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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
31.08.2026journal-article

Acute and Critical Care

Decisions about palliative care and social determinants of health in intensive care units: a scoping review

Hyeyoung Yun, Jung Yeon Kim, Eugene Han, Yeonsoo Jang

Social determinants of health (SDoH) play important roles not only in a patient's health status but also in access to palliative care, the family's decision-making process, and the formation of patient values and preferences. In this scoping review, we analyze the social determinants that influence palliative care decision-making and examine the relationship between palliative care decisions and SDoH in the intensive care unit (ICU). We conducted a literature search of five databases including the search terms “Int …

31.08.2026journal-article

Frontiers in Immunology

SAVI: molecular mechanisms, clinical spectrum and precision medicine approaches beyond type-I IFN

Michele Manganelli, Paola Cantalice, Jona Papri, Enrico Drago, Nicole De Lucchi, Giulia Accorsi, Chiara Fresia, Simonetta Simonetti, Gabriella Guida, Gerardo Cazzato, Mario Della Mura, Giuseppe Ingravallo, Roberta Caorsi, Stefano Volpi, Francesco La Torre, Marco Gattorno

Type I interferonopathies (TI-IFN) represent a heterogeneous group of autoinflammatory disorders characterized by upregulated type I interferon (IFN) signaling. Among them, STING-associated vasculopathy with onset in infancy (SAVI) is a rare, severe autoinflammatory disease caused by gain-of-function mutations in the STING1 gene. Mechanistically, these mutations lead to a constitutive activation of the STING protein, resulting in excessive type I interferon production, which drives chronic inflammation and damage t …

31.08.2026journal-article

Psychoactives

The Next Drug Crisis Has Already Started: Rethinking Surveillance, Toxicology and Public Health in the Era of Rapidly Evolving Psychoactive Substances

Ricardo Jorge Dinis-Oliveira, Daniel José Barbosa

The global drug landscape is undergoing its most profound transformation since the emergence of the modern illicit drug market during the twentieth century. For decades, drug policies, analytical toxicology, forensic science, and public health responses have been developed around a relatively limited number of well-characterized substances, including heroin, cocaine, cannabis, and amphetamines such as 3,4-methylenedioxymethamphetamine (MDMA). Although new psychoactive substances (NPS) have received increasing atten …

31.08.2026journal-article

Global Spine Journal

Discrepancy Between Clinician- and Patient-Reported Definitions of Mild Degenerative Cervical Myelopathy and Surgical Outcomes

Takahiro Kitagawa, Narihito Nagoshi, Junichi Yamane, Toshiki Okubo, Reo Shibata, Yoshiomi Kobayashi, Kanehiro Fujiyoshi, Yoshiyuki Yato, Tatsuya Yamamoto, Kazuya Kitamura, Takeshi Ikegami, Takahito Iga, Kazuki Takeda, Masahiro Ozaki, Satoshi Suzuki, Morio Matsumoto, Masaya Nakamura, Kota Watanabe

Study Design Prospective multicenter observational cohort study. Objective To redefine mild degenerative cervical myelopathy (DCM) using a patient-reported severity framework derived from Japanese Orthopaedic Association Cervical Myelopathy Evaluation Questionnaire (JOACMEQ) and to compare surgical outcomes with the conventional clinician-reported definition. Methods Patients with DCM undergoing surgery at 10 spine centers were enrolled. Mild DCM was defined using two criteria: a clinician-reported definition based …

31.08.2026journal-article

Clinical and Experimental Otorhinolaryngology

Human Papillomavirus (HPV)-Infected Epithelial Cells and FBLN1-Positive Fibroreticular Cells Govern the Immunogenic Tumor Microenvironment in HPV-Associated Oropharyngeal Squamous Cell Carcinoma

Doeon Gu, Joonho Shim, Soo Yoon Kim, Hye Jin Kim, Da-Yong Shin, Hyun-Tae Shin, Nayeon Choi, Woong-Yang Park, Man Ki Chung, Sung Yong Choi

Objectives. Oropharyngeal squamous cell carcinoma (OPSCC) exhibits distinct clinical behaviors according to human papillomavirus (HPV) status. HPV-associated OPSCC is typically associated with a more favorable prognosis and improved response to therapy than non-HPV–associated OPSCC; however, the underlying differences in the tumor microenvironment (TME) remain incompletely understood.Methods. To investigate cellular and molecular factors associated with improved outcomes in HPV-associated OPSCC, we performed single …

31.08.2026journal-article

Pakistan Journal of Health Sciences

Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio as Markers of Disease Activity in Rheumatoid Arthritis

