Frag' FlorenceEvidenz. Klar. Anwendbar.
Uhr 7/8Sources Journal Tree
Easy Demo

Florence Themenbrowser · Onkologie · Seite 120

Was ist neu im Gesundheitswesen?

Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

Themen erkunden

Aktuelle Forschung nach Fachgebiet

24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
22.08.2026journal-article

Diagnostics

Ultrasound-Visible 3D Nickel–Titanium Clip for Tumor Localization After Neoadjuvant Therapy in Early Breast Cancer: A Prospective Multicenter Real-World Study

Mattea Reinisch, Efstathia Cremer, Kilian Pankert, Diana Weber, Volker Hanf, Katja Engellandt, Sebastian Hentsch, Cordula Müller, Peter Dall, Matthias Losch, Petra Deuschle, Alexander Traut, Satyen Shenoy, Anita Engel, Dorothea Schindowski, Sherko Kuemmel, Simona Gipe

Background: Neoadjuvant systemic therapy (NST) enables tumor downsizing and increases the feasibility of breast-conserving surgery (BCS) in patients with early breast cancer (EBC). Reliable tumor localization after NST remains challenging, particularly in patients with a complete clinical response. If clips are not visible on ultrasound, stereotactic mammography-guided wire localization is required, which involves additional radiation exposure and may increase patient discomfort and procedural complexity. The 3D-sh …

22.08.2026journal-article

Diseases of the Esophagus

P1.207. Reduced Risk of Postoperative Chyle Leak in Patients With Obesity After Esophagectomy for Esophageal Cancer - a Nationwide Cohort Study

Ellinor Eriksson, Jakob Hedberg, Gustav Linder

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications Background Esophagectomy is a cornerstone in the treatment of esophageal cancer. Although postoperative chyle leak (PCL) is uncommon, it is clinically important due to its associated morbidity and often challenging management. This study aimed to investigate risk factors for PCL and associations with survival in a nationwide cohort. Methods All patients with esophageal cancer, registered in the Swedish Natio …

22.08.2026journal-article

Diseases of the Esophagus

P1.132. Assessing the Impact of Radiomics Features on Machine Learning Models for Predicting Multidisciplinary Treatment Decisions in Oesophageal Cancer

Dylag Jakub, Dan Burns, Nav Thavanesan, Tayyaba Azim, Zehor Belkhatir, Zoë Walters, Sarvapali Ramchurn, Timothy Underwood, Ganesh Vigneswaran

Abstract Topic Esophageal Cancer: Other Background Medical Artificial Intelligence (MAI) is expanding within surgical oncology with new tools emerging for assisting cancer multidisciplinary teams (MDTs) in cancer types such as oesophageal cancer (OC). Radiomics has similarly gained popularity with proponents arguing that it provides comparable performance to human agents when assessing medical imaging however it’s value within OC remains unclear. This study evaluated machine learning (ML) models which combine radio …

22.08.2026journal-article

Neurosurgical Review

Brain-spine interface: an exploration of a potential future treatment for spinal cord injury

Vijay Sivan, Zahin Alam, Hanish Polavarapu, Shreyes Manivel, Rohit Prem Kumar, Geoffrey R. O’Malley, Francis Ruzicka, Nitesh V. Patel

Abstract Spinal cord injuries (SCIs) profoundly impact millions globally, leading to loss of motor and sensory functions below the injury site. Brain-spine interfaces (BSIs) represent an early-stage neuroprosthetic strategy that attempts to restore functional communication between cortical motor-intention signals and spinal sensorimotor circuits below the level of injury. Although early preclinical and highly selected clinical studies have shown encouraging motor outcomes, the evidence remains preliminary, and rout …

22.08.2026journal-article

European Journal of Nuclear Medicine and Molecular Imaging

Total-body [11C]carfentanil PET: Liver-brain axis in methadone vs. buprenorphine treatment

Elizabeth J. Li, Corinde E. Wiers, Chia-Ju Hsieh, Hsiaoju Lee, Alexander Schmitz, Anthony J. Young, Timothy Pond, Joseph Chang, Erin K. Schubert, Robert H. Mach, Henry R. Kranzler, Jacob G. Dubroff

