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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
22.08.2026journal-article

Diseases of the Esophagus

OA04.2. Single Cell Transcriptomic and T-Cell Receptor Diversity Analysis of Peripheral Blood Lymphocytes Comparing Proton Versus Photon-Based Chemoradiation in Esophageal Cancer

Steven Lin, Chen Braun, Ye Lin Son, Min Wang, Clemens Grassberger, Jacob Smith, Patrick Reeves, Ada Argueta, Ryan Park, Harald Paganetti, Theodore Hong, Mark Poznansky, Radhe Mohan

Abstract Topic Esophageal Cancer: Oncology/Radiation Therapy Background Radiation-induced lymphopenia (RIL) is a common toxicity during and after chemoradiation (CRT) but can be significantly mitigated with proton therapy (PT). The objective of this study is to determine if quantitative sparing of lymphocytes could also result in qualitative improvements in lymphocytes after CRT with PT compared to photons in esophageal cancer patients. Methods Patients were prospectively enrolled for longitudinal blood collection …

22.08.2026journal-article

European Radiology

Quantitative dynamic contrast-enhanced magnetic resonance imaging for early assessment of treatment response in pancreatic ductal adenocarcinoma

Martin D. Holland, Ezinwanne E. Onuoha, Darryl Outlaw, Mehmet Akce, Midhun Malla, Salila Hashmi, Sushanth Reddy, J. Bart Rose, Desiree E. Morgan, Grant R. Williams, Moh’d Khushman, Dana B. Cardin, Katherine Frederick-Dyer, Xiaoyu Jiang, Zarine K. Shah, Bassel El-Rayes, Junzhong Xu, Harrison Kim

Abstract Objectives To prospectively evaluate whether quantitative DCE-MRI can predict early chemotherapy response in pancreatic ductal adenocarcinoma (PDAC), and to assess the added value of a point-of-care portable perfusion phantom (P4) for correcting scanner-dependent errors. Materials and methods Fifty-four patients with biopsy-confirmed PDAC were prospectively enrolled at two institutions; 42 completed MRI scans at baseline (1 ± 1 weeks before chemotherapy) and 7 ± 2 weeks after treatment initiation. P4s were …

22.08.2026journal-article

Diseases of the Esophagus

P1.234. Analysis of Prognostic Factors in Elderly Patients Following Minimally Invasive Esophagectomy for Esophageal Cancer

Jun Takahashi, Yohei Ozawa, Yusuke Taniyama, Chiaki Sato, Hiroshi Okamoto, Hirotaka Ihida, Naoto Ujiie, Takashi Kamei

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – long term outcomes Background With the aging of the global population, an increasing number of elderly patients undergo esophagectomy for esophageal cancer. Elderly populations exhibit considerable heterogeneity in overall health status due to differences in comorbidities. However, the factors influencing long-term outcomes after minimally invasive esophagectomy in this population have not been fully elucidated. This study aimed to identify …

22.08.2026journal-article

Diseases of the Esophagus

P1.183. Salvage Surgery and Conversion Surgery for Esophageal Cancer in Patients Aged 80 Years or Older

Hiroshi Sato, Yutaka Miyawaki, Yusuke Suzuki, Yutaka Kishimoto, Shinichi Sakuramoto

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background With the rapid aging of the population, esophageal cancer in individuals aged 80 and older continues to increase. Conversely, with recent advances in multidisciplinary treatment, including novel chemotherapies and immune checkpoint inhibitors, “salvage surgery” and “conversion surgery” are increasingly being performed. These procedures often involve more invasive techniques than standard approaches, and their applicability in the e …

22.08.2026journal-article

International Journal of Research Publications

Prognostic Value of Pretreatment Monocyte-to-Lymphocyte Ratio in Prostate Cancer: A Focused Systematic Review and Corrected Meta-analysis

