Frag' FlorenceEvidenz. Klar. Anwendbar.
Uhr 7/8Sources Journal Tree
Easy Demo

Florence Themenbrowser · Onkologie · Seite 125

Was ist neu im Gesundheitswesen?

Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

Themen erkunden

Aktuelle Forschung nach Fachgebiet

24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
22.08.2026journal-article

Diseases of the Esophagus

P1.010. Personalized Approach to Surgical Treatment of Epiphrenal Diverticula of the Esophagus

Oleg Vasnev, Roman Izrailov, Kirill Shishin, Mikhail Koshkin, Konstantin Lesko, Elen Valitova, Eduard Bulgakov

Abstract Topic Benign Disease: Esophageal Surgery Background Epiphrenal diverticula of the esophagus are a rare pathology, pathogenetically associated with disorders of esophageal motility. Despite the evolution of treatment methods towards minimally invasiveness, the incidence of postoperative complications (suture failure) remains high (up to 45%), which necessitates the search for new approaches to surgical tactics. Methods The prospective study included 7 patients with symptomatic epiphrenal diverticula who wer …

22.08.2026journal-article

Diseases of the Esophagus

OA02.1. Radiation-Induced Lymphopenia During Neoadjuvant Chemoradiotherapy as Predictive Biomarker for Nivolumab Benefit in Esophageal Cancer

Pim Damen, Gulsah Ozden, Maaike Berbée, Jacco de Haan, Sarah Derks, Nadia Haj Mohammad, Erik Korevaar, Hanneke van Laarhoven, Marlinde de Leede, Radhe Mohan, Bianca Mostert, Stella Mook, Remi Nout, Barbara Stam, Famke Schneiders, Mathijs Tomassen, Joost Verhoeff, Rob Verhoeven, Fabienne Warmerdam, Christina Muijs, Steven Lin, Peter van Rossum

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background Radiation-induced lymphopenia (RIL) is an established prognostic factor associated with poorer pathologic response, disease-free survival (DFS), and overall survival (OS) in locally advanced esophageal cancer patients undergoing concurrent chemoradiotherapy (CRT). In resectable patients, standard treatment can consist of neoadjuvant CRT followed by surgery, with adjuvant nivolumab indicated (since 2022) for incomplete pathologic respon …

22.08.2026journal-article

Diseases of the Esophagus

PD03.03. Clinical Characteristics and Selected Treatment in Patients With Transient Esophageal Motility Abnormalities Detected During Esophagogastroduodenoscopy

Hiroko Hosaka, Shiko Kuribayashi, Nozomi Furuichi, Yu Maruyama, Keiichi Oshima, Yuki Itoi, Keigo Sato, Hirohito Tanaka, Yoji Takeuchi, Toshio Uraoka

Abstract Topic Benign Disease: Esophageal Function and Motility Background Major esophageal motility disorders such as achalasia often present with characteristic abnormalities on esophagogastroduodenoscopy (EGD). However, transient abnormal esophageal contractions or mucosal color changes are occasionally observed during EGD and their meaning are not well understood, and the pathological significance of these findings remains unclear. This study aimed to elucidate symptom profiles, barium esophagography findings, …

22.08.2026journal-article

Diseases of the Esophagus

P1.244. Robotic-Assisted Versus Conventional Minimally Invasive Oesophagectomy for Oesophageal Cancer: A Comparative Meta-Analysis of Perioperative and Oncological Outcomes

Theo Reback, James Butterworth, Guillaume Lafaurie, William Butterworth, Yassar Qureshi, Borzoueh Mohammadi, Khaled Dawas

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – technique Background Robotic-assisted minimally invasive oesophagectomy (RAMIE) is increasingly adopted to improve surgical precision, mediastinal dissection, and surgeon ergonomics. However, its clinical and oncological advantages over conventional minimally invasive oesophagectomy (cMIE) remain uncertain. This study presents the largest contemporary comparative meta-analysis between RAMIE and cMIE focusing on peri-operative and oncologica …

22.08.2026journal-article

Diseases of the Esophagus

P1.066. Prognostic Equivalence of ypN and pN Staging in Esophageal Cancer After Neoadjuvant Therapy: A Multicenter Cohort Study of 2,545 Patients

