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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
12.08.2026journal-article

Cancer Biome and Targeted Therapy

Patient-derived organoids in pancreatic cancer: Advances and applications in precision oncology

Hee Seung Lee, Bon-Kyoung Koo

Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest malignancies owing to late diagnosis, extensive intratumoral heterogeneity, a dense desmoplastic tumor microenvironment, and limited therapeutic responsiveness. Although current treatment regimens, including FOLFIRINOX and gemcitabine plus nab-paclitaxel, have modestly improved survival, chemoresistance and the lack of reliable predictive biomarkers continue to hinder precision oncology. Conventional two-dimensional cell lines and many in vivo mod …

12.08.2026journal-article

Polish Journal of Radiology

Endovascular therapy for acute non-terminal internal carotid artery occlusions

Milena Miszczuk, Christoph Riegler, Christian H. Nolte, Georg Bohner, Eberhard Siebert

Purpose Acute stroke from non-terminal internal carotid artery (non-T ICA) occlusions presents with variable symptoms. Although collaterals influence stroke severity, their role in non-T ICA occlusions remains unclear. This study evaluated the safety and efficacy of endovascular therapy (EVT) for isolated non-T ICA occlusions and examined the impact of collateral status. Material and methods Patients treated with EVT for acute isolated non-T ICA occlusion between August 2015 and February 2023 were retrospectively a …

12.08.2026journal-article

International Journal of Evidence Based Coaching and Mentoring

Coaching Versus Therapy: A Quantitative, Qualitative and Conceptual Analysis

Iain McCormick, Stewart Forsyth

Coaching is widely employed in organisations, which has led to a debate about the differences between coaching and therapy. This study used quantitative, qualitative and conceptual analyses to examine this. The qualitative data suggested that coaches have a clear idea of the differences between modalities. Qualitative data indicated that coaching is seen as having six features: performance versus emotional outcomes, future versus past focus, emphasis on action-based experimentation, the work context, higher client …

12.08.2026journal-article

Frontiers in Medical Technology

Intelligent data governance and quality control for chest Bi syndrome/coronary heart disease across the prevention–treatment–rehabilitation continuum: integrating a standardized framework, adversarially-optimized trigger engine, and domain-adaptive AI

Huisi Hong, Guiyuan Yang, Weihan Shen, Shiqi Luo, Yiming Yuan, Yong Zhao, Hong Zhang, Shuangyan Li, Juhua Wu, Wenge Chen, Shaoyang Men, Kaixuan Lin

Background Digital transformation in Traditional Chinese Medicine (TCM) is hindered by data silos, poor standardization, and inefficient quality control. This study developed and validated an intelligent data governance system to address these gaps. Methods Using Chest Bi syndrome (coronary heart disease) as a model, we established a standardized data system (9 subsets, 352 elements; 42.6% TCM-specific) based on the “Triple-Loop Coupling” theory and HL7 FHIR (Fast Healthcare Interoperability Resources)/SNOMED CT st …

12.08.2026journal-article

European Journal of Nuclear Medicine and Molecular Imaging

Radiolabelled somatostatin receptor antagonist versus agonist for peptide receptor radionuclide therapy in patients with metastatic pheochromocytoma or paraganglioma: a retrospective pilot study

Felix Schmidt, Sofia-Maria Lider, Lisa McDougall, Christopher Eigler, Peter Bernhardt, Abdulrafee Mushaweh, Andreas Bauman, Melpomeni Fani, Emanuel Christ, Damian Wild

Abstract Purpose Metastatic pheochromocytomas and paragangliomas (mPPGLs) are rare neuroendocrine tumours with limited therapeutic options. Peptide receptor radionuclide therapy (PRRT) using somatostatin receptor (SSTR) antagonists (e.g. [ 177 Lu]Lu-DOTA-JR11) may achieve higher tumour and organ absorbed doses compared with standard SSTR agonist therapy (e.g. [ 177 Lu]Lu-DOTA-TOC). This study aimed to perform an intra-patient comparison of tumour and organ dosimetry between [ 177 Lu]Lu-DOTA-TOC and [ 177 Lu]Lu-DOTA …

