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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
22.08.2026journal-article

Diseases of the Esophagus

P1.219. Functional Radiology Assessment of Gastric Conduit Emptying After Esophagectomy for Cancer With Gastric Conduit Reconstruction; a Pilot Study

Jens Hultkrantz, Magnus Konradsson, Mats Andersson, Torkel Brismar, Magnus Nilsson, Fredrik Klevebro

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications Background Symptoms of delayed gastric conduit emptying are common in patients with a gastric conduit reconstruction after esophagectomy, but standardized radiologic evaluation is missing. We aim to describe the pattern of gastric conduit emptying by functional upper gastrointestinal contrast series, and to determine whether Barium or water soluble contrast is more suitable. Methods The study was approved by …

22.08.2026journal-article

Diseases of the Esophagus

PD01.02. Renin–Angiotensin System Blockade During Neoadjuvant Therapy is Associated With Enhanced Tumor Regression and Survival in Esophageal Squamous Cell Carcinoma

Maohui Chen, Yizhou Huang, Zhenyuan Yang, Taidui Zeng, Chun Chen, Bin Zheng

Abstract Topic Esophageal Cancer: Other Background Beyond blood pressure regulation, the renin–angiotensin system (RAS) has been implicated in tumor angiogenesis, stromal remodeling, and immune modulation. Pharmacologic blockade of this pathway through angiotensin-converting enzyme inhibitors or angiotensin receptor blockers has demonstrated potential antineoplastic properties in several malignancies. Whether exposure to these agents during neoadjuvant treatment influences pathological response or long-term outcome …

22.08.2026journal-article

Diseases of the Esophagus

P1.225. The Impact of Metformin Use During Neoadjuvant Chemoradiotherapy in Esophageal Cancer Patients: A Propensity Score-Matched Nationwide Study

Taeyoung Yun, Chang Hyun Kang, Ji Hyeon Park, Kwon Jung Na, Samina Park, Hyun Joo Lee, In Kyu Park, Young Tae Kim

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – long term outcomes Background Our previous study suggested an association between metformin use and complete response rates in esophageal cancer patients undergoing neoadjuvant concurrent chemoradiotherapy (CCRT). This study aims to evaluate the impact of metformin use during neoadjuvant CCRT on overall survival (OS) and cancer-specific survival (CSS) in esophageal cancer patients undergoing surgery, using a nationwide database. Methods We …

22.08.2026journal-article

Current Cancer Drug Targets

Ubiquitination–Androgen Receptor Coupling in Prostate Cancer Therapeutics

Gali Sri Venkata Sai Rishma Reddy, Krishna Samanta, Pulak Kar

Abstract: Prostate cancer is one of the most frequently diagnosed malignancies in men and a leading cause of cancer-related mortality worldwide. The androgen receptor (AR) remains the principal driver of prostate cancer progression and castration-resistant prostate cancer (CRPC), with its stability, localization, and transcriptional activity being tightly regulated by the ubiquitin–proteasome system (UPS). E3 ubiquitin ligases and deubiquitinases (DUBs) critically govern AR turnover and signalling output, thereby i …

22.08.2026journal-article

Scientific Reports

Caputo fractional-order modelling of HPV-induced cervical cancer progression under vaccination, screening and treatment controls

Engin Can

Abstract Cervical cancer is mainly associated with persistent infection by high-risk human papillomavirus (HPV) types and develops through a slow transition from infection to precancerous lesions and invasive disease. This multi-stage nature makes HPV-induced cervical cancer suitable for mathematical modeling. In this paper, we propose a Caputo fractional-order compartmental model describing HPV infection, precancerous progression and cervical cancer development under vaccination, screening and treatment controls. …

22.08.2026journal-article

Cancer Cell International

Cold atmospheric plasma affects metabolic processes in malignant melanoma

Erika Rein, Tom Zimmermann, Stefan Fischer, Zubeir El Ahmad, R. Verena Taudte, Arne Gessner, Martin F. Fromm, Melanie Kappelmann-Fenzl, Anja Bosserhoff