Simiao Lu, Xuefeng Leng

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background Current staging systems apply ypN and pN categories interchangeably after neoadjuvant therapy plus esophagectomy; however, their prognostic equivalence has not been rigorously established. We investigated whether ypN0–3 confers equivalent disease-free survival (DFS) to pN0–3. Methods We analyzed 2,545 consecutive esophagectomy patients from three high-volume centers with complete DFS data. Patients were stratified by treatment type …

22.08.2026journal-article

Diseases of the Esophagus

P1.162. Does Deprivation Drive Outcomes? Socioeconomic Factors in Esophageal Cancer Resections

Jakub Chmelo, Natawadee Chantima, Isabel Miglior, Alexander Phillips

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background Esophageal cancer incidence is higher in socioeconomically deprived populations. While deprivation is linked to established risk factors, its impact on tumour stage, comorbidity burden, and postoperative outcomes among patients undergoing esophagectomy remains unclear. This study assessed whether socioeconomic deprivation influences perioperative and oncological outcomes following Ivor Lewis esophagectomy. Methods This retrospectiv …

22.08.2026journal-article

Cancers

T-Cell Engagers in Lung Cancer: A Comprehensive Literature Review from Tarlatamab Approval to Next-Generation Strategies

Adnan Saydawi, Sameh Madanieh, Stephanie L. Echeverria, Angad Gill, Sweta Modha, Beyan El Emin, Waqar Haider, Bsher Almaalouli, Mohamed Shanshal

Background: Lung cancer remains the leading cause of cancer-related mortality worldwide, with five-year survival below 5% for metastatic small cell lung cancer (SCLC) and below 10% for metastatic non-small cell lung cancer (NSCLC). Immune checkpoint inhibitors have improved outcomes, but primary and acquired resistance, driven by tumor microenvironment immunosuppression, antigen heterogeneity, and T-cell exhaustion, leaves a substantial unmet need. T-cell engagers (TCEs), bispecific antibodies that redirect cytotox …

22.08.2026journal-article

Bioengineering

DGTN: Graph-Enhanced Transformer with Diffusive Attention and Gating Mechanism for Multi-Task Breast Ultrasound Tumor Analysis

Asfand Ali, Basit Raza, Kiran Zahra, Rizwan Ali Naqvi, Fayaz Ali Dharejo

Early and accurate analysis of breast cancer is critical for improving patient outcomes. Ultrasound imaging is widely used for breast tumor screening due to its safety, accessibility, and low cost. We propose DGTN (Diffused Graph-Transformer Network), a lightweight, end-to-end deep learning model that jointly performs breast tumor segmentation and multi-class classification (benign, malignant, and normal) from ultrasound images. DGTN integrates Graph Convolutional Networks (GCNs) and Transformer encoders through a …

22.08.2026journal-article

Diseases of the Esophagus

P1.043. Chylothorax After Esophagectomy for Esophageal Cancer: Incidence, Risk Factors, and Clinical Outcomes After Esophageal Resection. a Systematic Review and Meta-Analysis

Rawat Waratchanont, Napasakorn Yodtawee, Jirat Leelapatanadist, Vijittra Arsanpakit, Viriya Keawkungsadan, Sukchai Sattaporn

Abstract Topic Benign Disease: Iatrogenic Esophageal Disease, Perforation and Postsurgical Complications Background Chylothorax is an uncommon but potentially life-threatening complication after esophagectomy. Reported rates and proposed risk factors vary considerably across surgical eras, operative approaches, and institutional practices. Methods A systematic review was conducted according to PRISMA 2020 principles. MEDLINE via PubMed, Embase, Cochrane Library, and Web of Science were searched from inception to 31 …

22.08.2026journal-article

Diseases of the Esophagus

OA06-LBA01.1. Radical 3-Field Versus Standard 2-Field Lymphadenectomy for Operable Esophageal Cancer: A Randomized Controlled Trial

Prof C S Pramesh, Prof Sabita Jiwnani, Prof Priya Ranganathan, Dr George Karimundackal, Dr Devayani Niyogi, Dr Virendra Tiwari, Dr Karthik Venkataramani, Prof Madhavi Shetmahajan, Prof Swapnil Parab, Dr Apurva Ashok, Dr Pallavi Purwar, Dr Parveen Yadav, Dr Srinivas Gopinath, Dr Rajesh Mistry

