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Was ist neu im Gesundheitswesen?

Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
04.08.2026journal-article

Physics in Medicine & Biology

Machine learning for predicting full-count FDG PET brain images from low-count acquisitions in suspected dementia: a clinical and quantitative evaluation

Lydia Lim, David Little, Stewart Redman, Andrew Cookson

Abstract Objective. Artificial intelligence methods for denoising low-count (LC) FDG positron emission tomography (PET) brain images are usually evaluated using image quality metrics alone, with limited direct clinical assessment, particularly in suspected dementia. This study evaluated a machine-learning image quality transfer (IQT) method for predicting full-count FDG PET brain images from LC acquisitions using both quantitative metrics and blinded clinical assessment. Approach . Forty-one FDG PET/CT patients wit …

04.08.2026journal-article

Cells

Vesicular Communication in the Bone–Muscle Unit: Physiological Functions, Aging, and Therapeutic Potential

Virginia Veronica Visconti, Chiara Greggi, Antonio Matticari, Riccardo Iundusi, Elena Gasbarra, Annalisa Botta, Umberto Tarantino

Extracellular vesicles (EVs) have emerged as fundamental pillars of intercellular communication, acting as primary mediators of the bidirectional biochemical crosstalk within the integrated bone–muscle unit. This review provides a comprehensive synthesis of EV-mediated signaling across the bone–muscle axis, offering a side-by-side mapping of vesicular biogenesis, cargo composition, and functional roles in both tissues. Under physiological conditions, skeletal muscle- and bone-derived EVs orchestrate tissue homeosta …

04.08.2026journal-article

Materials

Influence of Temperature on the Chemical and Rheological Aging Kinetics of Corn Starch-Modified Bitumen

Paulina Rozpędowska, Małgorzata Wójcik, Mateusz Golda, Agnieszka Woszuk, Lidia Bandura, Szymon Malinowski, Wojciech Franus

The increasing demand for sustainable bitumen modifiers has stimulated interest in bio-based materials capable of improving binder performance while reducing environmental impact. This study investigates the influence of corn starch on the thermo-oxidative aging kinetics of paving-grade bitumen. Unmodified 50/70 bitumen and binders containing 4, 6 and 8 wt.% corn starch were subjected to laboratory aging at 100 °C and 140 °C for up to 120 h. The aging process was evaluated using dynamic viscosity measurements, FTIR …

04.08.2026journal-article

The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences

A technology-blended exercise intervention for cognitive risk reduction and brain health in middle-aged and older adults with type 2 diabetes in Singapore: a mixed-methods study

Jinghua Zhang, Wilson Wai San Tam, Jinhua Lu, Junjie Chen, Jed Montayre, Joji Kusuyama, Yanhong Dong, Xin Yi Yap, Wentao Zhou, Na Wang, Hui Nan Yeo, Frena Jia Sy Lee, Vivien Xi Wu

Abstract Background Type 2 diabetes mellitus (T2DM) is a major modifiable risk factor for accelerated brain ageing, cognitive decline, and dementia. However, sustainable lifestyle interventions targeting cognitive health in at-risk older adult populations remain limited. This mixed-methods study evaluated the effects of a 12-week technology-blended Intensive Aerobic and Resistance Exercise Program (IAREP) on cognitive risk and related health outcomes among middle-aged and older adults with T2DM in a primary care se …

04.08.2026journal-article

Frontiers in Aging Neuroscience

Abdominal CT-derived metabolic phenotypes are associated with the MRI-derived brain age gap in women

Chongwon Pae, Minchul Kim, Inpyeong Hwang, Joon Ho Moon, Kyu Sung Choi

Background Metabolic dysfunction is increasingly recognized as a systemic contributor to adverse brain aging; however, conventional clinical markers may not fully capture tissue-level variations in liver attenuation, abdominal adiposity, and muscle quality. We examined whether abdominal CT-derived metabolic phenotypes were associated with MRI-derived brain age gap (BAG) in women. Methods This retrospective health-screening cohort included 1,280 women who underwent both abdominal CT and brain MRI between 2019 and 20 …

04.08.2026journal-article

Journal of Advanced Nursing

Nurse‐Led Multicomponent Interventions for Delirium Prevention in Hospitalised Older Adults: A Systematic Review and Meta‐Analysis

