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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
12.08.2026journal-article

Смоленский медицинский альманах

АНАЛИЗ УДОВЛЕТВОРЕННОСТИ БОТУЛИНОТЕРАПИЕЙ У ПАЦИЕНТОВ С ЦЕРВИКАЛЬНОЙ ДИСТОНИЕЙ

Е. А. Кислякова, А. В. Матусевич, М. В. Скоблова

Цель. Оценить клиническую эффективность, профиль нежелательных явлений и удовлетворённость пациентов с цервикальной дистонией результатами ботулинотерапии. Методика. В исследование включено 24 пациента с цервикальной дистонией, находящихся на лечении ботулотоксином типа А. Для сбора данных использовалась специально разработанная анкета по оценке субъективной эффективности ботулинотерапии, удовлетворенности лечением, характере нежелательных явлений и визуально аналоговая шкала для оценки болевого синдрома. Результат …

12.08.2026journal-article

Journal of Speech, Language, and Hearing Research

Multi-Atlas–Based Segmentation of Pediatric Vocal Tract Anatomy in Dynamic Magnetic Resonance Imaging

Hahn Kang, Fangxu Xing, Imani R. Gilbert, Jiyoon Kim, Abigail Kostolansky, Bradley Sutton, Jonghye Woo, Jamie L. Perry

Purpose: Segmentation of velopharyngeal and vocal tract anatomy is crucial for quantifying structures and analyzing dynamics during speech. Automatic methods are needed to replace labor-intensive and poorly reproducible manual segmentation. To address this, we compared four multi-atlas–based methods to determine which provides the most accurate segmentation of the tongue, velum, and adenoid and how segmentation accuracy varies with the number of temporal frames. Method: Five spatiotemporal atlases of speech tasks w …

12.08.2026journal-article

Health, sport, rehabilitation

Velocity-based functional strength training on neuromuscular performance in kabaddi players: a randomized controlled trial

Suba Murugan, Navaraj Rajkumar, Jun Mizushima, Priyanka Rana, Anoop Kumar, Neena Thekkan, Swamynathan Sanjaykumar

Background and Purpose Kabaddi demands explosive power, sprint speed, and rapid changes of direction. Traditional strength training improves maximal strength but may not optimize sport-specific performance. This study evaluated the effects of a 12-week Velocity-Based Functional Strength Training (VBFST) programme on countermovement jump, 20-m sprint, and 505 change-of-direction performance in elite male kabaddi players. Material and Methods Thirty elite male kabaddi players (18-25 years) were randomly divided into …

12.08.2026journal-article

Cancer Biome and Targeted Therapy

The Tumor Microenvironment in Non-Small Cell Lung Cancer Brain Metastases: Composition, Dynamics, and Therapeutic Implications

Marcel Kemper, Lea Reitnauer, Alessandro Leonetti, Yago Garitaonaindia, Melanie Janning, Mihaela Aldea, Andreas Pircher, Annalen Bleckmann, Lizza Hendriks

Brain metastases (BM) are a common and clinically significant complication of non-small cell lung cancer (NSCLC), representing a major contributor to its high mortality. Among all metastatic sites, involvement of the central nervous system (CNS) is associated with a particularly profound deterioration in patients' quality of life. The incidence of BM varies considerably across different histological subtypes and molecularly defined groups of NSCLC. The development of BM is a multistep process involving primary tumo …

12.08.2026journal-article

PLOS One

Cognitive Behavior Therapy (CBT) and Positive Psychotherapy (PPT) for the treatment of anxiety disorders in an online group setting: A randomized controlled trial

Catiana L. Engelhardt, Sabrina Keller, Thomas Berger, Anton-Rupert Laireiter

Objective The goal of this randomized controlled trial is to evaluate the efficacy of PPT compared to CBT and to test whether PPT is as effective or even more effective than CBT in reducing anxiety symptoms and improving the patients’ quality of life. The interventions last ten weeks and takes place in an online group setting. Methods A total of 110 patients were divided into two intervention groups (PPT: n = 53; CBT: n = 57). The measurements were conducted using online questionnaires to evaluate the anxiety, subj …

