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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
30.08.2026journal-article

Journal of Clinical Medicine

Comparison of the Effects of Sorafenib and Stem Cell Secretome on HepG2 Cancer Cells with Respect to the Ras/Raf/MEK/ERK Pathway

Aleksandra Gładyś, Aleksandra Skubis-Sikora, Bartosz Sikora, Kinga Pogoda-Mieszczak, Patrycja Wieczorek, Edyta Bogunia, Piotr Czekaj

Background/Objective: Liver cancer is a global health challenge due to its resistance to most systemic therapies. Human mesenchymal and epithelial stem cells exhibit anti-proliferative and pro-apoptotic effects on some cancer cell lines, which can be used to support standard therapy. The aim of this study was to investigate the effects of conditioned media (CM) derived from mesenchymal adipose tissue-derived stem cells (hADSCs) and amniotic membrane-derived cells expressing both mesenchymal and epithelial markers ( …

30.08.2026journal-article

Clinical Medicine (Russian Journal)

Causes of pulmonary bleeding in cancer patients

Roman S. Kiselev, Evgeniy A. Tarabrin, Z. G. Berikkhanov, S. Yu. Muravev, M. Yu. Ivanova

Objective. To analyze the causes of pulmonary hemorrhage (PH) in cancer patients. Material and methods. During the period 2010–2022, pulmonary hemorrhage was treated in cancer patients. The causes of PH were analyzed based on the nosology of cancer diseases. The involvement of the great circle of circulation (GCC) was determined based on the presence of direct or indirect radiological signs of bronchial angiography, the clinical outcome of endovascular treatment for PH, and the results of autopsy. CT of the chest w …

30.08.2026journal-article

Clinical Medicine (Russian Journal)

Secondary haemophagocytic lymphohistiocytosis in blood malignancies. The multicentre retrospective study

Vsevolod G. Potapenko, Alina S. Antipova3, Julia A. Zhuravleva, Yulia V. Zabutova, Alina Yu. Zavyalova, Irina V. Ishmatova, Elena V. Karyagina, Natalia A. Kotova, Valeria V. Kozyro, Tatiana G. Kulibaba, Daniil A. Manaenkov, Nadezhda V. Medvedeva, Natalia B. Mikhailova, Olga V. Nebelitskaya, Elena S. Pavlyuchenko, Victoria V. Ryabchikova, Irina A. Samorodova, Alexander V. Serkov, Irina A. Skorokhod, Kseniya A. Skoryukova, Tatiana V. Fedorenko, Darya A. Chaginskaya, Vasily A. Shuvaev, Vadim I. Mazurov

Haemophagocytic syndrome (HPS) or haemophagocytic lymphohistiocytosis is a reaction of severe but ineffective inflammation. Blood malignancies (BlM) are among the frequent causes of HPS in adults. Objective. To analyse survival, causing trigger haemoblastosis, relationship with tumor and efficacy of including etoposide in chemotherapy of patients with secondary HPS-BlM. Material and methods. A retrospective analysis of case histories of patients with BlM complicated by SHPS was performed. The diagnosis of SHPS was …

30.08.2026journal-article

ANZ Journal of Surgery

Managing Outliers in Australian Surgical Clinical Quality Registries

Alun Cameron, Konstance Nicolopoulos, R. James Aitken, Helena Kopunic, Wendy Babidge, Guy J. Maddern

ABSTRACT Clinical quality registries (CQRs) are central to improving surgical safety and quality by enabling systematic monitoring of outcomes and proactive identification of outliers. Published guidelines provide important advice on methods and activities for CQRs. Guideline flexibility allows for the varied and unique requirements of each CQR, but some aspects around guideline implementation are less certain, particularly for outlier management. In order to describe activities in Australia and the UK, searches we …

30.08.2026journal-article

Journal of the American Heart Association

Sex Differences in Treatment Effect of Adjunctive Intra‐Arterial Urokinase After Successful Thrombectomy: A Post Hoc Secondary Analysis of the POST‐UK Randomized Clinical Trial

