Frag' FlorenceEvidenz. Klar. Anwendbar.
Uhr 7/8Sources Journal Tree
Easy Demo

Florence Themenbrowser · Medizin · Seite 114

Was ist neu im Gesundheitswesen?

Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

Themen erkunden

Aktuelle Forschung nach Fachgebiet

24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
29.08.2026journal-article

Journal of the Pediatric Infectious Diseases Society

Time to Antibiotics and Clinical Outcomes in Pediatric Cancer Patients with Fever: Evaluating the "Golden Hour" Concept

Medalit Luna Vilchez, Grisell Leonor Portilla Uribe, Mitsi Lorraine Santiago Abal, Victoria Angélica Godoy Vila, Alicia Janeth Mafaldo Rengifo, Gloria Francia Oscanoa

Abstract Background In low- andmiddle-income countries, infections remain the leading cause of treatment-related mortality in pediatric patients with cancer. The "Golden Hour" concept advocates antibiotic administration within 60 minutes of emergency department (ED) triage to reduce sepsis and ICU admission. We evaluated whether time to antibiotic administration (TTA) >60 min versus ≤60 min impacts adverse clinical outcomes in children with cancer and fever. Methods We conducted a prospective longitudinal at the …

29.08.2026journal-article

European Spine Journal

Trends and postoperative complications of spinal metastasis surgery in Thailand between 2015 and 2024: a nationwide retrospective cohort study

Sarunya Poolpol, Borriwat Santipas, Korawish Mekariya, Sirichai Wilartratsami, Panya Luksanapruksa

Abstract Study design Nationwide retrospective cohort study. Objective To evaluate 10-year national trends, postoperative complications of spinal metastasis surgery in Thailand. Methods Individual-level data were obtained from five national healthcare databases covering the Thai population, with spinal metastasis patients identified using ICD-10 TM (C79.5, C79.8) and ICD-9 CM codes (03.0, 03.09, 03.4, 81.00–81.08). The index surgical utilization rate was calculated by selecting only first-time surgeries, whereas th …

29.08.2026journal-article

Scientific Reports

Analysis of sex and BMI influence on power delivery in high-power RF ablation for atrial fibrillation using virtual patient simulations

Minha Anees, Zoraida Moreno Weidmann, David Viladés Medel, Aurel Neic, Edward J. Vigmond, Jose M. Guerra, Luca Gerardo-Giorda, Argyrios Petras

Abstract Radiofrequency Ablation (RFA) is an effective treatment for atrial fibrillation (AF), in which thermal energy is delivered to eliminate abnormal cardiac tissue and restore normal electrical conduction. The aim of this study is to assess the extent to which procedural variability is influenced by patient-specific anatomical characteristics, with particular emphasis on Body Mass Index (BMI) and sex-based differences. To address this, we developed patient-specific in-silico models to simulate the ablation pro …

29.08.2026journal-article

European Journal of Nuclear Medicine and Molecular Imaging

Variational autoencoders can detect coronary artery disease in myocardial perfusion SPECT images

Koichi Okuda, Kenichi Nakajima, Takeshi Hara, Hiroto Yoneyama, Seigo Kinuya

Abstract Purpose Variational autoencoders (VAEs) can detect unsupervised anomalies in medical images. We aimed to determine whether a VAE could automatically detect anomalies in myocardial perfusion SPECT (MPS) images. We then interpreted the training and generative processes of the VAE. Methods We trained a VAE on polar maps to learn the variability of normal myocardial perfusion profiles in latent space. The training dataset comprised 3,432 polar map images (49% male) without coronary artery disease (CAD) and the …

29.08.2026journal-article

International Journal of Medical Science and Pharmaceutical Research

Benefits of Using Hydroxychloroquine/Chloroquine in the Treatment of Immunomediated Rheumatic Diseases

Jozelio Freire de Carvalho, Mariana Fernandes Carneiro

Antimalarial drugs, particularly hydroxychloroquine (HCQ) and chloroquine (CQ), have been used for decades as cornerstone therapies in the management of immune‑mediated rheumatic diseases (IMRDs). Beyond their classical role in disease activity control, these agents exert pleiotropic effects encompassing immunomodulation, anti‑inflammatory signaling, antithrombotic activity, and metabolic and cardiovascular protection. Robust clinical evidence supports their ability to reduce disease flares, limit cumulative organ …