Luqmanul Hakim, Ginanda Putra Siregar, Syah Mirsya Warli

Background : The monocyte-to-lymphocyte ratio (MLR) is an inexpensive systemic inflammatory marker, but its prognostic value in prostate cancer remains uncertain. This focused review evaluated whether pretreatment MLR is associated with overall survival (OS). Methods : A broader systematic search of Semantic Scholar, Scopus, PubMed/MEDLINE, Crossref, the Cochrane Library, and Web of Science identified studies of blood-cell ratios in prostate cancer. For this focused analysis, reports were rechecked for direct MLR m …

22.08.2026journal-article

Diseases of the Esophagus

P1.208. Long-Term Health Related Quality of Life Following Curative Treatment for Esophageal Cancer: A Systematic Review and Meta-Analysis

Josipa Petric, Ravi Vissapragada, David Watson, Norma Bulamu

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – long term outcomes Background Treatment for esophageal cancer has a significant impact on health-related quality of life (HRQoL). Advances in treatment have resulted in improved survival rates, and the need to improve patient quality of life. This review summarizes the evidence on the impact of various treatments on long-term quality of life in order to inform practice. Methods A systematic literature search of MEDLINE (OVID), PubMed, CINAH …

22.08.2026journal-article

Diseases of the Esophagus

P1.123. Deep Learning and Machine Learning Radiomics-Based Models Predicting Esophagogastric Cancer Recurrence: A Systematic Review

Angeline Praveena Enton Raj, Morgan McLaughlin, Magnus Nilsson, Fredrik Klevebro, Gustav Strijkers, Bram Coolen, Mariska Leeflang, Antonios Tzortzakakis

Abstract Topic Esophageal Cancer: Oncology/Radiation Therapy Background Esophageal and gastric cancers are associated with recurrence rates approaching 50% despite curative-intent treatment. Non-invasive imaging modalities including computed tomography (CT), positron emission tomography (PET/CT), and magnetic resonance imaging (MRI) are routinely used for staging and surveillance. Radiomics combined with machine learning (ML) and deep learning (DL) enables extraction of high-dimensional imaging features that may pr …

22.08.2026journal-article

Diseases of the Esophagus

P1.117. Photodynamic Therapy for Esophageal Cancer: A Single-Center Experience With Clinical Outcomes

YOUNGGI JUNG, JAEHO CHUNG, EUNJUE YI, HYOJUNG KIM, SUNGHO LEE, Jieon Kim

Abstract Topic Esophageal Cancer: Non-Surgical Treatment of Esophageal Cancer Background Photodynamic therapy (PDT) is a minimally invasive local treatment that selectively destroys malignant cells with minimal systemic toxicity. It has emerged as an alternative therapeutic option for superficial esophageal lesions such as carcinoma in situ or high-grade dysplasia, and as a palliative or salvage modality in inoperable cases. This study aimed to evaluate the clinical outcomes and safety of PDT in patients with esoph …

22.08.2026journal-article

Diseases of the Esophagus

P1.231. Patients With Anastomotic Stricture After McKeown Operation for Esophageal Cancer Is Associated With Lower Rate of Recurrence: Retrospective Cohort Study

Yutaka Miyawaki, Tetsuro Toriumi, Yusuke Suzuki, Yutaka Kishimoto, Masatoshi Yoshizawa, Shinichi Sakuramoto, Hiroshi Sato

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – long term outcomes Background This was a single institutional retrospective study. Patients with esophageal squamous cell carcinoma who underwent esophagectomy with radical lymph node dissection reconstructed by gastric tube with cervical anastomosis were included in this study. Univariable and multivariable analysis were performed to reveal the effect of anastomotic stricture on long–term outcomes. Methods This was a single institutional r …

22.08.2026journal-article

Diseases of the Esophagus

PD04.08. Impact of Locoregional Treatment in Synchronous Oligometastatic Esophageal Cancer: Evidence From a Real-World Cohort

Matteo Pittacolo, Lucia Moletta, Arianna Vittori, Giovanni Capovilla, Giulia Nezi, Luca Provenzano, Gianpietro Zanchettin, Elisa Sefora Pierobon, Sabina Murgioni, Floriana Nappo, Sara Lonardi, Renato Salvador, Michele Valmasoni