12.08.2026journal-article

Science Translational Medicine

Ultrasound-guided renal artery administration of angiopoietin-1 RNA therapy slows the progression of preclinical WT1 glomerular disease

Saif N. Malik, Jennifer C. Chandler, Ruhina Maeshima, Maria Kolatsi-Joannou, William J. Mason, Lauren G. Russell, Shunping Han, Yanis Harfouche, Daniyal J. Jafree, Emily A. E. Moore, Hanna Gautier, Christina Katsiva, Reem Al-Saadi, Kathy Pritchard-Jones, Daniel J. Stuckey, Andrew V. Benest, David O. Bates, Paul J. Winyard, Aoife M. Waters, Luigi Gnudi, Stephen L. Hart, Tammy L. Kalber, David A. Long

Mutations in the transcription factor gene Wilms Tumor 1 ( WT1 ) are one of the leading causes of congenital glomerular disease, characterized by severe urinary protein loss and glomerular scarring. No disease-modifying therapies exist for WT1 glomerulopathies, and affected children rely on dialysis or kidney transplantation. We evaluated a previously uncharacterized treatment in a mouse model with an orthologous human mutation in Wt1 ( Wt1 + /R394W ) that replicates the pathology of WT1 glomerulopathy. Lipid nanoc …

12.08.2026journal-article

Frontiers in Immunology

Hypothesis-driven salvage therapy with corticosteroids, tofacitinib, and nintedanib for progressive radiation pneumonitis with possible immune-mediated contribution: a case report

Xi Yu, Bowen Xu, Jiaxing Sun, Hongmei Wang, Yongzhong Guo, Dunqiang Ren

Sequential or concurrent thoracic radiotherapy and immune checkpoint inhibitors (ICIs) increase the risk of severe overlapping pulmonary toxicity. Progressive pneumonitis after thoracic radiotherapy and ICI exposure remains a clinically challenging condition, particularly when it shows an inadequate response to systemic corticosteroid therapy. We report a 65-year-old man with esophageal cancer who developed progressive radiation pneumonitis with possible immune-mediated contribution after pembrolizumab therapy and …

12.08.2026journal-article

Frontiers in Neurology

Multimodal assessment of the effects of radial pressure wave therapy on spastic muscles in patients with traumatic brain injury

Mika Kobayashi, Toshiko Iidaka, Takemi Murayama, Haruhi Inokuchi, Tomohiro Yamaki, Toru Ogata

Objectives Radial pressure wave therapy (rPWT) has shown promise in reducing spastic symptoms; however, its application in patients with spasticity following traumatic brain injury, particularly in those with prolonged disorders of consciousness (pDoC), remains underreported. The study aimed to investigate the immediate effects of rPWT on spastic muscles in patients with TBI-associated pDoC. Methods Ten patients with pDoC and upper limb spasticity and ten healthy controls received a single session of rPWT (2.5 Bar, …

12.08.2026journal-article

Journal of International Health Sciences and Management

The Effect of Perceived Overqualification on Time Theft: The Mediating Roles of Presenteeism and Occupational Humorous Coping Among Healthcare Professionals

Mehmet Kılınç, Vahit Yiğit

When medical professionals perceive that their accumulated expertise, formal education, and competencies surpass the actual demands of their assigned roles, it triggers a cascade of complex organizational and behavioral repercussions. Consequently, this study explores the direct impact of perceived overqualification on time theft within the healthcare sector, while specifically investigating the potential mediating mechanisms of presenteeism and occupational humorous coping. Utilizing a quantitative, cross-sectiona …

12.08.2026journal-article

Revista de Psicopatología y Psicología Clínica

Terapia de aceptación y compromiso (ACT) para el duelo prolongado por suicidio: Estudio de caso único