Mostafa Shaban, Huda Hamdy Mohammed, Yasmine M. Osman, Marwa Mamdouh Shaban

ABSTRACT Aims To quantify the effect of nurse‐led or nurse‐coordinated multicomponent non‐pharmacological interventions on delirium incidence in hospitalised older adults and to examine secondary outcomes, intervention components and moderators of effect. Design Systematic review and meta‐analysis. Data Sources Nine electronic databases (PubMed/MEDLINE, EMBASE, CINAHL, CENTRAL, Web of Science, Scopus, PsycINFO, LILACS and ICTRP) were searched from January 1999 to March 2026. Review Methods Randomised controlled tri …

04.08.2026journal-article

Endocrinology, Diabetes & Metabolism

Effects of Oral Semaglutide on Dietary Intake and Body Composition in Japanese People With Type 2 Diabetes: A Prospective Observational Study in Clinical Practice

Mika Sawada, Naoko Nakanishi, Masakazu Aihara, Kanako Ohkuma, Shoko Hamano, Yoshitaka Sakurai, Rie Sekine, Satoshi Usami, Toshimasa Yamauchi, Naoto Kubota

ABSTRACT Introduction Glucagon‐like peptide‐1 receptor agonists are effective glucose‐lowering agents with established benefits on body weight and cardiometabolic outcomes. However, their precise effects on body composition and dietary intake patterns, including food group consumption and macronutrient energy distribution, particularly in clinical settings, remain incompletely understood. Methods In this prospective observational study, we enrolled Japanese adults with Type 2 diabetes who were newly initiated on or …

04.08.2026journal-article

British Journal of Learning Disabilities

Editorial: People With Intellectual Disabilities Working or Studying in Higher Education Institutions

Donatella Camedda, Sadbh Feehan, Nicola Maxwell, Anne‐Marie Martin, Wolfgang Plaute, Sabine Harter‐Reiter

Summary This paper is about 20 studies on people with intellectual disabilities in universities in different countries. It shows more people are getting the chance to study and work, but many people are still left out. It explains how universities try to include people, but there are still problems like money, rules, and support. Some of the research is written with people with intellectual disabilities, so their real voices and experiences are heard. This research matters because it shows people with intellectual …

04.08.2026journal-article

African Journal of Primary Health Care & Family Medicine

Sociocultural beliefs and palliative care needs among older adults in low- and middle-income countries: A narrative review

Hussaini M. Yusuf, Felix Archibong, Monica N. Adekoya, Ekanem A. Edet, Abdulgafar L. Olawumi, Attahiru Muhammad, Muhammad H. Dauda

Palliative care is an integral component of comprehensive primary health care and is particularly relevant for older adults living with chronic and progressive illnesses. In low- and middle-income countries (LMICs), including many African settings, access to palliative care remains limited despite substantial need. Sociocultural beliefs shape perceptions of ageing, illness, suffering and death, and influence how palliative care needs are recognised and addressed within primary care and family medicine contexts. To …

04.08.2026journal-article

Proceedings of the National Academy of Sciences

Early-life sugar restriction causally reduces adult cancer incidence and slows biological aging

Chen Zhu, Weilong Zhang

Excess sugar consumption is implicated in multiple cancers through insulin resistance, chronic inflammation, and metabolic reprogramming, yet whether early-life sugar exposure causally shapes long-term cancer risk remains an open question. We exploit the abrupt end of United Kingdom sugar rationing in September 1953 as a natural experiment, analyzing 64,761 UK Biobank participants born 1951–1956. Cohorts whose first 1,000 d of life fell under rationing exhibit dose-dependent reductions in adult cancer incidence: li …

04.08.2026journal-article

ACS Energy Letters

Distinct Microstructural Evolution of Li- and Mn-Rich Oxide Cathodes during Calendar and Cycle Aging of Lithium-Ion Batteries

Peng Zuo, Pavan Badami, Daniel P. Abraham, Chongmin Wang

Abstract The respective microstructural impacts of calendar and cycle aging of Li-ion battery cathodes remain difficult to distinguish because both processes often occur simultaneously. Here, we isolate the microstructural evolution of these aging modes on a Li- and Mn-rich (LMR) layered oxide cathode using aberration-corrected scanning transmission electron microscopy (STEM), energy-dispersive X-ray spectroscopy (STEM-EDS), and electron energy-loss spectroscopy (STEM-EELS). Both aging modes induce similar near-sur …

04.08.2026journal-article

Nutrients

A Weighted Multidomain Score for Prioritizing Nutritional Review in Institutionalized Older Adults: Development and Internal Assessment

Elena Moreno-Guillamont, Carmen I. Sáez-Lleó, Maria Auxiliadora Dea-Ayuela, Jose M. Soriano