Abstract Purpose To examine the relationship between brain mu opioid receptor (MOR) availability and liver activity in opioid use disorder (OUD) patients treated with methadone (MET) or buprenorphine (BUP). Methods 10 OUD patients, 5 treated with MET and 5 with BUP, as well as 13 healthy controls (HCs) underwent total-body PET [ 11 C]carfentanil (CFN) imaging. MOR availability was quantified using distribution volume ratio (DVR) in key MOR-rich brain regions, and hepatic distribution volume (Vt) was used as an inde …

22.08.2026journal-article

Diseases of the Esophagus

P1.165. Low Preoperative Fat-Free Mass Index Predicts Anastomotic Leakage and Poor Survival in Esophageal Cancer

Jiarong Zhang, Weiming Chen, Weikun Su, Ruirong Lin, Yijin Lin, Guibin Weng, Lin Chen, Weimin Fang

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – long term outcomes Background Esophageal cancer is one of the most common gastrointestinal malignancies worldwide. In China, most patients are diagnosed at intermediate and advanced stages, and the treatment mainly includes neoadjuvant therapy, surgery and postoperative adjuvant therapy. Although the therapeutic effect has been greatly improved, clinical challenges still exist. Therefore, it's urgent to explore new and effective prognostic …

22.08.2026journal-article

Diseases of the Esophagus

V-23. Double-Flap Technique for Reconstruction After Thoracoscopic/Laparoscopic or Robot Assisted Ivor-Lewis Esophagectomy for EGJ Cancer

Hirofumi Kawakubo, Masashi Takeuchi, Satoru Matsuda, Yuko Kitagawa

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – technique Background The selection of surgical procedures for esophagogastric junction (EGJ) cancer varies among institutions. Thoracoscopic/Laparoscopic or Robot assisted proximal gastrectomy (LPG/RPG) has been performed as a minimally invasive procedure for gastric cancer in the upper third of the stomach. However, gastroesophageal reflux disease (GERD) remains a significant concern after PG. Thus, several techniques have been reported to …

22.08.2026journal-article

Diseases of the Esophagus

PD02.05. Long-Term Incidence and Treatment Outcomes of Gastric Conduit Cancer After Esophagectomy

Hyun Ki Jeong, Sung Yong Park, Tae Se Kim, Yang Won Min, Dong Ryul Oh, Seh Hoon Park, Jong Mu Sun, Yeong Jeong Jeon, Jung Hee Lee, Jong Ho Cho, Hong Kwan Kim, Yong Soo Choi

Abstract Topic Esophageal Cancer: Other Background Gastric conduit cancer (GCC), a primary carcinoma arising in the reconstructed gastric conduit after esophagectomy, is rare, and its true incidence and long-term outcomes remain unclear. We aimed to determine its cumulative incidence and treatment-related outcomes. Methods We retrospectively reviewed 4,490 patients who underwent esophagectomy with gastric conduit reconstruction between 1994 and August 2025. Among them, 93 developed GCC during follow-up. Clinical ch …

22.08.2026journal-article

Annals of Surgical Oncology

Impact of Textbook Outcome (TO) and Textbook Oncological Outcome (TOO) on Survival Following Surgery for Esophagogastric Cancer: A Systematic Review and Meta-analysis

Shahd Mobarak, Hasanat K. Ahmed, Zak Shehata, Sorrel Burden, Matthew Gittins, Bilal H. Alkhaffaf

Abstract Background Textbook outcome (TO) and textbook oncological outcome (TOO) are increasingly used as composite measures of surgical success but are limited by heterogeneity in their definitions. This systematic review and meta-analysis aims to synthesize the association between composite outcome measures (TO/TOO) and survival in both gastric and esophageal cancer. Materials and Methods A systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) …

22.08.2026journal-article

Bioconjugate Chemistry

“Imaging Triplets on Two Wheels”: 61Cu-, 64Cu-, and 68Ga-labeled Bicyclic Peptides Targeting Nectin-4 Enable High-Contrast PET Imaging of Urothelial Carcinoma and Triple-Negative Breast Cancer