Xuanyu Chen, Linyu Li, Gaoming Li, Lingyu Zhang, Haoxuan Zhu, Xu Xu, Jinfu Ma, Lilan Wang, Zhixi Wang, Jiayu Li, Qiuyi Yang, Yian Chen, Mingyang Chen, Yihui Yang, Yuhan Fan, Kaiyuan Feng, Chunye Chen, Jiaxing Song, Wenjie Zi, Kunxin Lin

Background Whether adjunct intra‐arterial urokinase has differential effectiveness and safety by sex among patients with acute ischemic stroke who achieve near‐complete to complete reperfusion after endovascular thrombectomy (EVT) remains unknown. Methods This post hoc analysis of the POST‐UK (Adjunctive Intra‐Arterial Urokinase After Successful Endovascular Thrombectomy in Patients With Large‐Vessel Occlusion Stroke) multicenter randomized clinical trial included 534 patients with proximal intracranial large‐vesse …

30.08.2026journal-article

Journal of International Medical Research

Clinical features of primary intestinal follicular lymphoma: A single-center retrospective study

Chun-Lin Ying, Tian-Qi Zhao, Qin-Xue Pu, Han-Cheng Huang, Wei Liu

Objective To characterize the clinical features of primary intestinal follicular lymphoma and provide insights into its diagnosis and management. Methods We retrospectively analyzed the clinical, endoscopic, imaging, pathological, and long-term follow-up data of eight patients with primary intestinal follicular lymphoma who were admitted between January 2019 and August 2025. Results The mean patient age was 58.13 years, and 75.00% of patients were women. Abdominal pain (62.50%) was the most common clinical manifest …

30.08.2026journal-article

Journal of Artificial Intelligence and Information

Construction and Practice of an Industry-Education Integration Curriculum System for Vocational Rehabilitation Therapy Technology Based on the ERAS Concept — Evaluation of Clinical Internship Teaching Effectiveness

Tian Zhu, Xianting Ju, Zidi Guo, Futian Ren, Yumeng Zhao

Accelerated Recovery After Surgery (ERAS) refers to a multidisciplinary collaborative approach centered around the perioperative period. While some hospitals in China have already implemented ERAS, it has not yet been introduced into the teaching or internship programs of higher vocational rehabilitation therapy technology majors. Currently, vocational rehabilitation programs face limited progress in industry-education collaboration, with few jointly developed courses by schools and enterprises, and insufficiently …

30.08.2026journal-article

Brain and Behavior

Comorbidity Mechanism and Management of Chronic Low Back Pain and Major Depressive Disorder: From Neural Circuit Remodeling to Precision Medicine

Lin Faqu, Lin Chenjuan, Xiang Xiangyin, Li Xin

ABSTRACT Objective This review systematically elaborates multi‐system interactive mechanisms underlying comorbid chronic low back pain (CLBP) and major depressive disorder (MDD), synthesizes recent advances in diagnosis, treatment, and management, and proposes precision medicine directions to address clinical challenges, including missed diagnosis, treatment resistance, and poor prognosis. Method We reviewed 86 studies published between 2015 and 2025 from the PubMed, Embase, and CNKI databases. We focused on basic …

30.08.2026journal-article

Libyan Journal of Medical Research

Study on Ginger as a Treatment for Stress and Anxiety Comparing With Diazepam

Ashraf Alzalitini, Naima El-Kakalli, Wafa Issadiq

Background: The psychological anxiety is considered one of the most significant animals of the modern era. The most common causes natural indictors that lead to tension, severe stress and un-desirable mental problems or disease are stress Anxiety problems or disease that considered as most frequently appearing as disorders. Anxiety disease is diagnosing as condition that showed or indicate to serious and severe or pathological case as the essential disturbance emotional tone. Aim: In this study, ginger was tested i …

30.08.2026journal-article

Journal of Family Medicine and Preventive Medicine

Ideas from Complex Systems Theory: Peer-led Community Preventive Health for a WHO (2007) ‘Whole Prison’ Approach to Health

Graham Betts-Symonds

This article is presented following fourteen years of experience with an innovative approach to preventive health in all Irish Prisons. During this period, University-led and internal evaluations have demonstrated increased engagement with prison populations by trained inmate peer educators, linked to formal prison health, psychology and addiction service professionals [1-3].