12.08.2026journal-article

Health, sport, rehabilitation

Three-dimensional correction methods for idiopathic scoliosis in adolescents: a randomized controlled trial

Mina Rezk, Maya Aly, Khaled Olama, Rania Hegazy

Background and purpose Adolescent idiopathic scoliosis (AIS) is a three-dimensional spinal deformity characterized by lateral curvature and vertebral rotation. Physiotherapeutic scoliosis-specific exercises (PSSE), such as the Schroth and SEAS methods, are utilized for curve correction and improving quality of life. This randomized controlled trial aimed to compare the effectiveness of the Schroth method versus the SEAS technique for spinal deformity correction and health-related quality of life in adolescents with …

12.08.2026journal-article

Cancers

Calcium-Orchestrated Vascular Collapse in Cancer Therapy: Mechanisms, Nanotherapeutic Platforms, and Translational Perspectives

Fatima Zahra Kamal, Radu Lefter, Vasile Burlui, Alin Stelian Ciobîcă, Gabrielle Dăscălescu, Said Rammali, Andrei Luca, Ancuța Andreea Miler, Hina Alim, Otilia Novac, Bouchaib Bencharki, Bogdan Novac

Cancer therapy is increasingly focused on manipulating the tumor microenvironment rather than directly eradicating malignant cells. Vascular-targeting strategies are emerging, and calcium-mediated vascular disruption is an exciting approach through which rapid and irreversible blood flow shutdown can be achieved. Here, we overview the molecular and physiological basis of calcium signaling in vascular homeostasis and outline how unregulated calcium dysfunctions in endothelial cells compromise their functionality and …

12.08.2026journal-article

Journal of Speech, Language, and Hearing Research

Intelligibility of Emotional Speech in Chinese Older Adults: Effects of Age-Related Hearing Loss

Xinran Fan, Jing Zhang, Minhui Cai, Jiayi Wu, Runci Wang, Jingjing Guan, Hongwei Ding

Purpose: The intelligibility of speech with emotional prosody may decline with aging and hearing loss. In Mandarin Chinese, both lexical tone and emotional prosody rely on pitch variations, raising the possibility that emotional prosody modulates speech intelligibility. This study examined the effects of aging and age-related hearing loss on word recognition for Mandarin words spoken with different emotional prosodies. Method: Four groups participated: older adults with normal hearing (ONH; n = 35, 60–86 years of a …

12.08.2026journal-article

Diseases of the Colon & Rectum

Building Machine Learning Models Based on Oxidative Stress Index Score to Predict Survival of Locally Advanced Rectal Cancer Receiving Different Neoadjuvant Therapy Patterns

Baoqiu Liu, Li Zhuo, Yirui Wang, Huilong Luo, Qiaoxuan Wang, Hui Chang, Rui Sun, Ting Jiang, Xin Zhen, Yuanhong Gao, Peirong Ding, Zhizhong Pan, Xicheng Wang, Weiwei Xiao

BACKGROUND: Liver enzyme biomarkers are known to contribute to the onset and progression of colorectal cancer. OBJECTIVE: To develop a novel oxidative stress index score integrating γ-glutamyl transferase and total bilirubin, evaluate its prognostic value in locally advanced rectal cancer patients receiving neoadjuvant therapy, and construct and validate machine learning–based survival prediction models incorporating oxidative stress index score. DESIGN: A novel liver enzyme indicator – oxidative stress index score …

12.08.2026journal-article

Frontiers in Cardiovascular Medicine

Long-term effects of permanent pacemaker therapy on growth in children with complete heart block

Kutay Sel, Yasemin Nuran Dönmez, Hayrettin Hakan Aykan, Aydın Adıgüzel, İlker Ertuğrul, Tevfik Karagöz