Johanna Mauersberger, Tobias Krönke, Martin Ullrich, Markus Laube, Florian Brandt, Marc Pretze, Fabian Lohaus, Sebastian Hoberück, Christian Thomas, Matthias Miederer, Ralph A. Bundschuh, Sven Stadlbauer, Klaus Kopka, Jens Pietzsch, Robert Wodtke

Abstract Nectin-4 is a validated target for theranostic approaches toward urothelial carcinoma, and radiolabeled ligands for PET and SPECT imaging are gaining increasing interest for noninvasive quantification of Nectin-4 prior to a targeted therapy. The goal of this study was to develop bicyclic peptides that allow radiolabeling with three different radionuclides (61Cu, 64Cu, and 68Ga) and to evaluate their suitability for high-contrast PET imaging in urothelial carcinoma (UC) and triple-negative breast cancer (TN …

22.08.2026journal-article

Effective Pharmacotherapy

Gynecological Oncology Service in Krasnodar Region: History of its Formation, Current Status

Kuban State Medical University, Krasnodar, M.G. Leonov, Clinical Oncology Dispensary No. 1, Krasnodar, Oncology Dispensary No. 3, Novorossiysk, L.G. Teslenko

The history of the creation and organization of oncology services in Kuban, and particularly gynecologic oncology, are crucial for shaping the correct professional direction for future generations of oncologists. Mikhail Vasilyevich Lomonosov noted: "A people ignorant of its past has no future." Currently, oncology care in Krasnodar region is rapidly developing. Innovative treatment methods are being introduced into practice, and the population is provided with high-tech medical care. The human resources are availa …

22.08.2026journal-article

Barw Medical Journal

Safety and Efficacy of Atezolizumab in Ovarian Cancer

Rebaz M. Ali, Sami S. Omar, Shano M. Ali, Shvan H. Mohammed, Karokh K. Mohammed, Mohammed Q. Mustafa, Yousif M. Mahmood, Suhaib H. Kakamad, Hawkar A. Nasralla, Ahmed Gh. Hamasaeed, Zheer T. Hamasalih, Danar D. Mahmood, Mohammed Jalal Mohammed, Shahan Syamand Rasull, Fryad Mustafa Qadir, Berun A. Abdalla

Abstract Introduction Although the efficacy of PD-L1 blockade has been evaluated in analyses that combine pharmacologically distinct antibodies, the specific efficacy and safety of atezolizumab remain unclear. This review aimed to evaluate the efficacy and safety profile of atezolizumab specifically. Methods PubMed/MEDLINE and CENTRAL were searched (June 2026) for phase I to III trials of atezolizumab in ovarian cancer, reported in full-text English with at least 10 evaluable patients. Randomized and single-arm des …

22.08.2026journal-article

Diseases of the Esophagus

PD09.07. Impact of Type 2 Diabetes on Outcomes of Neoadjuvant Therapy and Surgery for Esophageal Cancer: A Multi-Center Retrospective Study

Xipeng Wang, Zhichao Liu, Xuefeng Leng, Xinmin Li, Jingwen Zhang, Xiaoting Yu, Wei Guo, Chengqiang Li, Yongtao Han, Zhigang Li, Hecheng Li, Yuqin Cao

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications Background The prognostic impact of type 2 diabetes in esophageal cancer patients receiving neoadjuvant therapy followed by surgery remains unclear. We evaluated its association with perioperative outcomes and long-term survival. Methods We retrospectively analyzed 1,099 patients who underwent neoadjuvant therapy followed by surgery between 2013 and 2024 across three high-volume centers. Type 2 diabetes was …

22.08.2026journal-article

Diseases of the Esophagus

P1.048. 14 Years of Esophageal and Esophago-Gastric Junction Cancer Epidemiology in a National Cancer Center in México

Alberto Mitsuo Leon Takahashi, Ashley Yunue Hernandez Flores, Alix Vega Rodriguez, Estefania Soto Rangel, Dennis Cerrato Izaguirre, Yesennia Sanchez Perez, Maria Del Consuelo Diaz Romero, Javier Melchor Ruan