30.08.2026journal-article

Journal of Gazi University Health Sciences Institute

Perioperative Care in Breast-Conserving Surgery Patients: An Evidence-Based Perioperative Care Protocol

Büşra Çırak Sağdıç, Sevil Güler

Breast-conserving surgery (BCS) is a commonly used treatment method for early-stage breast cancer that offers cosmetic benefits while ensuring oncological safety. However, postoperative complications and the current trend toward shorter hospital stays necessitate the systematic and standardized planning of perioperative care. The aim of this review is to comprehensively address the perioperative care process in patients undergoing BCS based on the literature and to present an evidence-based care protocol that can b …

30.08.2026journal-article

Frontiers on Healthcare Research

Factors Associated with Platelet Recovery in Dengue Patients on Fever Day 7

Faculty of Medicine, Universitas Andalas, Padang, Indonesia, Ghina Shofi Ikrima Ghina Shofi, Department of Clinical Pathology, Faculty of Medicine, Universitas Andalas, Padang, Indonesia, Elfira Yusri Elfira, Department of Internal Medicine, Faculty of Medicine, Universitas Andalas, Padang, Indonesia, Fadrian Fadrian Fadrian, Department of Physiology, Faculty of Medicine, Universitas Andalas, Padang, Indonesia, Efrida Efrida Efrida, Mutia Lailani Mutia, Department of Biochemistry, Faculty of Medicine, Universitas Andalas, Padang, Indonesia, Yustini Alioes Yustini

<p style="font-weight: 400;"><strong>Background:</strong> Thrombocytopenia is a common hematological feature of dengue infection, and platelet recovery is a reliable prognostic indicator. The seventh day of fever typically marks the beginning of the recovery phase, but some patients show delayed platelet recovery. This study aimed to identify the factors affecting platelet recovery in adult dengue patients on fever day 7.</p> <p style="font-weight: 400;"><strong>Methods:</strong> This cross-sectional study was cond …

30.08.2026journal-article

Magnetic Resonance in Medicine

Servo Navigation and Phase Equalization Enhanced by Run‐Time Stabilization (PEERS) for 3D EPI Time Series

Malte Riedel, Thomas Ulrich, Samuel Bianchi, Klaas P. Pruessmann

Purpose To enhance time‐resolved segmented imaging by synergy of run‐time stabilization and retrospective data‐driven phase correction. Methods A segmented 3D EPI sequence for fMRI time series is equipped with servo navigation based on short orbital navigators and a linear perturbation model, enabling run‐time correction for rigid‐body motion, bulk phase, and frequency fluctuations. Complementary retrospective phase correction is based on the repetitive structure of the time series and serves to address residual ph …

30.08.2026journal-article

Diagnostics

Preoperative Bioelectrical Impedance Analysis Identifies Altered Body Composition, Which Is Associated with Severe Postoperative Complications in Major Hepatopancreaticobiliary Surgery

Clemens Schmutzhart, Martin Varga, Julian Seethaler, Tarkan Jäger, Gunnar Treff, Giorjines Boppre, Jan David Smeddinck, Josef Niebauer, Wolfgang Hitzl, Klaus Emmanuel, Stefan Löb

Background: Altered body composition is common in patients undergoing major hepatopancreaticobiliary (HPB) surgery and may be associated with increased postoperative morbidity. Conventional markers such as body mass index (BMI) and serum albumin have limited sensitivity for detecting early nutritional changes. Bioelectrical impedance analysis (BIA) provides an objective assessment of body composition, and phase angle (PA) may serve as a proxy for cellular status. Methods: This single-center retrospective observatio …