29.08.2026journal-article

Journal of Clinical Medicine

Gut Dysbiosis in Selected Gynecological Diseases Associated with Female Infertility: A Scoping Review

Łukasz Nowakowski, Katarzyna Warchoł, Agnieszka Kuźniar, Barbara Zimoń, Michał M. Skoczylas, Paweł Marzec, Grzegorz Krawczyk, Dorota Jegorow, Robert Pankiewicz, Andrew Z. Warchoł, Maciej Banach, Kinga Kuranty, Piotr Olcha

Background/Objectives: Female infertility represents a significant public health issue. Available evidence supports the hypothesis that the gut microbiota may play an essential role in women’s reproductive health and may serve as a diagnostic or prognostic biomarker in specific gynecological disorders. A substantial part of current research concerns disturbed communication between the hypothalamic–pituitary–ovarian axis and the gut microbiota, providing the basis for analyzing this phenomenon as the gut–ovary axis …

29.08.2026journal-article

Journal of Mechanics in Medicine and Biology

EARLY GAIT REHABILITATION WITH A TORQUE-ASSISTING HIP-WEARABLE ROBOT IN PARKINSON’S DISEASE AFTER ACUTE URINARY TRACT INFECTION–RELATED FUNCTIONAL DETERIORATION: A CASE REPORT

IN YOUNG CHOI, SEUNG ICK CHOI, HUI WOO YANG, NA YOUNG KIM

Evidence on effective gait rehabilitation strategies for patients with Parkinson’s disease (PD) who experience acute functional deterioration due to medical complications remains limited. We report a case of torque-assisting hip wearable robot training in a patient with PD during acute post-infectious gait deterioration. An 80-year-old woman with PD was admitted with acute gait deterioration following urosepsis. Upon admission, she was unable to stand or ambulate. In the levodopa ON state, her Berg Balance Scale (B …

29.08.2026journal-article

Nature Medicine

Dual antithrombotic therapy using potent antiplatelet inhibitors in atrial fibrillation and acute coronary syndrome: a randomized controlled trial

Konstantinos D. Rizas, Konstantinos Mourouzis, Dominik Rath, Christoph B. Olivier, Laura Elisa Villegas Sierra, Theofanis Korovesis, Amin Polzin, Amani Al Tawil, Reza Wakili, Lukas von Stuelpnagel, Katharina Mayer, Marion Janisch, Tanja Ulrich, Sarah Lang, Sebastian K. G. Maier, Florian Brattinger, Lorenz Bott-Flügel, Harilaos Bogossian, Konstantinos Iliodromitis, Luisa Freyer, Julius Steffen, Konstantin Stark, Elodie Eiffener, Lauren E. Sams, Tobias Petzold, Axel Linke, Felix M. Heidrich, Samuel Sossala, Saif Zako, Nikolaos Dagkonakis, Andreas Schäfer, Frank Edelmann, David M. Leistner, Mariya Maslarska, Fabian Knebel, Georg Nickenig, Blerim Luani, Tienush Rassaf, Hüseyin Ince, Ibrahim Akin

Abstract The selection of the optimal antithrombotic regimen in patients with atrial fibrillation and acute coronary syndrome remains challenging. Previous trials have demonstrated that dual antithrombotic therapy (DAT), consisting of direct oral anticoagulants (DOACs) plus a P2Y12 inhibitor, reduces bleeding compared to a triple-therapy regimen using vitamin K antagonists. However, subsequent meta-analyses have suggested an increased risk of ischemic events with DAT, particularly within the first month of treatmen …

29.08.2026journal-article

Familial Cancer

The evolution of hereditary cancer genetic counselling: mainstreaming, service redesign and patient experience in Lynch syndrome

Kelly Kohut, Sarah Cable, Alekhya Ashokan, Stefania Vicari, Hannah Ditchfield, Julie Young, Ben Bux, Fiona Lalloo

