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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
30.08.2026journal-article

International Journal of Medical Science and Dental Health

Comorbidity Patterns Associated with Renal Dysfunction Across COPD Severity Stages and Clinical Phenotypes

Abdigaffar G. Gadaev, Muborak S. Salaeva, Dinora A. Parpibaeva, Nargiza D. Salimova, Fazilat R. Ismoilova, Abdisalim K. Kulkarayev

Background: Chronic obstructive pulmonary disease (COPD) is frequently accompanied by cardiovascular, metabolic, haematological and urinary system comorbidities. The presence of renal dysfunction may further modify the clinical profile and prognostic significance of these comorbid conditions. Objective: To comparatively evaluate comorbidities associated with renal dysfunction in patients with COPD across different disease severity stages and clinical phenotypes. Methods: A total of 609 patients with COPD were inclu …

30.08.2026journal-article

Journal of Clinical Medicine

Restoration of Radial Bowing After Elastic Stable Intramedullary Nailing in Pediatric Forearm Fractures: The Importance of Bowing Location in Addition to Magnitude

Osman Görkem Muratoğlu, Hasan Ceylan, Gökhan Güzel, Fatih Günaydın, Fevzi Mehmet Kuyumcu, Mehmet Ali Talmaç, Cem Yıldırım

Background/Objectives: Elastic stable intramedullary nailing (ESIN) is widely used for the treatment of pediatric diaphyseal forearm fractures. Although fracture union is commonly achieved, restoration of physiological radial bowing is essential for optimal forearm biomechanics. Most previous studies have focused on bowing magnitude, whereas the anatomical location of maximal radial bowing has received limited attention. Methods: This retrospective observational study included pediatric patients aged 4–16 years who …

30.08.2026journal-article

Clinical Cardiology

Comparison of Guideline‐Directed Medical Therapy in Black versus White Patients With Heart Failure With Reduced Ejection Fraction in a Large, Integrated Health Care System

Natalia C. Berry, Yi‐Shin Sheu, Karen Chesbrough, R. Clayton Bishop, Suma Vupputuri

ABSTRACT Background Guideline‐directed medical therapy (GDMT) improves clinical outcomes for patients with heart failure with reduced ejection fraction (HFrEF). While GDMT treatment differences have been described for Black patients, data are limited. Aims We sought to evaluate, among Black and White HFrEF patients, differences in GDMT use and target dosing by race. Materials & Methods We examined health records of Black and White patients with HFrEF between 2015 and 2022. GDMT was defined by four medication classe …

30.08.2026journal-article

Journal of Clinical Medicine

Comparison of the Effects of Sorafenib and Stem Cell Secretome on HepG2 Cancer Cells with Respect to the Ras/Raf/MEK/ERK Pathway

Aleksandra Gładyś, Aleksandra Skubis-Sikora, Bartosz Sikora, Kinga Pogoda-Mieszczak, Patrycja Wieczorek, Edyta Bogunia, Piotr Czekaj

Background/Objective: Liver cancer is a global health challenge due to its resistance to most systemic therapies. Human mesenchymal and epithelial stem cells exhibit anti-proliferative and pro-apoptotic effects on some cancer cell lines, which can be used to support standard therapy. The aim of this study was to investigate the effects of conditioned media (CM) derived from mesenchymal adipose tissue-derived stem cells (hADSCs) and amniotic membrane-derived cells expressing both mesenchymal and epithelial markers ( …

30.08.2026journal-article

Journal of Artificial Intelligence and Information

Construction and Practice of an Industry-Education Integration Curriculum System for Vocational Rehabilitation Therapy Technology Based on the ERAS Concept — Evaluation of Clinical Internship Teaching Effectiveness

Tian Zhu, Xianting Ju, Zidi Guo, Futian Ren, Yumeng Zhao

Accelerated Recovery After Surgery (ERAS) refers to a multidisciplinary collaborative approach centered around the perioperative period. While some hospitals in China have already implemented ERAS, it has not yet been introduced into the teaching or internship programs of higher vocational rehabilitation therapy technology majors. Currently, vocational rehabilitation programs face limited progress in industry-education collaboration, with few jointly developed courses by schools and enterprises, and insufficiently …