Objectives Complete heart block (CHB) is a rare but potentially life-threatening condition in childhood. A permanent pacemaker (PM) can provide a physiologically appropriate heart rate under defined criteria. It is known that normal cardiac function plays an important role in growth, which is the main indicator of health in childhood. While a holistic health approach is increasingly emphasized, there are limited data in the literature evaluating long-term growth in pediatric patients with a PM. This study aimed to …

12.08.2026journal-article

ACS Applied Bio Materials

Dual-Responsive Biomimetic Nanoplatform for Cascade Synergistic Therapy of Endometrial Cancer

Huaibin Yu, Zhuorong Miao, Meng Wang, Tianyi Guo, Deyuan Zhang, Zhengbao Zha, Ping Jin

Abstract Endometrial cancer is a common malignant tumor in the female reproductive system. Traditional chemotherapy has limitations such as poor targeting, dose-limiting toxicity, and treatment intensity restrictions. To address these issues, this study constructed an intelligent nanoplatform–GOD-Fe3+&DOX-Membrane@Polymer (GOD-Fe3+&DM@Poly.)–based on reversible addition-fragmentation chain transfer (RAFT) polymerization technology. The incorporation of pyridine disulfide bonds as polymer side chains through RAFT po …

12.08.2026journal-article

Journal of Humanistic Psychology

Integrating Wang Yangming’s Philosophy of Innate Knowledge into Solution-Focused Brief Therapy: Toward a Relational-Ethical Framework

Bowen Xue, Hong Luo

This study addresses longstanding critiques of Solution-Focused Brief Therapy (SFBT), particularly its tendencies toward value neutrality and excessive positivism, which may limit its ethical depth and cultural adaptability. Drawing on Wang Yangming’s Neo-Confucian philosophy of liangzhi (innate knowledge), the paper proposes a Relational-Ethical SFBT Framework that integrates clients’ self-evident moral awareness into therapeutic dialogue. The findings suggest that reinterpreting core SFBT techniques through the l …

12.08.2026journal-article

Human Gene Therapy

Streamlining Genetically Modified Organism Regulatory Classification in UK Gene Therapy Clinical Trials: A UK Pharmacy Perspective

Annalisa Del Prete, Beatriz Duran Jimenez, Anne Black

Accurate classification of Genetically Modified Organism (GMO) gene therapies remains a significant challenge to initiating clinical trials in the United Kingdom, often delaying patient access to innovative treatments. Current regulatory processes require separate GMO risk assessments at each National Health Service (NHS) trial location, leading to inconsistent approaches and duplication of effort. This article presents the development of a decision tree designed to streamline GMO classification for Gene Therapy In …

12.08.2026journal-article

Nursing & Midwifery Research Journal

Missed Opportunities of Vaccination Among Children During the COVID-19 Pandemic in India: Mapping the Impact on Sustainable Development Goals Targets 3.2, 3.3, and 3.B

Gurpreet Kaur, Latika Rohilla, Nabaneeta Dash, Sanjay Verma

Background The COVID-19 pandemic disrupted routine immunization services, creating missed opportunities for childhood vaccination and threatening progress toward Sustainable Development Goal (SDG) targets 3.2, 3.3, and 3.B. Objectives To assess the missed routine immunizations among children in India during the pandemic and examine parental experiences of accessing services. Methods This cross-sectional study was conducted at a tertiary-level pediatric hospital. Using convenience sampling, parents of all children w …

12.08.2026journal-article

JMIR Rehabilitation and Assistive Technologies

Usability and Functional Outcomes of the Obi3 Robotic Feeding Device Among People With Disabilities, Caregivers, and Providers: Mixed Methods Study

Andrea D Fairman, Ryan B Osal, Heather Keeton, Jonathan P Dekar

Background Loss of self-feeding ability due to severe bilateral upper extremity motor impairment (BUEMI) limits functional independence with a critical activity of daily living, increases medical risks, reduces social participation, and affects overall well-being. Robotic feeding devices are an emerging category of assistive technology. OObi3 is a third-generation, robotic feeding device, regulated in the United States as a Class I medical device and CE marked as a Class I device under the European Union Medical De …