Abstract Genetic counselling for hereditary cancer predisposition has evolved substantially over more than three decades, driven by advances in genomic technologies and the growing use of tumour and germline testing. These developments have expanded access to hereditary cancer testing, treatment and prevention, while also introducing new clinical, psychosocial and system-level challenges. This review examines the transition from traditional specialist-led genetic counselling to mainstreamed testing pathways. Using …

29.08.2026journal-article

International Journal of Research in Medical Sciences

Bilateral undescended testes with intraabdominal non seminomatous germ cell tumor – a rare clinical challenge

Kalyani D. Aher, Minakshi Gadahire

Cryptorchidism is the most common congenital anomaly of the male genitalia, with nearly 72-77% of undescended testes located in the inguinal canal. Among malignancies arising in undescended testes, seminoma is the most frequent type, accounting for approximately 50-60% of cases. Tumors arising from intra-abdominal testes may grow to considerable sizes before detection, and delayed diagnosis often results in advanced-stage disease at presentation. We report a case of bilateral cryptorchidism in a young male who pres …

29.08.2026journal-article

Discover Medicine

Navigating the sedation challenge in frail older patients undergoing endoscopic retrograde cholangiopancreatography: a narrative review

Koji Takahashi, Nana Yamada, Terunao Iwanaga, Takafumi Sakuma, Hidehiro Kamezaki

Abstract The global increase in life expectancy has resulted in a higher volume of endoscopic retrograde cholangiopancreatography (ERCP) procedures among frail older patients. Frailty, a multidimensional syndrome characterized by decreased physiological reserve, presents significant risks for sedation-related adverse events. Current sedation practices frequently rely on data derived from younger cohorts, often failing to account for the distinct pharmacokinetic and pharmacodynamic profiles associated with frailty. …

29.08.2026journal-article

Journal of Gastrointestinal and Abdominal Radiology

Radiologic Insights into Autoimmune Cholangiopathy: Diagnosis and Differentials

Seyed Mohammad Hossein Tabatabaei, Laksika Bhuthathorn, Mark A. Anderson, Avinash Kambadakone

Abstract To review the imaging manifestations of autoimmune cholangiopathies, highlight key differential diagnostic considerations and disease-specific complications, summarize current surveillance strategies, and discuss recent advances in quantitative imaging. This review discusses the clinical and imaging features of primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC), IgG4-related sclerosing cholangitis (IgG4-SC), and overlap syndrome, with emphasis on imaging-based differentiation, associat …

29.08.2026journal-article

Issues in Law & Medicine

Risk factors predictive of post-abortion distress demonstrate that most abortions are contraindicated: A retrospective cross-sectional study

David Reardon, Martha Shuping, Patricia Giebink

Introduction: The subgroup of women at highest risk of post-abortion distress can be identified using known risk factors. At highest risk are women who feel pressured to undergo unwanted abortions. But abortion providers seldom screen for these, which violates ethical principles of informed consent and of justice. This study examines the effectiveness of an 8-item scale for risk assessment. Materials and methods: Topic blind surveys were distributed to a random sample of 41- to 45-year-old women. Reproductive histo …

29.08.2026journal-article

The Turkish Journal of Pediatrics

The face of pediatric and adult brain abscesses, differences and clinical characteristics: a single center 10-year experience

Tamer Çelik, Merve Kılıç Çil, Ümit Çelik, Mehmet Can, Ali İhsan Ökten

Background. Brain abscesses (BA) are a medical emergency in all age groups and require early diagnosis and treatment. Childhood BA constitute 25% of all abscesses and may have a different clinical course than adults. This article aims to investigate patients followed up for adult and child BA over a 10-year period. Materials and Methods. A retrospective analysis was performed on adult and pediatric patients diagnosed with BA. Demographic, clinical, predisposing factors, imaging, treatment modalities, and prognosis …

29.08.2026journal-article

Biomedicines

Liposomal Delivery of Hepatoprotective Phytochemicals for Liver Diseases: Advances in Formulation, Targeted Delivery, and Clinical Translation