30.08.2026journal-article

Clinical Medicine (Russian Journal)

Causes of pulmonary bleeding in cancer patients

Roman S. Kiselev, Evgeniy A. Tarabrin, Z. G. Berikkhanov, S. Yu. Muravev, M. Yu. Ivanova

Objective. To analyze the causes of pulmonary hemorrhage (PH) in cancer patients. Material and methods. During the period 2010–2022, pulmonary hemorrhage was treated in cancer patients. The causes of PH were analyzed based on the nosology of cancer diseases. The involvement of the great circle of circulation (GCC) was determined based on the presence of direct or indirect radiological signs of bronchial angiography, the clinical outcome of endovascular treatment for PH, and the results of autopsy. CT of the chest w …

30.08.2026journal-article

Clinical Medicine (Russian Journal)

Secondary haemophagocytic lymphohistiocytosis in blood malignancies. The multicentre retrospective study

Vsevolod G. Potapenko, Alina S. Antipova3, Julia A. Zhuravleva, Yulia V. Zabutova, Alina Yu. Zavyalova, Irina V. Ishmatova, Elena V. Karyagina, Natalia A. Kotova, Valeria V. Kozyro, Tatiana G. Kulibaba, Daniil A. Manaenkov, Nadezhda V. Medvedeva, Natalia B. Mikhailova, Olga V. Nebelitskaya, Elena S. Pavlyuchenko, Victoria V. Ryabchikova, Irina A. Samorodova, Alexander V. Serkov, Irina A. Skorokhod, Kseniya A. Skoryukova, Tatiana V. Fedorenko, Darya A. Chaginskaya, Vasily A. Shuvaev, Vadim I. Mazurov

Haemophagocytic syndrome (HPS) or haemophagocytic lymphohistiocytosis is a reaction of severe but ineffective inflammation. Blood malignancies (BlM) are among the frequent causes of HPS in adults. Objective. To analyse survival, causing trigger haemoblastosis, relationship with tumor and efficacy of including etoposide in chemotherapy of patients with secondary HPS-BlM. Material and methods. A retrospective analysis of case histories of patients with BlM complicated by SHPS was performed. The diagnosis of SHPS was …

30.08.2026journal-article

ANZ Journal of Surgery

Managing Outliers in Australian Surgical Clinical Quality Registries

Alun Cameron, Konstance Nicolopoulos, R. James Aitken, Helena Kopunic, Wendy Babidge, Guy J. Maddern

ABSTRACT Clinical quality registries (CQRs) are central to improving surgical safety and quality by enabling systematic monitoring of outcomes and proactive identification of outliers. Published guidelines provide important advice on methods and activities for CQRs. Guideline flexibility allows for the varied and unique requirements of each CQR, but some aspects around guideline implementation are less certain, particularly for outlier management. In order to describe activities in Australia and the UK, searches we …

30.08.2026journal-article

Brain and Behavior

Comorbidity Mechanism and Management of Chronic Low Back Pain and Major Depressive Disorder: From Neural Circuit Remodeling to Precision Medicine

Lin Faqu, Lin Chenjuan, Xiang Xiangyin, Li Xin

ABSTRACT Objective This review systematically elaborates multi‐system interactive mechanisms underlying comorbid chronic low back pain (CLBP) and major depressive disorder (MDD), synthesizes recent advances in diagnosis, treatment, and management, and proposes precision medicine directions to address clinical challenges, including missed diagnosis, treatment resistance, and poor prognosis. Method We reviewed 86 studies published between 2015 and 2025 from the PubMed, Embase, and CNKI databases. We focused on basic …

30.08.2026journal-article

Journal of International Medical Research

Clinical features of primary intestinal follicular lymphoma: A single-center retrospective study

