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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
12.08.2026journal-article

B-ENT

Timing of Hyperbaric Oxygen Therapy in Idiopathic Sudden Sensorineural Hearing Loss

Osman Türkmen, Selçuk Tatar, Recep Özkan, Gamze Aydın

Background: To evaluate the efficacy of hyperbaric oxygen therapy (HBOT) in the treatment of idiopathic sudden sensorineural hearing loss (ISSNHL), with particular emphasis on the impact of treatment initiation timing. Methods: This retrospective study included 127 patients with ISSNHL who received HBOT at the Ankara Etlik City Hospital, between February 2023 and August 2024. Patients were categorized into 3 groups based on treatment initiation time: Group 1 (0-14 days), Group 2 (15-30 days), and Group 3 (>30 days) …

12.08.2026journal-article

Artefactum - revista de estudos interdisciplinares

ADJUNCTIVE PHOTODYNAMIC THERAPY IN THE ENDODONTIC TREATMENT OF A PERMANENT MOLAR WITH CHRONIC APICAL ABSCESS: A CASE REPORT

Victor Oliveira de Andrade, Ericka Rodrigues de Oliveira, Kleber Maia Pereira

Introduction: Antimicrobial photodynamic therapy (aPDT) has been proposed as an adjunct to chemomechanical preparation because light activation of a photosensitizer generates reactive oxygen species and may enhance antimicrobial action in areas that are difficult to reach within the root canal system. Objective: To report the adjunctive use of aPDT during root canal treatment of a permanent molar with chronic apical abscess. Case report: A 10-year-old female patient presented with an extensive carious lesion, a sin …

12.08.2026journal-article

Frontiers in Education

The role of organizational and psychological effect on teachers’ occupational stress

Anna Cheng, Nur Fauziyah, Junaidi Junaidi

Introduction Occupational stress among college teachers is a growing concern, particularly in emerging economies with rapidly expanding academic institutions. This study explores how job satisfaction, psychological ownership, work-family conflict, scientific research pressure, organizational justice, and organizational support affect teachers’ occupational stress. Method A total of 633 valid responses the questionnaires and Structural Equation Modelling (SEM) were used to test research constructs and hypotheses. Re …

12.08.2026journal-article

Frontiers in Oncology

Longitudinal evaluation of health-related quality of life in Chinese patients with early-stage HER2-positive breast cancer undergoing neratinib extended adjuvant therapy: a real-world prospective cohort study

Xuanhua Liang, Zibai Guo, Jinhong Wei, Anping Gui, Mengru Jian, Jie Min, Mengwen Wang, Shihui Ma

Background Neratinib, an irreversible pan-HER tyrosine kinase inhibitor, is a well-established extended adjuvant therapy for early-stage human epidermal growth factor receptor 2-positive (HER2+) breast cancer. However, its clinical application is often constrained by the high incidence of treatment-related diarrhea. This study sought to assess the dynamic changes in health-related quality of life (HRQoL) and the tolerability of neratinib, with a particular focus on dose escalation strategies and anti-diarrheal prop …

12.08.2026journal-article

International Journal of Computer Information Systems and Industrial Management Applications

Model Development and Validation for Repetition Severity Assessment in Stuttered Speech Using Clinical Speech Datasets

Pooja J N, H Y Vani, Rakshith P, M A Anusuya, Swetha P M

Stuttering disrupts the forward flow of speech through involuntary repetitions, prolongations, and blocks, with repetitions being the most common and clinically telling of the three. Quantifying how severe those repetitions are matters for diagnosis, therapy planning, and tracking whether treatment is actually working. The catch is that severity has long been judged by ear, by trained speech-language pathologists counting disfluent events and assigning ratings on standardised scales. That process is slow, variable …

12.08.2026journal-article

Acción Psicológica

Efectividad y abandono de la Terapia Dialéctico-Conductual en el Trastorno Límite de la Personalidad: una revisión sistemática