Abstract Topic Esophageal Cancer: Management of Metastatic Cancer Background In metastatic esophageal cancer, systemic therapy is standard of care. The oligometastatic paradigm suggests that selected patients with limited metastatic burden may benefit from multimodal strategies including metastasis-directed locoregional therapy. Comparative data in synchronous oligometastatic esophageal/GEJ cancer remain limited. Methods We performed a single-center retrospective cohort study (2015–2025) including patients with syn …

22.08.2026journal-article

Diseases of the Esophagus

P1.036. Early-Onset Gastric Cancer (EOGC): A Meta-Analysis of Risk Factors, Clinicopathological Features, and Survival Outcomes

Unaiza Waheed, Abigail Burn, Alexander Ribbits, Stewart Walsh, Vijayendran Sujendran, Andrew Hindmarsh, Kiran Purushothaman, Ayesha Noorani

Abstract Topic Esophageal Cancer: Other Background Early onset gastric cancer (EOGC), defined as diagnosis before 55 years, represents a growing global health challenge. Although traditionally rare, its incidence is rising and now constitutes the second most common early onset gastrointestinal malignancy after colorectal cancer. EOGC has been hypothesised to reflect distinct biology, yet risk factors, clinicopathological features and survival outcomes remain poorly synthesised. We aimed to evaluate global evidence …

22.08.2026journal-article

Diseases of the Esophagus

P1.200. Reducing Failure to Rescue Improves Long Term Survival After Oesophago-Gastric Cancer Surgery

Stephen Lam, Ashraf Tokhi, Fady Yanni, Ravinder Vohra, James Catton, Neil Welch, Isabel Pereira, Ashika Dhondee, Ziyaad Surtee, Simon L Parsons

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications Background Outcomes after oesophago-gastric cancer surgery have improved over time, and this is likely to be multifactorial. In addition to better oncologic treatments, safer surgery should reduce complications, whereas safer peri-operative care should reduce deaths once complications occur. We examined which of the latter two mechanisms explained survival improvement over 24 years of practice. Methods All p …

22.08.2026journal-article

Diseases of the Esophagus

PD01.08. Optimizing Postoperative Systemic Therapy Following Neoadjuvant Chemoimmunotherapy and Resection for Locally Advanced Esophageal Cancer: A Multicenter Real-World Analysis

Yizhou Huang, Maohui Chen, Zhenyuan Yang, Taidui Zeng, Chun Chen, Bin Zheng

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background Neoadjuvant chemoimmunotherapy (nICT) followed by surgical resection has emerged as a standard approach for locally advanced esophageal cancer. However, the role and optimal modality of postoperative immunotherapy in patients who have already received immune checkpoint blockade remain uncertain, particularly outside the context of prospective trials. We sought to evaluate the impact of different adjuvant immunotherapy strategies on sur …

22.08.2026journal-article

Diseases of the Esophagus

P1.113. Optimization of Cervical Lymph Node Ultrasound Partitioning in Esophageal Cancer: A Cross-Sectional Survey of Surgeons and Ultrasound Physicians in China

Yi Zhu, Simiao Lu, Yuting Fan, Xuefeng Leng

Abstract Topic Esophageal Cancer: New Diagnostic Modalities (Including PET, PET-CT, New Tracers) Background Accurate ultrasound evaluation of cervical lymph nodes (LNs) is essential for staging and treatment planning in esophageal cancer, particularly for decisions regarding three-field lymphadenectomy and neoadjuvant strategies. However, cervical LN assessment in routine ultrasound practice typically follows the AAO-HNS/ASHNS neck level system, which was not designed for esophageal cancer and may not correspond we …

22.08.2026journal-article

Behavioral Sciences

Incidental and Intentional Object–Location Memory: The Effects of Stimulant Treatment on Adults with ADHD

Efrat Barel, Orna Tzischinsky, Shir Tahel Hai Tal

The relation between Attention Deficit/Hyperactivity Disorder (ADHD) and memory performance has attracted growing interest in recent years. However, one of the more complex memory abilities, object–location memory (OLM), remains scarcely studied within the context of ADHD. In this study, we examine incidental and intentional OLM performance in treated and untreated adults with ADHD and in controls. Fifty-eight adults with ADHD (26 medicated and 32 unmedicated) and 51 neurotypical individuals are assessed in a paper …