30.08.2026journal-article

Small

Poly (Lipoic Acid) Nanoparticles With High Blood‐Brain Barrier Permeability and Enhanced Anti‐Ferroptotic Activity for Ischemic Stroke Treatment

Qing‐Zhang Tuo, Juan Tan, Hong‐Fa Yan, Xueying Zhou, Peng Lei, Shiyong Zhang

ABSTRACT Lipoic acid (LA) scavenges free radicals and was clinically tested for ischemic stroke. However, the short half‐life and weak efficacy in penetrating the blood‐brain barrier (BBB) limit its use in the brain. Here, we developed poly (lipoic acid) nanoparticles (pLANs) with a half‐life of more than 15 h and a high efficiency to penetrate the BBB for ischemic stroke treatment. With intraperitoneal injection, imaging studies using fluorescently labelled pLANs of different sizes revealed that 30 nm pLANs entere …

30.08.2026journal-article

Arthroscopy

Dermal Allograft Patch Augmentation With Mini‐Open Triple‐Row Repair for Large to Massive Rotator Cuff Tears Results in a Low Retear Rate and Favorable Clinical Outcomes Without Adverse Events

Du‐Han Kim, Seong Woo Jeon, Eun‐Seok Son, Chul‐Hyun Cho

Purpose To evaluate radiological and clinical outcomes, as well as adverse events, after dermal allograft patch (DAP) augmentation with rotator cuff repair for large to massive rotator cuff tears (RCTs). Methods Fifty consecutive patients who underwent DAP augmentation with arthroscopic‐assisted mini‐open triple‐row suture bridge repair for large to massive RCTs were retrospectively reviewed. The inclusion criteria were posterosuperior large to massive RCTs (>3 cm) and a minimum 24‐month follow‐up after surgery. St …

30.08.2026journal-article

Caucasian Medical Journal

Systemic lupus erythematosus masquerading as ulcerative colitis: a clinical case of lupus enteritis

Ilkana Guliyeva, Fidan Gasimova, Gulnara Nur-Mammadova, Nargiz Guseynova, Magrur Mammadov, Nijat Bayimov

Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease with a wide range of clinical features. Involvement of the gastrointestinal tract (GIT), especially in the form of lupus enteritis, can imitate inflammatory bowel disease (IBD), making diagnosis difficult. We present the case of a young woman with previously diagnosed ulcerative colitis, who subsequently showed immunological and clinical signs of SLE with the development of lupus enteritis. This case highlights the need for a comprehensive immun …

30.08.2026journal-article

Clinical and Experimental Dental Research

Antibiofilm Activity of a Thermoformable Material Loaded With Essential Oil Solution

Alexandra Stähli, Markus Laky, Anton Sculean, Tino Töpper, Sigrun Eick

ABSTRACT Background Interest in antimicrobial surfaces for dental devices, such as aligners and brackets, is growing. These surfaces are designed to retard biofilm formation. One approach is to load essential oils (EOs) into the material. The focus of this study was the antibacterial, anti‐biofilm, and anti‐inflammatory activities of an EO solution. Methods The EO solution contained cinnamaldehyde, methyl salicylate, eucalyptol, limonene, and trans‐anethole dissolved in distilled water (dH 2 O) with polyglycerol‐4‐ …

30.08.2026journal-article

Chronic Diseases and Translational Medicine

Baseline Body Mass Index Category and Incident Treated Hypertension in Australian Men: A Linked Prospective Cohort Study Using PBS/MBS Data

Ebenezer Afrifa‐Yamoah

ABSTRACT Background Excess adiposity is a major modifiable risk factor for hypertension; however, the incremental prognostic value of body mass index (BMI) beyond standard predictors remains unclear. We examined the associations between baseline BMI category and incident treated hypertension, and assessed whether BMI improved risk prediction. Methods Data were obtained from the Ten to Men longitudinal study (2013–2024) linked to Pharmaceutical Benefits Scheme (PBS) and Medicare Benefits Schedule (MBS) records. The …