Evelin Astrid Calva Camacho, Angie Nicolle Ortiz Bastidas

El presente trabajo constituye una revisión sistemática orientada a analizar la efectividad y las tasas de abandono de la Terapia Dialéctico-Conductual (DBT) en adultos con Trastorno Límite de la Personalidad (TLP). Se siguieron las directrices PRISMA 2020 y se realizaron búsquedas en PubMed, Scopus y ScienceDirect, considerando estudios publicados entre 2014 y 2024. Tras el proceso de identificación, cribado y elegibilidad, se incluyeron 10 estudios que evaluaron la DBT como intervención principal y reportaron res …

12.08.2026journal-article

Science and Innovation

A SOCIO-COGNITIVE-PRAGMATIC ANALYSIS OF POLITENESS AND ADDRESS FORMS IN THE SPEECH OF A DIALECTAL LINGUISTIC PERSONALITY: EVIDENCE FROM SAMARKAND UZBEK

Sh Normuminov

This study examines the socio-cognitive and pragmatic organization of politeness and address forms in the speech of dialectal linguistic personalities in the Samarkand Region of Uzbekistan. The empirical basis is field material collected from 112 native speakers in Samarkand city and several districts of the region between 2024 and 2026 through participant observation and spontaneous everyday interaction. The analysis is explicitly qualitative and does not make population-level frequency claims. The analysis integr …

12.08.2026journal-article

Renal Replacement Therapy

Successful management of acquired hemophilia A with life-threatening bleeding and MRSA bacteremia in a hemodialysis patient: importance of a multimodal approach

Naokazu Sato, Masako Omata, Ryujiro Hara, Nene Yamakawa, Takumi Seto, Masahiro Yoneyama, Nanao Shimada, Kiichi Obata, Junji Shichi, Takeshi Yamagiwa, Yoshiyuki Yoshida, Naoki Goto, Hideyuki Katori

Abstract Background Acquired hemophilia A (AHA) is a rare and fatal bleeding disorder. AHA in patients undergoing hemodialysis (HD) often leads to impaired hemostasis, necessitating temporary catheters that increase the risk of catheter-related infection. This complication hinders the use of immunosuppressive therapy, often resulting in treatment failure. We herein report the case of AHA in a patient undergoing HD with life-threatening bleeding and MRSA bacteremia, which was successfully managed with a multimodal a …

12.08.2026journal-article

Journal of Endovascular Therapy

Immediate Ultrasound Confirmation With Rescue Compression for Femoral Hemostasis After Endovascular Therapy for Lower Extremity Artery Disease

Kazuki Haraguchi, Hisashi Koga, Tomohiro Kawasaki

Background: Femoral artery pseudoaneurysm (FAP) is a recognized complication following endovascular therapy (EVT). Routine ultrasound surveillance has been criticized for inflating reported FAP incidence (surveillance bias). We hypothesized that ultrasound could be repurposed from passive surveillance to an active “confirmation and rescue” strategy to detect and correct incomplete hemostasis immediately. Methods and Results: We retrospectively analyzed 1002 consecutive patients undergoing femoral access EVT for low …

12.08.2026journal-article

The Cleft Palate Craniofacial Journal

Child and Parent-Reported Outcomes in Children Historically Managed as Nonsyndromic Pierre Robin Sequence: Feeding, Speech, and Sleep-Disordered Breathing

Bruno Matos Santos, Alexis Poirier, Hassan Youssef, Anthony S. de Buys Roessingh

Objective To assess child- and parent-reported quality of life and functional outcomes in children managed as nonsyndromic Pierre Robin sequence (nsPRS), using child-reported and parent-reported outcome measures. Design Retrospective observational cross-sectional study. Setting Single tertiary craniofacial center. Participants Children aged 11-20 years followed for nsPRS between 2010 and 2021. Twelve child-parent dyads participated. A pre-specified sensitivity analysis was restricted to children meeting strict nsPR …

