms compared with transdermal estradiol (E2) alone for patients without a uterus and transdermal E2 in combination with micronized progesterone for patients with a uterus, assuming 5 years of use. Using a health system perspective, we expressed t …

13.08.2026journal-article

Diseases of Aquatic Organisms

Blood analytes in California sea lion Zalophus californianus pups: reference intervals and malnutrition effects, from admission to rehabilitation

Faye E. Giebink, Alissa C. Deming, Justin R. Perrault, Malena Berndt, Sharon R. Melin, Nicole I. Stacy

Blood analyte data are limited for California sea lion Zalophus californianus pups despite frequent admission to rehabilitation facilities. The objectives of this study were to establish blood analyte reference intervals for rehabilitated California sea lion pups (n = 58) deemed clinically normal for release and for free-ranging California sea lion pups (n = 37) during routine health assessment on San Miguel Island, California, USA; to compare manual white blood cell (WBC) differentials to an in-house hematology an …

13.08.2026journal-article

Current Oncology

Durable Hematologic Response in Therapy-Related Myelodysplastic Syndrome During Nivolumab Treatment for Metastatic Melanoma: A Case Report

Fathima Nashfa M. Hamza, Fatima Eltayeb, Mohammed Al Katari, Mohammed F. K. Ibrahim

Immunotherapy is the standard first-line palliative treatment for metastatic melanoma; however, its role in myelodysplastic syndrome (MDS) remains uncertain. We report a case in which nivolumab, administered for metastatic melanoma, was associated with a marked improvement in concurrent treatment-related MDS. A 67-year-old man with a history of oligosecretory multiple myeloma developed transfusion-dependent MDS following autologous stem cell transplantation, requiring twice-weekly blood transfusions. He subsequentl …

13.08.2026journal-article

HIV Infection and Immunosuppressive Disorders

Features of the course of HIV infection and the structure of comorbid diseases in women of childbearing age during antiretroviral therapy

E. B. Yastrebova, V. Ya. Rosenberg, I. E. Nebozhin, Ya. V. Romanova

The aim : to analyze the characteristics of HIV infection and the structure of comorbid diseases in women of childbearing age. Materials and methods . A total of 100 women of childbearing age were studied at the Republican Clinical Infectious Diseases Hospital. The average age was 42.5±0.6 years (range: 35 to 52 years). The duration of HIV infection was 15.6±1.2 years (range: 2 to 26 years). Transmission routes: sexual (63%) and parenteral (37%), HCV infection (42%) (90% treated). Marital status: married (62%), coh …