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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
22.08.2026journal-article

Diseases of the Esophagus

P1.227. A Composite Body Composition Score Independently Predicts Long-Term Survival After Esophagectomy for Cancer

Tyler Wilson, Ernest Chan, Jules Lin, Sang Mee Lee, Brian Derstine, Stewart Wang, Mark Ferguson

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – long term outcomes Background Body composition (BC) measures are established determinants of esophageal cancer outcomes. Beyond known survival predictors such as cancer stage and performance status, a composite BC score independently predicts post-resection survival in lung cancer. We adapted this score for esophageal cancer patients to evaluate its association with long-term survival following esophagectomy. Methods This is a single-instit …

22.08.2026journal-article

Diseases of the Esophagus

OA09.6. Multi-Society Clinical Practice Guideline for the Treatment of Adult Patients With Achalasia

Bright Huo, Sofia Tsokani, Milos Bjelovic, Sonia Fernandez-Ananin, Ivy Haskins, Geoffrey P Kohn, Siva Raja, Biniam Kidane, Zuzana Vackova, Irene Marafini, Suzanne Dore, Ian Tuddenham, Silvana Perretta, Aaron J Yu, Roi Anteby, Daniel Moritz Felsenreich, Dimitris Mavridis, Stephanie Sanger, Bethany J Slater, Xiaomei Yao, Stavros A Antoniou, Gordon Guyatt

Abstract Topic Benign Disease: Esophageal Function and Motility Background We developed multi-society recommendations addressing the question: should adult patients with achalasia receive botox, pneumatic dilation (PD), POEM, or Heller myotomy with fundoplication? Methods We performed a systematic review of randomized trials across PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials from inception to July 9th, 2025. We recruited an international, multidisciplinary panel including members from the …

22.08.2026journal-article

Diseases of the Esophagus

OA01.5. Preoperative Assessment of Fitness for Surgery in Patients Planned for Esophagectomy for Cancer, an International Survey to Uncover Current Practices

Ward Seurs, Yarno Verbeeck, Hans Van Veer, Stijn Vanstraelen, Philippe Nafteux, Lieven Depypere

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background Identifying high-risk patients through preoperative assessment of fitness is crucial to mitigate complications after esophagectomy for cancer. However, no international consensus currently exists on which investigations should be included in this assessment. This survey aimed to describe current international practices and explore attitudes towards standardization. Methods An international cross-sectional online survey consisting o …

22.08.2026journal-article

Diseases of the Esophagus

P1.125. Challenging a Histology-Led Paradigm: Comparable Real-World Survival After Definitive Non-Surgical Treatment in Oesophageal Adenocarcinoma and Squamous Cell Carcinoma

Mohammed AlHilali, Anthony Waton, Philip Atherton, Alexander Bradshaw

Abstract Topic Esophageal Cancer: Oncology/Radiation Therapy Background Histology is often treated as a surrogate for radiosensitivity in oesophageal cancer, sustaining the prevailing assumption that squamous cell carcinoma (SCC) benefits more from definitive chemoradiotherapy than adenocarcinoma (AC). We examined whether overall survival (OS) is better discriminated by histology within a fixed pathway, or by the delivered treatment pathway. Methods Retrospective 10-year single-centre regional cohort of oesophageal …

22.08.2026journal-article

Diseases of the Esophagus

P1.251. Minimally Invasive Technique of Esophagojejunal Reconstruction After Extended Total Gastrectomy for OG Junction Cancer

Dr Ramakrishnan Parthasarathi, Prof C Palanivelu, Dr M Bharath Cumar, Dr S Saravana Kumar, Dr N Ramesh, Dr Jami Jami Yaswanth Sai

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – technique Background Esophagojejunal reconstruction following extended total gastrectomy for OG junction cancer is technically demanding due to limited lower mediastinal access and the requirement for a secure, tension-free anastomosis. Minimally invasive transhiatal approaches may reduce surgical morbidity while maintaining oncological adequacy. This study demonstrates the technical feasibility and surgical strategy of intracorporeal esoph …

22.08.2026journal-article

World Journal of Urology

Clinical characteristics, treatment patterns, and survival outcomes in ductal prostate cancer: a multicenter retrospective analysis

A. Handke, P. Paffenholz, K. Schlack, K. E. Seifert, J. Linxweiler, J. Mink, F. Flockerzi, T. Nestler, M. Wenzel, C. Siech, C. Darr, V. Grünwald, F. Roghmann, K. H. Tully

Abstract Purpose Prostatic ductal adenocarcinoma (PDA) is a rare, aggressive prostate cancer subtype associated with advanced disease and poorer prognosis than acinar adenocarcinoma. Small ductal components influence management and preclude active surveillance. This study analyzed oncologic outcomes and therapeutic patterns in a multicenter German cohort. Methods Retrospective multicenter cohort, seven high-volume German centers. 82 patients with histologically confirmed PDA diagnosed 2014–2024 included. Histopatho …