Chun-Lin Ying, Tian-Qi Zhao, Qin-Xue Pu, Han-Cheng Huang, Wei Liu

Objective To characterize the clinical features of primary intestinal follicular lymphoma and provide insights into its diagnosis and management. Methods We retrospectively analyzed the clinical, endoscopic, imaging, pathological, and long-term follow-up data of eight patients with primary intestinal follicular lymphoma who were admitted between January 2019 and August 2025. Results The mean patient age was 58.13 years, and 75.00% of patients were women. Abdominal pain (62.50%) was the most common clinical manifest …

30.08.2026journal-article

Journal of the American Heart Association

Sex Differences in Treatment Effect of Adjunctive Intra‐Arterial Urokinase After Successful Thrombectomy: A Post Hoc Secondary Analysis of the POST‐UK Randomized Clinical Trial

Xuanyu Chen, Linyu Li, Gaoming Li, Lingyu Zhang, Haoxuan Zhu, Xu Xu, Jinfu Ma, Lilan Wang, Zhixi Wang, Jiayu Li, Qiuyi Yang, Yian Chen, Mingyang Chen, Yihui Yang, Yuhan Fan, Kaiyuan Feng, Chunye Chen, Jiaxing Song, Wenjie Zi, Kunxin Lin

Background Whether adjunct intra‐arterial urokinase has differential effectiveness and safety by sex among patients with acute ischemic stroke who achieve near‐complete to complete reperfusion after endovascular thrombectomy (EVT) remains unknown. Methods This post hoc analysis of the POST‐UK (Adjunctive Intra‐Arterial Urokinase After Successful Endovascular Thrombectomy in Patients With Large‐Vessel Occlusion Stroke) multicenter randomized clinical trial included 534 patients with proximal intracranial large‐vesse …

30.08.2026journal-article

European Journal of Medical Research

Intelligent diagnosis of vocal cord lesions via multimodal deep learning: integrating laryngoscopy, voice, and biomarkers

Xue Zhao, Shuang Li, Linlin Zheng, Tuanjie Wang, Haixian Guo, Dan Yu

Abstract Background Accurate pre‑operative diagnosis of vocal cord lesions remains challenging. We developed a multimodal deep learning model that integrates laryngoscopic images, voice recordings, and biochemical markers to improve diagnostic accuracy. Methods In this retrospective study (2020–2025), a total of 425 patients were enrolled. Of these, 374 patients treated between January 2020 and May 2025 formed the development cohort (contributing 1,947 aligned multimodal samples), and the remaining 51 consecutive c …

30.08.2026journal-article

Journal of Vascular Societies Great Britain & Ireland

The effect of preoperative natriuretic peptide testing on outcome in vascular surgery: a systematic review and meta-analysis

G Imperatore, N Bradley, L Hanna, J Gudgeon, P Chong

Objective: The aim of this systematic review and meta-analysis was to evaluate the prognostic utility of natriuretic peptide testing for predicting adverse postoperative outcomes in patients undergoing vascular surgery, and to assess their incremental value within established perioperative risk stratification frameworks. Specific endpoints included mortality, myocardial infarction, stroke and prolonged hospitalisation. A secondary objective was to determine whether natriuretic peptide testing offers incremental pro …

30.08.2026journal-article

Libyan Journal of Medical Research

Study on Ginger as a Treatment for Stress and Anxiety Comparing With Diazepam

Ashraf Alzalitini, Naima El-Kakalli, Wafa Issadiq

Background: The psychological anxiety is considered one of the most significant animals of the modern era. The most common causes natural indictors that lead to tension, severe stress and un-desirable mental problems or disease are stress Anxiety problems or disease that considered as most frequently appearing as disorders. Anxiety disease is diagnosing as condition that showed or indicate to serious and severe or pathological case as the essential disturbance emotional tone. Aim: In this study, ginger was tested i …

30.08.2026journal-article

Journal of Family Medicine and Preventive Medicine

Ideas from Complex Systems Theory: Peer-led Community Preventive Health for a WHO (2007) ‘Whole Prison’ Approach to Health

Graham Betts-Symonds

This article is presented following fourteen years of experience with an innovative approach to preventive health in all Irish Prisons. During this period, University-led and internal evaluations have demonstrated increased engagement with prison populations by trained inmate peer educators, linked to formal prison health, psychology and addiction service professionals [1-3].