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – long term outcomes Background The therapeutic value of extended lymphadenectomy in esophageal cancer remains unresolved. While 2-field lymph node dissection (2FLND) is standard, prophylactic 3-field lymphadenectomy (3FLND) is practiced selectively despite limited high-level evidence. We conducted a large randomized trial to determine whether radical 3FLND confers a survival advantage over standard 2FLND. Methods In this randomized controlle …

22.08.2026journal-article

International Journal of Food Science and Technology

Thermal, Structural, and Functional Interactions of Date Seed Powder-Sucrose Composites Produced by Thermal Treatment

Muna Al-Mawali, Maha Al-Khalili, Abdullahi Idris Muhammad, Myo Tay Zar Myint, Htet Htet Kyaw, Mohammad Shafiur Rahman, Pankaj B Pathare, Nasser Al-Habsi

Abstract The incorporation of dietary fibers into sucrose-rich food systems represents a promising strategy for developing healthier reduced-sugar formulations; however, the structural interactions governing their functionality during thermal processing remain poorly understood. This study investigated the physicochemical, thermal, and microstructural interactions between sucrose (SU) and date seed powder (DC) in composite systems prepared at 40 °C (M1-M5) and 70 °C (N1-N5). Progressive DC incorporation significant …

22.08.2026journal-article

Pharmaceuticals

Marbofloxacin Suppresses Breast Cancer Growth Through Oxidative Stress and Metabolic Reprogramming with Predicted HSP90AA1–EGFR Network Modulation

Mervenur Yavuz, Firli R. P. Dewi, İlknur Keskin, Turan Demircan

Background: Drug repurposing represents an accelerated and cost-effective approach to discovering novel oncologic therapeutics. Here, we investigated the anticancer potential and underlying mechanisms of marbofloxacin (MBF), a veterinary fluoroquinolone (FQ), against breast cancer (BC) cells. Methods: The cellular impacts of MBF on cell viability, anchorage-dependent growth, tumorigenicity, migration, apoptosis, proliferation, senescence, and mitochondrial function were thoroughly characterized. To further elucidat …

22.08.2026journal-article

Healthcare

Factors Associated with Treatment Burden in Older Adults with Multimorbidity and Implications for Potential Reduction Strategies: A Scoping Review

Leandro Amato, Gianluca Ciccaglione, Noemi Giannetta, Emanuele Di Simone, Nicolò Panattoni, Sara Dionisi, Alessandra Improta, Sofia Taborri, Marco Di Muzio

Background: Treatment Burden (TB) refers to the workload imposed on patients by healthcare-related tasks involved in the management of chronic conditions. Despite increasing evidence on this phenomenon, strategies for its reduction in older adults with multimorbidity remain poorly explored. Aim: To map the factors associated with treatment burden reported for older patients with multimorbidity and to derive implications for potential reduction strategies, regardless of the care setting. Methods: A scoping review wa …

22.08.2026journal-article

Angewandte Chemie

MitoGPS: A Mitochondrial DNA G‐Quadruplex‐Targeting Strategy for Tumor‐Preferential Type I Photodynamic Therapy

Yu‐Hui Guo, Yao‐Hui Shi, Pei‐Min Huang, Gui‐Xue Tang, Shu‐Min Xu, Mao‐Lin Li, Jia‐Hao Yuan, Xiu‐Cai Chen, Zhi‐Shu Huang, Yi‐Yong Yan, Jia‐Heng Tan, Jin‐Wu Yan, Shuo‐Bin Chen

ABSTRACT Photodynamic therapy (PDT) is a clinically promising, minimally invasive cancer treatment offering precise spatiotemporal control. However, achieving preferential tumor accumulation remains a critical challenge, which limits therapeutic efficacy and induces off‐target toxicity. Here, we introduce the mitoGPS (mitochondrial G‐quadruplex–targeting photosensitizer) strategy, a rational design framework for developing photosensitizers (PSs) with prolonged intratumoral retention through targeting mitochondrial …