22.08.2026journal-article

Advanced Functional Materials

Membrane Protein‐Instructed Peptide Self‐Assembly for Cancer Therapy

Jiaying Zhang, Yanyan Zhou, Ruo‐Chen Guo, Junyan Du, Wenjun Zhan, Gaolin Liang

ABSTRACT Abnormal membrane proteins often play a crucial role in the development and progression of cancer, making them ideal targets for cancer treatment. However, traditional membrane protein inhibitor‐based therapies only benefit a small part of patients and suffer from notorious drug resistance due to their occupation‐driven pharmacology. Recently, membrane protein‐instructed peptide self‐assembly has emerged as a powerful tool in precision cancer treatment. Due to its unique merits such as high tumor targeting …

22.08.2026journal-article

BMC Neurology

Patient perspectives from the BEYOND Delphi panel: burden of remaining symptoms and their fluctuations, despite treatment, in patients with generalised myasthenia gravis

Sophie Lehnerer, Maria Bonaria Uccheddu, Diana Sufragiu, Charlotte Carpenter, Daisy Bridge, Medi Stone, Camille Chassat, Anouska Jha, Gonçalo M.C. Rodrigues, Maartje Mangelaars, Wim Noel, Charlotte Gary, Francesco Saccà

Abstract Background Patients with generalised myasthenia gravis (gMG) can experience remaining symptoms despite treatment. Our study aimed to describe how remaining symptoms and their fluctuations may affect a person’s daily life while living with gMG. Methods A modified-Delphi panel (two survey rounds) was conducted with adult patients with gMG ( n =20) from seven European countries (France, Germany, Italy, the Netherlands, Sweden, Switzerland, and the UK). A scientific advisory committee including two neurologist …

22.08.2026journal-article

International Journal of Molecular Sciences

Phytochemical Modulation of the Kynurenine Pathway (KYNP) and Its Emerging Mechanistic Insights into Cancer Progression: A Systematic Review

Evgenia Maria Tsantila, Marios C. Christodoulou, Nils Esslinger, Christiana M. Neophytou

Dysregulation of the kynurenine pathway (KYNP) is increasingly recognized as a hallmark of cancer-associated metabolic reprogramming, contributing to immune evasion, oxidative stress, and tumor progression through the activity of enzymes such as indoleamine 2,3-dioxygenase 1 (IDO1), indoleamine 2,3-dioxygenase 2 (IDO2), and tryptophan 2,3-dioxygenase (TDO2). This systematic review aimed to evaluate the current evidence on the ability of phytochemicals to modulate the KYNP and their potential implications for cancer …

22.08.2026journal-article

International Journal of Computer Assisted Radiology and Surgery

Clinical outcome prediction of Contour Neurovascular System treatment based on pre-treatment geometric and hemodynamic characteristics

Fina Gießler, Anna Bernovskis, Franziska Gaidzik, Jana Korte, Philipp Berg, Sönke Peters, Naomi Larsen, Sylvia Saalfeld

Abstract Purpose The contour neurovascular system (CNS) is increasingly used for endovascular treatment of intracranial aneurysms, but outcome and post-treatment device behavior vary between patients. This study investigated whether pre-treatment geometric and hemodynamic characteristics from image-based blood flow simulations are associated with clinical outcome and follow-up CNS shape modifications. Methods Pre-treatment vascular geometries and blood flow simulations were analyzed in 39 CNS-treated cases. Geometr …

22.08.2026journal-article

Diseases of the Esophagus

PD04.02. Outcome and Dosimetric Comparison Between Intensity-Modulated Radiotherapy and Three-Dimensional Radiotherapy for Thoracic Esophageal Cancer in Japanese Population

Masahiro Inada, Kiyoshi Nakamatsu, Saori Imamura, Naoko Hamazawa, Takahiro Okamoto, Junki Fukuda, Takuya Uehara, Makoto Hosono, Yukinori Matuso

Abstract Topic Esophageal Cancer: Oncology/Radiation Therapy Background Intensity-modulated radiotherapy (IMRT) enables the delivery of optimal doses to the target while reducing doses to normal organs. Compared to three-dimensional conformal radiotherapy (3D-CRT), it is expected to reduce adverse events and improve treatment outcomes. However, concerns about increased risk of radiation pneumonitis due to low-dose exposure have hindered the widespread adoption of IMRT for thoracic esophageal cancer (TEC) in Japan. …

22.08.2026journal-article

Diseases of the Esophagus

P1.209. Long-Term Survival Outcomes After Esophagectomy for Cancer in Australia

Josipa Petric, Muktar Ahmed, Norma Bulamu, David Pilcher, Shailesh Bihari, Tim Bright, David Watson