Abstract Background Partially ionized gas, also known as cold atmospheric plasma (CAP), is reported to have anti-tumor specific properties via reactive oxygen and nitrogen species (RONS) in different tumor entities. Many CAP effects have already been studied, but the exact influence on metabolism has yet to be defined. Methods Analyses of metabolic substrates, metabolic pathways, genes, mRNA and nitration were performed to investigate CAP-treated and untreated melanoma and non-malignant cells. Results We discovered …

22.08.2026journal-article

Diseases of the Esophagus

PD02.08. Robot-Assisted Extended Free Jejunum Interposition Versus McKeown Esophagectomy in Thoracic Esophageal Cancer: A Comparative Study of Perioperative and Quality-of-Life Outcomes

Xinyu Yang, Bin Li, Zhigang Li

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background Gastrointestinal complications related to gastric conduit reconstruction adversely affect quality of life (QoL) in patients undergoing esophagectomy for esophageal cancer (EC). We introduced a robot-assisted extended free jejunal interposition (EFJI) technique for intrathoracic esophageal cancer that preserves gastric and cardiac function (Figure 1A). This study aimed to compare perioperative outcomes and QoL between robot-assisted …

22.08.2026journal-article

Diseases of the Esophagus

P1.081. The Effect of Pre-Rehabilitation During Neoadjuvant Chemotherapy in Esophageal Cancer

Ryoma Haneda, Eisuke Booka, Takahiro Kuroda, Shuhei Yasumoto, Keita Misu, Yuki Sakai, Kenichi Sekimori, Shunta Nakamura, Wataru Soneda, Tomohiro Murakami, Tomohiro Matsumoto, Hirotoshi Kikuchi, Yoshihiro Hiramatsu, Hiroya Takeuchi

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background The standard treatment for resectable advanced esophageal squamous cell carcinoma is neoadjuvant chemotherapy (NAC) followed by surgery. Rehabilitation is recommended during NAC; however several adverse events often hinder its completion. This study examined the impact of rehabilitation completion rates during NAC on postoperative complications. Methods We retrospectively analyzed 111 patients who had esophagectomy after NAC for thorac …

22.08.2026journal-article

Diseases of the Esophagus

P1.232. Treatment Outcomes of Conversion Surgery for Advanced Esophageal Cancer Following ICI-Combined Chemotherapy

YUSUKE SUZUKI, YUKI HOSHI, MASATOSHI YOSHIZAWA, KAZUHIKO HISAOKA, TETSUROU TORIUMI, YUTAKA KISHIMOTO, GEN EBARA, YUTAKA MIYAWAKI, HIROSHI SATO, SHINICHI SAKURAMOTO

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – long term outcomes Background Immune checkpoint inhibitor (ICI)-based combination chemotherapy for advanced esophageal cancer demonstrates high response rates, enabling conversion surgery in some cases. However, reports on the safety and prognosis of cases undergoing resection after ICI-combined chemotherapy remain limited. We retrospectively reviewed the treatment outcomes of nine Stage IV esophageal cancer patients who underwent conversio …

22.08.2026journal-article

Diseases of the Esophagus

P1.152. Quality of Life Outcomes Post Esophagectomy: a Prospective Study in an Apex Cancer Care Institution

JAI HARI M S

Abstract Topic Esophageal Cancer: Other Background Carcinoma of the esophagus significantly affects quality of life (QOL), particularly due to symptoms such as dysphagia and nutritional compromise. While transthoracic esophagectomy remains a standard curative modality, it is associated with substantial perioperative morbidity. Evaluation of postoperative QOL is essential to understand functional recovery and patient outcomes. Methods AIM To study the impact of esophagectomy on health related quality of life (HR QOL …