22.08.2026journal-article

International Journal of Cancer

Is Body Roundness Index a Predictor of Cancer Incidence and Mortality? A Prospective Cohort Study

Yangyang Liu, Xuanli Zhao, Shuting Shen, Yizi Chen, Le Wang, Yiqin Wu, Fuhua Wu, Zichen Liu, Shiyuan Li, Jiayu Li, Ding Ye, Jing Guo, Yingying Mao, Yehua Lin, Xiaohui Sun

ABSTRACT Body Roundness Index (BRI) is a novel measure of visceral and total body fat. Its association with multiple cancers and predictive value relative to Body Mass Index (BMI) remain unclear. The associations between BRI and the incidence and mortality (specific, overall and all causes death) risk of 23 site‐specific cancers were evaluated using Cox proportional hazards models in UK Biobank participants. Restricted cubic spline (RCS) was further employed to assess the nonlinear association between BRI and 23 ca …

22.08.2026journal-article

Water, Air, & Soil Pollution

Smarter Chemical Oxygen Demand (COD) Prediction in Urban Wastewater Treatment Based on Post-Hoc Residual-Correction: A Comparative Machine Learning Analysis

Rabab Abdelfattah, Moustafa M. Zagho, Sajim Ahmed, Ahmed Sherif, Ahmad A. Imam, Mostafa H. Sliem, Ramy F. Elsalhy

Abstract Accurate prediction of water quality is essential for the sustainable management of water resources. The composition and concentration of pollutants in urban sewage vary significantly and are highly complex, making it challenging to control the process parameters in wastewater treatment plants (WWTPs). To meet effluent regulatory standards, increasing the input of chemicals and aeration becomes necessary, resulting in higher treatment costs and energy consumption. In this context, machine learning models ( …

22.08.2026journal-article

Nature Communications

XPO1-mediated TRIM21 nuclear export reprograms TREM2+ macrophage polarization by targeting IRF3 to augment anti-PD-1 efficacy in small cell lung cancer

Qingwu Du, Tingting Qin, Jingya Wang, Yantao Jiang, Qi Xu, Xueyang Li, Huiyan Liu, Junjie Yu, Yi Lu, Luyao Tong, Tao Sun, Peng Chen, Richeng Jiang, Dingzhi Huang

Abstract Small cell lung cancer (SCLC) is an aggressive malignancy that responds poorly to immune checkpoint inhibitor (ICI) therapy, due to its immunosuppressive tumor microenvironment. Here, we analyse preclinical mouse tumor models and patient-derived SCLC samples and identify Exportin 1 (XPO1) as a regulator of immune suppression in SCLC. Mechanistically, XPO1 drives the nuclear export of TRIM21, enabling TRIM21-dependent proteasomal degradation of IRF3 and repressing the immunostimulatory cytokine TNFSF15. Los …

22.08.2026journal-article

Diseases of the Esophagus

PD02.01. The Association Between the Gastro-Esophageal Micro-Organisms and Anastomotic Leakage in Esophageal Cancer Surgery: A Prospective Observational Cohort Study

Hidde Overtoom, Serhat Ciftci, Jarne van Hattum, Wietse Eshuis, Mark van Berge Henegouwen, Suzanne Gisbertz

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background Anastomotic leakage (AL) following esophagectomy with gastric conduit reconstruction is a severe complication. The influence of the gastric and esophageal microbiome on anastomotic leakage after esophageal cancer surgery is yet to be determined. The aim of this study was to evaluate the gastro-esophageal micro-organisms and its association with anastomotic leakage. Methods This prospective observational cohort study was conducted b …

22.08.2026journal-article

Diseases of the Esophagus

P1.156. Outcomes of Curative Esophagectomy in Octogenarians vs Non-Octogenarians With Esophageal Cancer: A Systematic Review and Meta-Analysis

Isaac Chan, Liyang Xiao, Aung Myint Oo, Kai Siang Chan

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background Esophageal cancer (EC) poses a growing global challenge in the context of an aging population. Evidence on the role of curative esophagectomy in octogenarians is limited. This study aims to compare the long-term survival and post-operative mortality and morbidity in octogenarians undergoing curative esophagectomy for EC, vs in non-octogenarians. Methods A systematic search was performed on PubMed, Embase, Web of Science and Cochran …