Background/Objectives: Institutionalized older adults often present overlapping functional, cognitive, nutritional, intake-related, anthropometric, and biochemical abnormalities. We developed a prespecified weighted multidomain nutritional priority score (VIVA-NIPI) to organize the urgency of comprehensive nutritional review and assessed its internal construct concordance and ranking stability. Methods: Routine-care data from 124 residents in 10 long-term care facilities in Valencia, Spain, collected from June 2022 …

04.08.2026journal-article

Health & Justice

‘Even if you are guilty, you’re still a human being’: the impact of stigma on dignity and quality of healthcare from the perspective of people detained in police custody in England

Michelle Addison, Stephanie Mulrine, Iain McKinnon, Gethin Rees

Abstract Background The aim of this paper is to explore harms to health and dignity generated through stigma from the perspective of people detained in police custody, a neglected population in healthcare research. We adopt an original theoretical approach, bringing together a human rights lens to health, stigma, and the Inverse Care Law (ICL) to show how stigma contributes to the degradation of dignity and poor experiences of quality care within custody. Methods The study utilises qualitative semi-structured inter …

04.08.2026journal-article

International Journal of STD & AIDS

Joint British association for sexual health and HIV/British HIV association guidelines for the sexual and reproductive health of people with HIV 2026

Laura Waters, Emily Lord, Nicola Mackie, Jane Ashby, Chitra Babu, Tristan J. Barber, Rageshri Dhairyawan, Adam Freedman, Jessica Gaddie, Yvonne Gilleece, Carole Gilling-Smith, Sharon Jay, Deirdre Lyons, Margaret Kingston, Pank Sethi, Alison Wright, Tara Suchak, Shema Tariq, Michael Yates

These guidelines are an update to the 2008 UK guidelines for the management of sexual and reproductive health of people living with HIV. The writing group has followed updated British Association for Sexual Health and HIV (BASHH) guideline methodology, notably using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system for assessing evidence and making recommendations. We have made significant changes to the recommendations which are summarised below.

04.08.2026journal-article

Microbiology Spectrum

Diagnostic accuracy and inter-lot precision of the FujiLAM II point-of-care assay to detect tuberculosis in stored urine specimens from people living with HIV

Nestor Biatu, Cyrille Mbuli, Comfort Vuchas, Rita Nsamenang, Nadege Bonkar Chifu, Asonganyi Etiendem, Diana Kolieghu Tcheumeni, Angela Neh, Ngha Ndze Mbuh, Nadia Kontogianni, Rachel Owen, Ndi Norah Nyah, Luan Nguyen Quang Vo, Andrew Codlin, Jacob Creswell, Melissa Sander, Ana Isabel Cubas Atienzar

ABSTRACT The Fujifilm SILVAMP TB LAM II (FujiLAM II) assay is a lateral flow assay that detects TB from urine specimens. This updated version of the assay has been redesigned to address inter-lot variability issues of the original FujiLAM assay. We evaluated the diagnostic accuracy and inter-lot variability of the FujiLAM II assay on biobanked urine specimens collected from inpatients and outpatients living with HIV in two prospective studies conducted at hospitals in Cameroon. Diagnostic performance was evaluated …

1 Zitationen
04.08.2026journal-article

JMIR Research Protocols

Co-Designing a Care Coordination Intervention for People With Motor Neuron Disease: Protocol for a Mixed Methods Study

Bryony Waters-Harvey, Kathleen Kane, Alys Wyn Griffiths, Grahame Smith, Clare M Bartlett, Lise Sproson, Sandra Smith, Jennie Starkey, Amy Clift, Theocharis Stavroulakis, Esther Hobson, Emily Mayberry, Alicia O'Cathain, Caroline Bidder, Katherine Kennedy, Jane Gibson, Christopher McDermott, Liam Knox

Abstract Background Motor neuron disease (MND), also known as amyotrophic lateral sclerosis (ALS), is a rapidly progressive neurological condition that requires complex multidisciplinary care. Within the United Kingdom, specialist centers provide expert interventions, while day-to-day support often relies on local nonspecialist community health and social care professionals. This is due to the distance between people’s homes and specialist centers, as well as the availability of specialist health and social care pr …

04.08.2026journal-article

Frontiers in Public Health

A network analysis of physical resilience and social alienation among older adults with ischemic stroke

Xiaoyan Sheng, Wenying Wang

Objective To investigate the current status of physical resilience (PR) and social alienation among older adults with ischemic stroke, construct a joint network model, identify core nodes and bridge nodes, and provide evidence for precise intervention. Methods A convenience sampling method was used to recruit 210 older adults with ischemic stroke from Nantong Sixth People’s Hospital and Nanjing Gaochun People’s Hospital between January 2025 and April 2026. Participants were surveyed using a general information ques …