22.08.2026journal-article

Diseases of the Esophagus

VA03.3. Laparoscopic Treatment of Intramural Diverticulum in Type III Achalasia

Andre Brandalise, Claudia Lorenzetti

Abstract Topic Benign Disease: Esophageal Surgery Background Achalasia is a primary esophageal motility disorder characterized by impaired lower esophageal sphincter relaxation and absent peristalsis. Chronic functional obstruction may lead to structural complications, including esophageal dilation and, rarely, diverticulum formation. The coexistence of achalasia and esophageal diverticulum presents diagnostic and therapeutic challenges. Methods We present a video of a 67-year-old female presenting with dysphagia, …

22.08.2026journal-article

Diseases of the Esophagus

P1.114. Endoscopic Diagnosis of Esophageal Cancer Using Ultra-High Magnification Endocytoscopy

Youichi Kumagai, Kenro Kawada, Kaiyo Takubo

Abstract Topic Esophageal Cancer: New Diagnostic Modalities (Including PET, PET-CT, New Tracers) Background Background Ultra-high magnification endoscopic observation using endocytoscopy (EC) enables cellular-level visualization and allows in vivo assessment comparable to histopathological diagnosis. We previously proposed a three-tier classification system based on surface cellular morphology and reported that Type 3 lesions can be diagnosed histologically as malignant using EC images alone. Methods Patients and M …

22.08.2026journal-article

Diseases of the Esophagus

P1.104. Potential Survival Benefit of Longitudinal ctDNA-Guided Treatment Adaptation in Advanced Esophageal Cancer

Takeshi Iwaya, Fumitaka Endo, Ryosuke Fujisawa, Haruka Nikai, Hayato Hiraki, Akiko Yashima-Abo, Hiroaki Itamochi, Satoshi Nishizuka

Abstract Topic Esophageal Cancer: Management of Metastatic Cancer Background We have developed a tumor-specific circulating tumor DNA (ctDNA) monitoring test using digital PCR, termed the OTS (off-the-shelf)-assay. While recent attention has focused on minimal residual disease detection for early relapse diagnosis and to guide adjuvant therapy decisions, we have emphasized the importance of timely treatment management based on serial ctDNA dynamics. Methods In our previous study of 42 patients with esophageal cance …

22.08.2026journal-article

Diseases of the Esophagus

PD07.09. Neoadjuvant Immuno-Chemotherapy as an Initial Treatment Strategy for Esophageal Squamous Cell Carcinoma With Synchronous Primary Cancers in Pharynx and Larynx

Haojun Hong, Yuchen Su, Hui Chen, Kaiyuan Zhu, Hong Zhang, Wei Xu, Jiapeng Ding, Chang Yuan, Yuxin Yang, Yang Yang, Chunguang Li, Ning Ma, Zhichao Liu, Zhigang Li

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background Esophageal squamous cell carcinoma (ESCC) with synchronous primary cancers in pharynx and larynx (SPC-PL) is rare and lacks standard-of-care treatment. This study examined tumor response and survival after neoadjuvant immuno-chemotherapy (nICT) in ESCC patients with SPC-PL. Methods This retrospective single-center study analyzed 21 patients with ESCC and SPC-PL who received nICT between 2020 and 2024. Treatment response was evaluated u …

22.08.2026journal-article

Nature Communications

Constitutive natural killer cell features associated with post-treatment control of SIV infection in the pVISCONTI study

Anaïs Chapel, Luis Romero-Martín, Caroline Passaes, Valérie Monceaux, Stevenn Volant, Delphine Desjardins, Adeline Melard, Annie David, Nathalie Dereuddre-Bosquet, Christine Rouzioux, Véronique Avettand-Fenoel, Michaela Müller-Trutwin, Roger Le Grand, Asier Sáez-Cirión

Abstract Post-treatment HIV controllers (PTC) offer a unique opportunity to uncover the determinants of durable remission after antiretroviral therapy (ART) interruption. Here, using six PTC and six post-treatment non-controllers from the pVISCONTI study in cynomolgus macaques, we identify associations between Natural Killer (NK) cell subsets and outcomes following ART interruption. NKG2Ahigh NK cells lacking NKp30/NKp46 (NKG2AhighNKp30-NKp46-), shaped by the MHC backgrounds of the animals, were linked to improved …