José I. Cruz -Gaitán

ABSTRACTObjective: To evaluate the effects of acceptance and commitment therapy (ACT) in a single case of prolonged grief following a suicide loss. Method: A single-case design with repeated assessments and follow-up was conducted with a 41-year-old woman. The intervention comprised two assessment sessions and ten ACT sessions organized around the Open, Centered, and Committed response styles, followed by assessments at 1 and 9 months posttreatment. Outcomes were assessed at four time points using the BDI-II, BAI, …

12.08.2026journal-article

Смоленский медицинский альманах

СРАВНИТЕЛЬНЫЙ АНАЛИЗ РАСПРОСТРАНЁННОСТИ СИМПТОМОВ СДВГ И ОБРАЩАЕМОСТИ ЗА ПОМОЩЬЮ У СТУДЕНТОВ МЕДИЦИНСКИХ И НЕМЕДИЦИНСКИХ СПЕЦИАЛЬНОСТЕЙ

Е. А. Кислякова, Е. А. Федорова, Д. А. Костенюк, Е. А. Маслякова

Актуальность исследования обусловлена высокой учебной нагрузкой в вузах и колледжах, предъявляющей максимальные требования к исполнительным функциям мозга, а также возможной недиагностированностью синдрома дефицита внимания и гиперактивности (СДВГ). Цель исследования - провести сравнительный анализ распространенности симптомов, характерных для СДВГ, а также проанализировать современные подходы к диагностике и лечению данного состояния. Материалы: обследованы 2 группы: 52 студента различных учебных заведений и 43 ст …

12.08.2026journal-article

Frontiers in Psychiatry

The postictal systems window hypothesis of electroconvulsive therapy in major depression

Bernard Rybczynski, Maciej Maslyk, Bartosz Wojciech Maj, Michal Pruc, Iwona Niewiadomska, Lukasz Szarpak

Electroconvulsive therapy (ECT) remains the most effective acute treatment for severe major depressive disorder, particularly in melancholic, psychotic, suicidal, catatonic or retarded, and treatment-resistant presentations. Existing mechanistic accounts are biologically valid but are often presented as parallel lists: monoamine release, excitatory-inhibitory rebalancing, neuroendocrine activation, immune modulation, neurotrophic plasticity, hippocampal change, and network rewiring. We propose the postictal systems …

12.08.2026journal-article

Frontiers in Human Neuroscience

Multidisciplinary rehabilitation and eye tracker-assisted communication in locked-in syndrome: a case report and literature review

Qi Zhang, Weibo Tian, Xinyu Miao, Kaidan Chi, Zhe Chen, Xinyi Li, Wei Liu, Zhongliang Liu, Xiaoqin Duan

Background Locked-in syndrome (LIS) is a rare and severe neurological condition characterized by quadriplegia and anarthria with preserved consciousness. Communication impairment is a major barrier to psychosocial adaptation and long-term rehabilitation. A new rehabilitation strategy is needed to restore multi-sensory impairments. Case presentation A patient underwent eye tracker therapy as part of a comprehensive multidisciplinary rehabilitation program following the diagnosis of LIS, which aimed to improve ocular …

12.08.2026journal-article

BMC Pulmonary Medicine

Impact of rapid pathogen detection in ICU patients with suspected pneumonia on antimicrobial therapy: randomized, controlled open-label feasibility trial (IRISPAT-1)

Christopher KC Lai, Alfred Lok Hang Lee, Grace Chung Yan Lui, Jack Zhenhe Zhang, Eddie Leung, Albe Wong, Patricia Leung, Gordon Choi, Eunise Ho, David Ng, Wai Tat Wong, Yu-Yeung Yip, Benjamin Siu, Katy Li, Kwok Ming Ho, Viola CY Chow, Lowell Ling

Abstract Background Evidence that multiplex polymerase chain reaction (mPCR) improves antimicrobial therapy and clinical outcomes in the critical care setting is limited. We assessed the impact of rapid mPCR on antibiotic therapy in mechanically ventilated critically ill patients with suspected pneumonia. Methods IRISPAT-1 was a single center, randomized, controlled open-label trial designed to determine the feasibility, safety, and potential impact of rapid respiratory pathogen detection on antibiotic therapy in m …