30.08.2026journal-article

Frontiers on Healthcare Research

Factors Associated with Platelet Recovery in Dengue Patients on Fever Day 7

Faculty of Medicine, Universitas Andalas, Padang, Indonesia, Ghina Shofi Ikrima Ghina Shofi, Department of Clinical Pathology, Faculty of Medicine, Universitas Andalas, Padang, Indonesia, Elfira Yusri Elfira, Department of Internal Medicine, Faculty of Medicine, Universitas Andalas, Padang, Indonesia, Fadrian Fadrian Fadrian, Department of Physiology, Faculty of Medicine, Universitas Andalas, Padang, Indonesia, Efrida Efrida Efrida, Mutia Lailani Mutia, Department of Biochemistry, Faculty of Medicine, Universitas Andalas, Padang, Indonesia, Yustini Alioes Yustini

<p style="font-weight: 400;"><strong>Background:</strong> Thrombocytopenia is a common hematological feature of dengue infection, and platelet recovery is a reliable prognostic indicator. The seventh day of fever typically marks the beginning of the recovery phase, but some patients show delayed platelet recovery. This study aimed to identify the factors affecting platelet recovery in adult dengue patients on fever day 7.</p> <p style="font-weight: 400;"><strong>Methods:</strong> This cross-sectional study was cond …

30.08.2026journal-article

Journal of Gazi University Health Sciences Institute

Perioperative Care in Breast-Conserving Surgery Patients: An Evidence-Based Perioperative Care Protocol

Büşra Çırak Sağdıç, Sevil Güler

Breast-conserving surgery (BCS) is a commonly used treatment method for early-stage breast cancer that offers cosmetic benefits while ensuring oncological safety. However, postoperative complications and the current trend toward shorter hospital stays necessitate the systematic and standardized planning of perioperative care. The aim of this review is to comprehensively address the perioperative care process in patients undergoing BCS based on the literature and to present an evidence-based care protocol that can b …

30.08.2026journal-article

Small

Poly (Lipoic Acid) Nanoparticles With High Blood‐Brain Barrier Permeability and Enhanced Anti‐Ferroptotic Activity for Ischemic Stroke Treatment

Qing‐Zhang Tuo, Juan Tan, Hong‐Fa Yan, Xueying Zhou, Peng Lei, Shiyong Zhang

ABSTRACT Lipoic acid (LA) scavenges free radicals and was clinically tested for ischemic stroke. However, the short half‐life and weak efficacy in penetrating the blood‐brain barrier (BBB) limit its use in the brain. Here, we developed poly (lipoic acid) nanoparticles (pLANs) with a half‐life of more than 15 h and a high efficiency to penetrate the BBB for ischemic stroke treatment. With intraperitoneal injection, imaging studies using fluorescently labelled pLANs of different sizes revealed that 30 nm pLANs entere …

30.08.2026journal-article

Magnetic Resonance in Medicine

Servo Navigation and Phase Equalization Enhanced by Run‐Time Stabilization (PEERS) for 3D EPI Time Series

Malte Riedel, Thomas Ulrich, Samuel Bianchi, Klaas P. Pruessmann

Purpose To enhance time‐resolved segmented imaging by synergy of run‐time stabilization and retrospective data‐driven phase correction. Methods A segmented 3D EPI sequence for fMRI time series is equipped with servo navigation based on short orbital navigators and a linear perturbation model, enabling run‐time correction for rigid‐body motion, bulk phase, and frequency fluctuations. Complementary retrospective phase correction is based on the repetitive structure of the time series and serves to address residual ph …