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – long term outcomes Background Five-year overall survival following esophagectomy for esophageal cancer is infrequently reported at a national level. This study investigated the influence of hospital annual volume on long-term survival in patients with esophageal cancer treated with esophagectomy in Australia. Methods All elective esophagectomy patients admitted to ICU in Australian hospitals between 2017 and 2023 were identified from the Au …

22.08.2026journal-article

Diseases of the Esophagus

OA01.6. Reshaping Esophageal Cancer N Staging With a Target-Ring Burden Framework: A Multicenter Retrospective Study

Ruichen Cui, Xiang Li, Shenglu Lian, Yushang Yang, Longqi Chen

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – long term outcomes Background Given the limited integration of nodal count and spatial distribution in current esophageal cancer N staging, we sought to develop and validate a newN staging system that incorporates both dimensions. Methods We used prospectively maintained, retrospective databases from three centers (2008–2022). The primary endpoint was overall survival (OS). We constructed a Target–Ring Burden framework by computing Spearman …

22.08.2026journal-article

Diseases of the Esophagus

P1.143. Effectiveness of 3-Months of Home Enteral Nutrition After Esophagectomy for Esophageal Cancer

Kosei Uehara, Makoto Sakai, Kengo Kuriyama, Takuya Shiraishi, Yuji Kumakura, Akiharu Kimura, Akihiko Sano, Makoto Sohda, Ken Shirabe, Hiroshi Saeki

Abstract Topic Esophageal Cancer: Other Background After esophagectomy for esophageal cancer, postoperative weight loss and sarcopenia are common and associated with poor prognosis. Although enteral nutrition is recommended when oral intake is insufficient, the effectiveness and optimal duration of home enteral nutrition remain unclear. Methods This retrospective single-center study included patients with thoracic esophageal cancer who underwent radical McKeown esophagectomy with gastric tube reconstruction and jej …

22.08.2026journal-article

Diseases of the Esophagus

P1.219. Functional Radiology Assessment of Gastric Conduit Emptying After Esophagectomy for Cancer With Gastric Conduit Reconstruction; a Pilot Study

Jens Hultkrantz, Magnus Konradsson, Mats Andersson, Torkel Brismar, Magnus Nilsson, Fredrik Klevebro

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications Background Symptoms of delayed gastric conduit emptying are common in patients with a gastric conduit reconstruction after esophagectomy, but standardized radiologic evaluation is missing. We aim to describe the pattern of gastric conduit emptying by functional upper gastrointestinal contrast series, and to determine whether Barium or water soluble contrast is more suitable. Methods The study was approved by …

22.08.2026journal-article

Diseases of the Esophagus

PD01.02. Renin–Angiotensin System Blockade During Neoadjuvant Therapy is Associated With Enhanced Tumor Regression and Survival in Esophageal Squamous Cell Carcinoma

Maohui Chen, Yizhou Huang, Zhenyuan Yang, Taidui Zeng, Chun Chen, Bin Zheng

Abstract Topic Esophageal Cancer: Other Background Beyond blood pressure regulation, the renin–angiotensin system (RAS) has been implicated in tumor angiogenesis, stromal remodeling, and immune modulation. Pharmacologic blockade of this pathway through angiotensin-converting enzyme inhibitors or angiotensin receptor blockers has demonstrated potential antineoplastic properties in several malignancies. Whether exposure to these agents during neoadjuvant treatment influences pathological response or long-term outcome …

22.08.2026journal-article

Diseases of the Esophagus

P1.225. The Impact of Metformin Use During Neoadjuvant Chemoradiotherapy in Esophageal Cancer Patients: A Propensity Score-Matched Nationwide Study

Taeyoung Yun, Chang Hyun Kang, Ji Hyeon Park, Kwon Jung Na, Samina Park, Hyun Joo Lee, In Kyu Park, Young Tae Kim

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – long term outcomes Background Our previous study suggested an association between metformin use and complete response rates in esophageal cancer patients undergoing neoadjuvant concurrent chemoradiotherapy (CCRT). This study aims to evaluate the impact of metformin use during neoadjuvant CCRT on overall survival (OS) and cancer-specific survival (CSS) in esophageal cancer patients undergoing surgery, using a nationwide database. Methods We …

22.08.2026journal-article

Current Cancer Drug Targets

Ubiquitination–Androgen Receptor Coupling in Prostate Cancer Therapeutics

Gali Sri Venkata Sai Rishma Reddy, Krishna Samanta, Pulak Kar

Abstract: Prostate cancer is one of the most frequently diagnosed malignancies in men and a leading cause of cancer-related mortality worldwide. The androgen receptor (AR) remains the principal driver of prostate cancer progression and castration-resistant prostate cancer (CRPC), with its stability, localization, and transcriptional activity being tightly regulated by the ubiquitin–proteasome system (UPS). E3 ubiquitin ligases and deubiquitinases (DUBs) critically govern AR turnover and signalling output, thereby i …

