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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
22.08.2026journal-article

Diseases of the Esophagus

P1.152. Quality of Life Outcomes Post Esophagectomy: a Prospective Study in an Apex Cancer Care Institution

JAI HARI M S

Abstract Topic Esophageal Cancer: Other Background Carcinoma of the esophagus significantly affects quality of life (QOL), particularly due to symptoms such as dysphagia and nutritional compromise. While transthoracic esophagectomy remains a standard curative modality, it is associated with substantial perioperative morbidity. Evaluation of postoperative QOL is essential to understand functional recovery and patient outcomes. Methods AIM To study the impact of esophagectomy on health related quality of life (HR QOL …

22.08.2026journal-article

Diseases of the Esophagus

VA03.3. Laparoscopic Treatment of Intramural Diverticulum in Type III Achalasia

Andre Brandalise, Claudia Lorenzetti

Abstract Topic Benign Disease: Esophageal Surgery Background Achalasia is a primary esophageal motility disorder characterized by impaired lower esophageal sphincter relaxation and absent peristalsis. Chronic functional obstruction may lead to structural complications, including esophageal dilation and, rarely, diverticulum formation. The coexistence of achalasia and esophageal diverticulum presents diagnostic and therapeutic challenges. Methods We present a video of a 67-year-old female presenting with dysphagia, …

22.08.2026journal-article

Diseases of the Esophagus

P1.114. Endoscopic Diagnosis of Esophageal Cancer Using Ultra-High Magnification Endocytoscopy

Youichi Kumagai, Kenro Kawada, Kaiyo Takubo

Abstract Topic Esophageal Cancer: New Diagnostic Modalities (Including PET, PET-CT, New Tracers) Background Background Ultra-high magnification endoscopic observation using endocytoscopy (EC) enables cellular-level visualization and allows in vivo assessment comparable to histopathological diagnosis. We previously proposed a three-tier classification system based on surface cellular morphology and reported that Type 3 lesions can be diagnosed histologically as malignant using EC images alone. Methods Patients and M …

22.08.2026journal-article

Diseases of the Esophagus

P1.104. Potential Survival Benefit of Longitudinal ctDNA-Guided Treatment Adaptation in Advanced Esophageal Cancer

Takeshi Iwaya, Fumitaka Endo, Ryosuke Fujisawa, Haruka Nikai, Hayato Hiraki, Akiko Yashima-Abo, Hiroaki Itamochi, Satoshi Nishizuka

Abstract Topic Esophageal Cancer: Management of Metastatic Cancer Background We have developed a tumor-specific circulating tumor DNA (ctDNA) monitoring test using digital PCR, termed the OTS (off-the-shelf)-assay. While recent attention has focused on minimal residual disease detection for early relapse diagnosis and to guide adjuvant therapy decisions, we have emphasized the importance of timely treatment management based on serial ctDNA dynamics. Methods In our previous study of 42 patients with esophageal cance …

22.08.2026journal-article

Diseases of the Esophagus

PD07.09. Neoadjuvant Immuno-Chemotherapy as an Initial Treatment Strategy for Esophageal Squamous Cell Carcinoma With Synchronous Primary Cancers in Pharynx and Larynx

Haojun Hong, Yuchen Su, Hui Chen, Kaiyuan Zhu, Hong Zhang, Wei Xu, Jiapeng Ding, Chang Yuan, Yuxin Yang, Yang Yang, Chunguang Li, Ning Ma, Zhichao Liu, Zhigang Li

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background Esophageal squamous cell carcinoma (ESCC) with synchronous primary cancers in pharynx and larynx (SPC-PL) is rare and lacks standard-of-care treatment. This study examined tumor response and survival after neoadjuvant immuno-chemotherapy (nICT) in ESCC patients with SPC-PL. Methods This retrospective single-center study analyzed 21 patients with ESCC and SPC-PL who received nICT between 2020 and 2024. Treatment response was evaluated u …

22.08.2026journal-article

Nature Communications

Constitutive natural killer cell features associated with post-treatment control of SIV infection in the pVISCONTI study