Hazrat Hussain, Muhammad Asghar, . Naila, . Musa, . Zeeshan, Alam Zeb

Rheumatoid arthritis (RA) is an inflammatory disease that adversely affects quality of life by impairing joint function. Objectives: To examine the use of NLR and PLR as activity indicators in RA. To ascertain their independent prediction by examining the relationships between these DAS28-ESR fractions of disease activity and other conventional inflammatory indicators like ESR and CRP. Methods: This study involved 230 rheumatoid arthritis patients assessed in the Department of Rheumatology, Khyber Teaching Hospital …

31.08.2026journal-article

Pakistan Journal of Health Sciences

Comparative efficacy of High-Flow Nasal Cannula (HFNC) versus Continuous Positive Airway Pressure (CPAP) in Preventing Bronchopulmonary Dysplasia (BPD) among Preterm Neonates

Wajid Iqbal, Shaukat Zaman, Javeria Iqbal, Faiz Alam, Muhammad Khalid Khan, Samina Shams Alam

Bronchopulmonary dysplasia (BPD) remains a major cause of respiratory morbidity in preterm infants requiring respiratory support. Non-invasive ventilation strategies such as nasal continuous positive airway pressure (CPAP) and high-flow nasal cannula (HFNC) are commonly used, but evidence comparing their effectiveness in preventing BPD remains limited, particularly in low- and middle-income settings. Objectives: To compare HFNC and CPAP as primary non-invasive respiratory support in preterm neonates <34 weeks’ gest …

31.08.2026journal-article

Pakistan Journal of Health Sciences

Digital Literacy in Medical Education: Strengths, Gaps, and the Way Forward

Humaira Shamim, Nomira Waheed, Zunaira Azher, Hammad Karim, Fatima Abid, Saba Iqbal

Digital transformation of healthcare has transformed clinical practice, medical education, and professional competencies around the world. Digital literacy includes technological skills, ethical use, artificial intelligence (AI), and cybersecurity. It is now regarded as a safe, effective, and future-ready healthcare practice. Despite increased exposure to digital tools, evidence reveals that healthcare students may lack structured capabilities in new digital domains. Objectives: To evaluate the level of digital lit …

31.08.2026journal-article

The Egyptian Journal of Critical Care Medicine

Safety and performance evaluation of EZVent mechanical ventilator system in hospitalized mechanically ventilated patients: a single-center, open-label, self-controlled clinical trial

Yasser Nassar, Rania A. Galhom, Israa Abdel Raouf, Mohamed Gamal Elansary

Abstract Background Mechanical ventilation remains a critical intervention for patients with acute respiratory failure, yet selecting optimal ventilation strategies is a challenge. Modern ventilators require rigorous clinical evaluation before widespread adoption. This study evaluated the safety and performance of the novel EZVent ventilator system compared to standard intensive care unit ventilators. Methods This single-center, open-label, non-randomized, self-controlled study was conducted at Al Kasr Al Ainy Hosp …

31.08.2026journal-article

The Journal of Korean Academic Society of Nursing Education

Relationship between grit and academic failure tolerance among nursing students: The mediating effect of psychological safety

Chung Hee Woo, Hyeoeun Lee

Purpose: The aim of this study was to examine the mediating effect of psychological safety on the relationship between grit and academic-failure tolerance among nursing students.Methods: Data were collected from 168 nursing students recruited through online communities between October 13 and 27, 2025, using convenience sampling. The data were analyzed using independent t-test, one-way ANOVA, Pearson’s correlation coefficients, and hierarchical regression analysis with IBM SPSS version 25.0. The mediating effect was …

31.08.2026journal-article

Al-madinah: Journal of Islamic Civilization

The Transformation of Religious Identity in the Public Sphere: A Phenomenological Study of the Hijrah Movement among Urban Millennials<b></b>

Abdullah Safei, Agus Handoko

The phenomenon of the hijrah movement among urban millennials has transformed the landscape of religiosity in the urban public sphere. This study aims to analyze the transformation of religious identity among urban millennials and examine how they negotiate that identity within the context of urban modernity. Employing a qualitative method with Alfred Schutz's phenomenological approach, this research explores the subjective experiences of hijrah participants in major Indonesian cities (Jakarta and Bandung) during t …

31.08.2026journal-article

Applied Sciences

A Risk-Stratified Management Framework for Tattooed Patients in MRI: Integrating Physicochemical Properties with Clinical Safety Protocols

Vasiliki Kefala, Eleni Andreou, Vasiliki-Sofia Grech, Niki Tertipi, Eleni Sfyri, Efstathios Rallis

