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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
22.08.2026journal-article

BMC Cancer

Prognostic relevance of ZEB1, ZEB2 and CD105 expression in breast carcinomas

Fatih Demir, Zeliha Esin Çelik, Harun Yonar, Özge Keskin, Özlem Yavaş Ata

Abstract Background The epithelial–mesenchymal transition (EMT) transcription factors ZEB1 and ZEB2 play critical roles in cancer progression and metastasis. CD105 (endoglin), a marker of neovascularization, has also been implicated in tumor aggressiveness. However, their combined prognostic and clinicopathological relevance in breast carcinoma remains underexplored. Methods We evaluated ZEB1, ZEB2, and CD105 expression in the epithelial compartment of the tumor and tumor stroma via immunohistochemistry in 258 inva …

22.08.2026journal-article

Journal of Clinical Medicine

Machine Learning-Based Comparison of Non-Contrast ASL and DSC-MRI Perfusion for Differentiating Recurrent High-Grade Glioma from Treatment Effects

Seyit Erol, Halil Özer, Abdussamet Batur, Mehmet Sedat Durmaz, Abidin Kılınçer, Emine Uysal, Hakan Cebeci

Background/Objectives: Differentiating high-grade glioma recurrence from treatment-related changes remains challenging on conventional MRI. This study evaluated non-contrast arterial spin labeling (ASL) perfusion MRI for this distinction and compared its performance with dynamic susceptibility contrast (DSC) perfusion MRI. Methods: Postoperative follow-up MRI examinations obtained between November 2019 and May 2021 were retrospectively reviewed. The cohort included 63 MRI examinations from 36 adults treated for hig …

22.08.2026journal-article

Journal of Veterinary Dentistry

Full Metal Crown for the Treatment of a Damaged Restoration in an Alaskan Brown Bear ( Ursus arctos gyas )

Grace K. Brown

The purpose of this article is to provide a step-by-step description of the creation and cementation of a full metal crown to restore a damaged maxillary canine tooth in an Alaskan brown bear. It outlines the complete process, including obtaining a tooth-specific impression, fabricating the full metal crown, and performing the final cementation procedure. The goal is to ensure long-term durability, structural integrity, and functional strength of the restored tooth.

22.08.2026journal-article

Journal of Family Nursing

Family Systems and Cultural Adaptation in Psychosocial Cancer Interventions for Latinx Families: A Critical Review

Nicole M. Vélez Agosto, Gladys Stephanie Hernandez, Sarah Chavez Chacon, Danielle Moreno, Cecilia Montiel-Nava

Cancer creates significant distress to Latinx family dynamics. Research on family interventions has omitted critical aspects that could significantly improve mental health outcomes in this vulnerable population, including the development of interventions with a robust theoretical framework that are simultaneously culturally aligned with deeply rooted Latinx values. This critical review addressed existing psychosocial interventions for families with a cancer patient, their strengths, and limitations. It expanded on …

22.08.2026journal-article

Nicotine & Tobacco Research

Stakeholder perspectives on community tobacco use and the implementation of tobacco use treatment in Eastern Ethiopia: a qualitative study

Maleda Tefera, Shiferaw Letta, Jennifer H LeLaurin, Rahma Mkuu, Tara Wilfong, Abebe Tolera, Magda Montague, Dima Bteddini, Rima Nakkash, Damen Haile Mariam, Ramzi G Salloum

Abstract Background Smoking tobacco causes over 8 million deaths annually and is the leading cause of non-communicable diseases globally. In Eastern Ethiopia, tobacco use is culturally ingrained, often combined with alcohol and khat use. This study explores stakeholders’ experiences addressing tobacco use in the region, aiming to identify obstacles and opportunities for implementing telephone counseling as an evidence-based strategy to support tobacco cessation. Methods This is a qualitative descriptive study using …

22.08.2026journal-article

Diseases of the Esophagus

PD07.05. Tumor Enlargement on CT During Neoadjuvant Chemotherapy Predicts Poor Prognosis After Esophagectomy

Kengo Kanetaka, Shinichiro Kobayashi, Shunsuke Murakami, Kentaro Kubo, Kunihito Matsuguma, Yasumasa Hashimoto, Keiko Hamasaki, Junichi Arai, Kazuma Kobayashi, Susumu Eguchi

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background Although there have been reports on the use of PET/CT for evaluating the therapeutic effects of preoperative neoadjuvant chemotherapy for esophageal cancer, issues remain regarding insurance coverage. Additionally, the histopathological evaluation after resection is based on the percentage of cancer cells in tissue sections, so when chemotherapy causes the entire tumor to shrink, there can be a discrepancy with the clinical impression. …