Anaïs Chapel, Luis Romero-Martín, Caroline Passaes, Valérie Monceaux, Stevenn Volant, Delphine Desjardins, Adeline Melard, Annie David, Nathalie Dereuddre-Bosquet, Christine Rouzioux, Véronique Avettand-Fenoel, Michaela Müller-Trutwin, Roger Le Grand, Asier Sáez-Cirión

Abstract Post-treatment HIV controllers (PTC) offer a unique opportunity to uncover the determinants of durable remission after antiretroviral therapy (ART) interruption. Here, using six PTC and six post-treatment non-controllers from the pVISCONTI study in cynomolgus macaques, we identify associations between Natural Killer (NK) cell subsets and outcomes following ART interruption. NKG2Ahigh NK cells lacking NKp30/NKp46 (NKG2AhighNKp30-NKp46-), shaped by the MHC backgrounds of the animals, were linked to improved …

22.08.2026journal-article

International Journal of Biomedical Research and Innovations

MULTILEVEL DETERMINANTS OF HUMAN PAPILLOMAVIRUS VACCINE ACCEPTANCE AND UPTAKE, AND CERVICAL CANCER SCREENING UPTAKE, AMONG WOMEN ATTENDING TERTIARY HEALTHCARE FACILITIES IN NASARAWA STATE, NIGERIA: A CROSS-SECTIONAL STUDY

Dogara Manga Manga, Ishaku Akyala Adamu, Yusuf Ibrahim Ibrahim, Bashir Shafa Abubakar, Michael Idoko Abah

Nigeria introduced the human papillomavirus (HPV) vaccine into its national routine immunization programme in October 2023, yet population-level data on vaccine acceptance, actual uptake, and cervical cancer screening remain limited, particularly in north-central Nigeria. This study examined the prevalence and multilevel determinants of HPV vaccine acceptance, vaccine uptake, and cervical cancer screening uptake among women attending tertiary healthcare facilities in Nasarawa State, Nigeria. A facility-based cross- …

22.08.2026journal-article

JNCI: Journal of the National Cancer Institute

Benchmarking female breast cancer survival in africa, Central and South america, and asia (SURVCAN-3)

Mariam Zahwe, Ariana Znaor, Aude Bardot, Shalaka Joshi, Kyu-Won Jung, Reza Malekzadeh, Maria Paula Curado, Gholamreza Roshandel, Maria Cristina Diumenjo, Armando Cortés, Rama Ranganathan, Patumrat Sripan, Daniel Jurado-Fajardo, Andrea Falaschi, Imjai Chitapanarux, Isabelle Soerjomataram, SURVCAN-3 Registry Group

Abstract Background In limited-resource settings with high cancer mortality, conditional survival which is the probability of surviving given on survival after a certain period of time since diagnosis, can provide a patient-centred and clinically relevant prognosis indicator. We aimed to benchmark breast cancer prognosis using conditional survival estimates in Africa, Central and South America, and Asia. Methods We included data for 197,766 females with breast cancer diagnosed in 2008-2012, from 53 population-based …

22.08.2026journal-article

Current Gene Therapy

Efficacy and Safety of Immune Checkpoint Inhibitors for Recurrent or Metastatic Cervical Cancer: A Systematic Review and Meta-Analysis

Yuanyuan Li, Songyi Wang, Yirui Mai, Zhixi You, Yu Wang, Jiake Wang, Ye Lei

Background: Cervical cancer is a major global health challenge and requires the exploration of novel treatment strategies. Immune checkpoint inhibitors, particularly those targeting Programmed Death 1 (PD-1) and Programmed Death-Ligand 1 (PD-L1), have emerged as promising therapeutic agents in oncology. This study aimed to evaluate the efficacy and safety of these inhibitors in the treatment of cervical cancer. Methods: A comprehensive literature search was conducted across PubMed, Embase, Web of Science, Scopus, t …

22.08.2026journal-article

Brazilian Journal of Chemical Engineering

Integrating sequencing batch hybrid membrane bioreactor with ozonation for treatment of tissue paper wastewater