Tattooing has transitioned from a specialized segment practice to a mainstream form of self-expression, with global prevalence estimates ranging from 20% to 30% in adult populations across Western countries. As the tattooed demographic expands, the intersection between tattoo pigments and magnetic resonance imaging (MRI) has emerged as a clinically relevant concern. This review provides a comprehensive analysis of the physicochemical properties of modern tattoo inks, their interactions with MRI-generated electromag …

31.08.2026journal-article

Blockchain in Healthcare Today

Lightweight Privacy-Preserving Blockchain Framework for Healthcare: A Simulation-Based Approach to Reducing Computational Overhead

MD. Asrar Ahmed, Mohammed Abid Ali Sameer, Mousmi Ajay Chaurasia, S. Nallusamy

Background: The privacy and security of electronic health records (HER) in blockchain-based systems remains a major research problem because of high computational overhead and scalability restrictions. Privacy-preserving techniques such as encryption and zero-knowledge proofs strengthen blockchain’s transparency and immutability but often add significant latency and resource use. This study proposes a lightweight, simulation-based blockchain model balancing privacy protection and computational efficiency for health …

31.08.2026journal-article

HCA Healthcare Journal of Medicine

Approaching Well-Being Through the Research Lens: How HCA Healthcare Colleagues are Building Healthy Work and Learning Environments

Gregory Guldner, Allison Woodall, Deepinder Bal, Jennifer Larkin, Cynthia Borum, Sunny Hull, Annette Edens, Lisa H. Moore, Elaine K. Miller, Harold Gomez Acevedo, Katia M Lugo Enriquez, Noor Judge, Yanie Oliva, Pablo E. Ramirez Caraballo, Faraz Jaffer, Prerna S. Sharma, Daniel Heller, Siddarth Kathuria, Nathaniel Banet, Orlando Nieves-Lugo, Adrienne Madison, Lily Martin, Oliwier Dziadkowiec

At the heart of our commitment to the care and improvement of human life are the physicians who dedicate themselves to delivering exceptional care. To support not only our physicians’ professional excellence but also to foster personal fulfillment, HCA Healthcare partnered with Claremont Graduate University to establish the Physician Wellness Research Lab (PWR Lab). In his new role as the Vice President of Academic Affairs for Graduate Medical Education (GME), Dr Guldner led a nationwide search to establish and imp …

31.08.2026journal-article

HCA Healthcare Journal of Medicine

Gallbladder Ascariasis Presenting as Acalculous Biliary Colic

Carmen A Urbina, Luigi G Cubeddu, Luigi X. Cubeddu

We detail a case of gallbladder ascariasis, presenting as an acute episode of acalculous biliary colic, nausea, bloating, an unremarkable abdominal ultrasound, and negative helminth and protozoa stool smears. A follow-up ultrasound provided unexpected images consistent with gallbladder infection by Ascaris lumbricoides. Repeat ultrasonography performed 10 days after anthelmintic therapy showed no live worms and 2 newly appearing echogenic areas suggestive of gallbladder calculi that were confirmed following electiv …

31.08.2026journal-article

Current Oncology

Patient-Controlled Real-Time Transcutaneous Electrical Acupoint Stimulation at Neiguan (PC6) for Chemotherapy-Induced Nausea and Vomiting in Breast Cancer: An Exploratory Single-Arm Two-Stage Trial

Huiting Liu, Jie Zhou, Junying Du, Qiongying Shen, Chao Lu, Jianxing Zhang, Weiping Zhang, Ran Ran, Jianqiao Fang, Jiongyao Ye, Hong Gao, Junfan Fang

Chemotherapy-induced nausea and vomiting (CINV) remain difficult to control after discharge despite guideline-based antiemetics. This multicenter exploratory single-arm two-stage trial evaluated patient-controlled, real-time transcutaneous electrical acupoint stimulation (TEAS) at Neiguan (PC6) as an adjunct to standard antiemetic therapy in patients with breast cancer. Forty-eight patients who had experienced CINV and were scheduled at enrollment to receive the same chemotherapy and antiemetic regimens during two …

31.08.2026journal-article

Korean Journal of Clinical Oncology

Suppression of MCM2 reduces cancer stem cells and epithelial-mesenchymal transition-related phenotypes in breast cancer cells

Rae-Kwon Kim

Purpose: Minichromosome maintenance protein 2 (MCM2) is a key regulator of DNA replication and has been implicated in tumor progression. While previous studies have demonstrated its role in lung cancer stem cells (CSCs), its role in breast cancer remains unclear. This study aimed to investigate whether MCM2 regulates CSCs and epithelial-mesenchymal transition (EMT) in breast cancer.Methods: MCM2 expression and its prognostic significance were analyzed using public breast cancer datasets. MDA-MB-231 breast cancer ce …