22.08.2026journal-article

BMC Medicine

Prediagnostic circulating 25-hydroxyvitamin D and prostate cancer-specific survival: a collaborative pooled analysis of 13 prospective studies

Jiaqi Huang, Aurora Perez-Cornago, Ruth C. Travis, Paul N. Appleby, Danrui Chen, Mahboubeh Parsaeian, Urwah Noor, Stephanie J. Weinstein, Neal D. Freedman, Andreas Josefsson, Ingegerd Johansson, Elizabeth A. Platz, Corinne E. Joshu, Bu B. Yeap, Leon Flicker, Lorelei A. Mucci, Konstantinos K. Tsilidis, Paul Knekt, Pamela L. Lutsey, Alison Mondul, Kala Visvanathan, Kathy J. Helzlsouer, Graham G. Giles, Matthias B. Schulze, Mélanie Deschasaux-Tanguy, Mathilde Touvier, Jose M.ª Huerta, Loic Le Marchand, Meir Stampfer, Timothy J. Key, Demetrius Albanes, Naomi E. Allen

Abstract Background Previous research suggests higher risk of prostate cancer diagnosis in men with high vitamin D serology, but there are limited data related to prostate cancer survival. In this study, we examine the associations between prediagnostic circulating levels of 25-hydroxyvitamin D [25(OH)D] with risk of prostate cancer-specific mortality, as well as mortality from other causes, in participants diagnosed with prostate cancer. Methods We conducted a prospective multi-national collaborative analysis of p …

22.08.2026journal-article

Diseases of the Esophagus

P1.173. Endoscopic Resection Versus Esophagectomy for T1b Esophageal Cancer – a Systematic Review and Meta-Analysis

Nader Hanna, Bright Huo, Zuhaib Mir, John Agzarian

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background Esophagectomy remains the standard of care for most esophageal cancer. Newer evidence supports the use of endoscopic resection (ER) including endoscopic mucosal resection (EMR) or endoscopic submucosal dissection (ESD) for T1a and T1b disease, respectively. We compared survival of patients with T1b esophageal cancer who underwent ER or esophagectomy. Methods We searched MEDLINE, EMBASE and CENTRAL from inception to April 2025 for s …

22.08.2026journal-article

Discover Oncology

Prognostic factors influencing overall and cancer-specific survival in elderly patients with oral and maxillofacial squamous cell carcinoma

Qiang Bao, Ting Zhang

Abstract Background Oral and maxillofacial squamous cell carcinoma (OMSCC) is prevalent in the elderly, yet comprehensive prognostic analyses integrating host-related factors for this population are scarce. This study aimed to identify prognostic factors for overall survival (OS) and cancer-specific survival (CSS) in elderly OMSCC patients, with a focus on the neutrophil-to-lymphocyte ratio (NLR) and prognostic nutritional index (PNI). Materials and methods This retrospective study evaluated clinicopathological and …

22.08.2026journal-article

Journal of Public Health

Interventions to increase breast cancer screening attendance among immigrants: a cross-sectional international survey

Sameer Bhargava, Marie Vigdis Heimseter, Gunhild Mangerud, Eli Nina Hølleland Eikefjord, Hanna Dyrstad Hartvigsen, Livia Giordano, Veli-Matti Partanen, Marthe Larsen, Silje Sagstad, Ana Natale-Pereira, Arlinda Ruco, Kelly Bunzeluk, Anne Mette Fløe Hvass, Solveig Hofvind

Abstract Background Immigrant populations demonstrate lower attendance in organized breast cancer screening programs than non-immigrants. Evidence on interventions to increase attendance, and their effectiveness, remains limited. We aimed to map interventions implemented in nationally or regionally organized screening programs to enhance immigrants' attendance and to assess the extent of their systematic evaluation. Methods We conducted a survey using an electronic questionnaire distributed through the Internationa …