Dignesh Khunt, Jigna Khasiya, Sanjay Chauhan, Bhupendra G. Prajapati, Udaykumar Vegad, Sagar Salave

Background/Objectives: Chronic liver diseases (CLDs), including viral hepatitis, alcohol-related liver disease, non-alcoholic fatty liver disease, hepatic fibrosis, and hepatocellular carcinoma, account for approximately two million deaths annually and remain a global health challenge. Although phytochemicals exhibit antioxidant, anti-inflammatory, antifibrotic, and metabolic regulatory activities through modulation of Nrf2/Keap1, NF-κB/MAPK, TGF-β/Smad, and lipid metabolism pathways, their therapeutic translation …

29.08.2026journal-article

Asian Journal of Medicine and Health

Artificial Intelligence in the Analysis of the Fetal Genome in Utero: A Critical Review of Current Paradigms, Clinical Utility and Future Horizons

S. Bittmann, E. Luchter, E. Moschüring-Alieva

Prenatal genomic medicine now generates data at a scale that exceeds what unaided human interpretation can process within the time available to a continuing pregnancy. Cell-free DNA screening, chromosomal microarray, exome sequencing and, increasingly, genome sequencing produce millions of candidate observations per case, and computational methods described as artificial intelligence have been proposed at almost every step of the resulting pipeline. This critical narrative review evaluates the strength, consistency …

29.08.2026journal-article

Current Anesthesiology Reports

The Impact of Intrathecal Hydrophilic Opioids on Postoperative Pain, Opioid Consumption and Adverse Events for Abdominal Surgery: A Systematic Review and Meta-analysis

Katrina Pirie, Andrea Yap, Maria A. Lopez-Olivo, Bernhard Riedel, Paul S. Myles

Abstract Purpose of Review Intrathecal morphine (ITM) is a promising analgesic option for major abdominal surgery, but its clinical efficacy, potential adverse events and optimal dosing require further investigation. Methods We searched MEDLINE, Embase, and Cochrane Central Register of Controlled Trials (CENTRAL) for data from 1990 until July 2024 to identify studies comparing a preoperative intrathecal dose of hydrophilic opioid to alternative analgesia in adult patients undergoing abdominal surgery under general …

29.08.2026journal-article

Journal of the Pediatric Infectious Diseases Society

Association Between Antimicrobial Resistance and the Clinical Evolution of Patients with Infections in the Pediatric Intensive Care Unit of the National Institute of Pediatrics

Scott Macías, Alejandra Aquino, Agustín R de Colsa, Jocelin Merida, Virginia Diaz, Damaris Manzano, Isabel Medina

Abstract Background Sepsis is the most common cause of the over two million annual deaths from worldwide infections. The World Health Organization is focused on optimizing early diagnosis, treatment, and prevention. The rise of multidrug-resistant (MDR) bacteria limits conventional antibiotics. Healthcare-associated infections (HAIs) are frequent in pediatric and neonatal intensive care units, leading to higher mortality and costs. Essential strategies include strengthening surveillance, infection control, and deve …

29.08.2026journal-article

Journal of the Pediatric Infectious Diseases Society

Optimizing Empirical Antibiotic Therapy in Febrile Pediatric Oncology Patients through a Clinical Decision Pathway

Yamileth Arellano, Martha Avilés Robles, Fernando Ríosvelasco

Abstract Background Timely management of a child with cancer and fever (CCF) requires accurate evaluation and appropriate antibiotic selection to prevent infectious complications. Clinical decision tools, such as Clinical Decision Pathways (CDPs), are increasingly adopted in healthcare systems for their ability to standardize and optimize clinical practice. The aim of this study was to assess the effectiveness and utility of an adapted CDP for initial antibiotic selection in children with cancer and fever. Methods …

29.08.2026journal-article

Archiv Euromedica

GLP-1-BASED THERAPIES BEYOND DIABETES: EMERGING CLINICAL APPLICATIONS AND FUTURE PERSPECTIVES

Anna Szeszko, Małgorzata Lubowiecka, Weronika Czernek, Magdalena Cichorzewska, Martyna Płachta, Rafał Wojtan