30.08.2026journal-article

Diagnostics

Preoperative Bioelectrical Impedance Analysis Identifies Altered Body Composition, Which Is Associated with Severe Postoperative Complications in Major Hepatopancreaticobiliary Surgery

Clemens Schmutzhart, Martin Varga, Julian Seethaler, Tarkan Jäger, Gunnar Treff, Giorjines Boppre, Jan David Smeddinck, Josef Niebauer, Wolfgang Hitzl, Klaus Emmanuel, Stefan Löb

Background: Altered body composition is common in patients undergoing major hepatopancreaticobiliary (HPB) surgery and may be associated with increased postoperative morbidity. Conventional markers such as body mass index (BMI) and serum albumin have limited sensitivity for detecting early nutritional changes. Bioelectrical impedance analysis (BIA) provides an objective assessment of body composition, and phase angle (PA) may serve as a proxy for cellular status. Methods: This single-center retrospective observatio …

30.08.2026journal-article

Arthroscopy

Dermal Allograft Patch Augmentation With Mini‐Open Triple‐Row Repair for Large to Massive Rotator Cuff Tears Results in a Low Retear Rate and Favorable Clinical Outcomes Without Adverse Events

Du‐Han Kim, Seong Woo Jeon, Eun‐Seok Son, Chul‐Hyun Cho

Purpose To evaluate radiological and clinical outcomes, as well as adverse events, after dermal allograft patch (DAP) augmentation with rotator cuff repair for large to massive rotator cuff tears (RCTs). Methods Fifty consecutive patients who underwent DAP augmentation with arthroscopic‐assisted mini‐open triple‐row suture bridge repair for large to massive RCTs were retrospectively reviewed. The inclusion criteria were posterosuperior large to massive RCTs (>3 cm) and a minimum 24‐month follow‐up after surgery. St …

30.08.2026journal-article

Caucasian Medical Journal

Systemic lupus erythematosus masquerading as ulcerative colitis: a clinical case of lupus enteritis

Ilkana Guliyeva, Fidan Gasimova, Gulnara Nur-Mammadova, Nargiz Guseynova, Magrur Mammadov, Nijat Bayimov

Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease with a wide range of clinical features. Involvement of the gastrointestinal tract (GIT), especially in the form of lupus enteritis, can imitate inflammatory bowel disease (IBD), making diagnosis difficult. We present the case of a young woman with previously diagnosed ulcerative colitis, who subsequently showed immunological and clinical signs of SLE with the development of lupus enteritis. This case highlights the need for a comprehensive immun …

30.08.2026journal-article

Clinical and Experimental Dental Research

Antibiofilm Activity of a Thermoformable Material Loaded With Essential Oil Solution

Alexandra Stähli, Markus Laky, Anton Sculean, Tino Töpper, Sigrun Eick

ABSTRACT Background Interest in antimicrobial surfaces for dental devices, such as aligners and brackets, is growing. These surfaces are designed to retard biofilm formation. One approach is to load essential oils (EOs) into the material. The focus of this study was the antibacterial, anti‐biofilm, and anti‐inflammatory activities of an EO solution. Methods The EO solution contained cinnamaldehyde, methyl salicylate, eucalyptol, limonene, and trans‐anethole dissolved in distilled water (dH 2 O) with polyglycerol‐4‐ …

30.08.2026journal-article

Chronic Diseases and Translational Medicine

Baseline Body Mass Index Category and Incident Treated Hypertension in Australian Men: A Linked Prospective Cohort Study Using PBS/MBS Data

Ebenezer Afrifa‐Yamoah

ABSTRACT Background Excess adiposity is a major modifiable risk factor for hypertension; however, the incremental prognostic value of body mass index (BMI) beyond standard predictors remains unclear. We examined the associations between baseline BMI category and incident treated hypertension, and assessed whether BMI improved risk prediction. Methods Data were obtained from the Ten to Men longitudinal study (2013–2024) linked to Pharmaceutical Benefits Scheme (PBS) and Medicare Benefits Schedule (MBS) records. The …