22.08.2026journal-article

Diseases of the Esophagus

P1.122. Feasibility and Efficacy of Immunochemotherapy in Patients With Advanced Esophageal Cancer Ineligible for Pivotal Trials

Daisuke Oshikawa, Takahiro Tsushima, Kunihiro Fushiki, Akihiro Ohba, Kotoe Oshima, Takeshi Kawakami, Satoshi Hamauchi, Tomoya Yokota, Yusuke Onozawa, Kentaro Yamazaki, Hirofumi Yasui

Abstract Topic Esophageal Cancer: Oncology/Radiation Therapy Background Immunochemotherapy combining immune checkpoint inhibitors (ICIs) with cytotoxic chemotherapy is a standard first-line treatment for unresectable advanced or recurrent esophageal cancer. However, pivotal trials such as KEYNOTE-590, CheckMate 648, and RATIONALE-306 enrolled highly selected patients, and the safety and efficacy of immunochemotherapy in trial-ineligible patients remain unclear. Methods We retrospectively analyzed patients with unre …

22.08.2026journal-article

Diseases of the Esophagus

P1.160. Role of Minimally Invasive Esophagectomy in Multidisciplinary Treatment for T4b Cervical Esophageal Cancer

Masazumi Sakaguchi, Shigeru Tsunoda, Shintaro Okumura, Yusuke Fujii, Shoichi Kitano, Atsushi Fukugaki, Yoshiyuki Kiyasu, Ryo Narukami, Kenjiro Hirai, Shigeo Hisamori, Katsuyuki Sakanaka, Takashi Mizowaki, Kazutaka Obama

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background No standard treatment exists for T4b (UICC 8th) cervical esophageal cancer. At our institution, definitive chemoradiotherapy (dCRT) (total dose > 50.4 Gy) is prioritized as initial therapy, and salvage surgery is performed only for persistent or recurrent disease. This strategy aims to maximize organ preservation while maintaining oncologic safety in this anatomically complex region. Methods We retrospectively reviewed outcomes …

22.08.2026journal-article

EMBO Molecular Medicine

IRE1 activity is prognostic in localised and metastatic prostate cancer and affects epithelial lineage states

Dimitrios Doultsinos, Ingrid Tomljanovic, Eleftherios Pilalis, Sophia M Abusamra, Mohammed Alshalalfa, Romuald Parmentier, Vidhula Ahire, Imogen E Bridges, Sandy Figiel, Joanna Hester, Damien Leach, Ashwin Nandakumar, Rensheng Wan, Yanis Zekri, Jichang Zhang, Charlotte L Bevan, Edward O’Neill, Alastair D Lamb, Valentine Macauley, Jean Phillipe Theurillat, Alfonso Urbanucci, R Jeffrey Karnes, Daniel E Spratt, Elai Davicioni, David Quigley, Wilbert Zwart, Clementine Le Magnen, Aristotelis Chatziioannou, Ian G Mills

Abstract Prostate cancer (PCa) is an androgen receptor (AR) driven, high-incidence disease significantly contributing to cancer mortality. To improve treatment outcomes for patients at high risk of metastasis, PCa is in need of better risk stratification at diagnosis. The unfolded protein response (UPR) is an AR-dependent process. However, the impact of the UPR transducer IRE1 on AR-dependent biology and acquired treatment resistance has not been defined. We use pre-clinical models of stress response to describe th …

22.08.2026journal-article

Urology Herald

First Russian experience of artificial urinary sphincter implantation in a woman using the da Vinci robotic system: technical aspects and long-term treatment outcomes

V. L. Medvedev, S. N. Lepetunov, G. A. Palaguta, K. U. Muratov, V. N. Manuilov

Introduction. Artificial urinary sphincter (AUS) implantation in women remains a challenging procedure due to the technical difficulties of open surgery, particularly in the setting of scar tissue following prior interventions. Robotic technology may improve outcomes through precise dissection in the narrow pelvic space. Objective. To demonstrate the technical feasibility and efficacy of robot-assisted AUS implantation in a patient with total stress urinary incontinence and a history of multiple unsuccessful surger …