22.08.2026journal-article

Diseases of the Esophagus

P1.210. Improving Quality of Life in Resectable Oesophageal Cancer Patients Through Perioperative Allied Health Interventions: A Systematic Review

Josipa Petric, Ravi Vissapragada, Steven Tran, David Watson, Norma Bulamu

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications Background In patients with resectable disease, the 5-year survival is higher, with a rate of 44-52% for those who have undergone an esophagectomy, however there is an overall decline in global health-related quality of life (HRQOL). Perioperative exercise and nutrition interventions, such as prehabilitation, may help to improve HRQOL. Methods A systematic literature search of MEDLINE (OVID), PubMed, CINAHL, …

22.08.2026journal-article

Diseases of the Esophagus

P1.099. Esophageal Cancer After Distal Gastrectomy

Naoki Hashimoto

Abstract Topic Esophageal Cancer: Esophageal Carcinogenesis Background The effect of gastrectomy on the subsequent development of esophageal cancer was investigated. Duodenogastroesophageal reflux is thought to be common in patients after distal gastrectomy, but whether this contributes to the development of esophageal cancer in such patients is controversial. Methods We retrospectively evaluated 153 patients who underwent subtotal esophagectomy for thoracic esophageal cancer for the past three years. They were div …

22.08.2026journal-article

Diseases of the Esophagus

PD09.06. Frailty in Patients Undergoing Esophagectomy for Cancer Is Associated With Complication Cascade and Failure to Rescue

Lye Yeng Wong, Ernest Chan, Tyler Wilson, Vivek Prachand, Mitchell Posner, Sang Mee Lee, Mark Ferguson

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications Background Esophagectomy is poorly tolerated in frail patients. Frailty is associated with decreased resilience, resulting in "failure to rescue" (FTR) after a complication. This study investigates the intersection between frailty and FTR in patients undergoing this operation and introduces the concept of the Complication Cascade in the setting of esophagectomy. Methods This is a single-institution retrospec …

22.08.2026journal-article

Diseases of the Esophagus

PD04.01. Multimodal Treatment Strategies Incorporating Conversion Therapy for Thoracic Esophageal Cancer With Adjacent Organ Invasion

Kohei Kanamori, Rie Nakashima, Kohei Tajima, Mika Ogimi, Yamato Ninomiya, Yoshiaki Shoji, Akihito Kazuno, Miho Yamamoto, Takayuki Nishi, Kazuo Koyanagi

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background Management of thoracic esophageal cancer with suspected adjacent organ invasion remains challenging because of diagnostic uncertainty and limited curative options. Recent advances in induction chemotherapy, including DCF and immune checkpoint inhibitors, have enabled downstaging and subsequent conversion to curative-intent treatment in selected patients. Methods We retrospectively reviewed 57 patients with locally advanced, initial …

22.08.2026journal-article

International Journal of Recent Engineering Science

Optimization of Dye Concentration and Energy Consumption in Electrochemical Treatment of Reactive Blue 19 Textile Effluent for Efficient Color and COD Removal

Dave Ami N, U K Khare

The present study introduces a novel investigation into the electrochemical treatment of synthetic Reactive Blue 19 dye using aluminium electrodes in batch mode, with particular emphasis on optimizing operational parameters such as retention time, electrolysis time, and initial dye concentration to enhance process performance. Unlike conventional studies, this work highlights the comparative stability and performance at varying concentrations (50 and 100 mg/L), demonstrating maximum Color Removal Efficiencies (CRE) …

22.08.2026journal-article

International Journal of Molecular Sciences

Protease-Activated Receptor-2 as a Proteolytic Rheostat in Colorectal and Pancreatic Cancer: From Mechanism to Biomarker-Guided Therapy

Hodasadat Tabatabaei Yeganeh, Malak Sellat, Zayd Anis, Reine Chiri, Rajashree Patnaik, Shloka Gambhir, Yajnavalka Banerjee

Protease-activated receptor-2 (PAR-2; encoded by F2RL1) is emerging as a context-dependent driver of gastrointestinal cancer. Activated by irreversible N-terminal cleavage, its signalling output is not fixed but is calibrated by the identity and source of the activating protease, the receptor cleavage state, cellular context and biased coupling to G-protein αq (Gαq), G-protein α12/13 (Gα12/13) and β-arrestin. PAR-2 is best understood not as a simple inflammatory receptor but as a proteolytic rheostat that converts …

22.08.2026journal-article

International Journal of Molecular Sciences

Biosynthesis of Phosphatidylethanolamine and Phosphatidylcholine via the Kennedy Pathway in Cancer and Other Pathological Conditions

Jan Korbecki, Mateusz Bosiacki, Mikołaj Chlubek, Edyta Dzięciołowska-Baran, Michał Lubkowski, Krystyna Kabacińska, Katarzyna Barczak