12.08.2026journal-article

Genetics and Molecular Research

EFFECTIVENESS OF BILATERAL NEUROMUSCULAR TRAINING IN COMBINATION WITH CONVENTIONAL REHABILITATION ON STRENGTH, POWER, BALANCE, AND AGILITY IN YOUNG ADULTS POST-ACL RECONSTRUCTION: A RANDOMIZED CONTROLLED TRIAL

Dr Aseem Yadav, Prof. Dr Anand Mishra, Prof. Dr Bhupesh Goyal, Dr. Himani Swami, Dr. Anil Saini, Prof. Dr Gaurav Bhatnagar

Background: Knee stability following an ACL injury is usually restored through an anterior cruciate ligament reconstruction (ACLR). However, after conventional rehabilitation, ACLR people still have residual deficits in muscle strength, lower limb power, balance, and agility. Overcoming musculoskeletal dysfunction through effective rehabilitation may result from bilateral neuromuscular training that enhances sensorimotor control, proprioception, and performance. Objective: This study aimed to compare the effectiven …

12.08.2026journal-article

Journal of Clinical Medicine

Virtual Reality-Assisted Rehabilitation for Adolescents with Cerebral Palsy: A Systematic Review and Meta-Analysis

Te-Wei Chen, Yu-Ching Lin

Background/Objectives: Cerebral palsy is a lifelong neurodevelopmental condition associated with motor impairment and activity limitation, and adolescence is a clinically important period during which functional decline or plateau may occur. Virtual reality-assisted rehabilitation may provide task-specific practice with augmented feedback and enhanced engagement. This systematic review and meta-analysis aimed to evaluate the effects of virtual reality-assisted rehabilitation on functional outcomes in adolescents ag …

12.08.2026journal-article

Смоленский медицинский альманах

ПОКАЗАТЕЛИ ЭЛЕКТРОЭНЦЕФАЛОГРАФИИ ДЕТЕЙ 11-15 ЛЕТНЕГО ВОЗРАСТА С ДЕФЕКТАМИ РЕЧИ, ВОСПИТЫВАЮЩИХСЯ В УЧРЕЖДЕНИЯХ СОЦИАЛЬНОЙ СФЕРЫ ДЛЯ НЕСОВЕРШЕННОЛЕТНИХ

В. Н. Шестакова, П. Н. Свобода, Т. Г. Морозова, В. А. Глущенко, Д. А. Захарова, П. С. Гапошкина

В структуре соматической патологии у детей с дефектами речевого развития, чаще возникают сочетанные неврологические заболевания, особенно при дислексических проявлениях. Среди неврологической патологии главное значение имеет малая церебральная дисфункция, особенности которой необходимо подтверждать не только клиническими методами, но и методами ультразвуковой и лучевой диагностиками, включая электроэнцефалографию. Это дает возможность акцентировать внимание на изменении со стороны амплитуды ритмов, что позволяет в …

12.08.2026journal-article

Multimedia Tools and Applications

Audio-guided articulatory distillation for multilingual visual speech recognition with large language model decoding

Bogdan Mocanu, Ruxandra Tapu

Abstract Visual Speech Recognition (VSR) remains challenging in multilingual and low-resource settings due to visual ambiguity, limited annotated data, and weak cross-lingual generalization. This paper introduces an audio-guided distillation framework for multilingual VSR that exploits synchronized audio-visual speech during training while preserving visual-only inference. The proposed architecture consists of an audio-visual teacher that learns articulation-aware representations from aligned acoustic and video str …

12.08.2026journal-article

European Journal of Nuclear Medicine and Molecular Imaging

Comparative assessment of KDIGO and CTCAE criteria for detecting renal function deterioration after peptide receptor radionuclide therapy

