Journal of the American Heart Association
Social Determinants of Health and Polygenic Susceptibility in Nonsyndromic Ascending Aortic Aneurysm
Background Nonsyndromic ascending aortic aneurysm (AsAA) may remain clinically silent until dissection or rupture. The contributions of multidomain social determinants of health (SDOH) and polygenic susceptibility to AsAA risk are not well defined. Methods In a cross‐sectional analysis of 124 180 participants in the National Institutes of Health All of Us Research Program, 14 SDOH measures were summarized as a standardized composite score, and an ascending aortic diameter polygenic risk score (PRS; polygenic score, …