Abstract Topic Esophageal Cancer: Other Background In 2022, the incidence of esophageal cancer was 11th, and mortality was 7th place. Mexico is a middle-income country, and incidence and mortality are not among the top 10, but we do not have a national cancer register, and the information could be underestimated. Moreover, Mexico in the Organization for Economic Co-operation and Development (OECD) is first in obesity, and this is one of the main risk factors for adenocarcinoma, so we think the incidence of esophage …

22.08.2026journal-article

Diseases of the Esophagus

P1.180. Retrospective RCT Study: Esophageal Cancer Surgical Reconstruction When the Gastric Tube Cannot Be Used - Jejunum vs. Colon

Kentaro Kubo, Shunsuke Murakami, Yasumasa Hashimoto, Keiko Hamasaki, Shinichiro Kobayashi, Junichi Arai, Kengo Kanetaka, Susumu Eguchi

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background Gastric tube reconstruction is the first choice for reconstructive organs in esophageal cancer surgery. However, when the gastric tube cannot be used due to some reasons, jejunum or colon reconstruction become an option. When selecting the organ, a multifaceted perspective is required, considering factors such as the stability of blood flow, the safety of the anastomotic site, nutritional status, and long-term function. However, no …

22.08.2026journal-article

Diseases of the Esophagus

P1.175. Lymph Node Assessment of the Thoracic Duct and Surrounding Compartment in Esophageal Cancer Surgery – the TUPEC Pilot-Study

Hidde Overtoom, Dillen van der Aa, Wietse Eshuis, Mark van Berge Henegouwen, Suzanne Gisbertz

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background Standardization of thoracic duct (TD) management during esophageal cancer surgery remains controversial. TD resection has been hypothesized to enhance oncologic radicality, since it may increase the total lymph node yield. This study aims to quantify the lymph node yield of the TD and surrounding compartment in esophageal cancer surgery. Methods This ongoing single-center, prospective pilot study evaluates the lymph node yield of i …

22.08.2026journal-article

Diseases of the Esophagus

PD01.03. Impact of Surgical Timing on Survival by Pathological Response Status in Esophageal Cancer Patients After Neoadjuvant Chemoradiotherapy

Xu Huang, Fangyi Liu, Zitao jian, Lijie Tan

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background Neoadjuvant chemoradiotherapy (nCRT) followed by esophagectomy is standard treatment for esophageal squamous cell carcinoma (ESCC). Optimal surgical timing after nCRT remains unclear. Patients achieving pathological complete response (pCR) may demonstrate distinct biological behavior. This study investigated whether surgical timing differentially impacts survival based on pathological response status. Methods This multicenter retrospec …

22.08.2026journal-article

Journal of Oncology Pharmacy Practice

Best practices to master robotic preparation of ready-to-administer systemic anticancer therapy in hospital pharmacies

M. Crul, C. Polidori, D. Paolucci, A. Rieutord, P. Salinas Silva, L. Bredesen Hatlelid, A. Riffle, G. Eggers, L. Amerine, I. Kraemer

Automated reconstitution or preparation of systemic anticancer therapy has gained traction in the past decade. Transitioning from traditional manual workflows to fully automated production offers multiple benefits: decreased pharmacy staff workload, reduced risk of repetitive strain injuries, minimized medication errors, and lower risk of occupational exposure to hazardous medicinal products, especially when the robotic preparation areas are fully enclosed. Several elements can facilitate efficient implementation a …

22.08.2026journal-article

Diseases of the Esophagus

P1.235. Clinicopathological Factors Associated With Early Recurrence Post-Surgery in Esophageal Squamous Cell Cancer

Virendra Kumar Tiwari, Devayani Niyogi, Sabita Jiwnani, Karthik Venkataramani, C S Pramesh

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – long term outcomes Background Esophageal cancer is the sixth leading cause of cancer-related mortality; it has a very poor outcome despite multimodality treatment. Some of these cases recur early, even after aggressive, curative intent management. The aim of this study was to investigate factors associated with early recurrence (with a cut-off of 12 months post-surgery). Methods We conducted a retrospective analysis of a prospectively maint …