22.08.2026journal-article

International Journal of Biomedical Research and Innovations

MULTILEVEL DETERMINANTS OF HUMAN PAPILLOMAVIRUS VACCINE ACCEPTANCE AND UPTAKE, AND CERVICAL CANCER SCREENING UPTAKE, AMONG WOMEN ATTENDING TERTIARY HEALTHCARE FACILITIES IN NASARAWA STATE, NIGERIA: A CROSS-SECTIONAL STUDY

Dogara Manga Manga, Ishaku Akyala Adamu, Yusuf Ibrahim Ibrahim, Bashir Shafa Abubakar, Michael Idoko Abah

Nigeria introduced the human papillomavirus (HPV) vaccine into its national routine immunization programme in October 2023, yet population-level data on vaccine acceptance, actual uptake, and cervical cancer screening remain limited, particularly in north-central Nigeria. This study examined the prevalence and multilevel determinants of HPV vaccine acceptance, vaccine uptake, and cervical cancer screening uptake among women attending tertiary healthcare facilities in Nasarawa State, Nigeria. A facility-based cross- …

22.08.2026journal-article

JNCI: Journal of the National Cancer Institute

Benchmarking female breast cancer survival in africa, Central and South america, and asia (SURVCAN-3)

Mariam Zahwe, Ariana Znaor, Aude Bardot, Shalaka Joshi, Kyu-Won Jung, Reza Malekzadeh, Maria Paula Curado, Gholamreza Roshandel, Maria Cristina Diumenjo, Armando Cortés, Rama Ranganathan, Patumrat Sripan, Daniel Jurado-Fajardo, Andrea Falaschi, Imjai Chitapanarux, Isabelle Soerjomataram, SURVCAN-3 Registry Group

Abstract Background In limited-resource settings with high cancer mortality, conditional survival which is the probability of surviving given on survival after a certain period of time since diagnosis, can provide a patient-centred and clinically relevant prognosis indicator. We aimed to benchmark breast cancer prognosis using conditional survival estimates in Africa, Central and South America, and Asia. Methods We included data for 197,766 females with breast cancer diagnosed in 2008-2012, from 53 population-based …

22.08.2026journal-article

Current Gene Therapy

Efficacy and Safety of Immune Checkpoint Inhibitors for Recurrent or Metastatic Cervical Cancer: A Systematic Review and Meta-Analysis

Yuanyuan Li, Songyi Wang, Yirui Mai, Zhixi You, Yu Wang, Jiake Wang, Ye Lei

Background: Cervical cancer is a major global health challenge and requires the exploration of novel treatment strategies. Immune checkpoint inhibitors, particularly those targeting Programmed Death 1 (PD-1) and Programmed Death-Ligand 1 (PD-L1), have emerged as promising therapeutic agents in oncology. This study aimed to evaluate the efficacy and safety of these inhibitors in the treatment of cervical cancer. Methods: A comprehensive literature search was conducted across PubMed, Embase, Web of Science, Scopus, t …

22.08.2026journal-article

Brazilian Journal of Chemical Engineering

Integrating sequencing batch hybrid membrane bioreactor with ozonation for treatment of tissue paper wastewater

Fernanda Filipaki, Tiago José Belli, André Aguiar Battistelli, Jeanette Beber de Souza, Carlos Magno de Sousa Vidal

Abstract This study assessed the performance of a sequencing batch hybrid membrane bioreactor (SB-HMBR) coupled with ozonation for the treatment of tissue paper wastewater. The SB-HMBR was operated for 90 d with a cycle time of 8.5 h under two aeration intensities, corresponding to specific aeration demand per membrane area (SADₘ) of 0.32 and 0.16 m 3 m⁻ 2 h⁻ 1 . The permeate obtained under the lower aeration regime was further subjected to batch ozonation (3 and 4 g O 3 h − 1 ). Despite substantial variations in i …

22.08.2026journal-article

Journal of Ultrasound in Medicine

Assessing Treatment Efficacy in Alopecia Areata: A Combined High‐Frequency Ultrasound and Superb Microvascular Imaging Study