12.08.2026journal-article

Journal of Experimental Medicine

Receptor-tethered orthogonal IL-2 enhances regulatory T cell therapy

Alyssa C. Indart, Huiyun Lyu, Vinh Q. Nguyen, Wendy Rosenthal, Jatin R. Palvai, Sophie S. Jang, Yue Chen, Kevin Jude, Leon Su, K. Christopher Garcia, Jeffrey A. Bluestone, Qizhi Tang

Regulatory T cell (Treg) therapy is an emerging platform for controlling immune overactivation. Persistence of infused Tregs is limited by insufficient IL-2, which is essential for Treg survival and function. IL-2 activates many immune cells, imposing a challenge for the selective provision of IL-2 to infused Tregs. In this study, we found that infusions of orthogonal (ortho) IL-2 failed to enhance Tregs expressing a corresponding orthoIL-2 receptor (IL-2R) in a mouse model of autoimmune diabetes. Engineering Tregs …

12.08.2026journal-article

Language and Speech

Tracking L2 English Vowel Perception and Production Among Graduate Professionals Over 18 Months

Inyoung Na, Charlie Nagle, Mahdi Duris, John M. Levis, Sebnem Kurt, Ivana Rehman

This study investigates changes in English vowel perception and production among 22 advanced-proficiency second-language (L2) learners from diverse first-language (L1) backgrounds over 18 months at a large U.S. university, with a particular focus on the influence of the L2 English-speaking environment and the impact of the COVID-19 pandemic. The study employed Bayesian mixed-effects models to analyze participants’ vowel identification accuracy using a perception oddity task and vowel production (intelligibility) ac …

12.08.2026journal-article

Cancer Biome and Targeted Therapy

Reprogramming CAR-T Cell Therapy for Solid Tumors: Combination Strategies to Overcome Resistance

Wei Cheng, Mei-Lan Liu, Yu-Hua Diao, Bing-Kun Chen, Yi-Peng Wen, Chi Zhang, Man-Ting Liu, Zi-Qi Shao, Jian-Yu Cai, Bihui Cao

Chimeric antigen receptor T (CAR-T) cell therapy has achieved unprecedented clinical success in hematologic malignancies, yet translating these outcomes to solid tumors has proven substantially more challenging. Unlike blood cancers, solid tumors present multiple interconnected barriers, including antigen heterogeneity, inefficient trafficking and infiltration, physical stromal constraints, metabolic competition, and profoundly immunosuppressive tumor microenvironments that collectively limit CAR-T cell persistence …

12.08.2026journal-article

Frontiers in Psychology

A theory-driven rationale for EMDR therapy among patients with a personality disorder

Christina W. Slotema, Ad de Jongh

Personality disorders (PDs) are prevalent and debilitating conditions characterised by enduring disturbances in self-functioning, affect regulation, impulse control, and interpersonal relationships. Although several evidence-based psychotherapies are available, their accessibility and efficiency remain limited due to long treatment durations, high intensity, substantial dropout rates, and restricted treatment capacity. The purpose of the present paper is to present an alternative developmental and treatment perspec …

12.08.2026journal-article

Смоленский медицинский альманах

ГИПОЛИПИДЕМИЧЕСКАЯ ТЕРАПИЯ НА АМБУЛАТОРНОМ ЭТАПЕ: ОТ ЖЕЛАЕМОГО К ВОЗМОЖНОМУ

А. П. Копич, К. Д. Володченкова

. Анализ результатов изучения амбулаторных карт и опроса 109 пациентов показал: несмотря на то, что 96% принимают известный препарат «аторвастатин», только 33% помнят название медикамента, и лишь единицы знают свою цель по холестерину. Отмечена связь комплаентности с возрастом и полом пациентов. Выявлена закономерность: больные, которым меняли схему лечения, в частности дозу препарата, оказались более информированными, чем остальные. При этом длительность приема никак не влияла на знания. Низкая комплаентность явля …