22.08.2026journal-article

Endocrine Pathology

Tumor Necrosis is Associated with an Increased Metastatic and Cardiovascular Risk in Paragangliomas: A Single-Center Series and Meta-Analysis Comparing Necrosis and Cystic Degeneration in Paragangliomas

Anna-Maria Wiejak, Georgiana Constantinescu, Gintare Zygiene, Mercedes Robledo, Christian G. Ziegler, Jens-Peter Kühn, Ronald de Krijger, Christina Pamporaki, Matthias Meinhardt, Nicole Bechmann

Abstract Paragangliomas (PGLs) are rare neural crest–derived tumors with highly variable morphology and clinical behavior. These tumors can present with cystic and necrotic alterations that may influence the clinical presentation of affected patients. However, prevalence and clinical significance of these pathological alterations remain poorly understood. In this retrospective study (2011–2021), 103 patients with confirmed PGLs were examined for cystic and necrotic alterations based on imaging and pathology reports …

22.08.2026journal-article

Journal of Marine Medical Society

Intracholecystic Papillary Neoplasm of Gallbladder: Clinicopathological Spectrum from Low-grade to High-grade Dysplasia – A Four Case Series

Amit Jaiswal, Amit Kumar Das, Natasha Dogra, Manish Sondhi, Shilpi Saxena

Abstract Intracholecystic papillary neoplasm (ICPN) is an uncommon preinvasive epithelial tumour of the gallbladder with variable malignant potential. This retrospective study evaluated the clinicopathological spectrum of four ICPN cases diagnosed on cholecystectomy specimens. Clinical, gross and histopathological features including epithelial subtype, grade of dysplasia and stromal invasion were analysed. Patients ranged from 32 to 68 years and lesion size varied from 0.8 to 9 cm. Gastric, biliary and mixed phenot …

22.08.2026journal-article

Current Cancer Drug Targets

MRPL35 Suppresses Autophagy-Mediated Ferroptosis in Hepatocellular Carcinoma via the AMPK/mTOR Axis

YuLiang Xu, LiShuai Xiao, ZhiHu Shi, Xi Chen

Introduction: Ferroptosis and autophagy are recently identified forms of non-apoptotic regulated cell death with strong therapeutic implications for hepatocellular carcinoma (HCC). Mitochondrial ribosomal protein L35 (MRPL35), a mitochondria- specific component of mitoribosomes, has been proposed as a potential therapeutic target for liver cancer. The study focused on autophagy-dependent ferroptosis in HCC, with an emphasis on the functional significance of MRPL35. Methods: Bioinformatics approaches, RT-qPCR, along …

22.08.2026journal-article

Current Medicinal Chemistry

Exploring Inhibitory Impacts of Anamorelin on Colorectal Cancer Proliferation via Regulation of Transketolase

Zhenkai Fu, Saiying Wang, Fei Li, Wenna Liu, Yujia Zhao, Dan Wu, An Liu, Ying Liang

Background/Objectives: Colorectal cancer (CRC) is a major cause of cancer- related deaths worldwide and poses a significant global health challenge. Metabolic reprogramming, including transketolase (TKT) upregulation in the pentose phosphate pathway, is a hallmark of CRC. Drugs targeting TKT have shown promise in cancer treatments; however, their mechanisms are poorly understood. Methods: In this study, by integrating bioinformatics analysis of 494 cases from the TCGA database, we identified that transketolase (TKT …

22.08.2026journal-article

BMC Nutrition

Home enteral nutrition management in postoperative oral cancer patients: an evidence summary

Yifan Wu, Changjuan Zeng, Lili Hou, Yueping Wang, Pingping Ji, Yufei Li

Abstract Background This study aimed to establish a standardized management system for home enteral nutrition (HEN) for patients with postoperative oral cancer and provide scientific guidance for clinical professionals by systematically searching relevant literature and summarizing the best evidence. Methods Literature retrieval was performed systematically across Chinese and English databases following the “5S” evidence hierarchy model to identify studies addressing home nutritional management in postoperative ora …