Meng Yang, Chen Zhao, Jia Chen, Xin Ai, Shouqiang Li, Zhuo Wang, Zhinuo Li, Zhirou Di, Bingxue Bai, Xiaoping Leng

Objectives The therapeutic goals for alopecia areata (AA) are to suppress local immune inflammation, restore hair follicle structure, and improve surrounding blood perfusion. However, current efficacy evaluations largely rely on subjective clinical observation and lack objective quantitative methods. High‐frequency ultrasound (HFUS) can clearly display the location and morphology of hair follicles. Combined with microvascular assessment techniques, it enables quantitative detection of low‐velocity blood flow and re …

22.08.2026journal-article

Scientific Reports

Enhanced liver injury and fibrosis markers after anti-PD-1 treatment in an HFD/CCl4-accelerated MASH-fibrosis mouse model

Panuwat Promsorn, Takashi Yamaguchi, Eriko Yamamoto, Syunsuke Shiba, Katsunori Yoshida, Noriyo Yamashiki, Koichi Tsuneyama, Shinji Shimoda, Makoto Naganuma

Abstract Immune checkpoint inhibitors show variable efficacy in hepatocellular carcinoma depending on etiology. In metabolic dysfunction-associated steatohepatitis (MASH), PD-1+ CD8+ T cells may paradoxically drive liver injury. We investigated whether PD-1 blockade exacerbates liver fibrosis in a non-neoplastic MASH environment. Male C57BL/6J mice were fed a high-fat diet (HFD) for 18 weeks, with weekly carbon tetrachloride (CCl4) during the final 12 weeks. Mice received anti-PD-1 antibody or isotype control every …

22.08.2026journal-article

Diseases of the Esophagus

P1.229. Prognostic Value of Tumor Length in Clinical T1–2N0M0 Esophageal Squamous Cell Carcinoma

YoHan Bae, JiYong Kim, Hyeong Ryul Kim, Yong-Hee Kim, Jae Kwang Yun

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – long term outcomes Background The TNM staging system for esophageal cancer defines the T stage by depth of invasion rather than tumor size. However, prognosis may vary within the same T stage. This study aimed to evaluate the prognostic value of tumor length in clinical T1–2N0M0 esophageal squamous cell carcinoma (ESCC). Methods This retrospective single-center study included 923 patients who underwent upfront surgery for cT1–2N0M0 ESCC bet …

22.08.2026journal-article

Diseases of the Esophagus

P1.127. A Case of Unresectable Advanced Esophageal Cancer Successfully Treated With ICI Regimen and RIC

Yoshihiro Tanaka, Noya Masuda, Jyun Takada, Yuta Sato, Yuji Hatanaka, Itaru Yasufuku, Masahiro Fukada, Asai Ryuichi, Tajima Jesse Yu, Nobuhisa Matsuhashi, Masahito Shimizu

Abstract Topic Esophageal Cancer: Oncology/Radiation Therapy Background Immune checkpoint inhibitors are used for unresectable, advanced, and recurrent esophageal cancer. Currently, the Japan Esophageal Society recommends a 5Fu/CDDP + ICI regimen as first-line treatment. Here, we present a suggestive case of a patient with dysphasia score 4 who had extensive infiltration of the aorta, trachea, and bronchi, in whom an ICI regimen and endoscopic treatment were effective. Methods Case presentation: A woman in her 60s …

22.08.2026journal-article

Diseases of the Esophagus

P1.195. A Machine Learning Model for Predicting Anastomotic Leak in Esophageal Cancer Patients Undergoing Esophagectomy: A Single-Center Retrospective Study

Chi Zhang, Yongde Liao

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications Background Anastomotic leak (AL) is one of the most severe complications after esophagectomy. Early identification of high-risk patients may help optimize perioperative management and improve outcomes. Machine learning (ML) offers promising tools for clinical prediction, yet studies applying ML to predict AL risk after esophagectomy remain scarce. This study aimed to develop and compare ML-based models using …