The de novo biosynthesis of two major glycerophospholipids, phosphatidylethanolamine and phosphatidylcholine, occurs through the Kennedy pathway. In this process, ethanolamine or choline is initially phosphorylated to phosphoethanolamine or phosphocholine, respectively, and subsequently converted by cytidylyltransferases into CDP-ethanolamine and CDP-choline. Dysregulation of this pathway has been implicated in various diseases. This review provides a comprehensive overview of the enzymatic components of the Kenned …

22.08.2026journal-article

Universa Medicina

Targeting tumor associated macrophages to alternate cancer stem cells and tumor microenvironment milieu

Mahdaleny Mahdaleny, Septelia Inawati Wanandi, Noorwati Sutandyo, Febriana Catur Iswanti

Macrophages in the tumor microenvironment are involved in promoting cancer growth and enabling it to evade therapies. By acting as something like a tumor's "underground," these cells dampen down the "calls for help" that chemotherapy or radiotherapy might otherwise trigger. They also appear to enable some cells in the cancers to reset themselves into cancer stem cells (CSCs), allowing them to divide and differentiate. Cancer stem cells are compelled to initiate tumors and maintain their growth. In part, the tumor-a …

22.08.2026journal-article

Diseases of the Esophagus

P1.227. A Composite Body Composition Score Independently Predicts Long-Term Survival After Esophagectomy for Cancer

Tyler Wilson, Ernest Chan, Jules Lin, Sang Mee Lee, Brian Derstine, Stewart Wang, Mark Ferguson

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – long term outcomes Background Body composition (BC) measures are established determinants of esophageal cancer outcomes. Beyond known survival predictors such as cancer stage and performance status, a composite BC score independently predicts post-resection survival in lung cancer. We adapted this score for esophageal cancer patients to evaluate its association with long-term survival following esophagectomy. Methods This is a single-instit …

22.08.2026journal-article

Diseases of the Esophagus

P1.251. Minimally Invasive Technique of Esophagojejunal Reconstruction After Extended Total Gastrectomy for OG Junction Cancer

Dr Ramakrishnan Parthasarathi, Prof C Palanivelu, Dr M Bharath Cumar, Dr S Saravana Kumar, Dr N Ramesh, Dr Jami Jami Yaswanth Sai

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – technique Background Esophagojejunal reconstruction following extended total gastrectomy for OG junction cancer is technically demanding due to limited lower mediastinal access and the requirement for a secure, tension-free anastomosis. Minimally invasive transhiatal approaches may reduce surgical morbidity while maintaining oncological adequacy. This study demonstrates the technical feasibility and surgical strategy of intracorporeal esoph …

22.08.2026journal-article

Diseases of the Esophagus

OA09.6. Multi-Society Clinical Practice Guideline for the Treatment of Adult Patients With Achalasia

Bright Huo, Sofia Tsokani, Milos Bjelovic, Sonia Fernandez-Ananin, Ivy Haskins, Geoffrey P Kohn, Siva Raja, Biniam Kidane, Zuzana Vackova, Irene Marafini, Suzanne Dore, Ian Tuddenham, Silvana Perretta, Aaron J Yu, Roi Anteby, Daniel Moritz Felsenreich, Dimitris Mavridis, Stephanie Sanger, Bethany J Slater, Xiaomei Yao, Stavros A Antoniou, Gordon Guyatt

Abstract Topic Benign Disease: Esophageal Function and Motility Background We developed multi-society recommendations addressing the question: should adult patients with achalasia receive botox, pneumatic dilation (PD), POEM, or Heller myotomy with fundoplication? Methods We performed a systematic review of randomized trials across PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials from inception to July 9th, 2025. We recruited an international, multidisciplinary panel including members from the …

22.08.2026journal-article

Diseases of the Esophagus

OA01.5. Preoperative Assessment of Fitness for Surgery in Patients Planned for Esophagectomy for Cancer, an International Survey to Uncover Current Practices

Ward Seurs, Yarno Verbeeck, Hans Van Veer, Stijn Vanstraelen, Philippe Nafteux, Lieven Depypere

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background Identifying high-risk patients through preoperative assessment of fitness is crucial to mitigate complications after esophagectomy for cancer. However, no international consensus currently exists on which investigations should be included in this assessment. This survey aimed to describe current international practices and explore attitudes towards standardization. Methods An international cross-sectional online survey consisting o …

22.08.2026journal-article

Diseases of the Esophagus

P1.125. Challenging a Histology-Led Paradigm: Comparable Real-World Survival After Definitive Non-Surgical Treatment in Oesophageal Adenocarcinoma and Squamous Cell Carcinoma