Fernanda Filipaki, Tiago José Belli, André Aguiar Battistelli, Jeanette Beber de Souza, Carlos Magno de Sousa Vidal

Abstract This study assessed the performance of a sequencing batch hybrid membrane bioreactor (SB-HMBR) coupled with ozonation for the treatment of tissue paper wastewater. The SB-HMBR was operated for 90 d with a cycle time of 8.5 h under two aeration intensities, corresponding to specific aeration demand per membrane area (SADₘ) of 0.32 and 0.16 m 3 m⁻ 2 h⁻ 1 . The permeate obtained under the lower aeration regime was further subjected to batch ozonation (3 and 4 g O 3 h − 1 ). Despite substantial variations in i …

22.08.2026journal-article

Journal of Ultrasound in Medicine

Assessing Treatment Efficacy in Alopecia Areata: A Combined High‐Frequency Ultrasound and Superb Microvascular Imaging Study

Meng Yang, Chen Zhao, Jia Chen, Xin Ai, Shouqiang Li, Zhuo Wang, Zhinuo Li, Zhirou Di, Bingxue Bai, Xiaoping Leng

Objectives The therapeutic goals for alopecia areata (AA) are to suppress local immune inflammation, restore hair follicle structure, and improve surrounding blood perfusion. However, current efficacy evaluations largely rely on subjective clinical observation and lack objective quantitative methods. High‐frequency ultrasound (HFUS) can clearly display the location and morphology of hair follicles. Combined with microvascular assessment techniques, it enables quantitative detection of low‐velocity blood flow and re …

22.08.2026journal-article

Scientific Reports

Enhanced liver injury and fibrosis markers after anti-PD-1 treatment in an HFD/CCl4-accelerated MASH-fibrosis mouse model

Panuwat Promsorn, Takashi Yamaguchi, Eriko Yamamoto, Syunsuke Shiba, Katsunori Yoshida, Noriyo Yamashiki, Koichi Tsuneyama, Shinji Shimoda, Makoto Naganuma

Abstract Immune checkpoint inhibitors show variable efficacy in hepatocellular carcinoma depending on etiology. In metabolic dysfunction-associated steatohepatitis (MASH), PD-1+ CD8+ T cells may paradoxically drive liver injury. We investigated whether PD-1 blockade exacerbates liver fibrosis in a non-neoplastic MASH environment. Male C57BL/6J mice were fed a high-fat diet (HFD) for 18 weeks, with weekly carbon tetrachloride (CCl4) during the final 12 weeks. Mice received anti-PD-1 antibody or isotype control every …

22.08.2026journal-article

Diseases of the Esophagus

P1.229. Prognostic Value of Tumor Length in Clinical T1–2N0M0 Esophageal Squamous Cell Carcinoma

YoHan Bae, JiYong Kim, Hyeong Ryul Kim, Yong-Hee Kim, Jae Kwang Yun

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – long term outcomes Background The TNM staging system for esophageal cancer defines the T stage by depth of invasion rather than tumor size. However, prognosis may vary within the same T stage. This study aimed to evaluate the prognostic value of tumor length in clinical T1–2N0M0 esophageal squamous cell carcinoma (ESCC). Methods This retrospective single-center study included 923 patients who underwent upfront surgery for cT1–2N0M0 ESCC bet …

22.08.2026journal-article

Diseases of the Esophagus

P1.127. A Case of Unresectable Advanced Esophageal Cancer Successfully Treated With ICI Regimen and RIC

Yoshihiro Tanaka, Noya Masuda, Jyun Takada, Yuta Sato, Yuji Hatanaka, Itaru Yasufuku, Masahiro Fukada, Asai Ryuichi, Tajima Jesse Yu, Nobuhisa Matsuhashi, Masahito Shimizu

Abstract Topic Esophageal Cancer: Oncology/Radiation Therapy Background Immune checkpoint inhibitors are used for unresectable, advanced, and recurrent esophageal cancer. Currently, the Japan Esophageal Society recommends a 5Fu/CDDP + ICI regimen as first-line treatment. Here, we present a suggestive case of a patient with dysphasia score 4 who had extensive infiltration of the aorta, trachea, and bronchi, in whom an ICI regimen and endoscopic treatment were effective. Methods Case presentation: A woman in her 60s …