12.08.2026journal-article

Journal of Ayurveda and Integrated Medical Sciences

Efficacy of Chyawanprash Avaleha as an Adjuvant in Anti-Tubercular Therapy

Sunil Kumar, Manu Rajagopalaiah

Background: Tuberculosis (TB) remains a major global health burden. Anti-Tubercular Therapy (ATT), though effective, is associated with adverse effects such as anorexia, weight loss, and reduced immunity. Ayurveda describes Chyawanprash Avaleha as a Rasayana with rejuvenative and immunomodulatory properties. Objective: To evaluate the efficacy of Chyawanprash Avaleha as an adjuvant to ATT in improving clinical outcomes and treatment tolerance. Materials and Methods: An observational clinical study was conducted on …

12.08.2026journal-article

International Journal of Language & Communication Disorders

Facilitators and Barriers to Accessing and Continuing Speech Therapy for Children With Cleft Palate: A Qualitative Study

Suvashis Dash, Priyam Arora, Archana Sinha, Akshya Dhiman, Raj Kumar Manas, Raja Tiwari, Shashank Chauhan, Sujata Sarabhai

ABSTRACT Background Orofacial clefts are among the most common congenital anomalies worldwide, affecting approximately 1 in 700 live births. Despite surgical repair, most children require long‐term speech therapy; parental perspectives on accessing and continuing this therapy remain poorly documented in Low resource contexts. Objective To explore the facilitators and barriers influencing access to and continuation of speech therapy for children with CP within the low resource context. Methods A qualitative descript …

12.08.2026journal-article

PULMONOLOGIYA

The efficacy of inhalation therapy with a thermal helium-oxygen mixture in patients with severe exacerbations of asthma

V. T. Nguyen, D. G. Soldatov

According to the current paradigm of Global Initiative for Asthma (GINA, 2026), the principal goal of treating patients with asthma is to achieve and maintain complete control of the disease. The level of asthma control directly determines the frequency and severity of exacerbations, the majority of which occur in patients with severe, partly controlled, or uncontrolled disease. Severe acute asthma exacerbations (SAAE) account for up to 10 – 20% of all annual asthma exacerbations and usually require hospitalization …

12.08.2026journal-article

Pharmacoepidemiology

Virologic Outcomes of Predominantly Tenofovir-Based First-Line Antiretroviral Therapy Among Treatment-Naïve HIV Patients in Davao City, Philippines

Alfredo A. Hinay, Avee Joy B. Dayaganon, Aprilyn F. Francisco-Breva, Jennifer Ashley H. Reyes, Reigner Jay B. Escartin

Background/Objectives: Tenofovir disoproxil fumarate (TDF)-containing regimens remain the cornerstone of first-line antiretroviral therapy (ART) in many low- and middle-income countries. However, concerns regarding treatment failure and antiretroviral resistance highlight the need to evaluate the effectiveness of treatments under routine clinical conditions. This study evaluated the virologic outcomes of treatment-naïve individuals living with HIV who received predominantly TDF-based first-line ART in Davao City, P …

12.08.2026journal-article

Journal of Clinical Medicine

Ethnic Differences in Cardiac Rehabilitation Enrolment, Participation, and Mortality: A Retrospective Cohort Study from Auckland, New Zealand

Paul W. Marshall, Alana McCambridge, Sasha Douglas, Tia Kendal-Lindbom, Wendy Marshall, Michael O’Sullivan, Gayatri Ganesh, Cameron Walker, Nikki J. Earle, Stacey Reading, Jocelyne Benatar, Michael Kingsley

Background/Objectives: Ethnic inequities in cardiovascular disease and healthcare access are well recognised worldwide, but it is unclear whether these inequities translate into differences in cardiac rehabilitation participation and subsequent clinical outcomes. This study examined ethnic differences in cardiac rehabilitation enrolment, participation, and mortality outcomes within a large multi-ethnic cohort to determine whether the association between rehabilitation exposure and mortality differed across ethnic g …