12.08.2026journal-article

Iranian Rehabilitation Journal

Retracted Article: Investigating the Effects of Dexteria App Therapy on Hand Function in Subacute Stroke Survivors

Siddharth S Mishra

Objectives: Hand function impairment causes limitations in activities of daily living among stroke survivors. Dexteria app therapy is a game-based therapy with the use of a touchscreen gadget that involves various hand movements. This study evaluates the effect of Dexteria app therapy on hand function in sub-acute stroke survivors. Methods: This study included 26 subacute stroke survivors, randomly allocated into 2 groups as follows: Group A (n=13) received conventional hand therapy while group B (n=13) received De …

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12.08.2026journal-article

Journal of Neurological Disorders and Stroke

Intravascular Lithotripsy as Salvage Therapy for Heavily Calcified Carotid Artery Stenosis during Carotid Artery Stenting: A Case Report

Diego A. Hernandez, Rodrigo Avila, Alexa Zuloaga, Jimena Gonzalez Salido, Niels Pacheco, Luis R. Virgen

Stroke remains a leading cause of death and disability worldwide. In appropriately selected patients with symptomatic carotid artery stenosis, carotid artery stenting (CAS) is an established strategy for stroke prevention. However, severe vascular calcification may limit adequate lesion preparation, resulting in suboptimal stent expansion, thereby compromising procedural success. Although intravascular lithotripsy (IVL) has emerged as a plaque-modification technique for heavily calcified vascular lesions, clinical …

12.08.2026journal-article

Journal of Endovascular Therapy

Multicentre Cohort of Acute Type B Intramural Haematoma: Outcomes and Predictors of Aortic Complications

Thomas Mesnard, Arthur Leroux, Alexandre Rossillon, Benjamin O. Patterson, Guillaume Badot, Blandine Maurel, Nicla Settembre, Justine Mougin, Stephan Haulon, Antoine Millon, Jonathan Sobocinski, Association Universitaire de Recherche en Chirurgie (AURC)

Purpose: To analyse predictors of aortic complications (ACs) and outcomes of patients admitted for acute type B intramural haematoma (IMH-B). Methods: A retrospective analysis of data of patients diagnosed with acute IMH-B from 7 French tertiary centres between December 2003 and December 2019 was conducted. Baseline demographics, initial anatomical features, indication and treatment modality during the acute phase including either thoracic endovascular aortic repair (TEVAR) and optimal medical therapy (OMT) or OMT …

12.08.2026journal-article

Cancer Biome and Targeted Therapy

Exosomal Non-Coding RNAs Orchestrate Immune-Metabolic Networks in Triple-Negative Breast Cancer

Huixin Chen, Rong Luo, Jiakang Ma, Weiheng Cui, Hongzheng Ren, Shuyao Zhang, Yunlong Pan, Ruijun Zhao, Wei Xiong, Hao Zhang, Hongmei Dong

Triple-negative breast cancer (TNBC) is characterized by the absence of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) expression, limiting the applicability of endocrine and HER2-targeted therapies. Clinically, TNBC exhibits marked molecular heterogeneity, aggressive behavior, early metastatic dissemination, and poor prognosis relative to other breast cancer subtypes. Increasing evidence indicates that the tumor microenvironment (TME) plays a central role in …

12.08.2026journal-article

Revista Ibero-Americana de Humanidades, Ciências e Educação

COMPARAÇÃO ENTRE A QUIMIOTERAPIA E O USO DE RIBOCICLIBE ASSOCIADO À HORMONIOTERAPIA NO TRATAMENTO DO CÂNCER DE MAMA

Laís Helena de Sousa Tavares, Maria Eduarda Santos de Moraes, Giovana Cunha dos Santos, Vitória da Silva Espindola, Silvia Fontes do Amaral Pereira