22.08.2026journal-article

Diseases of the Esophagus

P1.195. A Machine Learning Model for Predicting Anastomotic Leak in Esophageal Cancer Patients Undergoing Esophagectomy: A Single-Center Retrospective Study

Chi Zhang, Yongde Liao

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications Background Anastomotic leak (AL) is one of the most severe complications after esophagectomy. Early identification of high-risk patients may help optimize perioperative management and improve outcomes. Machine learning (ML) offers promising tools for clinical prediction, yet studies applying ML to predict AL risk after esophagectomy remain scarce. This study aimed to develop and compare ML-based models using …

22.08.2026journal-article

Annals of Surgical Oncology

Complete Resection of Simultaneous Hepatic and Pulmonary Metastases from Colorectal Cancer in the Era of Modern Systemic and Surgical Therapies: A Systematic Review and Meta-Analysis

Dominik Wróbel, Patryk Rogaczewski, Patryk Dąbrowski, Wojciech Olejek, Jędrzej Borowczak, Paweł Michał Potocki

Abstract Background Data suggest promising outcomes with resection of simultaneous hepato-pulmonary metastases (HPM) from metastatic colorectal cancer (mCRC). However, there is no consensus regarding the effectiveness of this approach. Therefore, we aimed to evaluate the feasibility and clinical benefit of metastasectomy of simultaneous HPM from mCRC. Methods A systematic review and meta-analysis were conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines …

22.08.2026journal-article

Current Medicinal Chemistry

CDC20B Dysregulation: Links to Tumor Prognosis and Immunity

Hongrong Wu, Liangli Hong

Objective: This study aimed to clarify the pan-cancer expression pattern, upstream regulatory mechanisms, prognostic relevance, and immune associations of CDC20B. Method: Using public databases (GTEx, GEO, and TCGA), we examined CDC20B expression and its associations with prognosis and tumor immunity across multiple cancers. Immunohistochemistry (IHC) on an independent clinical cohort was performed to validate CDC20B upregulation in tumor tissues. Promoter methylation, genetic alterations, and immune infiltration w …

22.08.2026journal-article

Scientific Journal of Technology

Research on the Treatment Technology of Sulfur-Containing Tail Gas Using Chelated Iron

Ye Sun, Peng Wang, Rui Liu, Xueri Nan, Nan Wang, Wei Wang, Yan Sun

This study investigates a chelated iron‑based process for H₂S removal from sulfur‑containing tail gas. Eight chelating agents were evaluated for iron complexation capacity at different pH values. The effects of pH, chelator mixing ratio, and Fe³⁺/Fe²⁺ molar ratio on desulfurization performance were examined through 42 complex systems using MATLAB regression analysis. Results show that pH 8–9 enables >90% H₂S absorption. HEDP exhibited the highest iron complexation capacity (30.8 g/L at pH 10) but poor stability; TE …

22.08.2026journal-article

Diseases of the Esophagus

P1.068. Design Features of PRO-Based Remote Symptom Monitoring Interventions With Alert-Triggered Clinical Response in Cancer RCTs: A Systematic Review

Simiao Lu, Yi Zhu, Yongtao Han, Qiuling Shi, Xuefeng Leng

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications Background Patient-reported outcome (PRO)-based remote symptom monitoring with alert-triggered clinical response improves survival and quality of life in cancer patients. However, the design features constituting these complex interventions remain poorly characterised, limiting replication and optimisation. We conducted a systematic review to characterise the methodological architecture of such interventions …

22.08.2026journal-article

Diseases of the Esophagus

P1.110. Overexpression of DTL Relates to Tumor Cell Proliferation and Malignant Outcome of Esophageal Squamous Cell Carcinoma