12.08.2026journal-article

Смоленский медицинский альманах

ЧАСТОТА ИСПОЛЬЗОВАНИЯ КОМБИНИРОВАННОЙ АНТИСКЛЕРОТИЧЕСКОЙ ТЕРАПИИ У БОЛЬНЫХ, ГОСПИТАЛИЗИРОВАННЫХ В СТАЦИОНАР С ОСТРЫМ КОРОНАРНЫМ СИНДРОМОМ

И. А. Литвинова, А. Д. Лагунова, Н. Н. Лапик, А. А. Петров

В статье проанализированы клинико-лабораторные характеристики, структура коморбидной патологии и особенности гиполипидемической терапии у пациентов с острым коронарным синдромом в условиях реальной клинической практики. В анализ и включены данные пациентов с подтвержденным диагнозом острый коронарный синдром, госпитализированных в кардиологическое отделение. Изучались демографические показатели, характер основного и фоновых заболеваний, уровни глюкозы, печеночных ферментов, показатели липидограммы, а также проводим …

12.08.2026journal-article

Hong Kong Physiotherapy Journal

Effects of trunk lean on lower-limb muscle activity ratios during single-leg squat in individuals with patellofemoral pain syndrome

Jong Min Kim, Geon Dong Lee, Tae Ho Kim

Background: Patellofemoral pain syndrome (PFPS) is associated with altered activation of the lower-limb muscles during functional tasks such as the single-leg squat (SLS). Although trunk position can influence the recruitment of the hip and knee muscles, the effects of different trunk lean angles on muscle activation ratios in individuals with PFPS remain unclear. Objective: This study aimed to examine how trunk lean angles of 0°, 15°, and 30° affect lower-limb muscle activation ratios during SLS in individuals wit …

12.08.2026journal-article

International Journal of Drug Delivery Technology

Impact of Long-Term Statin Therapy on the Severity and Treatment of Diabetic Retinopathy in Type 2 Diabetes Mellitus

Navya D, Swathi G, Dhanush H C

Background: Diabetic retinopathy (DR) is one of the leading microvascular complications of type 2 diabetes mellitus (T2DM) and remains a major cause of preventable vision loss worldwide. In addition to glycemic control, dyslipidemia has been implicated in the progression of retinal vascular damage. Statins, widely prescribed for lipid-lowering therapy, may provide additional protective effects against the development and progression of diabetic retinopathy. Aim: To assess the role of statin therapy in diabetic reti …

12.08.2026journal-article

Journal of Hypertension

Theoretical foundations of bloodletting therapy for primary hypertension in the southern school of Tibetan medicine: insights from Qinghai-Tibet Plateau medical theory

Wujin Danzeng, Ciwang Duoji, Gama Gele, Ga Wu

Primary hypertension (PH) remains a significant contributor to global morbidity and mortality. While contemporary biomedical treatments are widely utilized, traditional medical systems such as Tibetan medicine provide distinctive diagnostic frameworks and therapeutic modalities. Among these, venesection therapy constitutes a key external intervention, frequently employed in managing conditions corresponding to PH, referred to in classical texts as Trak lung tö tsang (khrag rlung stod ‘tshangs, blood-wind proliferat …

12.08.2026journal-article

Journal of Nursing Scholarship

Virtual Reality–Based Rehabilitation to Improve Mobility and Prevent Falls in Older People With Diabetic Peripheral Neuropathy: Evidence Synthesis and Development of a Geriatric‐Specific Framework

Leodoro J. Labrague, David M. Ha, Liza Visbal‐Dionaldo, Kacy L. Aderhold, Anna Nguyen

ABSTRACT Introduction Diabetic peripheral neuropathy (DPN) among older people is associated with significant gait and balance impairments, postural instability, and an increased fall risk. Virtual reality (VR)‐based interventions have been shown to be effective in improving balance and mobility; however, their design features and applicability for older people with DPN remain unclear. This systematic review was conducted to examine the effectiveness of VR systems on clinical outcomes in individuals with DPN and tra …