22.08.2026journal-article

Diseases of the Esophagus

PD08.07. Multimodal AI-Driven Postoperative Surveillance for Oesophageal Cancer: Automated Patient-Reported Outcome Assessment and Early Complication Warning in a Prospective Study

Simiao Lu, Yi Zhu, Yongtao Han, Qiuling Shi, Xuefeng Leng

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications Background Postoperative complications following oesophagectomy occur in 25–60% of patients, yet traditional patient-reported outcome (PRO) assessment relies on standardised questionnaires with limited reliability, particularly among elderly patients with low health literacy. We aimed to develop and externally validate a multimodal artificial intelligence (AI) system that automates PRO assessment from natura …

22.08.2026journal-article

Diseases of the Esophagus

P1.124. Clinical Outcomes of Esophageal Cancer With Lymph Node Metastasis Invasion Into Other Organs (T4LN)

Aya Ueda, Katsuyuki Sakanaka, Shinya Hiraoka, Ryo Narukami, Motoo Nomura, Chikatoshi Katada, Akira Yokoyama, Masashi Tamaoki, Shigeru Tsunoda, Manabu Muto

Abstract Topic Esophageal Cancer: Oncology/Radiation Therapy Background The standard treatment for T4 esophageal cancer without distant metastasis is definitive chemoradiotherapy (dCRT). In the Japanese Classification of Esophageal Cancer, 12th Edition, T4 refers to both primary tumor invasion into adjacent organs (T4ESO) and also lymph node metastasis invasion into other organs (T4LN). However, comprehensive data and reports on T4LN are scarce. This study aimed to compare the clinical outcomes of T4ESO and T4LN ca …

22.08.2026journal-article

Diseases of the Esophagus

PD03.05. Comparison of Laparoscopic and Robotic Heller Myotomy With Fundoplication for Achalasia Treatment: A Randomized Clinical Trial - Preliminary Results

Arthur Youssif Mota Arabi, Sergio Szachnowicz, Edno Tales Bianchi, Ary Nasi, Camila Maria de Camara, Ricardo Zugaib Abdalla, Rubens Antonio Aissar Sallum, Ulysses Jr Ribeiro, Paulo Herman

Abstract Topic Benign Disease: Esophageal Surgery Background Achalasia is an esophageal motor disorder characterized by impaired lower esophageal sphincter relaxation and aperistalsis, often associated with Chagas disease in Brazil. Heller myotomy with fundoplication is the gold standard treatment. However, randomized trials comparing laparoscopic and robotic approaches regarding the main postoperative aspects remain scarce in the literature. Methods This open-label randomized controlled trial is conducted at a Bra …

22.08.2026journal-article

Diseases of the Esophagus

P1.236. Surgical Decision Model for Elderly Patients With Esophageal Cancer: Development and Validation of a Geriatric Stage (gStage) System

Yasue Kimura, Naomichi Koga, Rena Yokomizo, Munehide Terashi, Ayako Iwanaga, Masahiko Sugiyama, Masaru Morita

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – long term outcomes Background The increasing age of patients with esophageal cancer poses significant challenges in surgical decision-making. Elderly individuals frequently present with multimorbidity, impaired physiological reserve, and nutritional vulnerability, all of which increase postoperative risk. Chronological age and performance status alone are insufficient to determine surgical eligibility. A structured approach incorporating mu …

22.08.2026journal-article

Diseases of the Esophagus

OA03-RF01.01. Patterns and Predictors of Recurrence in Patients With Esophageal Cancer Who Achieve Pathological Complete Response to Multimodal Therapy

Yuxin Yang, Zhigang Li

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background Neoadjuvant chemoradiotherapy (nCRT) and chemoimmunotherapy (nICT) are increasingly used for locally advanced esophageal squamous cell carcinoma. Although pathological complete response (pCR) is associated with favorable survival, nearly one third of pCR patients still experience recurrence. This study aimed to identify risk factors and recurrence patterns in this population. Methods We retrospectively reviewed 392 patients who achieve …