Masateru Yamauchi, Shuhei Komatsu, Keiji Nishibeppu, Takuma Ohashi, Taisuke Imamura, Jun Kiuchi, Hiroshi Arakawa, Ryo Ishida, Satoshi Hamada, Hiroyuki Kanazawa, Tsutomu Kawaguchi, Hirotaka Konishi, Hitoshi Fujiwara, Hitoshi Tsuda, Issei Imoto, Atsushi Shiozaki

Abstract Topic Esophageal Cancer: Molecular Biology/Pathology Background Comparative genomic hybridization (CGH) method has contributed to the analysis of amplification and deletion of various genes. We detected Denticleless E3 ubiquitin protein ligase homolog (DTL) using the Agilent 244k oligo-array CGH and FISH analyses for 1q32 amplification among 22 genes in esophageal squamous cell carcinoma (ESCC) and investigated DTL as a cancer promoting gene. Methods We analyzed 43 ESCC cell lines and 113 primary ESCC samp …

22.08.2026journal-article

Diseases of the Esophagus

P1.176. Cardiac Predictors of Esophageal Cancer Inoperability Using Coronary CT and Cardiac MRI

Tamás Vass, Miklós Vértes, Stephan Bennemann, András Herczeg, Ákos Balázs, Attila Szijártó, Zsófia Dóra Drobni

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background Surgery remains a key part of multimodal esophageal cancer treatment but carries high morbidity and mortality. Early detection of patients unfit for major surgery is essential. We examined if thorough cardiac evaluation can predict surgical operability in esophageal tumor patients. Methods We prospectively included patients with esophageal tumors during pre-treatment workup. Coronary CT angiography assessed Agatston calcium score ( …

22.08.2026journal-article

Diseases of the Esophagus

PD07.02. Real-World Outcomes of Adjuvant Nivolumab After Surgery Following NAC/NACRT for Esophageal Cancer

Hayato Shimoyama, Ryo Shibayama, Kentoku Fujisawa, Yusuke Ogawa, Shusuke Haruta, Masaki Ueno

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background The CheckMate 577 trial demonstrated the efficacy of adjuvant nivolumab in patients with esophageal cancer who did not achieve a pathological complete response after neoadjuvant chemoradiotherapy (NACRT). In Japan, however, adjuvant nivolumab is also administered to patients treated with neoadjuvant chemotherapy (NAC), although its real-world effectiveness in this population has not been fully validated. We evaluated the real-world out …

22.08.2026journal-article

Small

Efficient Colon Cancer Immunogene Therapy by Hydrogel Ball Loaded With Two Types of Cell Membrane‐Coated Nanoparticles

Jingmei Li, Jin Zhang, Xiayu Chen, Shan Wu, Jieping Wu, Xizi Fu, Yan Gao, Lixia Guo, Xingmei Duan, Ke Men

ABSTRACT Biomimetic technology has high potential for enhancing cancer immunogene therapy. Cell membrane‐coated nanoparticles (CMNPs) obtain extra targeting, recognition, and signaling transduction functions. However, a single kind of CMNPs is limited when facing complicated tumor immunogene therapy. Here reported the collaboration of two types of CMNPs using a double‐layered spherical scaffold. This scaffold was prepared by stacking photosensitive hydrogels with two concentrations. After implantation, the two laye …

22.08.2026journal-article

The Oncologist

Prognostic Significance of Positive Margin-Informed Tumor Status in Esophageal Squamous Cell Carcinoma Using Next-Generation Sequencing

Di Lu, Yu Tong, Chunhong He, Zhiming Chen, Zhizhi Wang, Jingwen Liu, Jiani C Yin, Shaobin Li, Shijie Mai, Xuguang Rao, Kaican Cai

Abstract Background Reliable prognostic biomarkers are urgently needed for operable esophageal squamous cell carcinoma (ESCC), as conventional histopathology often fails to detect minimal residual disease and accurately predict patient outcomes. Patients and Methods This study investigated the mutational patterns in ESCC and the prognostic value of shared mutations between tumors and margins (margin-informed tumor, MiT) using next-generation sequencing. We analyzed tumor, margin, and normal tissues from a total of …