Esta revisão integrativa da literatura avaliou as evidências disponíveis sobre a eficácia do ribociclibe associado à hormonioterapia, em comparação à quimioterapia convencional, na sobrevida livre de progressão de mulheres com câncer de mama avançado ou metastático. A pergunta norteadora foi estruturada com base na estratégia PICO, contemplando mulheres adultas e idosas com câncer de mama avançado ou metastático, o uso de ribociclibe associado à hormonioterapia, a quimioterapia convencional como comparador e a sobr …

12.08.2026journal-article

Смоленский медицинский альманах

УСТОЙЧИВОСТЬ БАКТЕРИЙ К АНТИБИОТИКАМ: ТЕКУЩЕЕ СОСТОЯНИЕ ПРОБЛЕМЫ И РОЛЬ ФАГОТЕРАПИИ В ЕЕ ПРЕОДОЛЕНИИ

Д. В. Махсудова

Проводя анализ данных Всемирной организации здравоохранения о распространении на глобальном уровне антибиотикорезистентности и рассматривая эффективность бактериофагов, как альтернативный метод терапии, авторы обосновывают необходимость внедрения новых стратегий борьбы с бактериальными инфекциями. В работе выявлены основные факторы прогрессирования резистентности, описаны преимущества фаготерапии. Особое внимание уделено эффективности комбинированного применения бактериофагов с антибиотиками, для преодоления лекарс …

12.08.2026journal-article

Смоленский медицинский альманах

АНАЛИЗ УДОВЛЕТВОРЕННОСТИ БОТУЛИНОТЕРАПИЕЙ У ПАЦИЕНТОВ С ЦЕРВИКАЛЬНОЙ ДИСТОНИЕЙ

Е. А. Кислякова, А. В. Матусевич, М. В. Скоблова

Цель. Оценить клиническую эффективность, профиль нежелательных явлений и удовлетворённость пациентов с цервикальной дистонией результатами ботулинотерапии. Методика. В исследование включено 24 пациента с цервикальной дистонией, находящихся на лечении ботулотоксином типа А. Для сбора данных использовалась специально разработанная анкета по оценке субъективной эффективности ботулинотерапии, удовлетворенности лечением, характере нежелательных явлений и визуально аналоговая шкала для оценки болевого синдрома. Результат …

12.08.2026journal-article

Journal of Speech, Language, and Hearing Research

Multi-Atlas–Based Segmentation of Pediatric Vocal Tract Anatomy in Dynamic Magnetic Resonance Imaging

Hahn Kang, Fangxu Xing, Imani R. Gilbert, Jiyoon Kim, Abigail Kostolansky, Bradley Sutton, Jonghye Woo, Jamie L. Perry

Purpose: Segmentation of velopharyngeal and vocal tract anatomy is crucial for quantifying structures and analyzing dynamics during speech. Automatic methods are needed to replace labor-intensive and poorly reproducible manual segmentation. To address this, we compared four multi-atlas–based methods to determine which provides the most accurate segmentation of the tongue, velum, and adenoid and how segmentation accuracy varies with the number of temporal frames. Method: Five spatiotemporal atlases of speech tasks w …

12.08.2026journal-article

Health, sport, rehabilitation

Velocity-based functional strength training on neuromuscular performance in kabaddi players: a randomized controlled trial

Suba Murugan, Navaraj Rajkumar, Jun Mizushima, Priyanka Rana, Anoop Kumar, Neena Thekkan, Swamynathan Sanjaykumar

Background and Purpose Kabaddi demands explosive power, sprint speed, and rapid changes of direction. Traditional strength training improves maximal strength but may not optimize sport-specific performance. This study evaluated the effects of a 12-week Velocity-Based Functional Strength Training (VBFST) programme on countermovement jump, 20-m sprint, and 505 change-of-direction performance in elite male kabaddi players. Material and Methods Thirty elite male kabaddi players (18-25 years) were randomly divided into …