30.08.2026journal-article

MedComm

Migraine: Epidemiology, Risk Factors, Pathophysiology, and Treatment

Weiwei Lu, Yuan Zhang, Chen Shi, Yu Tao, Shaoxin Li, Yufang Sun, Fuhai Ji, Dongsheng Jiang, Terrance P. Snutch, Jin Tao

ABSTRACT Migraine is a common, disabling brain disorder that affects about 1 billion people worldwide and disproportionately burdens women and working‐age adults. Once viewed mainly as a vascular headache, migraine is now understood as a heterogeneous neurobiological syndrome arising from interactions among genetic susceptibility, hormonal influences, environmental exposures, and cortical, brainstem, trigeminovascular, and neuroinflammatory networks. Although calcitonin gene‐related peptide (CGRP)‐pathway therapies …

30.08.2026journal-article

Pakistan Journal of Clinical Research

Frequency of Peripheral Neuropathy in Diabetic Patients with and Without Anemia: An Analytical Comparative Cross-Sectional Study

Farhat Ullah Bakhsh, Shamaila Burney

Background: Diabetic peripheral neuropathy (DPN) is a common complication of diabetes, causing sensory loss, pain, gait impairment, ulcers, and amputation. Its substantial burden in Pakistan warrants systematic screening, while anemia and vitamin B12 deficiency may further contribute to neuropathic clinical manifestations. To evaluate the DPN frequency in patients with and without anemia in diabetic patients to determine the independent predictors. Methods: 192 adults type 2 diabetes were studied using an analytic …

30.08.2026journal-article

Nephrology

Clinical Predictors of Non‐Diabetic Glomerular Disease in Type 2 Diabetic Patients With Nephrotic‐Range Proteinuria

Sittipath Tirasattayapitak, Kanin Thammavaranucupt, Kavee Limbutara, Nitcha Suphatheerawatr, Wanjak Pongsittisak, Chutima Chavanisakun, Nontawat Benjakul, Solos Jaturapisanukul

ABSTRACT Aim Nephrotic‐range proteinuria in patients with Type 2 diabetes mellitus (T2DM) may result from diabetic nephropathy or non‐diabetic glomerular disease (NDGD). Kidney biopsy risks and limited accessibility complicate patient selection. We aimed to identify predictors of NDGD and develop a score to guide biopsy decisions. Methods We conducted a single‐center retrospective study of T2DM patients undergoing native kidney biopsy for nephrotic‐range proteinuria at a tertiary hospital in Thailand between 2014 a …

30.08.2026journal-article

International Journal of Molecular Sciences

Unique Features of Melanoma Risk and Diagnosis in Red-Haired Populations

Kiran R. Ebrahimi, Stephen M. Ostrowski, David E. Fisher

Cutaneous melanoma is the most lethal skin cancer, and risk is strongly shaped by pigmentary phenotype. The red-hair color phenotype, marked by red hair, fair skin, freckling, and poor tanning, carries elevated melanoma risk driven largely by loss-of-function variants in the melanocortin 1 receptor gene (MC1R). This risk is not explained by reduced ultraviolet protection alone. Impaired MC1R signaling shifts melanogenesis from photoprotective eumelanin toward pheomelanin, a pigment associated with oxidative stress …

30.08.2026journal-article

International Journal of Human and Health Sciences (IJHHS)

Clinical Features and Outcomes of Dengue Fever in a Tertiary Paediatric Hospital in Dhaka, Bangladesh

Md Aktaruzzaman, Sharmin Afroze, Farhana Ahmed, Mostafizur Rahman, Gazi Abdul Bari, Kiriti Kumar Dhali

Globally, children, adolescents, and young adults constitute the largest burden of Dengue. Early diagnosis is crucial for timely intervention and better outcome. This cross-sectional study was conducted among 51 children with dengue fever admitted in the Department of Paediatrics, Dr. M R Khan Shishu Hospital & Institute, Dhaka, Bangladesh, between April and September of 2025, to assess the clinical features of the dengue infection in children and to evaluate the outcomes. The most common age of presentation was be …