22.08.2026journal-article

Scientific Reports

Caputo fractional-order modelling of HPV-induced cervical cancer progression under vaccination, screening and treatment controls

Engin Can

Abstract Cervical cancer is mainly associated with persistent infection by high-risk human papillomavirus (HPV) types and develops through a slow transition from infection to precancerous lesions and invasive disease. This multi-stage nature makes HPV-induced cervical cancer suitable for mathematical modeling. In this paper, we propose a Caputo fractional-order compartmental model describing HPV infection, precancerous progression and cervical cancer development under vaccination, screening and treatment controls. …

22.08.2026journal-article

Cancer Cell International

Cold atmospheric plasma affects metabolic processes in malignant melanoma

Erika Rein, Tom Zimmermann, Stefan Fischer, Zubeir El Ahmad, R. Verena Taudte, Arne Gessner, Martin F. Fromm, Melanie Kappelmann-Fenzl, Anja Bosserhoff

Abstract Background Partially ionized gas, also known as cold atmospheric plasma (CAP), is reported to have anti-tumor specific properties via reactive oxygen and nitrogen species (RONS) in different tumor entities. Many CAP effects have already been studied, but the exact influence on metabolism has yet to be defined. Methods Analyses of metabolic substrates, metabolic pathways, genes, mRNA and nitration were performed to investigate CAP-treated and untreated melanoma and non-malignant cells. Results We discovered …

22.08.2026journal-article

Diseases of the Esophagus

PD02.08. Robot-Assisted Extended Free Jejunum Interposition Versus McKeown Esophagectomy in Thoracic Esophageal Cancer: A Comparative Study of Perioperative and Quality-of-Life Outcomes

Xinyu Yang, Bin Li, Zhigang Li

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background Gastrointestinal complications related to gastric conduit reconstruction adversely affect quality of life (QoL) in patients undergoing esophagectomy for esophageal cancer (EC). We introduced a robot-assisted extended free jejunal interposition (EFJI) technique for intrathoracic esophageal cancer that preserves gastric and cardiac function (Figure 1A). This study aimed to compare perioperative outcomes and QoL between robot-assisted …

22.08.2026journal-article

Diseases of the Esophagus

P1.081. The Effect of Pre-Rehabilitation During Neoadjuvant Chemotherapy in Esophageal Cancer

Ryoma Haneda, Eisuke Booka, Takahiro Kuroda, Shuhei Yasumoto, Keita Misu, Yuki Sakai, Kenichi Sekimori, Shunta Nakamura, Wataru Soneda, Tomohiro Murakami, Tomohiro Matsumoto, Hirotoshi Kikuchi, Yoshihiro Hiramatsu, Hiroya Takeuchi

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background The standard treatment for resectable advanced esophageal squamous cell carcinoma is neoadjuvant chemotherapy (NAC) followed by surgery. Rehabilitation is recommended during NAC; however several adverse events often hinder its completion. This study examined the impact of rehabilitation completion rates during NAC on postoperative complications. Methods We retrospectively analyzed 111 patients who had esophagectomy after NAC for thorac …

22.08.2026journal-article

Diseases of the Esophagus

P1.232. Treatment Outcomes of Conversion Surgery for Advanced Esophageal Cancer Following ICI-Combined Chemotherapy

YUSUKE SUZUKI, YUKI HOSHI, MASATOSHI YOSHIZAWA, KAZUHIKO HISAOKA, TETSUROU TORIUMI, YUTAKA KISHIMOTO, GEN EBARA, YUTAKA MIYAWAKI, HIROSHI SATO, SHINICHI SAKURAMOTO

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – long term outcomes Background Immune checkpoint inhibitor (ICI)-based combination chemotherapy for advanced esophageal cancer demonstrates high response rates, enabling conversion surgery in some cases. However, reports on the safety and prognosis of cases undergoing resection after ICI-combined chemotherapy remain limited. We retrospectively reviewed the treatment outcomes of nine Stage IV esophageal cancer patients who underwent conversio …

22.08.2026journal-article

Diseases of the Esophagus

P1.152. Quality of Life Outcomes Post Esophagectomy: a Prospective Study in an Apex Cancer Care Institution

JAI HARI M S

Abstract Topic Esophageal Cancer: Other Background Carcinoma of the esophagus significantly affects quality of life (QOL), particularly due to symptoms such as dysphagia and nutritional compromise. While transthoracic esophagectomy remains a standard curative modality, it is associated with substantial perioperative morbidity. Evaluation of postoperative QOL is essential to understand functional recovery and patient outcomes. Methods AIM To study the impact of esophagectomy on health related quality of life (HR QOL …