Mohammed AlHilali, Anthony Waton, Philip Atherton, Alexander Bradshaw

Abstract Topic Esophageal Cancer: Oncology/Radiation Therapy Background Histology is often treated as a surrogate for radiosensitivity in oesophageal cancer, sustaining the prevailing assumption that squamous cell carcinoma (SCC) benefits more from definitive chemoradiotherapy than adenocarcinoma (AC). We examined whether overall survival (OS) is better discriminated by histology within a fixed pathway, or by the delivered treatment pathway. Methods Retrospective 10-year single-centre regional cohort of oesophageal …

22.08.2026journal-article

Advanced Functional Materials

Membrane Protein‐Instructed Peptide Self‐Assembly for Cancer Therapy

Jiaying Zhang, Yanyan Zhou, Ruo‐Chen Guo, Junyan Du, Wenjun Zhan, Gaolin Liang

ABSTRACT Abnormal membrane proteins often play a crucial role in the development and progression of cancer, making them ideal targets for cancer treatment. However, traditional membrane protein inhibitor‐based therapies only benefit a small part of patients and suffer from notorious drug resistance due to their occupation‐driven pharmacology. Recently, membrane protein‐instructed peptide self‐assembly has emerged as a powerful tool in precision cancer treatment. Due to its unique merits such as high tumor targeting …

22.08.2026journal-article

World Journal of Urology

Clinical characteristics, treatment patterns, and survival outcomes in ductal prostate cancer: a multicenter retrospective analysis

A. Handke, P. Paffenholz, K. Schlack, K. E. Seifert, J. Linxweiler, J. Mink, F. Flockerzi, T. Nestler, M. Wenzel, C. Siech, C. Darr, V. Grünwald, F. Roghmann, K. H. Tully

Abstract Purpose Prostatic ductal adenocarcinoma (PDA) is a rare, aggressive prostate cancer subtype associated with advanced disease and poorer prognosis than acinar adenocarcinoma. Small ductal components influence management and preclude active surveillance. This study analyzed oncologic outcomes and therapeutic patterns in a multicenter German cohort. Methods Retrospective multicenter cohort, seven high-volume German centers. 82 patients with histologically confirmed PDA diagnosed 2014–2024 included. Histopatho …

22.08.2026journal-article

BMC Neurology

Patient perspectives from the BEYOND Delphi panel: burden of remaining symptoms and their fluctuations, despite treatment, in patients with generalised myasthenia gravis

Sophie Lehnerer, Maria Bonaria Uccheddu, Diana Sufragiu, Charlotte Carpenter, Daisy Bridge, Medi Stone, Camille Chassat, Anouska Jha, Gonçalo M.C. Rodrigues, Maartje Mangelaars, Wim Noel, Charlotte Gary, Francesco Saccà

Abstract Background Patients with generalised myasthenia gravis (gMG) can experience remaining symptoms despite treatment. Our study aimed to describe how remaining symptoms and their fluctuations may affect a person’s daily life while living with gMG. Methods A modified-Delphi panel (two survey rounds) was conducted with adult patients with gMG ( n =20) from seven European countries (France, Germany, Italy, the Netherlands, Sweden, Switzerland, and the UK). A scientific advisory committee including two neurologist …

22.08.2026journal-article

Diseases of the Esophagus

P1.225. The Impact of Metformin Use During Neoadjuvant Chemoradiotherapy in Esophageal Cancer Patients: A Propensity Score-Matched Nationwide Study

Taeyoung Yun, Chang Hyun Kang, Ji Hyeon Park, Kwon Jung Na, Samina Park, Hyun Joo Lee, In Kyu Park, Young Tae Kim

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – long term outcomes Background Our previous study suggested an association between metformin use and complete response rates in esophageal cancer patients undergoing neoadjuvant concurrent chemoradiotherapy (CCRT). This study aims to evaluate the impact of metformin use during neoadjuvant CCRT on overall survival (OS) and cancer-specific survival (CSS) in esophageal cancer patients undergoing surgery, using a nationwide database. Methods We …

22.08.2026journal-article

Diseases of the Esophagus

OA01.6. Reshaping Esophageal Cancer N Staging With a Target-Ring Burden Framework: A Multicenter Retrospective Study

Ruichen Cui, Xiang Li, Shenglu Lian, Yushang Yang, Longqi Chen

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – long term outcomes Background Given the limited integration of nodal count and spatial distribution in current esophageal cancer N staging, we sought to develop and validate a newN staging system that incorporates both dimensions. Methods We used prospectively maintained, retrospective databases from three centers (2008–2022). The primary endpoint was overall survival (OS). We constructed a Target–Ring Burden framework by computing Spearman …