Sophie C. Siegmund, Mohamed Salem, Elma Dema, Liam Widjaja, Franz Josef Gildehaus, Christine Spitzweg, Christoph J. Auernhammer, Matthias Brendel, Rudolf A. Werner

Abstract Purpose Renal toxicity after peptide receptor radionuclide therapy (PRRT) is commonly assessed using Common Terminology Criteria for Adverse Events (CTCAE), whereas nephrological classification relies on Kidney Disease: Improving Global Outcomes (KDIGO)-based renal function categories. We compared CTCAE- and KDIGO-derived eGFR cr -based definitions of renal function deterioration after PRRT and evaluated their predictive value for subsequent long-term renal outcome. Methods 149 gastroenteropancreatic neuro …

12.08.2026journal-article

Frontiers in Drug Safety and Regulation

Deprescribing and Anti-CGRP preventive therapy in medication-overuse headache associated with migraine: pathophysiological rationale and single-center real world evidence

Matija Sošić, Valentino Rački, Almir Fajkić, Mladen Jašić, Andrej Belančić

Medication-overuse headache (MOH) associated with migraine is a biologically driven disorder involving central sensitization, maladaptive neuroplasticity, and enhanced calcitonin gene-related peptide (CGRP) signaling. While structured deprescribing addresses medication-related drivers, withdrawal alone often provides limited and unsustained benefit. Anti-CGRP preventive therapies offer targeted modulation of migraine pathways without reinforcing medication overuse. This study integrates pathophysiological insights …

12.08.2026journal-article

Frontiers in Psychiatry

Effects of occupational therapy on psychiatric symptoms and social functioning in patients with schizophrenia: a systematic review and meta-analysis

Liping Sun, He Teng, Liru Zhang, Xuebin Gao, Wenhang Li, WenLong Jiang, Linlin Song, Qian Xu

Objective The present study aimed to systematically evaluate the impact of occupational therapy on the psychiatric symptoms and social functions of patients with schizophrenia. Methods A comprehensive literature search was conducted in CNKI, Wanfang Data, VIP Database, PubMed, Web of Science, the Cochrane Library, and Embase from 2015 to February 2026. Randomized controlled trials (RCTs) of occupational therapy assessing its impact on mental symptoms and social functioning in patients with schizophrenia were includ …

12.08.2026journal-article

B-ENT

Timing of Hyperbaric Oxygen Therapy in Idiopathic Sudden Sensorineural Hearing Loss

Osman Türkmen, Selçuk Tatar, Recep Özkan, Gamze Aydın

Background: To evaluate the efficacy of hyperbaric oxygen therapy (HBOT) in the treatment of idiopathic sudden sensorineural hearing loss (ISSNHL), with particular emphasis on the impact of treatment initiation timing. Methods: This retrospective study included 127 patients with ISSNHL who received HBOT at the Ankara Etlik City Hospital, between February 2023 and August 2024. Patients were categorized into 3 groups based on treatment initiation time: Group 1 (0-14 days), Group 2 (15-30 days), and Group 3 (>30 days) …

12.08.2026journal-article

Artefactum - revista de estudos interdisciplinares

ADJUNCTIVE PHOTODYNAMIC THERAPY IN THE ENDODONTIC TREATMENT OF A PERMANENT MOLAR WITH CHRONIC APICAL ABSCESS: A CASE REPORT

Victor Oliveira de Andrade, Ericka Rodrigues de Oliveira, Kleber Maia Pereira

Introduction: Antimicrobial photodynamic therapy (aPDT) has been proposed as an adjunct to chemomechanical preparation because light activation of a photosensitizer generates reactive oxygen species and may enhance antimicrobial action in areas that are difficult to reach within the root canal system. Objective: To report the adjunctive use of aPDT during root canal treatment of a permanent molar with chronic apical abscess. Case report: A 10-year-old female patient presented with an extensive carious lesion, a sin …