04.08.2026journal-article

Proceedings of the Nutrition Society

The Protein Transition in Older Adults

Rikke Sand Andersen, Anique Julien, Laura E Marchese, Liana Pace, Hesti Retno Budi Arini, Bill Tiger Lam, Tracey Van Grunsven, Emma Lundin, Djin Gie Liem, Michael Tieland

Abstract The global population is ageing, accompanied by an increasing prevalence of age-related conditions, including cardiometabolic disease and sarcopenia. Adequate dietary protein intake is essential for healthy ageing, with more than 65% of protein intake in western countries derived from animal-based sources. At the same time, growing concerns regarding environmental sustainability, together with recognised cardiometabolic health benefits of plant-based dietary patterns, are driving a transition towards predo …

04.08.2026journal-article

Geriatrics

Association Between Cachexia Defined by the Asian Working Group for Cachexia Criteria and One-Year Post-Discharge Mortality in Older Adults with Acute Decompensated Heart Failure

Daisuke Suzuki, Toshimi Sato, Yuichiro Sasamoto, Shun Monoe, Keita Kaneko, Shinichiro Morishita

Background: Cachexia is a well-known clinically important condition in older adults with heart failure, but evidence regarding cachexia defined by the Asian Working Group for Cachexia (AWGC) criteria in those with acute decompensated heart failure (ADHF) remains limited. Methods: This prospective observational study included 78 patients aged 65 years or older who were hospitalized for ADHF. Cachexia on admission was diagnosed using the AWGC criteria. The primary outcome was all-cause mortality within one year after …

04.08.2026journal-article

Frontiers in Public Health

Chronic life stressors and pain incidence in adults 50 and older: a longitudinal analysis with implications for pain prevention and public health promotion

Antoinette L. Spector, Dina Flores, David Aaby, Patricia Coe

Background Chronic pain represents a pressing public health problem affecting more than one in five American adults. Yet, primary prevention efforts aimed at stopping pain before it begins remain substantially underutilized. Chronic life stressors (CLS)—including financial strain, personal health problems, and caregiving burdens—are upstream, modifiable psychosocial risk factors that may drive pain incidence in aging populations. Identifying and addressing these stressors at the population level offers a promising, …

04.08.2026journal-article

HAND

Relationship Between Bone Density and Loss of Reduction in Distal Radius Fractures Treated With Volar Locking Plate in Patients Older Than 65 Years

Mariano Oscar Abrego, Fernando Holc, Pedro Bronenberg Victorica, Ignacio Rellan, Agustin Guillermo Donndorff, Gerardo Luis Gallucci, Pablo De Carli, Jorge Guillermo Boretto

Background: Distal radius fractures (DRFs) are common fragility fractures and may be indicators of osteoporosis. The management of these fractures in older people is controversial, with osteoporosis identified as a potential cause of DRF instability. A correlation has been observed between the second metacarpal cortical percentage (2MCP) and bone density, which is essential for understanding postoperative reduction loss. This study aimed to evaluate the relationship between osteoporosis, measured by 2MCP, and loss …

04.08.2026journal-article

Nephrology Dialysis Transplantation

CKD-guideline adherence in primary and nephrology care for older patients with advanced CKD

Micha Jongejan, Janet M Kist, JHMarc Groeneveld, Mirjam M Timmerman, Mattijs E Numans, Willem Jan W Bos, Marjolijn van Buren

Abstract Background Older patients with chronic kidney disease (CKD) often experience relatively slow kidney function decline, suggesting that, despite meeting referral criteria, primary care management may be appropriate. We assessed guideline recommended CKD management in patients with CKD stage 4–5 across primary and nephrology care. Methods Population-based study using routine healthcare data from primary care and hospitals, including patients ≥ 65 years with incident or prevalent eGFR <30 ml/min/1.73m2 betw …

04.08.2026journal-article

The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences

Satellite-based evidence for heatwave-driven MCI-to-dementia transitions

Sun-Bi Um

Abstract This study aimed to provide satellite-based evidence on the potential role of heatwave exposure in the transition from mild cognitive impairment (MCI) to dementia by examining whether heatwave exposure statistically modifies the association between MCI and dementia prevalence using repeated district-level observations collected annually from 228 administrative districts across South Korea between 2015 and 2023. Satellite-derived land surface temperature from the Moderate Resolution Imaging Spectroradiomete …