31.08.2026journal-article

ASEAN Journal on Hospitality and Tourism

Inclusive Tourism in Public Spaces: An Accessibility and Visitor Experience Study of Mobility-Impaired Individuals on Malioboro Street

Zachary Ryan, Mohamad Rachmadian Narotama, Iswan Bahri, Hikmah Kamarudin

Everyone has the right to tourism, including individuals with disabilities. Unfortunately, not all tourist destinations can ensure a positive experience for disabled travelers. For instance, even popular sites like Malioboro Street in Yogyakarta may fail to provide an accessible and inclusive experience for people with disabilities. This study investigates the experiences of wheelchair users regarding facilities, culinary areas, and community responses in the Malioboro Street area. The research methodology employed …

31.08.2026journal-article

Bioinformation

Biological susceptibility to root resorption in clear aligner therapy: A mini review

Mariana Lourdes Barrionuevo

External apical root resorption (EARR) persists in clear aligner therapy and reflects individual biological susceptibility more than appliance type. Polymorphisms in inflammatory and vitamin D pathway genes, including IL1B, RANK and VDR, shift individual EARR risk. Gingival crevicular fluid biomarkers, such as interleukin-6, interleukin-8 and matrix metalloproteinase-8, track the active resorptive phase. AI-assisted three-dimensional imaging quantifies apical loss objectively, near 0.6 to 0.8 mm and comparable to f …

31.08.2026journal-article

Revista Ibero-Americana de Humanidades, Ciências e Educação

INTELIGÊNCIA ARTIFICIAL COGNITIVA COMO VETOR DE GOVERNANÇA E PRONTIDÃO OPERACIONAL: PROPOSIÇÃO DE UM MODELO INTEGRADO PARA A POLÍCIA MILITAR DO PARANÁ

Antonio Rogerio Custodio dos Santos

A crescente complexidade regulatória da Administração Pública impõe às organizações policiais o desafio de conciliar segurança jurídica, eficiência administrativa e fortalecimento da prontidão operacional. Nesse contexto, o presente estudo propõe o Modelo Integrado de Inteligência Artificial Cognitiva (MIIA), concebido como uma arquitetura de governança organizacional destinada à aplicação estratégica da Inteligência Artificial em processos administrativos complexos da Polícia Militar do Paraná. Trata-se de pesquis …

31.08.2026journal-article

AFRICAN JOURNAL OF REPRODUCTIVE HEALTH

Assessment of anxiety levels and marital relationships among women undergoing infertility treatment: A descriptive observational study

Naima M. Elsayed, Nabila S. Mohamed, Rabab S. Hassan, Eshrak S. Hashem, Randa M. Abobaker

This study aimed to assess anxiety levels and marital relationships among women undergoing infertility treatment. A descriptive observational design was conducted involving 300 infertile women over nine months at Zagazig University Hospital. Data were collected using a Structured Interview Questionnaire, the Female Sexual Function Index (FSFI), and the Taylor Anxiety Scale. Reliability analysis showed high internal consistency (Cronbach's alpha: 0.923 for FSFI; 0.845 for Taylor Scale). Results indicated that 32.6% …

31.08.2026journal-article

International Journal for Research in Applied Science and Engineering Technology

Stress and Mental Health Prediction Using Machine Learning

Divya S, Dr. Amutha S, Soumya Patil

Mentalhealthisanimportantpartofemployeewell-beingandorganizationalefficiency,especiallyinthetechnologyindustry where job stress is high. Predictive modeling would be able to recognize persons at risk of pursuing mental health treatment to enable early intervention and resource allocation. In this research, we used machine learning methods on a workplace mental health survey database to predict the respondents' treatment-seeking behavior. Preprocessing involved dealing with missing values, normalization of categoric …

31.08.2026journal-article

Journal of Evaluation in Clinical Practice

The Digital Transformation of Rehabilitation Medicine: A Narrative Review of Artificial Intelligence Innovations, Clinical Integration, and Future Paradigms

Hao Wu, Yali Yang, Li Wang, Hao Su, Xiaobing Li

ABSTRACT Background Traditional rehabilitation medicine, primarily dependent on qualitative clinical assessment and static therapeutic protocols, faces significant challenges in scalability, objectivity, and dynamic adaptability. The integration of Artificial Intelligence (AI) is catalyzing a paradigm shift from “experience‐driven” to “data‐driven” precision rehabilitation. Objective This narrative review delineates the current landscape of AI innovations in rehabilitation, evaluates their clinical integration acro …