Background Glucagon-like peptide-1 (GLP-1)-based therapies were initially developed for the treatment of type 2 diabetes mellitus, but their clinical use has expanded substantially because of their effects on body weight and obesity-related complications. GLP-1 receptor agonists, dual and triple receptor agonists, and GLP-1-containing combination therapies are now being evaluated across cardiovascular, hepatic, kidney, respiratory and musculoskeletal diseases, as well as other conditions with metabolic, neuroendocr …

29.08.2026journal-article

BMC Gastroenterology

Predictive value of epithelial lesion heterogeneity in the etiological diagnosis of chronic inflammatory bowel disease

H. Abdoulaye Biyou, M. Zaryouhi, I. Fadlallah, H. Bourkhime, Sanae Moqran, S. El-Yaagoubi, M. El-youssfi, L. Tahiri Elousrouti, N. Hammas, Laila Chbani

Abstract Introduction Chronic inflammatory bowel diseases (IBD) are characterized by chronic, intermittent, and continuous inflammation of a part of the digestive tract, with an increased risk of dysplasia and colorectal cancer (CRC). They typically include Crohn’s disease (CD) and ulcerative colitis (UC). The diagnosis of IBD is multidisciplinary. Multiple systematic mucosal biopsies (at least two per colonic segment plus ileal sampling) are essential for establishing a diagnosis, monitoring treatment, and/or iden …

29.08.2026journal-article

Obesity Surgery

Baseline Mental Health Status and Early Psychiatric Outcomes after Metabolic-Bariatric Surgery: A Retrospective Cohort Study

Patricia M. Ortega, Luke Boyle, Dana Mahdi, Zahra Al-Essah, Ali Abdul Hussein, Mina Abdul Hussein, Aslesha Deshraju, Elena Brachimi, Prasidha Rai, Elsie Ampomah, Neha Hussain, Faizan Kiani, Mary Obigbesan, Lucy Tweedlie, Samantha Scholtz, Sanjay Purkayastha, Christos Tsironis, Sherif Hakky, Ravi Aggarwal, Ahmed R. Ahmed, Tricia Tan, Julia Kenkre, Kleopatra Alexiadou, Saira Hameed, Harvinder Chahal, Jonathan Cousins, Chioma Izzi-Engbeaya

Abstract Objective To evaluate whether documented preoperative mental health (MH) conditions were associated with early postoperative psychiatric events and metabolic outcomes after primary metabolic-bariatric surgery (MBS). Methods A retrospective cohort study of adults who underwent primary MBS at a tertiary UK bariatric centre between April 2021 and March 2024 was conducted. Preoperative MH conditions and postoperative outcomes were identified via review of electronic health records. Comparisons between groups w …

29.08.2026journal-article

Medical Decision Making

Best–Worst Scaling as a Values Clarification Method within a Decision Aid for Kidney Treatment Decision Making

Semra Ozdemir, Juan Marcos Gonzalez, Eric Andrew Finkelstein

Background: Best–worst scaling (BWS) has been increasingly used as a values clarification method to help patients make value-concordant decisions. However, evidence on its use remains limited. Objective: To examine 1) the association between BWS-derived treatment preference scores and patients’ stated and real-world treatment choices and 2) whether BWS-identified best-match treatments were concordant with treatment choices among older adults with end-stage kidney disease (ESKD). Methods: We conducted a prospective …

29.08.2026journal-article

PKLI Journal of Health Sciences

Collaborating for Excellence, Strengthening Clinical Trials in Pakistan - Editorial Commentary

Sadia Hassan, Saeed Hamid, Zeba Aziz, Arishay Hussaini, Javed Akram, Irfan Ahmed

Pakistan, the world’s fifth most populous country, has immense clinical research potential given its diverse population and high disease burden, particularly in endocrinology, neurology and cardiology. Progress, however, is constrained by inconsistent ethical review, weak infrastructure, and limited resources. Strengthening clinical trials requires training, strong governance, incentives for faculty, industry partnerships, and patient and public involvement. In July 2025, Pakistan Kidney and Liver Institute and Res …